1,136
Views
140
CrossRef citations to date
0
Altmetric
Review

Therapeutic effects of EGCG: a patent review

, , , &
Pages 907-916 | Received 29 Mar 2016, Accepted 15 Jun 2016, Published online: 29 Jun 2016

References

  • World tea production and trade Current and future development. Food and agriculture organization of United Nation. 2015 [cited 2016 Mar 28]. Available from: http://www.fao.org
  • Thakur VS, Gupta K, Gupta S. The chemopreventive and chemotherapeutic potentials of tea polyphenols. Curr Pharm Biotechnol. 2012;13:191–199.
  • Saito ST, Gosmann G, Pungartnik C, et al. Green tea extract-patents and diversity of uses. Recent Pat Food Nutr Agric. 2009;1:203–215.
  • Reygaert WC. The antimicrobial possibilities of green tea. Front Microbiol. 2014;5:434.
  • Jeon J, Kim JH, Lee CK, et al. The antimicrobial activity of ()-epigallocatehin-3-gallate and green tea extracts against Pseudomonas aeruginosa and Escherichia coli isolated from skin wounds. Ann Dermatol. 2014;26:564–569.
  • Singh BN, Shankar S, Srivastava RK. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol. 2011;82:1807–1821.
  • Shen C, Chen L, Jiang L, et al. Neuroprotective effect of epigallocatechin-3-gallate in a mouse model of chronic glaucoma. Neurosci Lett. 2015;600:132–136.
  • Ahmed RS, Liu G, Renzetti A, et al. Biological and mechanistic characterization of novel prodrugs of green tea polyphenol epigallocatechin gallate analogs in human leiomyoma cell lines. J Cell Biochem. 2016. [Epub ahead of print], doi:10.1002/jcb.25533.
  • De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3:133–149.
  • Sanna V, Pala N, Dessì G, et al. Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities. Int J Nanomedicine. 2014;9:4935–4951.
  • Tsai LC, Hsieh HY, Lu KY, et al. EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment. Nanomedicine. 2016;11:9–30.
  • Singh M, Bhatnagar P, Mishra S, et al. PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma. Int J Nanomedicine. 2015;10:6789–6809.
  • Situ BC. Cancer Facts; [cited 2016 Mar 28]. Available from: http://www.cancer.org
  • Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin. 2015;65:5–29.
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674.
  • Chen SJ, Yao XD, Peng B, et al. Epigallocatechin-3-gallate inhibits migration and invasion of human renal carcinoma cells by downregulating matrix metalloproteinase-2 and matrix metalloproteinase-9. Exp Ther Med. 2016;11:1243–1248.
  • Zhu K, Wang W. Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1. Tumour Biol. 2016;37:4373–4382.
  • Koh YW, Choi EC, Kang SU, et al. Green tea (−)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met. J Nutr Biochem. 2011;22:1074–1083.
  • Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006;66:1234–1240.
  • Kumar NB, Pow-Sang J, Egan KM, et al. Randomized, placebo-controlled trial of green tea catechins for prostate cancer prevention. Cancer Prev Res. 2015;8:879–887.
  • Nicolai S, Rossi A, Di Daniele N, et al. DNA repair and aging: the impact of the p53 family. Aging. 2015;7:1050–1065.
  • Kürbitz C, Heise D, Redmer T, et al. Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti‐inflammatory activities in pancreatic tumor cells. Cancer Sci. 2011;102:728–734.
  • Mayr C, Wagner A, Neureiter D, et al. The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells. BMC Complement Altern Med. 2015;15:194.
  • Du GJ, Zhang Z, Wen XD, et al. Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients. 2012;4:1679–1691.
  • EGCG: Potent extract of green tea. Intelligent Medicine. 2013 [cited 2016 Mar 28]. Available from: http://www.drhoffman.com
  • Xie H, Sun J, Chen Y, et al. EGCG attenuates uric acid-induced inflammatory and oxidative stress responses by medicating the NOTCH pathway. Oxid Med Cell Longev. 2015;2015:214836.
  • Srividhya R, Jyothilakshmi V, Arulmathi K, et al. Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (−)-epigallocatechin-3-gallate. Int J Dev Neurosci. 2008;26:217–223.
  • Gao Z, Han Y, Hu Y, et al. Targeting HO-1 by epigallocatechin-3-gallate reduces contrast-induced renal injury via anti-oxidative stress and anti-inflammation pathways. Plos One. 2016;11:e0149032.
  • Hu B, Ting Y, Zeng X, et al. Bioactive peptides/chitosan nanoparticles enhance cellular antioxidant activity of (−)-epigallocatechin-3-gallate. J Agric Food Chem. 2013;61:875–881.
  • Chen L, Zhang HY. Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate. Molecules. 2007;12:946–957.
  • Zhou Y, Tang J, Du Y, et al. The green tea polyphenol EGCG potentiates the antiproliferative activity of sunitinib in human cancer cells. Tumour Biol. 2016 Jan 5. doi:10.1007/s13277-015-4719-x. [Epub ahead of print].
  • Katiyar SK, Afaq F, Azizuddin K, et al. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (−)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol. 2001;176:110–117.
  • Maeda-Yamamoto M, Suzuki N, Sawai Y, et al. Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells. J Agric Food Chem. 2003;51:1858–1863.
  • Fraley DS, Adler S, Bruns F, et al. Metabolic acidosis after hyperalimentation with casein hydrolysate: occurrence in a starved patient. Ann Intern Med. 1978;88:352–354.
  • Li M, Li JJ, Gu QH, et al. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncol Rep. 2016;35:2339–2347.
  • Ma J, Shi M, Li G, et al. Regulation of Id1 expression by epigallocatechin-3-gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells. Int J Oncol. 2013;43:1052–1058.
  • Liu S, Xu ZL, Sun L, et al. ()-Epigallocatechin-3-gallate induces apoptosis in human pancreatic cancer cells via PTEN. Mol Med Rep. 2016; doi:10.3892/mmr.2016.5277. [Epub ahead of print].
  • Siddiqui IA, Bharali DJ, Nihal M, et al. Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomedicine. 2014;10:1619–1626.
  • University of South Florida. Tea polyphenol esters and analogs thereof for cancer prevention and treatment. US6713506; 2004.
  • SRI International. Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents. US7109236; 2006.
  • SRI International. Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents. US7122573; 2006.
  • Purdue Research Foundation. Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer. US7192612; 2007.
  • Lifeline Nutraceuticals Corporation. Preparation of compositions to alleviate inflammation and oxidative stress in a mammal. US7384655; 2008.
  • Lifeline Nutraceuticals Corporation. Methods for enhancing antioxidant enzyme activity and reducing c-reactive protein levels. US7579026; 2009.
  • Research Development Foundation. Polyphenol inhibition of nucleoside diphosphate kinase-B activity and cancer metastasis. US7678549; 2010.
  • Genprofilers.r.l. Mixture of catechins or rather polyphenols extracted from Chinese green tea or other vegetables for the prevention of prostate cancer and for the treatment of prostate hypertrophy (BPH). US8044095; 2011.
  • MediGene AG Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin. US8455022; 2013.
  • University of South Florida, McGill University and The Hong Kong Polytechnic University. Polyphenol proteasome inhibitors, synthesis, and methods of use. US8563607; 2013.
  • Agency for Science, Technology and Research. Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents. US8753687; 2014.
  • Gold Nanotech, Inc. Physical nano-complexes for preventing and treating cancer and method for manufacturing the same. US8759546; 2014.
  • Mayo Foundation for Medical Education and Research. Methods of treating hematologic cancers. US8772264; 2014.
  • Georgia Regents Research Institute. Oral care compositions for treating xerostomia. US8920854; 2014.
  • The Hong Kong Polytechnic University, Wayne State University, University of south florida and McGILL University. (–)-Epigallocatechin gallate derivatives for inhibiting proteasome. US9169230; 2015.
  • WM. Wrigley Jr. Company. Oral compositions for skin benefits. US9186348; 2015.
  • Agency for Science, Technology and Research. Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents. US9226899; 2016.
  • Agency for Science, Technology and Research. Method of delivering an anti-cancer agent to a cell. US9248200; 2016.
  • Kassi E, Pervanidou P, Kaltsas G, et al. Metabolic syndrome: definitions and controversies. BMC Med. 2011;9:48.
  • Keske MA, Ng HL, Premilovac D, et al. Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate. Curr Med Chem. 2015;22:59–69.
  • Chen IJ, Liu CY, Chiu JP, et al. Therapeutic effect of high-dose green tea extract on weight reduction: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2015;22:59–69.
  • Hill AM, Coates AM, Buckley JD, et al. Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr. 2007;26:396S–402S.
  • Kucera O, Mezera V, Moravcova A, et al. In vitro toxicity of epigallocatechin gallate in rat liver mitochondria and hepatocytes. Oxid Med Cell Longev. 2015;2015:476180.
  • Collins QF, Liu HY, Pi J, et al. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem. 2007;282:30143–30149.
  • Zhang J, Nie S, Wang S. Nanoencapsulation enhances epigallocatechin-3-gallate stability and its antiatherogenic bioactivities in macrophages. J Agric Food Chem. 2013;61:9200–9209.
  • Zhang J, Nie S, Martinez-Zaguilan R, et al. Formulation, characteristics and antiatherogenic bioactivities of CD36-targeted epigallocatechin gallate (EGCG)-loaded nanoparticles. J Nutr Biochem. 2016;30:14–23.
  • Moorthi C, Kathiresan K. Nanotoxicology: toxicity of engineered nanoparticles and approaches to produce safer nanotherapeutics. Int J Pharm Sci. 2012;2:117–124.
  • Laboratoires Arkopharma. Green tea extract for treating obesity. US6830765; 2004.
  • Herbalife International, Inc. Herbal supplement to support weight loss. US7329419; 2008.
  • DSM IP Assets B.V. Compositions comprising epigallocatechingallate and protein hydrolysate. US8129337; 2012.
  • FHG Corporation. Dietary supplements containing extracts of aronia and methods of using same to promote weight loss. US8158683; 2012.
  • Finley;Jahahreeh. Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation. US8652518; 2014.
  • Nuc Electronics Co.Ltd. Composition for controlling increase in blood glucose. US9180156; 2015.
  • Nusirt Sciences,Inc. Compositions and methods for modulating metabolic pathways. US9198883; 2015.
  • Purdue Research Foundation. Compositions and methods for treating and preventing virus infections. US7491413; 2009.
  • Immune Guard, LLC. Methods and materials for reducing risk of cold and/or flu. US8465782; 2013.
  • Cook Medical Technologies. Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof. US9180226; 2015.
  • University of South Florida and Natura Therapeutics, Inc. Methods and compositions for improving bioavailability of epigallocatechingallate (EGCG). US8906414; 2014.
  • New York University. Method for enhancing remyelination using GLI1 inhibitors. US9248128; 2016.
  • Antibiotic Resistance Threats in the United States. U.S. Department Health Hum Serv. 2013 [cited 2016 Mar 28]. Available from: http://www.cdc.gov.org
  • Taylor PW, Hamilton-Miller JM, Stapleton PD. Antimicrobial properties of green tea catechins. Food Sci Technol Bull. 2005;2:71–81.
  • Yun B, Oh S, Song M, et al. Inhibitory effect of epigallocatechin gallate on the virulence of clostridium difficile PCR ribotype 027. J Food Sci. 2015;80:M2925–31.
  • Brown RC, Lockwood AH, Sonawane BR. Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect. 2005;113:1250–1256.
  • Murpy MP, LeVine III H. Alzheimer’s disease and the β-amyloid peptide. J Alzheimers Dis. 2010;19:311–323.
  • O’Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer’s disease. Annu Rev Neurosci. 2011;34:185–204.
  • Walker JM, Klakotskaia D, Ajit D, et al. Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer’s disease mouse model. J Alzheimers Dis. 2015;44:561–572.
  • Rasoolijazi H, Joghataie MT, Roghani M, et al. The beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of Alzheimer’s disease in rat: a behavioral analysis. Iranian Biomed J. 2007;11:237–243.
  • Wang LY, Li X, Han YZ. Neuroprotection by epigallo catechin gallate against bupivacaine anesthesia induced toxicity involves modulation of PI3/Akt/PTEN signalling in N2a and SH-SY5Y cells. Int J Clin Exp Med. 2015;8:15065–15075.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.