References
- St-louis R, Parmentier C, Grange-messent V. Free radical Biology and Medicine reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus. Free Radic Biol Med. 2014;71:231–239. doi:https://doi.org/10.1016/j.freeradbiomed.2014.03.024
- Angelova PR, Abramov AY. Role of mitochondrial ROS in the brain: from physiology to neurodegeneration. FEBS Lett. 2018;592:692–702. doi:https://doi.org/10.1002/1873-3468.12964
- Wang X, Hai C. Novel insights into redox system and the mechanism of redox regulation. Mol Biol Rep. 2016;43:607–628. doi:https://doi.org/10.1007/s11033-016-4022-y
- Alhashem F, Alkhateeb M, Alshahrani M, et al. Exercise protects against obesity induced semen abnormalities via downregulating stem cell factor, upregulating ghrelin and normalizing oxidative stress. EXCLI J. 2014;13:551–572.
- Markesbery WR. Oxidative stress hypothesis in Alzheimer’s disease. Free Radic Biol Med. 1997;23:134–147. doi:https://doi.org/10.1016/S0891-5849(96)00629-6
- Siracusa R, Paterniti I, Impellizzeri D, et al. The association of palmitoylethanolamide with luteolin decreases neuroinflammation and stimulates autophagy in Parkinson’s disease model. CNS Neurol Disord Drug Targets. 2015;14:1350–1366. doi:https://doi.org/10.2174/1871527314666150821102823
- Jiang T, Sun Q, Chen S. Oxidative stress : A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer‘s disease. Prog Neurobiol. 2016;147:1–19. doi:https://doi.org/10.1016/j.pneurobio.2016.07.005
- Akki R, Siracusa R, Morabito R, et al. Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2O2-induced oxidative stress. Cell Biochem Funct. 2018;36:56–64. doi:https://doi.org/10.1002/cbf.3317
- Zhang S-R, Fan X-M. Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2015;21:3214–3222. doi:https://doi.org/10.3748/wjg.v21.i11.3214
- Yu R, Li Z, Liu S, et al. Activation of mTORC1 signaling in gastric X/A-like cells induces spontaneous pancreatic fibrosis and derangement of glucose metabolism by reducing ghrelin production. EBioMedicine. 2018;36:304–315. doi:https://doi.org/10.1016/j.ebiom.2018.09.027
- Hosseini L, Vafaee MS, Badalzadeh R. Melatonin and nicotinamide mononucleotide attenuate myocardial ischemia/reperfusion injury via modulation of mitochondrial function and hemodynamic parameters in aged rats. J Cardiovasc Pharmacol Ther. 2019;25(3):240–250. doi:https://doi.org/10.1177/1074248419882002.
- Venkatesh S, Li M, Saito T, et al. Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2019;128:38–50. doi:https://doi.org/10.1016/j.yjmcc.2018.12.017
- Cencioni C, Spallotta F, Martelli F, et al. Oxidative stress and epigenetic regulation in ageing and Age-Related diseases. Int J Mol Sci. 2013;14:17643–17663. doi:https://doi.org/10.3390/ijms140917643
- Kohen R, Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol. 2002;30:620–650. doi:https://doi.org/10.1080/01926230290166724
- Quiñones M, Fernø J, Al-Massadi O. Ghrelin and liver disease. Rev Endocr Metab Disord. 2020;21:45–56. doi:https://doi.org/10.1007/s11154-019-09528-6
- Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660. doi:https://doi.org/10.1038/45230
- Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of Its receptor, GHS-R, in humans. J Clin Endocrinol Metab. 2002;87:2988–2991. doi:https://doi.org/10.1210/jcem.87.6.8739
- Kojima M, Hamamoto A, Sato T. Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid. J Biochem. 2016;160:189–194. doi:https://doi.org/10.1093/jb/mvw046
- Seyhanli ES, Lok U, Gulacti U, et al. Assessment of serum and urine ghrelin levels in patients with acute stroke. Int J Clin Exp Med. 2015;8:722–729.
- Satou M, Nakamura Y, Ando H, et al. Understanding the functional significance of ghrelin processing and degradation. Peptides. 2011;32:2183–2190. doi:https://doi.org/10.1016/j.peptides.2011.06.029
- Akamizu T, Takaya K, Irako T, et al. Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol. 2004;150:447–455. doi:https://doi.org/10.1530/eje.0.1500447
- Raghay K, Akki R, Bensaid D, et al. Ghrelin as an anti-inflammatory and protective agent in ischemia/reperfusion injury. Peptides. 2019;124:170226.
- Akki R, Siracusa R, Cordaro M, et al. Adaptation to oxidative stress at cellular and tissue level. Arch Physiol Biochem. 2019;0:1–11. doi:https://doi.org/10.1080/13813455.2019.1702059
- Coyoy-Salgado A, Segura-Uribe JJ, Guerra-Araiza C, et al. The importance of natural antioxidants in the treatment of spinal cord injury in animal models: An overview. Oxid Med Cell Longev. 2019;2019:1–22. doi:https://doi.org/10.1155/2019/3642491
- Goldstein BJ, Mahadev K, Wu X, et al. Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal. 2005;7:1021–1031. doi:https://doi.org/10.1089/ars.2005.7.1021
- Suzuki H, Matsuzaki J, Hibi T. Ghrelin and oxidative stress in gastrointestinal tract. J Clin Biochem Nutr. 2010;48:122–125. doi:https://doi.org/10.3164/jcbn.10-16GFR
- Elias RJ, Kellerby SS, Decker EA. Antioxidant activity of proteins and peptides. Crit Rev Food Sci Nutr. 2008;48:430–441. doi:https://doi.org/10.1080/10408390701425615
- Carniglia L, Ramírez D, Durand D, et al. Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases. Mediators Inflamm. 2017;2017:5048616. doi:https://doi.org/10.1155/2017/5048616
- Gholami M, Ahmadi SAY, Abaszadeh A, et al. Protective effects of melatonin and ghrelin on spermatogenesis: A narrative review of the literature. Int J Reprod biomed (yazd). Iran. 2017;15:265–272. doi:https://doi.org/10.29252/ijrm.15.5.265
- Dong MH, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2006;22:599–606. doi:https://doi.org/10.1097/01.mog.0000245540.87784.75
- Bianchi E, Boekelheide K, Sigman M, et al. Ghrelin modulates testicular damage in a cryptorchid mouse model. PLoS One. 2017;12:e0177995. doi:https://doi.org/10.1371/journal.pone.0177995
- Mani BK, Osborne-Lawrence S, Metzger N, et al. Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion. Am J Physiol Metab. 2020;319:E330–E337.
- Date Y. Ghrelin and the vagus nerve. Methods Enzymol. 2012;514:261–269. doi:https://doi.org/10.1016/B978-0-12-381272-8.00016-7
- Delporte C. Structure and physiological actions of ghrelin. Scientifica (Cairo). 2013;2013:1–25. doi:https://doi.org/10.1155/2013/518909
- Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255–4261. doi:https://doi.org/10.1210/endo.141.11.7757
- Ge T, Yang W, Fan J, et al. Preclinical evidence of ghrelin as a therapeutic target in epilepsy. Oncotarget. 2017;8:59929–59939. doi:https://doi.org/10.18632/oncotarget.18349
- Obay BD, Tasdemir E, Tümer C, et al. Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides. 2007;28:1214–1219. doi:https://doi.org/10.1016/j.peptides.2007.04.003
- Obay BD, Taşdemir E, Tümer C, et al. Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides. 2008;29:448–455. doi:https://doi.org/10.1016/j.peptides.2007.11.020
- Portelli J, Coppens J, Demuyser T, et al. Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway. Neuropeptides. 2015;51:1–7. doi:https://doi.org/10.1016/j.npep.2015.04.004
- Ku JM, Andrews ZB, Barsby T, et al. Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s). Endocrinology. 2015;156:280–290. doi:https://doi.org/10.1210/en.2014-1415
- Omrani H, Alipour MR, Mohaddes G. Ghrelin improves antioxidant defense in blood and brain in normobaric hypoxia in adult male rats. Adv Pharm Bull. 2015;5:283–288. doi:https://doi.org/10.15171/apb.2015.039
- Liu Y, Chen L, Xu X, et al. Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol. 2009;9: 17. doi:https://doi.org/10.1186/1472-6793-9-17.
- Spencer SJ, Miller AA, Andrews ZB. The role of ghrelin in neuroprotection after ischemic brain injury. Brain Sci. 2013;3:344–359. doi:https://doi.org/10.3390/brainsci3010344
- Lee JY, Oh TH, Yune TY. Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Endocrinology. 2011;152:2377–2386. doi:https://doi.org/10.1210/en.2011-0090
- Farzaei MH, Tewari D, Momtaz S, et al. Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration. Food Chem Toxicol. 2018;120:183–195. doi:https://doi.org/10.1016/j.fct.2018.07.010
- Sibilia V, Pagani F, Rindi G, et al. Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk. Br J Pharmacol. 2008;154:688–697. doi:https://doi.org/10.1038/bjp.2008.120
- Bochicchio G, Charlton P, Pezzullo JC, et al. Ghrelin agonist TZP-101/Ulimorelin accelerates gastrointestinal recovery independently of opioid Use and surgery type: covariate analysis of Phase 2 data. World J Surg. 2012;36:39–45. doi:https://doi.org/10.1007/s00268-011-1335-9
- Ejskjaer N, Vestergaard ET, HellstrÖm PM, et al. Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther. 2009;29:1179–1187. doi:https://doi.org/10.1111/j.1365-2036.2009.03986.x
- Ercan S, Basaranlar G, Gungor NE, et al. Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa. Food Chem Toxicol. 2013;56:154–161. doi:https://doi.org/10.1016/j.fct.2013.02.019
- Stempniewicz A, Ceranowicz P, Warzecha Z. Potential therapeutic effects of Gut hormones, Ghrelin and Obestatin in oral mucositis. Int J Mol Sci. 2019;20:1534. doi:https://doi.org/10.3390/ijms20071534
- Subbarao K, Nattuthurai G, Sundararajan S, et al. Gingival crevicular fluid: An overview. J Pharm Bioallied Sci. 2019;11(135–139).
- Junior HF L, Schiavon L dL, Rodrigues IK, et al. Effects of ghrelin on the oxidative stress and healing of the colonic anastomosis in rats. J Surg Res. 2019;234:167–177. doi:https://doi.org/10.1016/j.jss.2018.09.045
- Li Y, Hai J, Li L, et al. Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development. Endocrine. 2013;43:376–386. doi:https://doi.org/10.1007/s12020-012-9761-5
- Barazzoni R, Semolic A, Cattin MR, et al. Acylated ghrelin limits fat accumulation and improves redox state and inflammation markers in the liver of high-fat-fed rats. Obesity. 2014;22:170–177. doi:https://doi.org/10.1002/oby.20454
- Koyuturk M, Sacan O, Karabulut S, et al. The role of ghrelin on apoptosis, cell proliferation and oxidant-antioxidant system in the liver of neonatal diabetic rats. Cell Biol Int. 2015;39:834–841. doi:https://doi.org/10.1002/cbin.10464
- Kabil NN, Seddiek HA, Yassin NA, et al. Effect of ghrelin on chronic liver injury and fibrogenesis in male rats: possible role of nitric oxide. Peptides. 2014;52:90–97. doi:https://doi.org/10.1016/j.peptides.2013.11.022
- Çetin E, Kanbur M, Çetin N, et al. Hepatoprotective effect of ghrelin on carbon tetrachloride-induced acute liver injury in rats. Regul Pept. 2011;171:1–5. doi:https://doi.org/10.1016/j.regpep.2011.05.010
- Ahsan H. 3-Nitrotyrosine: a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions. Hum Immunol. 2013;74:1392–1399. doi:https://doi.org/10.1016/j.humimm.2013.06.009
- Sukumaran V, Tsuchimochi H, Fujii Y, et al. Ghrelin Pre-treatment attenuates local oxidative stress and End organ damage during Cardiopulmonary bypass in anesthetized rats. Front Physiol. 2018;9: 196. doi:https://doi.org/10.3389/fphys.2018.00196.eCollection2018.
- Ahmed KA, Mohamad YR, Khaled EAS. Protective effect of ghrelin on paracetamol induced acute hepatotoxicity in rats. J Physiol Pathophysiol. 2014;5:7–14. doi:https://doi.org/10.5897/JPAP2014.0091
- Dobutovic B, Sudar E, Tepavcevic S, et al. Effects of ghrelin on protein expression of antioxidative enzymes and iNOS in the rat liver. Arch Med Sci. 2014;4:806–816. doi:https://doi.org/10.5114/aoms.2014.44872
- Elsawy M, Emara E. The impact of ghrelin on oxidative stress and inflammatory markers on the liver of diabetic rats. Tanta Med J. 2016;44(163):163–169. doi:https://doi.org/10.4103/1110-1415.201723.
- Bonior J, Warzecha Z, Ceranowicz P, et al. Capsaicin-sensitive sensory nerves are necessary for the protective effect of ghrelin in cerulein-induced acute pancreatitis in rats. Int J Mol Sci. 2017;18:1402. doi:https://doi.org/10.3390/ijms18071402
- Jaworek J. Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. World J Gastroenterol. 2014;20(45):16902–16902. doi:https://doi.org/10.3748/wjg.v20.i45.16902.
- Bonior J, Warzecha Z, Ceranowicz P, et al. Capsaicin-sensitive sensory nerves are necessary for the protective effect of ghrelin in cerulein-induced acute pancreatitis in rats. Int J Mol Sci. 2017;18(7)). 1402. doi:https://doi.org/10.3390/ijms18071402.
- Dembinski A, Warzecha Z, Ceranowic Z, et al. Ghrelin attenuates the development of acute pancreatitis in rat. J Physiol Pharmacol. 2003;54:561–573.
- Faienza MF, Francavilla R, Goffredo R, et al. Oxidative stress in obesity and metabolic Syndrome in children and adolescents. Horm Res Paediatr. 2012;78:158–164. doi:https://doi.org/10.1159/000342642
- Perry B, Wang Y. Appetite regulation and weight control: The role of gut hormones. Nutr. Diabetes. Nature Publishing Group. 2012;2:e26. doi:https://doi.org/10.1038/nutd.2011.21.
- Razzaghy-Azar M, Nourbakhsh M, Pourmoteabed A, et al. An evaluation of acylated ghrelin and Obestatin levels in childhood obesity and their association with insulin resistance, Metabolic Syndrome, and oxidative stress. J Clin Med. 2016;5(7). 61. doi:https://doi.org/10.3390/jcm5070061.
- Altabas V, Rotkvic V. Anti-ghrelin antibodies in appetite suppression: recent advances in obesity pharmacotherapy . ImmunoTargets Ther. 2015;4: 123-30. https://doi.org/10.2147/ITT.S60398.
- Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, et al. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005;20:208–215. doi:https://doi.org/10.1093/humrep/deh569
- Jensen TK, Andersson AM, Jørgensen N, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 danish men. Fertil Steril. 2004;82:863–870. doi:https://doi.org/10.1016/j.fertnstert.2004.03.056
- Sallmén M, Sandler DP, Hoppin JA, et al. Reduced fertility among overweight and obese men. Epidemiology. 2006;17:520–523. doi:https://doi.org/10.1097/01.ede.0000229953.76862.e5
- Tena-Sempere M, Barreiro ML, González LC, et al. Novel expression and functional role of ghrelin in rat testis. Endocrinology. 2002;143:717–725. doi:https://doi.org/10.1210/endo.143.2.8646
- Barreiro ML, Gaytan F, Castellano JM, et al. Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology. 2004;145:4825–4834. doi:https://doi.org/10.1210/en.2004-0732
- Kheradmand A, Alirezaei M, Asadian P, et al. Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia. 2009;41:335–340. doi:https://doi.org/10.1111/j.1439-0272.2009.00932.x
- Packer L, Cadenas E. Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radic. Res. 2007;41:951–952. doi:https://doi.org/10.1080/10715760701490975
- Sachdev S, Davies KJA. Production, detection, and adaptive responses to free radicals in exercise. Free Radic. Biol. Med. 2008;44(2):215–223. doi:https://doi.org/10.1016/j.freeradbiomed.2007.07.019.
- Hikim APS, Lue Y, Diaz-Romero M, et al. Deciphering the pathways of germ cell apoptosis in the testis. J Steroid Biochem Mol Biol. Elsevier Ltd. 2003;85(2-5):175–182. doi:https://doi.org/10.1016/S0960-0760(03)00193-6.
- Hikim APS, Lue Y, Yamamoto CM, et al. Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology. 2003;144:3167–3175. doi:https://doi.org/10.1210/en.2003-0175
- Matsuki S, Iuchi Y, Ikeda Y, et al. Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline. Biochem Biophys Res Commun. 2003;312:843–849. doi:https://doi.org/10.1016/j.bbrc.2003.10.191
- Kheradmand A, Dezfoulian O, Alirezaei M. Ghrelin regulates Bax and PCNA but not Bcl-2 expressions following scrotal hyperthermia in the rat. Tissue Cell. 2012;44:308–315. doi:https://doi.org/10.1016/j.tice.2012.04.009
- Whirledge SD, Garcia JM, Smith RG, et al. Ghrelin partially protects against cisplatin-induced male murine gonadal toxicity in a GHSR-1a-dependent manner 1. Biol Reprod. 2015;92:76–77. doi:https://doi.org/10.1095/biolreprod.114.123570
- Micheli L, Collodel G, Cerretani D, et al. Relationships between Ghrelin and Obestatin with MDA, proinflammatory cytokines, GSH/GSSG ratio, catalase activity, and semen parameters in infertile patients with leukocytospermia and varicocele. Oxid Med Cell Longev. 2019;2019:1–9. doi:https://doi.org/10.1155/2019/7261842
- Ramírez ND, Luque EM, Jones XM, et al. Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet. Heliyon. 2019;5(11)). e02886. doi:https://doi.org/10.1016/j.heliyon.2019.e02886
- Fujimura K, Wakino S, Minakuchi H, et al. Ghrelin protects against renal damages induced by angiotensin-ii via an antioxidative stress mechanism in mice. 2014;9(4)). e94373. doi:https://doi.org/10.1371/journal.pone.0094373
- Boshra V, Abbas AM. Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension. J Basic Clin Physiol Pharmacol. 2017;28:347–354. doi:https://doi.org/10.1515/jbcpp-2016-0145
- Takeda R, Nishimatsu H, Suzuki E, et al. Ghrelin improves renal function in mice with ischemic acute renal failure. J Am Soc Nephrol. 2006;17:113–121. doi:https://doi.org/10.1681/ASN.2004080626
- Neamati S, Alirezaei M, Kheradmand A. Ghrelin acts as an antioxidant agent in the Rat kidney. Int J Pept Res Ther. 2011;17:239–245. doi:https://doi.org/10.1007/s10989-011-9263-y
- Neamati S, Alirezaei M, Kheradmand A, et al. Antioxidant enzyme activities assay and thiobarbituric acid reactive substances concentration following administration of ghrelin in the rat kidney. Int J Pharm Teach Pract. 2013;4:451–457.
- Alirezaei M, Dezfoulian O, Kheradmand A. Novel antioxidant properties of ghrelin and oleuropein versus lipopolysaccharide-mediated Renal Failure in rats. Int J Pept Res Ther. 2015;21:411–421. doi:https://doi.org/10.1007/s10989-015-9470-z
- Stenholm S, Metter EJ, Roth GS, et al. Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore longitudinal study of aging. Aging Clin Exp Res. 2011;23:153–158. doi:https://doi.org/10.1007/BF03351078
- Can N, Catak O, Turgut B, et al. Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model. Drug Des Devel Ther. 2015;9:2819–2829.
- Zaniolo K, Sapieha P, Shao Z, et al. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Investig Ophthalmol Vis Sci. 2011;52:5376–5386. doi:https://doi.org/10.1167/iovs.10-7152
- Rocha-Sousa A, Saraiva J, Henriques-Coelho T, et al. Ghrelin as a novel locally produced relaxing peptide of the iris sphincter and dilator muscles. Exp Eye Res. 2006;83:1179–1187. doi:https://doi.org/10.1016/j.exer.2006.06.005
- Zhu K, Zhang ML, Liu ST, et al. Ghrelin attenuates retinal neuronal autophagy and apoptosis in an experimental rat glaucoma model. Investig Ophthalmol Vis Sci. 2017;58:6113–6122. doi:https://doi.org/10.1167/iovs.17-22465
- Pinazo-Durán MD, Shoaie-Nia K, Zanón-Moreno V, et al. Strategies to reduce oxidative stress in glaucoma patients. Curr Neuropharmacol. 2018;16:903–918. doi:https://doi.org/10.2174/1570159X15666170705101910
- Rocha-Sousa A, Pereira-Silva P, Tavares-Silva M, et al. Identification of the ghrelin-GHSR 1 system and its influence in the modulation of induced ocular hypertension in rabbit and rat eyes. Peptides. 2014;57:59–66. doi:https://doi.org/10.1016/j.peptides.2014.04.013
- Liu S, Chen S, Ren J, et al. Ghrelin protects retinal ganglion cells against rotenone via inhibiting apoptosis, restoring mitochondrial function, and activating AKT-mTOR signaling. Neuropeptides. 2018;67:63–70. doi:https://doi.org/10.1016/j.npep.2017.11.007
- Andrews ZB. The extra-hypothalamic actions of ghrelin on neuronal function. Trends Neurosci. 2011;34(1):31–40. doi:https://doi.org/10.1016/j.tins.2010.10.001.
- Shimada T, Furuta H, Doi A, et al. Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway. Metab Clin Exp. 2014;63:469–474. doi:https://doi.org/10.1016/j.metabol.2013.12.011
- Zanetti M, Gortan Cappellari G, Graziani A, et al. Unacylated ghrelin improves vascular dysfunction and attenuates atherosclerosis during high-Fat diet consumption in rodents. Int J Mol Sci. 2019;20(3). 499. doi:https://doi.org/10.3390/ijms20030499.
- Akalu Y, Molla MD, Dessie G, et al. Physiological effect of ghrelin on body systems. Int J Endocrinol. 2020;2020:1–26. doi:https://doi.org/10.1155/2020/1385138
- Song N, Wang W, Jia F, et al. Assessments of plasma ghrelin levels in the early stages of Parkinson’s disease. Mov Disord. 2017;32:1487–1491. doi:https://doi.org/10.1002/mds.27095
- Sever S, White DL, Garcia JM. Is there an effect of ghrelin/ghrelin analogs on cancer? A systematic review. Endocr Relat Cancer. 2016;23:R393–R409. doi:https://doi.org/10.1530/ERC-16-0130
- Quiñones Mar, Fernø Johan, Al-Massadi Omar. Ghrelin and liver disease. Rev Endocr Metab Disord. 2020;21(1):45–56. doi:https://doi.org/10.1007/s11154-019-09528-6
- Amitani Author Marie, et al. The Role of Ghrelin and Ghrelin Signaling in Aging. Int. J. Mol. Sci. 2017;18; doi:https://doi.org/10.3390/ijms18071511.