114
Views
0
CrossRef citations to date
0
Altmetric
Patent Evaluation

Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1

&
Pages 1111-1114 | Received 08 Mar 2016, Accepted 18 Aug 2016, Published online: 14 Sep 2016

References

  • Jaisser F, Farman N. Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology. Pharmacol Rev. 2016 Jan;68(1):49–75.
  • Farman N. Molecular and cellular determinants of mineralocorticoid selectivity. Curr Opin Nephrol Hypertens. 1999 Jan;8(1):45–51.
  • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999 Sep 2;341(10):709–717.
  • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003 Apr 3;348(14):1309–1321.
  • Zannad F, McMurray JJV, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011 Jan 6;364(1):11–21.
  • Kolkhof P, Nowack C, Eitner F. Nonsteroidal antagonists of the mineralocorticoid receptor. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417–424.
  • Collin M, Niemann F, Jaisser F. Mineralocorticoid receptor modulators: a patent review (2007-2012). Expert Opin Ther Pat. 2014 Feb;24(2):177–183.
  • Yang C, Balsells J, Chu HD, et al. Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists. ACS Med Chem Lett. 2015 Apr 9;6(4):461–465.
  • Yang C, Shen HC, Wu Z, et al. Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4388–4392.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. US8933113. 2015.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. EP2665707. 2013.
  • Meyers MJ, Arhancet GB, Hockerman SL, et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g] indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53(16):5979–6002.
  • Pitt B, Filippatos G, Gheorghiade M, et al. Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease. Eur J Heart Fail. 2012 Jun;14(6):668–675.
  • Pitt B, Kober L, Ponikowski P, et al. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J. 2013 Aug;34(31):2453–2463.
  • Pitt B, Anker SD, Böhm M, et al. Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease. Eur J Heart Fail. 2015 Feb;17(2):224–232.
  • Ruilope LM, Agarwal R, Chan JC, et al. Rationale, design, and baseline characteristics of ARTS-DN: a randomized study to assess the safety and efficacy of finerenone in patients with type 2 diabetes mellitus and a clinical diagnosis of diabetic nephropathy. Am J Nephrol. 2014;40(6):572–581.
  • Bakris GL, Agarwal R, Chan JC, et al. Effect of finerenone on albuminuria in patients with diabetic nephropathy: a randomized clinical trial. JAMA. 2015 Sep 1;314(9):884–894.
  • Kolkhof P, Delbeck M, Kretschmer A, et al. Finerenone, a novel selective nonsteroidal mineralocorticoid receptor antagonist protects from rat cardiorenal injury. J Cardiovasc Pharmacol. 2014 Jul;64(1):69–78.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. WO2013055606. 2013.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. WO2013055607. 2013.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. WO2013055608. 2013.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. WO2014014794. 2014.
  • Merck Sharp & Dohme. Mineralocorticoid receptor antagonists. WO2012139495. 2012.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.