Publication Cover
Redox Report
Communications in Free Radical Research
Volume 26, 2021 - Issue 1
2,742
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

, , , , , , , , , & show all

References

  • Kazantseva MG, Highton J, Stamp LK, et al. Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. Arthritis Res Ther. 2012;14(5):R208.
  • Kurko J, Besenyei T, Laki J, et al. Genetics of rheumatoid arthritis — A comprehensive review. Clin Rev Allergy Immunol. 2013;45(2):170–179.
  • Soubrier M, Mathieu S, Payet S. Elderly-onset rheumatoid arthritis. Joint Bone Spine. 2010;77(4):290–296.
  • Cross M, Smith E, Hoy D, et al. The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1316–1322.
  • Brand DD, Latham KA, Rosloniec EF. Collagen-induced arthritis. Nat Protoc. 2007;2(5):1269–1275.
  • Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376(9746):1094–1108.
  • Zhang L, Li JM, Liu XG, et al. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol. 2011;31(4):606–614.
  • Yang L, Karin M. Roles of tumor suppressors in regulating tumor-associated inflammation. Cell Death Differ. 2014;21(11):1677–1686.
  • Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013;5(2):77–94.
  • Sohn DH, Sokolove J, Sharpe O, et al. Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patients. Arthritis Res Ther. 2012;14(1):R1.
  • Huh YH, Lee G, Lee KB, et al. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res Ther. 2015;17:302.
  • Alves CH, Farrell E, Vis M, et al. Animal models of bone loss in inflammatory arthritis: from cytokines in the bench to novel treatments for bone loss in the bedside—a comprehensive review. Clin Rev Allergy Immunol. 2016;51(1):27–47.
  • Park C, Jeong JW, Lee DS, et al. Sargassum serratifolium extract attenuates interleukin-1β-induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-κB, p38 MAPK, and PI3K/Akt. Int J Mol Sci. 2018;19(8):2308.
  • Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 2010;18(11):1441–1447.
  • Marcu KB, Otero M, Olivotto E, et al. NF-κB Signaling: multiple angles to target OA. Curr Drug Targets. 2010;11(50):599–613.
  • He Y, Wong AY, Chan EW, et al. Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2014;l(14):298.
  • Köhler BM, Günther J, Kaudewitz D, et al. Current therapeutic options in the treatment of rheumatoid arthritis. J Clin Med. 2019;8(7):938.
  • Yamanaka H, Tanaka Y, Takeuchi T, et al. Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study. Arthritis Res Ther. 2016;18(1):34.
  • Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180:114147.
  • Scott PA, Kingsley GH, Smith CM, et al. Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomised controlled trials. Ann Rheum Dis. 2007;66(10):1296–1304.
  • Baschant U, Lane NE, Tuckermann J. The multiple facets of glucocorticoid action in rheumatoid arthritis. Nat Rev Rheumatol. 2012;8(11):645–655.
  • Baschant U, Culemann S, Tuckermann J. Molecular determinants of glucocorticoid actions in inflammatory joint diseases. Mol Cell Endocrinol. 2013;380(1-2):108–118.
  • Cohen MD, Keystone E. Rituximab for rheumatoid arthritis. Rheumatol Ther. 2015;2(2):99–111.
  • Atzeni F, Batticciotto A, Masala IF, et al. Infections and biological therapy in patients with rheumatic diseases. Isr Med Assoc J. 2016;18:164–167.
  • Dragos D, Gilca M, Gaman L, et al. Phytomedicine in joint disorders. Nutrients. 2017;9(1):70.
  • Zhang M, Zhao R, Wang D, et al. Ginger (Zingiber officinale Rosc.) and its bioactive components are potential resources for health beneficial agents. Phytother Res. 2021;35(2):711–742.
  • Huang FY, Deng T, Meng LX, et al. Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus. Medicine (Baltimore). 2019;98(13):e15054.
  • Mao QQ, Xu XY, Cao SY, et al. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods. 2019;8(6):185.
  • Rajan I, Narayanan N, Rabindran R, et al. Zingerone protects against stannous chloride-induced and hydrogen peroxide-induced oxidative DNA damage in vitro. Biol Trace Elem Res. 2013;155(3):455–459.
  • Kim MK, Chung SW, Kim DH, et al. Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway. Exp Gerontol. 2010;45(6):419–426.
  • Kumar L, Chhibber S, Harjai K. Zingerone inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1. Fitoterapia. 2013;90:73–78.
  • Ahmad B, Rehman MU, Amin I, et al. A review on pharmacological properties of zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone). The Sci World J. 2015;2015:816364.
  • Ahmad B, Rehman MU, Amin I, et al. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: probable role of NF-kB activation. Saudi Pharm J. 2018;26(8):1137–1145.
  • Kumar L, Chhibber S, Harjai K. Structural alterations in Pseudomonas aeruginosa by zingerone contribute to enhanced susceptibility to antibiotics, serum and phagocytes. Life Sci. 2014;117(1):24–32.
  • Banerjee S, Haqqi TM, Luthra HS, et al. Possible role of V beta T cell receptor genes in susceptibility to collagen-induced arthritis in mice. J Exp Med. 1988;167(3):832–839.
  • Wright JR, Colby HD, Miles PR. Cytosolic factors which affect microsomal lipid peroxidation in lung and liver. Arch Biochem Biophys. 1981;206(2):296–304.
  • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–474.
  • Mohandas J, Marshall JJ, Duggin GG, et al. Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Biochem Pharmacol. 1984;33(11):1801–1807.
  • Claiborne A. Catalase activity. In: Greenwald RA, editor. CRC handbook of methods for oxygen radical research. Boca Raton: CRC Press; 1985. p. 283–284.
  • Rainsford KD. Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?. Agents Actions. 1982;12(4):452–458.
  • Neugebauer V, Han JS, Adwanikar H, et al. Techniques for assessing knee joint pain in arthritis. Mol Pain. 2007;28(3):8.
  • Amresh G, Singh PN, Rao CV. Antinociceptive and antiarthritic activity of cissampelos pareira roots. J Ethnopharmacol. 2007;111(3):531–536.
  • Costa MD, De Sutter P, Gybels J, et al. Adjuvant-induced arthritis in rats: a possible animal model of chronic pain. Pain. 1981;10(2):173–185.
  • Noguchi M, Kimoto A, Kobayashi S, et al. Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat. Eur J Pharmacol. 2005;513(3):229–235.
  • Rajendran R, Krishnakumar E. Anti-arthritic activity of premna serratifolia linn., wood against adjuvant induced arthritis. Avicenna J Med Biotechnol. 2010;2(2):101–106.
  • Shejawal N, Menon S, Shailajan S. A simple, sensitive and accurate method for rat paw volume measurement and its expediency in preclinical animal studies. Hum Exp Toxicol. 2014;33(2):123–129.
  • Yu Y, Xiong Z, Lv Y, et al. In vivo evaluation of early disease progression by X-ray phase-contrast imaging in the adjuvant-induced arthritic rat. Skeletal Radiol. 2006;35(3):156–164.
  • Woś I, Tabarkiewicz J. Effect of interleukin-6, -17, -21, -22, and -23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis. Immunol Res. 2021;69(1):26–42.
  • Ilchovska DD, Barrow DM. An overview of the NF-κB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-κB ligand RANKL and related nutritional interventions. Autoimmun Rev. 2021;20(2):102741.
  • Lawrence T. The nuclear factor NF-κB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651.
  • Mateen S, Moin S, Zafar A, et al. Redox signaling in rheumatoid arthritis and the preventive role of polyphenols. Clin Chim Acta. 2016;463:4–10.
  • Voon FL, Sulaiman MR, Akhtar MN, et al. Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) isolated from boesenbergia rotunda (L.) mansf. inhibits CFA-induced rheumatoid arthritis in rats. Eur J Pharmacol. 2017;794:127–134.
  • Srirangan S, Choy EH. The role of interleukin 6 in the pathophysiology of rheumatoid arthritis. Ther Adv Musculo Skelet Dis. 2010;2(5):247–256.
  • Rehman MU, Rashid SM, Rasool S, et al. Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy. Arch Physiol Biochem. 2019;125(3):201–209.
  • Uttra AM, Alamgeer, Shahzad M, et al. Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund complete adjuvant induced arthritis in sprague dawley rats by downregulating PGE2, COX2, IL-1β, IL-6, TNF-α, NF-κB and upregulating IL-4 and IL-10. J Ethnopharmacol. 2018;224:482–496.
  • Shabbir A, Shahzad M, Ali A, et al. Anti-arthritic activity of N′-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1(4H)-yl)acetohydrazide. Eur J Pharmacol. 2014;738:263–272.
  • Cheon H YUSJ, Yoo DH, et al. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-β1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol. 2002;127:547–552.
  • Ahmad SB, Rehman MU, Fatima B, et al. Antifibrotic effects of D-limonene (5(1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats. Environ Toxicol. 2018;33(3):361–369.
  • Gonzalo-Gil E, Galindo-Izquierdo M. Papel del factor de crecimiento transformador-beta (TGF-β) en la fisiopatología de la artritis reumatoide. Reumatol Clin. 2014;10(3):174–179.
  • Pohlers D, Beyer A, Koczan D, et al. Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 2007;9(3):R59.
  • Rhodes B, Furnrohr BG, Vyse TJ. C-reactive protein in rheumatology: biology and genetics. Nat Rev Rheumatol. 2011;7(5):282–289.
  • Kalaiselvan S, Rasool MK. Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-κB pathway. J Immunotoxicol. 2016;13(4):509–525.
  • Mititelu RR, Pădureanu R, Băcănoiu M, et al. Inflammatory and oxidative stress markers—mirror tools in rheumatoid arthritis. Biomedicines. 2020;8(5):125.
  • Prescha A, Zabłocka-Słowińska K, Płaczkowska S, et al. Diet quality and its relationship with antioxidant status in patients with rheumatoid arthritis. Oxid Med Cell Longev. 2018;2018:1.
  • Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008;7:567–573.
  • Halliwell BA, Hoult JR, Blake DR. Oxidants, inflammation, and anti-inflammatory drugs. Faseb J. 1988;2(13):2867–2873.
  • Krishnakantha TP, Lokesh BR. Scavenging of superoxide anions by spice principles. Indian J Biochem Biophys. 1993;30(2):133–144.
  • Oboh G, Akinyemi AJ, Ademiluyi AO. Antioxidant and inhibitory effect of red ginger (Zingiberofficinale var. Rubra) and white ginger (Zingiberofficinale Roscoe) on Fe2+ induced lipid peroxidation in rat brain in vitro. Exp Toxicol Pathol. 2012;64(1-2):31–36.
  • Hemalatha KL, Mainzen S, Prince P. Antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on experimentally induced myocardial infarcted rats. J Biochem Mol Toxic. 2015;29(4):182–188.
  • Alavala S, Nalban N, Sangaraju R, et al. Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats. Inflammopharmacology. 2020;28(6):1579–1597.
  • Rao BN, Rao BS. Antogonistic effects of zingerone, a phenolic alkaline against radiation- induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro. Mutagenesis. 2010;25(6):577–587.
  • Rahmani AH. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol. 2014;6(2):125–136.
  • Saleem A, Saleem M, Akhtar MF, et al. Moringa rivae leaf extracts attenuate complete Freund's adjuvant-induced arthritis in Wistar rats via modulation of inflammatory and oxidative stress biomarkers. Inflammopharmacology. 2020;28(1):139–151.