Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.

References

• Lim KB. Epidemiology of clinical benign prostatic hyperplasia. Asian Journal of Urology. 2017;4(3):148–151.
   PubMed Web of Science ®Google Scholar
• Lee SWH, Chan EMC, Lai YK. The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A systematic review and meta-analysis. Sci Rep. 2017;7(1):7984.
   PubMedGoogle Scholar
• Kullisaar T, Türk S, Punab M, et al. Oxidative stress–cause or consequence of male genital tract disorders? Prostate. 2012;72(9):977–983.
   PubMed Web of Science ®Google Scholar
• Ahmad M, Suhail N, Mansoor T, et al. Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls. Indian J Clin Biochem. 2012;27(4):385–388.
   PubMedGoogle Scholar
• Olinski R, Zastawny Tomasz H, Foksinski M, et al. DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia. Free Radical Biol Med. 1995;18(4):807–813.
   PubMed Web of Science ®Google Scholar
• Sajadimajd S, Khazaei M. Oxidative stress and cancer: The role of Nrf2. Curr Cancer Drug Targets. 2018;18(6):538–557.
   PubMed Web of Science ®Google Scholar
• Khor TO, Fuentes F, Shu L, et al. Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer. Cancer Prev Res (Phila). 2014;7(12):1186–1197.
   PubMed Web of Science ®Google Scholar
• Hao B, Miao Z, Yuan Y. Clinical significance of Nrf2 expression in benign prostatic hyperplasia and prostate cancer tissues. Int J Clin Exp Pathol. 2016;9(1):118–123.
   Web of Science ®Google Scholar
• Russo GI, Vanella L, Castelli T, et al. Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients. World J Urol. 2016;34(8):1183–1192.
   PubMed Web of Science ®Google Scholar
• Thapa D, Meng P, Bedolla RG, et al. NQO1 Suppresses NF-κB–p300 interaction to regulate Inflammatory Mediators associated with prostate Tumorigenesis. Cancer Res. 2014;74(19):5644–5655.
   PubMed Web of Science ®Google Scholar
• Thapa D, Kumar AP, Ghosh R. Implication of NQO1 knockdown on prostate carcinogenesis. 2012, AACR.
   Google Scholar
• Ryl A, Rotter I, Kram A, et al. Apoptosis and proliferation of the prostate cells in men with benign prostatic hyperplasia and concomitant metabolic disorders. Histol Histopathol. 2018;33(4):389–397.
   PubMed Web of Science ®Google Scholar
• La Vignera S, Condorelli RA, Russo GI, et al. Endocrine control of benign prostatic hyperplasia. Andrology. 2016;4(3):404–411.
   PubMed Web of Science ®Google Scholar
• Pawlowski J, Kraft AS. Bax-induced apoptotic cell death. Proc Natl Acad Sci U S A. 2000;97(2):529–531.
   PubMed Web of Science ®Google Scholar
• Saker Z, Tsintsadze O, Jiqia I, et al. IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER. Georgian Med News. 2015;249:7–14.
   Google Scholar
• Itoh A, Saitoh T, Tani K, et al. Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. Chem Pharm Bull (Tokyo). 2011;59(8):947–951.
   PubMed Web of Science ®Google Scholar
• Bharathi Priya L, Baskaran R, Huang C, et al. Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts. J Cell Biochem. 2018;119(2):1441–1452.
   PubMed Web of Science ®Google Scholar
• Sivalingam KS, Paramasivan P, Weng CF, et al. Neferine Potentiates the Antitumor effect of Cisplatin in human Lung Adenocarcinoma cells Via a Mitochondria-mediated apoptosis pathway. J Cell Biochem. 2017;118(9):2865–2876.
   PubMed Web of Science ®Google Scholar
• Kadioglu O, Law BYK, Mok SWF, et al. Mode of Action Analyses of neferine, a bisbenzylisoquinoline alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant tumor cells. Front Pharmacol. 2017;8:238–238.
   PubMed Web of Science ®Google Scholar
• Kumarihamy M, León F, Pettaway S, et al. In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower. J Ethnopharmacol. 2015;174:57–65.
   PubMed Web of Science ®Google Scholar
• Xu L, Zhang X, Li Y, et al. Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation. Tumour Biol. 2016;37(7):8721–8729.
   PubMedGoogle Scholar
• Guolan D, Lingli W, Wenyi H, et al. Anti-inflammatory effects of neferine on LPS-induced human endothelium via MAPK, and NF-kappabeta pathways. Pharmazie. 2018;73(9):541–544.
   PubMed Web of Science ®Google Scholar
• Liu X, et al. Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Oncotarget. 2016;7(38):61703–61715.
   PubMedGoogle Scholar
• Wu C, Chen J, Yang R, et al. Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke. Br J Pharmacol. 2019;176(3):400–415.
   PubMed Web of Science ®Google Scholar
• Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol. 2016;43(1):146–153.
   PubMed Web of Science ®Google Scholar
• Russo M, Spagnuolo C, Russo GL, et al. Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment. Crit Rev Food Sci Nutr. 2018;58(8):1391–1405.
   PubMed Web of Science ®Google Scholar
• Myzak MC, Hardin K, Wang R, et al. Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis. 2006;27(4):811–819.
   PubMed Web of Science ®Google Scholar
• Vasanwala FF, Wong MYC, Ho HSS, et al. Benign prostatic hyperplasia and male lower urinary symptoms: A guide for family physicians. Asian Journal of Urology. 2017;4(3):181–184.
   PubMed Web of Science ®Google Scholar
• Jiwrajka M, Yaxley W, Ranasinghe S, et al. Drugs for benign prostatic hypertrophy. Aust Prescr. 2018;41(5):150–153.
   PubMed Web of Science ®Google Scholar
• Chughtai B, Forde James C, Dana Marie TD, et al. Benign prostatic hyperplasia. Nature Reviews Disease Primers. 2016;2:16031.
   PubMed Web of Science ®Google Scholar
• Shadiack AM, Althof S. Preclinical effects of melanocortins in male sexual dysfunction. Int J Impot Res. 2008;20(1):S11–S16.
   PubMedGoogle Scholar
• Carson C, Rittmaster R. The role of dihydrotestosterone in benign prostatic hyperplasia. Urology. 2003;61(4 Suppl 1):2–7.
   PubMed Web of Science ®Google Scholar
• Griffiths, K., M.S. Morton, and R.I. Nicholson, Androgens, androgen receptors, antiandrogens and the treatment of prostate cancer. Eur Urol, 1997. 32 Suppl 3: p. 24-40.
   PubMed Web of Science ®Google Scholar
• Hamid AR, Umbas R, Mochtar CA. Recent role of inflammation in prostate diseases: chemoprevention development opportunity. Acta Med Indones. 2011;43(1):59–65.
   PubMedGoogle Scholar
• Meagher EA, FitzGerald GA. Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med. 2000;28(12):1745–1750.
   PubMed Web of Science ®Google Scholar
• Sireesh D, Ganesh M-R, Dhamodharan U, et al. Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade. J Nutr Biochem. 2017;44:11–21.
   PubMed Web of Science ®Google Scholar
• David JA, Rifkin WJ, Rabbani PS. The Nrf2/Keap1/ARE pathway and oxidative stress as a Therapeutic target in Type II Diabetes Mellitus. J Diabetes Res. 2017;2017:4826724.
   PubMed Web of Science ®Google Scholar
• Hao B, Miao Z, Yuan Y. Clinical significance of Nrf2 expression in benign prostatic hyperplasia and prostate cancer tissues. Int J Clin Exp Pathol. 2016;9:118–123.
   Web of Science ®Google Scholar
• Dinkova-Kostova AT, Abramov AY. The emerging role of Nrf2 in mitochondrial function. Free Radic Biol Med. 2015;88(Pt B):179–188.
   PubMedGoogle Scholar
• Niture SK, Khatri R, Jaiswal AK. Regulation of Nrf2-an update. Free Radic Biol Med. 2014;66:36–44.
   PubMed Web of Science ®Google Scholar
• Ren H, Li X, Cheng G, et al. The effects of ROS in prostatic stromal cells under hypoxic environment. Aging Male. 2015;18(2):84–88.
   PubMed Web of Science ®Google Scholar
• Bostwick DG, Meiers I, Shanks JH. Glutathione S-transferase: differential expression of alpha, mu, and pi isoenzymes in benign prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. Hum Pathol. 2007;38(9):1394–1401.
   PubMed Web of Science ®Google Scholar
• Chang SN, Han J, Abdelkader TS, et al. High animal fat intake enhances prostate cancer progression and reduces glutathione peroxidase 3 expression in early stages of TRAMP mice. Prostate. 2014;74(13):1266–1277.
   PubMed Web of Science ®Google Scholar
• Du C, Guo Y, Cheng Y, et al. Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2/Bax mediated apoptosis. Free Radic Res. 2017;51(2):113–123.
   PubMed Web of Science ®Google Scholar
• Liu S, Navarro G, Mauvais-Jarvis F. Androgen Excess Produces Systemic oxidative stress and Predisposes to β-cell Failure in Female Mice. PloS one. 2010;5(6):e11302–e11302.
   PubMed Web of Science ®Google Scholar
• Bellezza I, Guo Y, Cheng Y, et al. ROS-independent Nrf2 activation in prostate cancer. Oncotarget. 2017;8(40):67506–67518.
   PubMedGoogle Scholar
• Smith, J., Mun Tho Lye, Xu Naihan, A. Gillespie David, The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res, 2010. 108: p. 73-112.
   PubMed Web of Science ®Google Scholar
• Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116(2):205–219.
   PubMed Web of Science ®Google Scholar
• Slee EA, Adrain C, Martin SJ. Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 1999;6(11):1067–1074.
   PubMed Web of Science ®Google Scholar
• Kuribayashi K, Mayes PA, El-Deiry WS. What are caspases 3 and 7 doing upstream of the mitochondria? Cancer Biol Ther. 2006;5(7):763–765.
   PubMed Web of Science ®Google Scholar
• Schlechte, H., Lenk Severin V., Lning Thomas, Schnorr Dietmar, P53 tumour suppressor gene mutations in benign prostatic hyperplasia and prostate cancer. Eur Urol, 1998. 34(5): p. 433-440.
   PubMed Web of Science ®Google Scholar
• Sciarra A, Mariotti G, Salciccia S, et al. Prostate growth and inflammation. J Steroid Biochem Mol Biol. 2008;108(3-5):254–260.
   PubMed Web of Science ®Google Scholar
• Ub Wijerathne C, Park H-S, Jeong H-Y, et al. Quisqualis indica improves benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis. Biol Pharm Bull. 2017;40(12):2125–2133.
   PubMed Web of Science ®Google Scholar