Acetaminophen-induced liver oxidative stress and hepatotoxicity: influence of Kupffer cell activity assessed in the isolated perfused rat liver

REFERENCES

• Farber J L. Biochemical mechanisms of toxic cell injury. Klin Wochenschr 1986; 64: 142–143.
   PubMedGoogle Scholar
• Jollow D J, Thorgeirsson S S, Potter W Z, Hashimoto M, Mitchell J R. Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and non-toxic doses of acetaminophen. Pharmacology 1974; 12: 251–271.
   PubMed Web of Science ®Google Scholar
• Dahlin D C, Miwa G T, Lu A Y H, Nelson S D. N-Acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984; 81: 1327–1331.
   PubMed Web of Science ®Google Scholar
• Potter D W, Hinson J A. The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase. J Biol Chem 1987; 262: 974–980.
   PubMed Web of Science ®Google Scholar
• Ji S. A general theory of chemical cytotoxicity based on a molecular model of the living cell, the Bhopalator. Arch Toxicol 1987; 60: 95–102.
   PubMed Web of Science ®Google Scholar
• Jollow D J, Mitchell J R, Potter W Z, Davies D C, Gillette J R, Brodie B B. Acetaminophen-induced hepatic necrosis, II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187: 195–202.
   PubMed Web of Science ®Google Scholar
• Reiter R, Wendel A. Drug-induced lipid peroxidation in mice. IV. In vitro hydrocarbon evolution, reduction of oxygen and covalent binding of acetaminophen. Biochem Pharmacol 1983; 32: 665–670.
   PubMed Web of Science ®Google Scholar
• Gerson R J, Cosini A, Gilfer D, Serroni A, Farber J L. Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen. Biochem Biophys Res Commun 1985; 126: 1129–1137
   PubMed Web of Science ®Google Scholar
• Moore M, Thor H, Moore G, Nelson S, Moldeus P, Orrenius S. The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. J Biol Chem 1985; 260: 13035–13040.
   PubMed Web of Science ®Google Scholar
• Anundi I, Lähteenmäki T, Rundgren M, Moldeus P, Lindros K O. Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes. Biochem Pharmacol 1993; 45: 1251–1259.
   PubMed Web of Science ®Google Scholar
• Laskin D L, Pilaro A M, Ji S. Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol Appl Pharmacol 1986; 86: 204–215.
   PubMed Web of Science ®Google Scholar
• Laskin D L, Pilaro A M, Ji S. Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation. Toxicol Appl Pharmacol 1986; 86: 216–226.
   PubMed Web of Science ®Google Scholar
• Nathan C F. Secretory products of macrophages. J Clin Invest 1987; 79: 319–326.
   PubMed Web of Science ®Google Scholar
• Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 1990; 192: 245–262.
   PubMedGoogle Scholar
• Hardonk M J, Dijkhuis F W J, Hultaert C E, Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukocyte Biol 1992; 52: 296–302.
   PubMed Web of Science ®Google Scholar
• Videla L A, Smok G, Troncoso P, Simon K A, Junqueira V B C, Fernández V. Influence of hyperthyroidism on lindane-induced hepatotoxicity in the rat. Biochem Pharmacol 1995; 50: 1557–1565.
   PubMed Web of Science ®Google Scholar
• Bergmeyer H U, Bernt E. Lactate dehydrogenase. In: Bergmeyer H U, ed. Methods of Enzymatic Analysis. New York: Academic Press, vol. 2,1974: 574–579.
   Google Scholar
• Cowper K B, Currin R T, Dawson T L, Lindert K A, Lemasters J J, Thurman R G. A new method to monitor Kupffer-cell function continuously in the perfused rat liver. Biochem J 1990; 266: 141–147.
   PubMed Web of Science ®Google Scholar
• Tapia G, Pepper I, Smok G, Videla L A. Kupffer cell function in thyroid hormone-induced liver oxidative stress in the rat Free Radic Res 1997; 26: 267–279.
   PubMed Web of Science ®Google Scholar
• Pedersen P L, Greenawalt J W, Reynafarje B. Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues. Methods Cell Biol 1977; 20: 411–481.
   Google Scholar
• Ferreira J. Effect of butylated hydroxyanisole on electron transport in rat liver mitochondria. Biochem Pharmacol 1990; 40: 677–684.
   PubMed Web of Science ®Google Scholar
• Lowry C H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275.
   PubMed Web of Science ®Google Scholar
• Laskin D L, Gardner C R, Price V F, Jollow D L. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology 1995; 21: 1045–1050.
   PubMed Web of Science ®Google Scholar
• Blazka M E. Wilmer J L, Holladay S D, Wilson R E, Luster M I. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 1995; 133: 43–52.
   PubMed Web of Science ®Google Scholar
• Baeuerle P A, Baltimore D. The physiology of the NF-κB transcription factor. In: Cohen P, Foulkes J G, eds. Molecular Aspects of Cellular Regulation: Hormonal Control Regulation of Gene Expression. Amsterdam: Elsevier, 1991: 409–432.
   Google Scholar
• Kaul N K, Forman H J. Activation of NFκB by the respiratory burst of macrophages. Free Radic Biol Med 1996; 21: 301–405.
   Web of Science ®Google Scholar
• Steinberg P, Lafranconi W M, Wolf C R, Waxman D J, Oesch F, Friedberg T. Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver. Mol Pharmacol 1987; 32: 463–470.
   PubMed Web of Science ®Google Scholar
• Koop D R, Chernosky A, Brass E P. Identification and induction of cytochrome P450 2E1 in rat Kupffer cells. J Pharmacol Exp Ther 1991; 258: 1072–1076.
   PubMed Web of Science ®Google Scholar
• Germolec D R, Adams N H, Luster M I. Comparative assessment of metabolic enzyme levels in macrophage populations of the F344 rat. Biochem Pharmacol 1995; 50: 1495–1504.
   PubMed Web of Science ®Google Scholar