Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners

References

• Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: Cause and consequences. Free Radic Biol Med. 2011;51:942–950.
   PubMed Web of Science ®Google Scholar
• Azizbeigi K, Stannard SR, Atashak S, et al. Antioxidant enzymes and oxidative stress adaptation to exercise training: Comparison of endurance, resistance, and concurrent training in untrained males. J Exerc Sci Fit. 2014;12:1–6.
   Web of Science ®Google Scholar
• Ryu JH, Paik IY, Woo JH, et al. Impact of different running distances on muscle and lymphocyte DNA damage in amateur marathon runners. J Phys Ther Sci. 2016;28:450–455.
   PubMedGoogle Scholar
• Radak Z, Ishihara K, Tekus E, et al. Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve. Redox Biol. 2017;12:285–290.
   PubMed Web of Science ®Google Scholar
• Simioni C, Zauli G, Martelli AM, et al. Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018;9:17181–17198.
   PubMedGoogle Scholar
• Biswas SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev. 2016;2016:5698931.
   PubMed Web of Science ®Google Scholar
• Powers SK, Deminice R, Ozdemir M, et al. Exercise-induced oxidative stress: Friend or foe? J Sport Heal Sci. 2020;9:415–425.
   PubMed Web of Science ®Google Scholar
• Thirupathi A, Pinho RA, Ugbolue UC, et al. Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review. Front Physiol. 2021;11:610112.
   PubMed Web of Science ®Google Scholar
• Mastaloudis A, Leonard SW, Traber MG. Oxidative stress in athletes during extreme endurance exercise. Free Radic Biol Med. 2001;31:911–922.
   PubMed Web of Science ®Google Scholar
• Ammar A, Trabelsi K, Boukhris O, et al. Effects of aerobic-, anaerobic- and combined-based exercises on plasma oxidative stress biomarkers in healthy untrained young adults. Int J Environ Res Public Health. 2020;17(7):2601.
   PubMed Web of Science ®Google Scholar
• Wang F, Wang X, Liu Y, et al. Effects of Exercise-Induced ROS on the Pathophysiological Functions of Skeletal Muscle. Oxid Med Cell Longev. 2021;2021:3846122.
   PubMed Web of Science ®Google Scholar
• Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008;44:126–131.
   PubMed Web of Science ®Google Scholar
• Mason SA, Trewin AJ, Parker L, et al. Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights. Redox Biol. 2020;35:101471.
   PubMed Web of Science ®Google Scholar
• Hatcher H, Planalp R, Cho J, et al. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65:1631–1652.
   PubMed Web of Science ®Google Scholar
• Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471–480.
   PubMed Web of Science ®Google Scholar
• Wei Y, Gong J, Yoshida T, et al. Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radic Biol Med. 2011;51:216–224.
   PubMed Web of Science ®Google Scholar
• Sun Y, Oberley LW. Redox regulation of transcriptional activators. Free Radic Biol Med. 1996;21:335–348.
   PubMed Web of Science ®Google Scholar
• Priyadarsini KI, Maity DK, Naik GH, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med. 2003;35:475–484.
   PubMed Web of Science ®Google Scholar
• Gupta SC, Patchva S, Koh W, et al. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39:283–299.
   PubMed Web of Science ®Google Scholar
• Ms SAB, Waldman HS, Krings BM, et al. Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness. J Diet Suppl. 2021;17:401–414.
   Web of Science ®Google Scholar
• Zendedel E, Butler AE, Atkin SL, et al. Impact of curcumin on sirtuins: A review. J Cell Biochem. 2018;119:10291–10300.
   PubMed Web of Science ®Google Scholar
• Nogueiras R, Habegger KM, Chaudhary N, et al. Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism. Physiol Rev. 2012;92:1479–1514.
   PubMed Web of Science ®Google Scholar
• Chen Y, Fu LL, Wen X, et al. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell Death Dis. 2014;5:1047.
   PubMed Web of Science ®Google Scholar
• Chenari S, Safari F, Moradi A. Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis. Iran J Basic Med Sci. 2017;20:1306–1311.
   PubMed Web of Science ®Google Scholar
• Suhett LG, de Miranda Monteiro Santos R, Silveira BKS, et al. Effects of curcumin supplementation on sport and physical exercise: a systematic review. Crit Rev Food Sci Nutr. 2021;61:946–958.
   PubMed Web of Science ®Google Scholar
• Daniels J. (2014). Daniel’s running formula. Champaign (Illinois). Hum Kinet.
   Google Scholar
• Waśkiewicz Z, Kłapcińska B, Sadowska-Krȩpa E, et al. Acute metabolic responses to a 24-h ultra-marathon race in male amateur runners. Eur J Appl Physiol. 2012;112:1679–1688.
   PubMed Web of Science ®Google Scholar
• Czuba M, Maszczyk A, Gerasimuk D, et al. The effects of hypobaric hypoxia on erythropoiesis, Maximal oxygen uptake and energy cost of exercise under normoxia in elite biathletes. J Sport Sci Med. 2014;13(4):912–920.
   PubMed Web of Science ®Google Scholar
• Beutler E, Duron O, Kelly B. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963: 882–888.
   PubMed Web of Science ®Google Scholar
• Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158–169.
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase in Vitro. Methods Enzymol. 1984;105:121–126.
   PubMed Web of Science ®Google Scholar
• Buege JA, Aust SD. Microsomal Lipid Peroxidation. Methods Enzymol. 1978;52:302–310.
   PubMedGoogle Scholar
• Rice-Evans CA, Diplock AT, Symons MCR. Techniques in free radical research. Amsterdam (Netherlands): Elsevier. 1991;22:47–50.
   Google Scholar
• Peternelj TT, Coombes JS. Antioxidant supplementation during exercise training: Beneficial or detrimental? Sport Med. 2011;41:1043–1069.
   PubMed Web of Science ®Google Scholar
• Chang CK, Huang HY, Tseng HF, et al. Interaction of vitamin E and exercise training on oxidative stress and antioxidant enzyme activities in rat skeletal muscles. J Nutr Biochem. 2007;18:39–45.
   PubMed Web of Science ®Google Scholar
• Ristow M, Zarse K, Oberbach A, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci. 2009;106:8665–8670.
   PubMed Web of Science ®Google Scholar
• Chandwaney R, Leichtweis S, Leeuwenburgh C, et al. Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training. J Am Aging Assoc. 1998;21:109–117.
   Google Scholar
• Daussin FN, Rasseneur L, Bouitbir J, et al. Different timing of changes in mitochondrial functions following endurance training. Med Sci Sports Exerc. 2012;44:217–224.
   PubMed Web of Science ®Google Scholar
• de Sousa CV, Sales MM, Rosa TS, et al. The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis. Sport Med. 2017;47:277–293.
   PubMed Web of Science ®Google Scholar
• Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med. 2008;44:142–152.
   PubMed Web of Science ®Google Scholar
• Child RB, Wilkinson DM, Fallowfield JOL, et al. Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run. Med Sci Sports Exerc. 1998;30:1603–1607.
   PubMed Web of Science ®Google Scholar
• Kłapcińska B, Waśkiewicz Z, Chrapusta SJ, et al. Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners. Eur J Appl Physiol. 2013;113:2781–2793.
   PubMed Web of Science ®Google Scholar
• Sadowska-Krępa E, Rozpara M, Rzetecki A, et al. Strenuous 12-h run elevates circulating biomarkers of oxidative stress, inflammation and intestinal permeability in middle-aged amateur runners: A preliminary study. PLoS One. 2021;16(4):e0249183.
   PubMed Web of Science ®Google Scholar
• Gomez-Cabrera M-C, Martínez A, Santangelo G, et al. Oxidative stress in marathon runners: interest of antioxidant supplementation. Br J Nutr. 2006;96:S31–S33.
   PubMed Web of Science ®Google Scholar
• Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, et al. The influence of supplementation with Rhodiola rosea L. extract on Selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. 2009;19:186–199.
   PubMed Web of Science ®Google Scholar
• Sadowska-Krępa E, Kłapcińska B, Podgórski T, et al. Effects of supplementation with acai (Euterpe oleracea Mart.) berry-based juice blend on the blood antioxidant defence capacity and lipid profile in junior hurdlers. A pilot study. Biol Sport. Termedia. 2015;32:161–168.
   Google Scholar
• Sadowska-Krȩpa E, Domaszewski P, Pokora I, et al. Effects of medium-term green tea extract supplementation combined with CrossFit workout on blood antioxidant status and serum brain-derived neurotrophic factor in young men: A pilot study. J Int Soc Sports Nutr. 2019;16(1):13.
   PubMedGoogle Scholar
• Donatus IA S, Vermeulen NPE. Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochem Pharmacol. 1990;39:1869–1875.
   PubMed Web of Science ®Google Scholar
• Ahsan H, Parveen N, Khan NU, et al. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact. 1999;121:161–175.
   PubMed Web of Science ®Google Scholar
• Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105–125.
   PubMed Web of Science ®Google Scholar
• Trujillo J, Chirino YI, Molina-Jijón E, et al. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;1:448–456.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: Problems and promises. Mol Pharm. 2007;4:807–818.
   PubMed Web of Science ®Google Scholar
• Cas MD, Ghidoni R. Dietary curcumin: Correlation between bioavailability and health potential. Nutrients. 2019;11(9):2147.
   PubMed Web of Science ®Google Scholar
• Hewlings SJ, Kalman DS. Curcumin: A review of its effects on human health. Foods. 2017;6(10):92.
   PubMed Web of Science ®Google Scholar
• González-Reyes S, Guzmán-Beltrán S, Medina-Campos ON, et al. Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats. Oxid Med Cell Longev. 2013;2013:801418.
   PubMed Web of Science ®Google Scholar
• Zieliński J, Kusy K. Pathways of purine metabolism: effects of exercise and training in competitive athletes. Trends Sport Sci. 2015;22(3):103–112.
   Google Scholar
• Alsop RJ, Dhaliwal A, Rheinstädter MC. Curcumin Protects Membranes through a Carpet or Insertion Model Depending on Hydration. Langmuir. 2017;33:8516–8524.
   PubMed Web of Science ®Google Scholar
• Ak T, Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact. 2008;174:27–37.
   PubMed Web of Science ®Google Scholar
• He F, Li J, Liu Z, et al. Redox mechanism of reactive oxygen species in exercise. Front Physiol. 2016;7:486.
   PubMed Web of Science ®Google Scholar
• Tanabe Y, Chino K, Ohnishi T, et al. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019;29:524–534.
   PubMed Web of Science ®Google Scholar
• Tanabe Y, Chino K, Sagayama H, et al. Effective timing of curcumin ingestion to attenuate eccentric exercise–induced muscle soreness in men. J Nutr Sci Vitaminol (Tokyo). 2019;65:82–89.
   PubMed Web of Science ®Google Scholar