Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation

References

• Bisconti M, Simon JF, Grassi S, et al. Influence of risk factors for male infertility on sperm protein composition. Int J Mol Sci. 2021;22(23):13164. doi:10.3390/ijms222313164. PubMed PMID: 34884971; PubMed Central PMCID: PMCPMC8658491.
   PubMed Web of Science ®Google Scholar
• Wong DWS. Flavors. In: Wong DWS, editor. Mechanism and theory in food chemistry, second edition. 2nd ed. Cham: Springer International Publishing; 2018. p. 263–307.
   Google Scholar
• Igwebuike UI, Ochiogu B, Ihedinihu J, et al. The effects of oral administration of monosodium glutamate (MSG) on the testicular morphology and cauda eipididymal sperm reserves of young and adult male rats. Vet Arch. 2011;81(4):525–534.
   Google Scholar
• Al-Shahari EA, El-kott AF. Potential effect of grape seeds extract against monosodium glutamate induced infertility in rats. Int J Pharmacol. 2019;15(2):287–294.
   Google Scholar
• Subramanian P, Jayakumar M, Singaravel M, et al. Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats. J Funct Foods. 2015;12:409–419. doi:10.1016/j.jff.2014.11.025.
   Web of Science ®Google Scholar
• Tripathi R, Samadder T, Gupta S, et al. Anticancer activity of a combination of cisplatin and fisetin in embryonal carcinoma cells and xenograft tumors. Mol Cancer Ther. 2011;10(2):255–268. doi: 10.1158/1535-7163.MCT-10-0606. PubMed PMID: 21216935.
   PubMed Web of Science ®Google Scholar
• Barbagallo F, La Vignera S, Cannarella R, et al. Obesity and male reproduction: Do sirtuins play a role? Int J Mol Sci. 2022;23(2):973. doi:10.3390/ijms23020973. PubMed PMID: 35055159; PubMed Central PMCID: PMCPMC8779691.eng.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhang S, Liu C, et al. Resveratrol ameliorates microcystin-LR-induced testis germ cell apoptosis in rats via SIRT1 signaling pathway activation. Toxins (Basel). 2018;10(6). doi:10.3390/toxins10060235. PubMed PMID: 29890735; PubMed Central PMCID: PMCPMC6024601.
   Web of Science ®Google Scholar
• Nguyen TM. Impact of 5’-amp-activated protein kinase on male gonad and spermatozoa functions. Front Cell Dev Biol. 2017;5:25. doi:10.3389/fcell.2017.00025. PubMed PMID: 28386541; PubMed Central PMCID: PMCPMC5362614.
   PubMed Web of Science ®Google Scholar
• Ahmad A, Ali T, Rehman SU, et al. Phytomedicine-based potent antioxidant, fisetin protects CNS-insult LPS-induced oxidative stress-mediated neurodegeneration and memory impairment. J Clin Med. 2019;8(6):850. doi:10.3390/jcm8060850. PubMed PMID: 31207963; PubMed Central PMCID: PMCPMC6616651.
   PubMed Web of Science ®Google Scholar
• Liou CJ, Wei CH, Chen YL, et al. Fisetin protects against hepatic steatosis through regulation of the Sirt1/AMPK and fatty acid β-oxidation signaling pathway in high-fat diet-induced obese mice. Cell Physiol Biochem. 2018;49(5):1870–1884. doi:10.1159/000493650. PubMed PMID: 30235452; eng.
   PubMedGoogle Scholar
• Ochiogu IS, Ogwu D, Uchendu CN, et al. Effects of monosodium-L-glutamate administration on serum levels of reproductive hormones and cholesterol, epididymal sperm reserves and testicular histomorphology of male albino rats. Acta Vet Hung. 2015;63(1):125–139. doi:10.1556/AVet.2015.011. PubMed PMID: 25655420.
   PubMed Web of Science ®Google Scholar
• Shekarforoush S, Fatahi Z, Safari F. The effects of pentobarbital, ketamine-pentobarbital and ketamine-xylazine anesthesia in a rat myocardial ischemic reperfusion injury model. Lab Anim. 2016;50(3):179–184. doi:10.1177/0023677215597136. PubMed PMID: 26224732.
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Layton C. The hematoxylins and eosin. In: Suvarna SK, Layton C, Bancroft JD, editors. Bancroft’s theory and practice of histological techniques. 8th ed. Amsterdam, Netherlands: Elsevier; 2019. p. 126–138.
   Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265–275. PubMed PMID: 14907713; eng.
   PubMed Web of Science ®Google Scholar
• Brown CD, Forman CL, McEuen SF, et al. Metabolism and testicular toxicity of 1,3-dinitrobenzene in rats of different ages. Fundam Appl Toxicol. 1994;23(3):439–446. doi:10.1006/faat.1994.1126. PubMed PMID: 7835544; eng.
   PubMedGoogle Scholar
• Linder RE, Strader LF, Barbee RR, et al. Reproductive toxicity of a single dose of 1,3-dinitrobenzene in two ages of young adult male rats. Fundam Appl Toxicol. 1990;14(2):284–298. doi:10.1016/0272-0590(90)90208-2. PubMed PMID: 2318353; eng.
   PubMedGoogle Scholar
• Oliveira NNPM, Félix MARF, Pereira TCSP, et al. Sperm quality and testicular histomorphometry of wistar rats supplemented with extract and fractions of fruit of Tribulus terrestris L. Braz Arch Biol Technol. 2015;58(6):891–897. doi:10.1590/S1516-89132015060278.
   Web of Science ®Google Scholar
• Badkoobeh P, Parivar K, Kalantar SM, et al. Effect of nano-zinc oxide on doxorubicin- induced oxidative stress and sperm disorders in adult male Wistar rats. Iran J Reprod Med. 2013;11(5):355–364. PubMed PMID: 24639766; PubMed Central PMCID: PMCPMC3941413. eng.
   PubMedGoogle Scholar
• Prabu PC, Biravi K, Jarisa S, et al. Biochemical, pathomorphological and semen characteristics analysis in male wistar rats treated with withania somnifera root extract. Asian J Chem. 2014;26:3700–3704.
   Google Scholar
• Rouge M, Bowen R. Collection and evaluation of semen 2002 [cited 2021 May 3]. Available from: https://rabowen.org/hbooks/pathphys/reprod/semeneval/hemacytometer.html
   Google Scholar
• Rhodes J, Titherley AC, Norman JA, et al. A survey of the monosodium glutamate content of foods and an estimation of the dietary intake of monosodium glutamate. Food Addit Contam. 1991;8(5):663–672. doi:10.1080/02652039109374021. PubMed PMID: 1818840; eng.
   PubMed Web of Science ®Google Scholar
• Yang WH, Drouin MA, Herbert M, et al. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol. 1997;99(6 Pt 1):757–762. doi:10.1016/s0091-6749(97)80008-5. PubMed PMID: 9215242; eng.
   PubMed Web of Science ®Google Scholar
• Reynolds WA, Lemkey-Johnston N, Filer LJ, Jr., et al. Monosodium glutamate: absence of hypothalamic lesions after ingestion by newborn primates. Science (New York, NY). 1971;172(3990):1342–1344. doi:10.1126/science.172.3990.1342. PubMed PMID: 4996307; eng.
   Google Scholar
• Kolthur-Seetharam U, Teerds K, de Rooij DG, et al. The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling. Biol Reprod. 2009;80(2):384–391. doi:10.1095/biolreprod.108.070193. PubMed PMID: 18987333; eng.
   PubMed Web of Science ®Google Scholar
• Lewerenz J, Hewett SJ, Huang Y, et al. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal. 2013;18(5):522–555. doi:10.1089/ars.2011.4391. PubMed PMID: 22667998; PubMed Central PMCID: PMCPMC3545354.
   PubMed Web of Science ®Google Scholar
• Giovambattista A, Suescun MO, Nessralla CC, et al. Modulatory effects of leptin on leydig cell function of normal and hyperleptinemic rats. Neuroendocrinology. 2003;78(5):270–279. doi:10.1159/000074448. PubMed PMID: 14657608; eng.
   PubMed Web of Science ®Google Scholar
• Storto M, Sallese M, Salvatore L, et al. Expression of metabotropic glutamate receptors in the rat and human testis. J Endocrinol. 2001;170(1):71–78. doi:10.1677/joe.0.1700071. PubMed PMID: 11431139; eng.
   PubMed Web of Science ®Google Scholar
• Price NL, Gomes AP, Ling AJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15(5):675–690. doi:10.1016/j.cmet.2012.04.003. PubMed PMID: 22560220; PubMed Central PMCID: PMCPMC3545644.
   PubMed Web of Science ®Google Scholar
• Jiang S, Wang Y, Luo L, et al. AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events. J Cell Mol Med. 2019;23(6):3951–3961. doi:10.1111/jcmm.14279. PubMed PMID: 30993829; PubMed Central PMCID: PMCPMC6533503. eng.
   PubMed Web of Science ®Google Scholar
• Tatone C, Di Emidio G, Barbonetti A, et al. Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. Hum Reprod Update. 2018;24(3):267–289. doi:10.1093/humupd/dmy003. PubMed PMID: 29447380.
   PubMed Web of Science ®Google Scholar
• Cabrera-Pastor A, Llansola M, Reznikov V, et al. Differential effects of chronic hyperammonemia on modulation of the glutamate-nitric oxide-cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo. Neurochem Int. 2012;61(1):63–71. doi:10.1016/j.neuint.2012.04.006. PubMed PMID: 22521775; eng.
   PubMed Web of Science ®Google Scholar
• Lewerenz J, Maher P. Control of redox state and redox signaling by neural antioxidant systems. Antioxid Redox Signal. 2011;14(8):1449–1465. doi:10.1089/ars.2010.3600. PubMed PMID: 20812872.
   PubMed Web of Science ®Google Scholar
• Shukry M, El-Shehawi AM, El-Kholy WM, et al. Ameliorative effect of graviola (Annona muricata) on mono sodium glutamate-induced hepatic injury in rats: antioxidant, apoptotic, anti-inflammatory. Lipogenesis Markers, and Histopathological Studies. Animals (Basel). 2020;10(11). doi:10.3390/ani10111996. PubMed PMID: 33143024; PubMed Central PMCID: PMCPMC7693810.
   Google Scholar
• Radi R. Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine. Proc Natl Acad Sci USA. 2018;115(23):5839–5848. doi:10.1073/pnas.1804932115. PubMed PMID: 29802228; PubMed Central PMCID: PMCPMC6003358.
   PubMed Web of Science ®Google Scholar
• Nisimoto Y, Diebold BA, Cosentino-Gomes D, et al. Nox4: a hydrogen peroxide-generating oxygen sensor. Biochemistry. 2014;53(31):5111–5120. doi:10.1021/bi500331y. PubMed PMID: 25062272; PubMed Central PMCID: PMCPMC4131900. eng.
   PubMed Web of Science ®Google Scholar
• Montezano AC, Touyz RM. Reactive oxygen species and endothelial function–role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Basic Clin Pharmacol Toxicol. 2012;110(1):87–94. doi:10.1111/j.1742-7843.2011.00785.x. PubMed PMID: 21883939.
   PubMed Web of Science ®Google Scholar
• Kantartzi PD, Goulis Ch D, Goulis GD, et al. Male infertility and varicocele: myths and reality. Hippokratia. 2007;11(3):99–104. PubMed PMID: 19582201; PubMed Central PMCID: PMCPMC2658802.
   PubMedGoogle Scholar
• Mahaseth T, Kuzminov A. Potentiation of hydrogen peroxide toxicity: from catalase inhibition to stable DNA-iron complexes. Mutat Res Rev Mutat Res. 2017;773:274–281. doi:10.1016/j.mrrev.2016.08.006. PubMed PMID: 28927535; PubMed Central PMCID: PMCPMC5607474. eng.
   PubMed Web of Science ®Google Scholar
• Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem. 2006;97(6):1634–1658. doi:10.1111/j.1471-4159.2006.03907.x. PubMed PMID: 16805774; eng.
   PubMed Web of Science ®Google Scholar
• Sahu BD, Kalvala AK, Koneru M, et al. Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kappaB activation and antioxidant defence. PLoS One. 2014;9(9):e105070. doi:10.1371/journal.pone.0105070. PubMed PMID: 25184746; PubMed Central PMCID: PMCPMC4153571.
   PubMed Web of Science ®Google Scholar
• Maher P. How fisetin reduces the impact of age and disease on CNS function. Front Biosci (Schol Ed). 2015;7(1):58–82. doi:10.2741/S425. PubMed PMID: 25961687; PubMed Central PMCID: PMCPMC5527824.
   PubMedGoogle Scholar
• Maher P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr. 2009;4(4):297–307. doi:10.1007/s12263-009-0142-5. PubMed PMID: 19756810; PubMed Central PMCID: PMCPMC2775892.
   PubMed Web of Science ®Google Scholar
• Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med. 1997;22(5):749–760. doi:10.1016/s0891-5849(96)00351-6. PubMed PMID: 9119242.
   PubMed Web of Science ®Google Scholar
• Li S, Hong H, Lv H, et al. SIRT 1 overexpression is associated with metastasis of pancreatic ductal adenocarcinoma (PDAC) and promotes migration and growth of PDAC cells. Med Sci Monit. 2016;22:1593–1600. doi:10.12659/msm.896697. PubMed PMID: 27170223; PubMed Central PMCID: PMCPMC4917327. eng.
   PubMed Web of Science ®Google Scholar
• Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107(2):149–159. doi:10.1016/s0092-8674(01)00527-x. PubMed PMID: 11672523; eng.
   PubMed Web of Science ®Google Scholar