Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol

References

• De Souza HS, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol. 2016;13:13–27.
   PubMed Web of Science ®Google Scholar
• Ananthakrishnan AN, Bernstein CN, Iliopoulos D, et al. Environmental triggers in IBD: a review of progress and evidence. Nat Rev Gastroenterol Hepatol. 2018;15:39–49.
   PubMed Web of Science ®Google Scholar
• Judge TA, Lichtenstein GR. Inflammatory bowel disease. current diagnosis treatment in gastroenterology. 2th ed.: America: McGraw-Hill Companies; 2003.
   Google Scholar
• El-Deeb OS, Atef MM, Hafez MY. The interplay between microbiota dependent metabolite trimethylamine N-oxide,: transforming growth factor β/SMAD signaling and inflammasome activation in chronic kidney disease patients: a new mechanistic perspective. J. Cell Biochem. 2019;120:14476–14485.
   PubMed Web of Science ®Google Scholar
• Gkouskou K, Deligianni C, Tsatsanis C, et al. Gut microbiota in mouse models of inflammatory bowel disease. Front Cell Infect Microbiol. 2014;2014:00028.
   Google Scholar
• IKhan I, et al. Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome. Pathogens. 2019;8(3):126.
   PubMed Web of Science ®Google Scholar
• Wang D, Zhang Y, Yang S, et al. A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function. Int J Biol Macromol. 2019;125:572–579.
   PubMed Web of Science ®Google Scholar
• Hirose M, Kunstner A, Schilf P, et al. Mitochondrial gene polymorphism is associated with gut microbial communities in mice. Sci Rep. 2017;7(1):15293. DOI:10.1038/s41598-017-15377-7.
   PubMed Web of Science ®Google Scholar
• Rosch C, Taverne N, Venema K, et al. Effects of in vitro fermentation of barley beta-glucan and sugar beet pectin using human fecal inocula on cytokine expression by dendritic cells. Mol Nutr Food Res. 2017;61:1–11.
   Web of Science ®Google Scholar
• Delzenne NM, Cani PD. A place for dietary fibre in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2005;8:636–640.
   PubMed Web of Science ®Google Scholar
• Wong JM, De Souza R, Kendall CW, et al. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40:235–243.
   PubMed Web of Science ®Google Scholar
• Roberfroid M, Gibson GR, Hoyles L, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104:S1–S63.
   PubMed Web of Science ®Google Scholar
• Salminen A, Lehtonen M, Paimela T, et al. Celastrol: molecular targets of Thunder God Vine. Biochem Biophys Res Commun. 2010;394(3):439–442.
   PubMed Web of Science ®Google Scholar
• Brinker AM, Ma J, Lipsky PE, et al. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry. 2007;68:732–766.
   PubMed Web of Science ®Google Scholar
• Jia Z, Xu C, Shen J, et al. The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice. Int Immunopharmacol. 2015;29:552–559.
   PubMed Web of Science ®Google Scholar
• Kim JH, Hahm DH, Yang DC, et al. Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci. 2005;97:124–124.
   PubMed Web of Science ®Google Scholar
• Boirivant M, Fuss IJ, Chu A, et al. Oxazolone colitis: A murine model of  T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med. 1998;188:1929–1939.
   PubMed Web of Science ®Google Scholar
• Shen RL, Dang XY, Dong JL, et al. Effects of oat β-glucan and barley β-glucan on fecal characteristics,: intestinal microflora, and intestinal bacterial metabolites in rats. J Agric Food Chem. 2012;60:11301–11308.
   PubMed Web of Science ®Google Scholar
• Lin L, Sun Y, Wang D, et al. Celastrol ameliorates ulcerative colitis-related colorectal cancer in mice via suppressing inflammatory responses and epithelial-mesenchymal transition. Front Pharmacol. 2016;6:320.
   PubMed Web of Science ®Google Scholar
• Olivera AA, Meigs RA. Mitochondria from human term placenta. isolation and assay conditions for oxidative phosphorylation. Biochim Biophys Acta (BBA)-Bioenerg. 1975;376(3):426–435.
   PubMedGoogle Scholar
• Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1952;193:265–275.
   Web of Science ®Google Scholar
• Hagl S, Kocher A, Schiborr C, et al. Rice bran extract protects from mitochondrial dysfunction in Guinea pig brains. Pharmacol Res. 2013;76:17–27.
   PubMed Web of Science ®Google Scholar
• Maity P, Bindu S, Dey S, et al. Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: A novel role of mitochondrial aconitase oxidation. J Biol Chem. 2009;284(5):3058–3068.
   PubMed Web of Science ®Google Scholar
• Wekell JC, Barnett H. New method for analysis of trimethylamine oxide using ferrous sulfate and EDTA. J Food Sci. 1991;56:132–135.
   Web of Science ®Google Scholar
• Livak KJ, Schmittegen TD. Analysis of relative gene expression data using quantitative PCR and the 2 (Delta Delta CT) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Zhu L, MingDai L, Qing HS, et al. Granule ameliorates inflammation in experimental rats and cell model of ulcerative colitis through MEK/ERK signaling pathway. Biomed Pharmacother. 2019;116:108967.
   PubMed Web of Science ®Google Scholar
• Wu HG, Gong X, Yao LQ, et al. Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis. World J Gastroenterol. 2004;10:682–688.
   PubMed Web of Science ®Google Scholar
• Wilson A, Teft WA, Morse BL, et al. Trimethylamine-N-oxide: a novel biomarker for the identification of inflammatory bowel disease. Dig Dis Sci. 2015;60:3620–3630.
   PubMed Web of Science ®Google Scholar
• Sun X, Jiao X, Ma Y, et al. Trimethylamine noxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome. Biochem Biophys Res Commun. 2016;481:63–70.
   PubMed Web of Science ®Google Scholar
• Moos WH, Faller DV, Harpp DN, et al. Microbiota and neurological disorders: a gut feeling. Biores Open Access. 2016;5:137–145.
   PubMed Web of Science ®Google Scholar
• Li Q, Chen H, Zhang M, et al. Altered short chain fatty acid profiles induced by dietary fiber intervention regulate AMPK levels and intestinal homeostasis. Food Funct. 2019;10:7174.
   PubMed Web of Science ®Google Scholar
• Schippa S, Conte MP. Dysbiotic events in gut microbiota: impact on human health. Nutrients. 2014;6:5786–5805.
   PubMed Web of Science ®Google Scholar
• Zhou M, Pu C, Xia L, et al. Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum. Carbohydr Polym. 2014;102:772–779.
   PubMed Web of Science ®Google Scholar
• Samuel BS, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. PNAS USA. 2008;105:16767–16772.
   PubMed Web of Science ®Google Scholar
• Sidharth P, Karunakar P, Taraphder S, et al. Free fatty acid receptors 2 and 3 as microbial metabolite sensors to shape host health: pharmacophysiological view. Biomedicines. 2020;8:154.
   PubMed Web of Science ®Google Scholar
• Villa SR, Priyadarshini M, Fuller MH, et al. Loss of free fatty acid receptor 2 leads to impaired islet mass and beta cell survival. Sci Rep. 2016;6:28159.
   PubMed Web of Science ®Google Scholar
• Priyadarshini M, Villa SR, Fuller M, et al. An acetate-specific GPCR, FFAR2, regulates insulin secretion. Mol Endocrinol. 2015;29:1055–1066.
   PubMed Web of Science ®Google Scholar
• Bindels LB, Porporato PE, Ducastel S, et al. Ffar2 expression regulates leukaemic cell growth in vivo. Br J Cancer. 2017;117:1336–1340.
   PubMed Web of Science ®Google Scholar
• Masui R, Sasaki M, Funaki Y, et al. G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells. Inflamm Bowel Dis. 2013;19(13):2848–2856.
   PubMed Web of Science ®Google Scholar
• He XF, Lu Z, Ma BB, et al. Chronic heat stress damages small intestinal. epithelium cells associated with the adenosine 5′-monophosphate-activated protein kinase pathway in broilers. J Agric Food Chem 2018;66:7301–7309.
   PubMed Web of Science ®Google Scholar
• Schürmann G, Brüwer M, Klotz A, et al. Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease. Int J Colorectal Dis. 1999;14:41–46.
   PubMed Web of Science ®Google Scholar
• Sung HJ, Ma W, Wang PY, et al. Mitochondrial respiration protects against oxygen- associated DNA damage. Nat Commun. 2010;1(1):5.
   PubMedGoogle Scholar
• Bakar MHA, Tan JS. Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway. Biomed Pharmacother. 2017;93:903–912.
   PubMed Web of Science ®Google Scholar
• Kim JE, Lee MH, Nam DH, et al. Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS One. 2013;8:e62068.
   PubMed Web of Science ®Google Scholar
• Fang P, He B, Yu M, et al. Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption. Biochim Biophys Acta (BBA) Mol Basis Dis. 2019;1865(6):1341–1350.
   PubMed Web of Science ®Google Scholar
• Khazdouz M, Daryani NE, Alborzi F, et al. Effect of selenium supplementation on expression of SIRT1 and PGC-1α genes in ulcerative colitis patients: a double blind randomized clinical trial. Clin Nutr Res. 2020 Oct;9(4):284–295.
   PubMedGoogle Scholar
• Ma X, Xu L, Alberobello AT. Alberobello Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis. Cell Metab 2015;22:695–708.
   PubMed Web of Science ®Google Scholar
• Cunningham KE, Vincent G, Sodhi CP, et al. Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) protects against experimental murine colitis. J Biol Chem. 2016;291:10184–10200.
   PubMed Web of Science ®Google Scholar
• D'Errico I, Salvatore L, Murzilli S, et al. Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A. 2011;108:6603–6608.
   PubMed Web of Science ®Google Scholar