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Review

Therapeutic significance of quinolines: a patent review (2013-2015)

Pages 1201-1221 | Received 12 May 2016, Accepted 20 Jul 2016, Published online: 08 Aug 2016

References

  • Yan R, Liu X, Pan C, et al. Aerobic synthesis of substituted quinoline from aldehyde and aniline: copper-catalyzed intermolecular C–H active and C–C formative cyclization. Org Lett. 2013;15(18):4876–4879.
  • Chung P-Y, Bian Z-X, Pun H-Y, et al. Recent advances in research of natural and synthetic bioactive quinolines. Future Med Chem. 2015;7(7):947–967.
  • Rehan M, Hazra G, Ghorai P. Synthesis of polysubstituted quinolines via transition-metal-free oxidative cycloisomerization of o-cinnamylanilines. Org Lett. 2015;17(7):1668–1671.
  • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer. 2009;9(1):28–39.
  • Davis IJ, McFadden AW, Zhang YX, et al. Identification of the receptor tyrosine kinase c-met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. Cancer Res. 2010;70(2):639–645.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of pyrazolone containing quinoline compounds as c-Met kinase inhibitor for the treatment of c-Met overexpressed cancer patent. CN105017217A. 2015.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Quinoline derivatives as c-Met kinase inhibitors and their preparation and use for the treatment of c-Met kinase-mediated diseases patent. US20150307453A1. 2015.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of quinoline compounds for preventing and/or treating c-Met kinase abnormal over-expression induced diseases patent. WO2014067417A1. 2014.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of quinoline compounds for preventing and/or treating c-Met kinase abnormal over-expression induced diseases patent. CN102977014A. 2013.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. 1,2,3-Triazole-containing quinoline compound useful in treatment of diseases caused by c-Met kinase abnormally high expression and its preparation patent. CN104119317A. 2014.
  • Gong P, Liu Y, Zhao Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of 4-substituted quinoline compounds as c-met kinase inhibitors patent. CN104086530A. 2014.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of quinoline derivatives for treating and/or preventing cancer patent. CN104072480A. 2014.
  • Gong P, Liu Y, Zhao Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China. assignee. Preparation of 2-aryl-substituted quinoline compounds for treatment of cancer patent. CN103965107A. 2014.
  • Gong P, Zhao Y, Liu Y, et al., inventors; Shenyang Pharmaceutical University, Peop. Rep. China; Benxi Pharmaceutical Science and Technology Co., Ltd., Shenyang Pharmaceutical University. assignee. Preparation of hexahydropyrimidone containing quinoline compounds as c-Met kinase inhibitors patent. CN103709145A. 2014.
  • Chen C, inventor Tianjin Longbogen Pharmaceutical Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline derivatives for treating solid tumor and leukemia patent. CN104211686A. 2014.
  • Xu H, inventor Wuhan Shengyun Biopharma Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline compounds containing 1,2,4-triazine-dione and use as c-Met kinase inhibitors for treating proliferative diseases patent. US20130252958A1. 2013.
  • Yu J, Guo L, Zhao F, et al., inventors; Shanghai Pharmaceuticals Holding Co., Ltd., Peop. Rep. China. assignee. Quinoline-series compound, its preparation method, and pharmaceutical application patent. CN104109166A. 2014.
  • Liu P, Cheng H, Roberts TM, et al. Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer. Nat Rev Drug Discov. 2009;8(8):627–644.
  • Hu Y, Lv X, Dong X, inventors; Zhejiang University, Peop. Rep. China. assignee. Preparation of 3,4-disubstituted-6-(3-pyridyl)quinoline derivatives as PI3Kα inhibitors patent. CN105130954A. 2015.
  • Hu Y, Lv X, Dong X, inventors; Zhejiang University, Peop. Rep. China. assignee. 4-α,β-Unsaturated-sulfonylamino-quinolines as PI3Kα inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer patent. CN104961725A. 2015.
  • Cheng J, Qin J, inventors; Shanghai Huilun Life Science & Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of morpholino-quinoline compounds for the treatment of diseases associated with PI3K/mTOR patent. CN103936762A. 2014.
  • Zhu J, Song Y, Han J, et al., inventors; The Second Military Medical University, PLA, Peop. Rep. China. assignee. Preparation of N-(5-(quinolin-6-yl)pyridin-3-yl) benzenesulfamide derivatives for treating tumor and immune disease patent. CN103788071A. 2014.
  • Zhu J, Song Y, Han J, et al., inventors; Second Military Medical University, PLA, Peop. Rep. China. assignee. Preparation of N-(5-(quinolin-6-yl)pyridin-3-yl) benzenesulfamide derivatives for treating tumor and immune disease patent. WO2014067473A1. 2014.
  • Li X, Dong Q, Chen Y, et al., inventors; Shanghai Hengrui Pharmaceutical Co., Ltd., Peop. Rep. China; Jiangsu Hengrui Medicine Co., Ltd. assignee. Imidazo quinoline derivative as mTOR and PI3K-kinase inhibitor useful in the treatment of various diseases, and its preparation patent. WO2013053273A1. 2013.
  • Li X, Dong Q, Chen Y, et al., inventors; Shanghai Hengrui Pharmaceutical Co., Ltd., Peop. Rep. China; Jiangsu Hengrui Medicine Co., Ltd. assignee. Imidazo quinoline derivative as mTOR and PI3K-kinase inhibitor useful in the treatment of various diseases, and its preparation patent. CN103030637A. 2013.
  • Kumar S, Sharma R, Deore VB, et al., inventors; Piramal Enterprises Limited, India. assignee. Preparation of imidazo[4,5-c]quinoline derivatives that are kinase inhibitors useful in treatment of proliferative, neoplastic and other kinase-mediated diseases patent. WO2014141118A1. 2014.
  • Reddy EP, Reddy MVR, inventors; Temple University - of the Commonwealth System of Higher Education, USA. assignee. Preparation of 3-aminothieno[3,2-c]quinoline derivatives as antitumor agents patent. WO2013142010A1. 2013.
  • Wan H, Shen J, Li C, et al., inventors; Shanghai Pharmaceuticals Holding Co., Ltd., Peop. Rep. China. assignee. Deuterated 3-cyanoquinoline compounds as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer patent. WO2014086284A1. 2014.
  • Zhang D, inventor USA. assignee. Substituted quinolines as Bruton’s tyrosine kinases inhibitors patent. WO2013152135A1. 2013.
  • Lv H, Chen Y, Wang S, et al., inventors; Shanghai Hengrui Pharmaceutical Co., Ltd., Peop. Rep. China; Jiangsu Hengrui Medicine Co., Ltd. assignee. Preparation of quinoline derivatives protein kinase inhibitors patent. CN103382206A. 2013.
  • Bock MG, Moebitz H, Panigrahi SK, et al., inventors; Novartis AG, Switz. assignee. Preparation of 1-(cyclohexyl)-8-(phenyl)-1H-imidazo[4,5-c]quinoline derivatives as MEK kinase inhibitors useful in the treatment of cancer and inflammation patent. WO2015022664A1. 2015.
  • Schadt O, Esdar C, Schultz-Fademrecht C, et al., inventors; Merck Patent GmbH, Germany. assignee. Preparation of a quinoline inhibitor of the macrophage stimulating 1 receptor patent. WO2014194975A1. 2014.
  • Li Y-L, Burns DM, Feng H, et al., inventors; Incyte Corporation, USA. assignee. Preparation of bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors for treating proliferative and immune disorders patent. WO2014110574A1. 2014.
  • Chand P, Tapolsky GH, inventors; Advanced Cancer Therapeutics, LLC, USA. assignee. Preparation of pyridynyltrifluoromethylquinolinylpropenone derivatives for use as a PFKFB3 inhibitors patent. WO2013148228A1. 2013.
  • Larsen AK, Ouaret D, El Ouadrani K, et al. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther. 2011;131(1):80–90.
  • Zhu K, Mao C, Qin L, inventors; Nanjing Zhongruiyuan Biotechnology Co., Ltd., Peop. Rep. China. assignee. Preparation of alkynyl-substituted quinoline derivatives as antitumor agents patent. CN104817497A. 2015.
  • Ong WZ, Nowak PW, Askew BC, et al., inventors; Kala Pharmaceuticals, Inc., USA. assignee. Preparation of quinoline and quinazoline derivatives useful in treating and/or preventing diseases patent. WO2014127214A1. 2014.
  • Chen Y, Guo S, inventors; Hinova Pharmaceuticals Inc., Peop. Rep. China. assignee. Preparation of N-[2-chloro-4-(4-quinolinyloxy)phenyl]-N’-(3-isoxazolyl)urea derivatives as antitumor agents patent. CN104693196A. 2015.
  • Shanghai Renli Pharmaceutical Science & Technology Co., Ltd., Peop. Rep. China. assignee. Quinoline derivatives as a VEGFR inhibitor useful in treatment of cancer and their preparation patent. CN103524409A. 2014.
  • Xia G, Yu Y, Chen W, et al., inventors; Shanghai Pharmaceuticals Holding Co., Ltd., Peop. Rep. China; Zhejiang University. assignee. Preparation of quinoline and quinazoline derivatives as antitumor agents patent. CN103965120A. 2014.
  • Ntranos A, Casaccia P. Bromodomains: translating the words of lysine acetylation into myelin injury and repair. Neurosci Lett. 2016;623:4–10.
  • Sharma R, Kulkarni S, Kulkarni M, et al., inventors; Piramal Enterprises Limited, India. assignee. Preparation of imidazoquinoline compounds as bromodomain inhibitors patent. WO2015049629A1. 2015.
  • Sasmal S, Hosahalli S, inventors; Aurigene Discovery Technologies Limited, India. assignee. Preparation of substituted imidazo[4,5-c]quinoline derivatives as bromodomain inhibitors patent. WO2014128655A1. 2014.
  • Demont EH, Jones KL, Watson RJ, inventors; GlaxoSmithKline LLC, USA. assignee. Preparation of 4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole, its salts and isomers and their use as bromodomain inhibitors patent. WO2013024104A1. 2013.
  • Amans D, Atkinson SJ, Harrison LA, et al., inventors; GlaxoSmithKline Intellectual Property No.2 Limited, UK. assignee. Preparation of acylaminotetrahydroquinoline derivatives for use as bromodomain inhibitors patent. WO2014140076A1. 2014.
  • Babaoglu K, Corkey BK, Jiang RH, et al., inventors; Gilead Sciences, Inc., USA. assignee. prepn. of quinoline derivs. as bromodomain inhibitors useful for treatment of solid tumors and lymphoma patent. US20150148344A1. 2015.
  • Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov. 2014;13(9):673–691.
  • Yun Z, Wang H, inventors; Guangzhou Esa Biotech Co., Ltd, Peop. Rep. China. assignee. Quinoline-hydroxamic acid derivatives as protein kinase and histone deacetylase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases patent. WO2013040801A1. 2013.
  • Fang H, Wang L, Yang X, et al., inventors; Shandong University, Peop. Rep. China. assignee. Substituted quinoline histone deacetylase (HDAC) inhibitor and preparation method and application thereof in preparation of drug for preventing or treating mammal disease caused by HDAC abnormal expression patent. CN104592114A. 2015.
  • Deng W, Liu J, An N, et al., inventors; East China University of Science and Technology, Peop. Rep. China. assignee. Pyrazoloquinoline compounds as histone deacetylase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancers patent. CN102977095A. 2013.
  • Zhang L, Song Y, Qi Y, et al., inventors; The Second Military Medical University, PLA, Peop. Rep. China. assignee. Preparation of quinoline derivatives as histone deacetylase inhibitors patent. CN104926726A. 2015.
  • Hoves S, Kuhn B, Ricklin F, et al., inventors; Hoffmann-La Roche Inc., USA. assignee. Preparation of 4-amino-imidazoquinoline compounds as TLR agonists patent. US20150299194A1. 2015.
  • Huang H-S, Chen T-C, Chen S-J, et al., inventors; National Defense Medical Center, Taiwan. assignee. Preparation of novel indeno[1,2-c]quinolin-11-one derivatives as antitumor agents patent. US20150197492A1. 2015.
  • Heisler I, Mueller T, Siebeneicher H, et al., inventors; Bayer Pharma Aktiengesellschaft, Germany. assignee. N-Pyrazolyl quinolinecarboxamides as glucose transport inhibitors and their preparation patent. WO2015091428A1. 2015.
  • Faernegaardh K, Gravenfors Y, Ernfors P, et al., inventors; Glionova AB, Swed. assignee. 2,4-Disubstituted quinoline derivatives and their preparation and use for the treatment of cancer patent. WO2015033228A2. 2015.
  • Inukai T, Takeuchi J, Yasuhiro T, inventors; Ono Pharmaceutical Co., Ltd., Japan. assignee. Preparation of quinolinecarboxamide compounds, their medical compositions, and preventive and/or therapeutic method for Axl-related disorders patent. WO2015012298A1. 2015.
  • Wang S, Cao X, Cao C, et al., inventors; Jiangsu Tangguo Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of 3-cyano-4-(arylamino)quinoline derivatives as HDM2 and HDMX dual inhibitors useful in the treatment of cancer patent. CN103804292A. 2014.
  • Zhou H-J, Wustrow D, inventors; Cleave Biosciences, Inc., USA. assignee. Preparation of quinolines and quinazolines and their compositions and methods for JAMM protein inhibition patent. WO2014066506A2. 2014.
  • Brown KK, Chai D, Dodson CS, et al., inventors; GlaxoSmithKline LLC, USA. assignee. Preparation of quinoline derivatives as inhibitors of lactate dehydrogenase a useful in the treatment of cancer patent. WO2013096153A1. 2013.
  • Brown KK, Chai D, Dodson CS, et al., inventors; GlaxoSmithKline LLC, USA. assignee. Preparation of quinoline derivatives as inhibitors of lactate dehydrogenase a useful in the treatment of cancer patent. WO2013096151A1. 2013.
  • Ceccarelli SM, Conte A, Kuehne H, et al., inventors; F. Hoffmann-La Roche AG, Switz. assignee. Preparation of arylquinoline derivatives as dual FABP inhibitors patent. WO2013064465A1. 2013.
  • Chabot G, Giorgi-Renault S, Desbene-Finck S, et al., inventors; Centre National de la Recherche Scientifique CNRS, Fr.; Universite Paris Descartes; Institut National de la Sante et de la Recherche Medicale Inserm; Ecole Nationale Superieure de Chimie de Paris. assignee. Preparation of water soluble 4-azapodophyllotoxin analogs as medicaments for the treatment of cancer patent. WO2015107119A1. 2015.
  • Zhu H, Tao X, Duan Y, et al., inventors; Nanjing University, Peop. Rep. China. assignee. Preparation of quinoline imidazole derivatives for inhibiting telomerase activity patent. CN104402864A. 2015.
  • Huang Z, Gu L, Du G, et al., inventors; Sun Yat-Sen University, Peop. Rep. China. assignee. Preparation of peptide-substituted coumarone quinoline derivatives as antitumor agents patent. CN104017047A. 2014.
  • Huang Z, Gu L, Du G, et al., inventors; Sun Yat-Sen University, Peop. Rep. China. assignee. Preparation of methylbenzofuran quinoline derivatives as antitumor agents patent. CN103382207A. 2013.
  • Sidoryk K, Kaczmarska M, Bujak I, et al., inventors; Instytut Farmaceutyczny, Pol. assignee. Preparation of 5H-indolo[2,3-b]quinoline compounds as cytotoxic agents for treatment of neoplastic diseases patent. WO2015147666A1. 2015.
  • Iguchi T, El Sayed IET, Sasaki K, et al., inventors; Okayama University, Japan. assignee. Indoloquinoline derivative as antimalarial/anticancer agent and method for the preparation thereof patent. JP2013107869A. 2013.
  • Iguchi T, Wang N, Imai T, et al., inventors; Okayama University, Japan. assignee. Preparation of indolo[3,2-c]quinoline derivatives as antimalarial and anticancer agents patent. JP2015063476A. 2015.
  • Gakh AA, Krasavin M, Karapetian R, et al., inventors; United States Dept. of Energy, USA. assignee. Preparation of anti-cancer agents based on N-acyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinoline derivatives patent. US8420815B1. 2013.
  • Yong J, Lu C, inventors; Fujian Institute of Research on the Structure of Matter, CAS, Peop. Rep. China. assignee. Preparation of quinoline derivatives and their application as anticancer agents patent. CN104230912A. 2014.
  • Courcambeck J, Bassissi F, Brun S, et al., inventors; Genoscience Pharma, Fr. assignee. Preparation of arylquinolines as anticancer agents patent. WO2014147611A1. 2014.
  • Ji M, Cai J, Zhang S, et al., inventors; Southeast University, Peop. Rep. China. assignee. Quinoline derivatives as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer patent. CN103772353A. 2014.
  • Lee H, Solomon VR, Pundir S, inventors; Advanced Medical Research Institute of Canada, Can. assignee. Preparation of quinoline sulfonyl derivatives for the treatment of cancer patent. WO2014134705A1. 2014.
  • Shi L, Xue J, Wu T, et al., inventors; China Pharmaceutical University, Peop. Rep. China. assignee. Quinoline-4-amine derivatives containing benzimidazole structure and its preparation method and application in preparing antitumor drug patent. CN103709146A. 2014.
  • Tang Y, Wang L, Xiang J, inventors; Institute of Chemistry, Chinese Academy of Sciences, Peop. Rep. China. assignee. 2,2ʹ-bipyridine-6,6ʹ-diformyl-quinoline-2-amine derivatives, their preparation method and application as antitumor agents patent. CN103601719A. 2014.
  • Kamal A, Hussaini SMA, Sucharitha ML, et al. Synthesis and antimicrobial potential of nitrofuran-triazole congeners. Org Biomol Chem. 2015;13(36):9388–9397.
  • Shen Y, Tang J, Liang X, et al., inventors; Shaoxing University, Peop. Rep. China. assignee. Preparation of tetrahydropyrrolo[3,4-c]quinoline-1,3-dione derivatives as antibacterial agents patent. CN104974152A. 2015.
  • Alapati C, Banerjee A, Rangarajan R, et al., inventors; Vitas Pharma Research Pvt Ltd., India. assignee. Preparation of heterocyclic compounds as inhibitors of DNA gyrase for the treatment of bacterial infections patent. WO2014057415A2. 2014.
  • Egan SM, inventor The University of Kansas, USA. assignee. Inhibiting microbial infections with quinoline compounds patent. US20140088144A1. 2014.
  • Guillemont JEG, Motte MMS, Lancois DFA, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of antibacterial quinoline derivatives patent. WO2013160431A1. 2013.
  • Guillemont JEG, Motte MMS, Lancois DFA, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of quinoline derivatives useful as antibacterials patent. WO2013160435A1. 2013.
  • Sun X, He X, Wen X, et al., inventors; Heilongjiang Bayi Agricultural University, Peop. Rep. China. assignee. 4,5-Dihydroimidazolo[1,2-a]quinoline derivative useful in the treatment of bacterial infection and its preparation patent. CN102898425A. 2013.
  • Taylor RK, Gribble GW, inventors; Trustees of Dartmouth College, USA. assignee. Preparation of bis-quinoline derivatives as type 4 prepilin peptidase inhibitors and methods of using them as antibacterial agents patent. WO2015123130A1. 2015.
  • Deng J, Lei H, Wang W, et al., inventors; Chongqing Pharmaceutical Research Institute Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline derivatives as antitubercular agents patent. CN103664877A. 2014.
  • Deng J, Lei H, Wang W, et al., inventors; Chongqing Pharmaceutical Research Institute Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline derivatives as antitubercular agents patent. WO2015096611A1. 2015.
  • Nazarenko AB, Fedorov VE, Il’in VI, et al., inventors; ZAO “Pharm-Sintez”, Russia. assignee. Quinoline derivatives, in particular 5,6,7-substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols, method for producing same and use of said compounds patent. WO2013039428A2. 2013.
  • Zhu Q, Zhang T, Liu L, et al., inventors; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Peop. Rep. China. assignee. Preparation of indole[3,2-c]quinolines as tuberculostatics patent. CN103554103A. 2014.
  • Yang Z, inventor Ruian Puluo Biotechnology Co., Ltd., Peop. Rep. China. assignee. 3-Fluoro-4-(5-(4-methylpiperazine-1-yl)-3,4-dihydro quinoline-1(2H)-yl) benzamides useful in treatment of fungal infection and their preparation patent. CN104230801A. 2014.
  • Higuchi T, Kato N, Umezawa N, inventors; Public University Corporation Nagoya City University, Japan. assignee. Preparation of quinoline derivatives as antimalarial agents patent. WO2015133280A1. 2015.
  • Gilbert IH, Norcross N, Baragana Ruibal B, et al., inventors; University of Dundee, UK. assignee. Preparation of quinoline-4-carboxamides as antimalarial agents patent. WO2013153357A1. 2013.
  • Crusz SM, Balkwill FR. Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol. 2015;12(10):584–596.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of quinolinyl secondary alcohols as modulators of retinoic acid-related nuclear receptor gamma t (RORγt) patent. WO2015057206A1. 2015.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica N.V., Belg. assignee. Preparation of 3-benzylquinoline and 3-heterocyclylmethylquinoline derivatives as modulators of retinoic acid-related nuclear receptor gamma t (RORγt) patent. US20150105366A1. 2015.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica N.V., Belg. assignee. Preparation of heteroaryl linked quinoline derivatives as modulators of retinoic acid-related nuclear receptor gamma t (RORγt) patent. US20150105365A1. 2015.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica N.V., Belg. assignee. Preparation of phenylquinoline derivatives as modulators of retinoic acid-related nuclear receptor gamma t (RORγt) patent. US20150105404A1. 2015.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of alkylquinoline derivatives as modulators of retinoic acid-related nuclear receptor gamma t (RORγt) patent. US20150105369A1. 2015.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of heteroaryl linked quinolinyl modulators of RORγt patent. US20140107097A1. 2014.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of methylene linked quinolinyl modulators of RORγt patent. US20140107094A1. 2014.
  • Leonard KA, Barbay K, Edwards JP, et al., inventors; Janssen Pharmaceutica NV, Belg. assignee. Preparation of heteroaryl linked quinolinyl as modulators of RORγt patent. US20140107096A1. 2014.
  • Huang C, Bai C, inventors; Sun Yat-Sen University, Peop. Rep. China. assignee. Application of quinoline-sulfonamide compounds as Th17 cell differentiation inhibitor patent. CN105147686A. 2015.
  • Gaweco A, Tilley JW, Walker J, et al., inventors; USA. assignee. Preparation of quinoline compounds as ROR (retinoid-related orphan receptor) modulators and their therapeutic uses patent. WO2013159095A1. 2013.
  • Hoffmann M, Bischoff D, Dahmann G, et al., inventors; Boehringer Ingelheim International GmbH, Germany. assignee. Preparation of substituted quinolines as Syk inhibitors for therapy patent. WO2013014060A1. 2013.
  • Anderson DR, Bunnage ME, Curran KJ, et al., inventors; Pfizer Inc., USA. assignee. Bicyclic-fused heteroaryl or aryl compounds as IRAK4 inhibitors and their preparation patent. WO2015150995A1. 2015.
  • Takemura S, Miyake Y, Kouketsu A, et al., inventors; Kowa Company, Ltd., Japan. assignee. Preparation of quinoline derivative having TLR inhibitory activity patent. WO2014034719A1. 2014.
  • Abeywardane A, Broadwater J, Takahashi H, inventors; Boehringer Ingelheim International GmbH, Germany. assignee. Preparation of pyrazolylpyridinylquinolines as inhibitors of leukotriene production for treatment of cardiovascular, inflammatory and other diseases patent. US20150018333A1. 2015.
  • Abeywardane A, Broadwater J, Brunette SR, et al., inventors; Boehringer Ingelheim International GmbH, Germany. assignee. Preparation of pyrazolylpyridinyl quinolines and similar compds. as leukotriene prodn. inhibitors for treatment of cardiovascular, inflammatory and other diseases patent. US20150018334A1. 2015.
  • Cai Z, inventor Foshan Saiweisi Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline derivatives containing nitrophenyl group as glucokinase activator useful for the treatment of type-II diabetes patent. CN104592112A. 2015.
  • Cai Z, inventor Foshan Saiweisi Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline derivatives containing cyanophenyl group as glucokinase activator useful for the treatment of type-II diabetes patent. CN104592113A. 2015.
  • Cai Z, inventor Foshan Saiweisi Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of alkoxy substituted quinoline derivatives as glucokinase activator useful for the treatment of type-II diabetes patent. CN104557697A. 2015.
  • Cai Z, inventor Foshan Saiweisi Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. preparation of quinoline containing glucokinase activators for treatment of type 2 diabetes patent. CN104557695A. 2015.
  • Cai Z, inventor Foshan Saiweisi Pharmaceutical Technology Co., Ltd., Peop. Rep. China. assignee. Preparation of quinoline containing glucokinase activator for treating type 2 diabetes patent. CN104672133A. 2015.
  • Babaoglu K, McFadden R, Mitchell ML, inventors; Gilead Sciences, Inc., USA. assignee. Preparation of quinoline derivatives useful in treatment of HIV infection patent. WO2015179448A1. 2015.
  • Old DW, inventor Allergan, Inc., USA. assignee. Preparation of alkyl or hydroxyalkyl-1-naphthamide or quinoline derivatives useful in treatment of glaucoma and ocular hypertension patent. US20150175586A1. 2015.
  • Gu J, Zhu H, Kuang Y, et al., inventors; General Hospital of Chengdu Military Region of PLA, Peop. Rep. China. assignee. Preparation of quinoline-4-carboxamide derivatives and their medicinal use for treating posttraumatic stress disorder patent. CN104710358A. 2015.
  • Basinger J, Breitenbucher J, Freestone G, et al., inventors; Dart NeuroScience, LLC, USA. assignee. Preparation of substituted naphthyridine and quinoline compounds as MAO inhibitors patent. US20140275548A1. 2014.
  • Esteban G, Unzeta M, Inokuchi T, et al., inventors; Universitat Autonoma de Barcelona, Spain; Consejo Superior de Investigaciones Cientificas; National University Corporation Okayama University; Universidad de Alcala. assignee. Preparation of quinoline derivatives as neuroprotective multi-target directed drugs patent. EP2727916A1. 2014.
  • Hadida-Ruah SS, Anderson C, Arumugam V, et al., inventors; Vertex Pharmaceuticals Incorporated, USA. assignee. Preparation of quinoline and quinazoline amides as modulators of sodium channels patent. WO2014120815A1. 2014.

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