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Review

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

, &
Pages 179-189 | Received 02 May 2016, Accepted 07 Nov 2016, Published online: 23 Nov 2016

References

  • Stebbins N, Ouimet M, Uhrich K. Antibiotic-containing polymers for localized, sustained drug delivery. Adv Drug Deliv Rev. 2014;78:77–87.
  • Mahajan G, Thomas B, Parab R, et al. In vitro and in vivo activities of antibiotic PM181104. Antimicrob Agents Chemother. 2013;57(11):5315–5319.
  • Leeb M. Antibiotics: A shot in the arm. Nature. 2004;431:892.
  • Butler M, Blaskovich M, Cooper M. Antibiotics in the clinical pipeline in 2013. J Antibiot. 2013;66:571–591.
  • Xiong M-H, Bao Y, Yang X-Z, et al. Delivery of antibiotics with polymeric particles. Adv Drug Deliv Rev. 2014;78:63–76.
  • Abed N, Couvreur P. Nanocarriers for antibiotics: A promising solution to treat intracellular bacterial infections. Int J Antimicrob Agents. 2014;43:485–496.
  • Bera S, Zhanel G, Schweizer F. Design, synthesis, and antibacterial activities of neomycin−lipid conjugates: polycationic lipids with potent gram-positive activity. J Med Chem. 2008;51:6160–6164.
  • Kalhapure R, Suleman N, Mocktar C, et al. Nanoengineered drug delivery systems for enhancing antibiotic therapy. J Pharm Sci. 2015;104:872–905.
  • Ibrahim M, Panda S, Birs A, et al. Synthesis and antibacterial evaluation of amino acid–antibiotic conjugates. Bioorg Med Chem Lett. 2014;24:1856–1861.
  • Cytogen Corporation. Polymer/antibiotic conjugate. WO1990/015628.
  • Helfgott & Karas PC, Yissum Res Dev C. Water-soluble polyene conjugate. WO1996/005212.
  • Competitive Technologies of PA, Inc. Amphiphilic polyene macrolide antibiotic compounds. WO1996/032404.
  • Proctor & Gamble Pharmaceuticals Inc. Antimicrobial quinolonyl lactam esters. US5434147; 1993.
  • Gruppo Lepetit SPA Antibiotics ge 37468 a, b and c. WO1994/014838.
  • Piramal Life Sciences Ltd. Novel antibacterial compounds. WO2007/119201.
  • Stella S, Montanini N, Le Monnier F, et al. Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization. J Antibiot. 1995;48(8):780–786.
  • Martín J, Sousa TS, Crespo G, et al. Kocurin, the true structure of PM181104, an anti-methicillin-resistant staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium kocuria palustris. Mar Drugs. 2013;11:387–398.
  • Piramal Enterprises Limited. Polymeric prodrug conjugates. WO2014/053873.
  • Yemparala V, Damre A, Manohar V, et al. Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice. Pharma Sci. 2014;4:34–41.
  • Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers. WO1999/043357.
  • Instituto Biochimico Pavese Pharma SPA. Antibiotic-natural polysaccharide polymer adducts. WO2000/078287.
  • Biosynexus Incorporated. Antimicrobial polymer conjugates. WO2003/082926.
  • Ethicon Inc. Antimicrobial composition. WO2007/014087.
  • Odintsov S, Sabala I, Marcyjaniak M, et al. Latent LytM at 1.3 Å resolution. J Mol Biol. 2004;335(3):775–785.
  • The Bionic Ear Institute. Biodegradable polymer-bioactive moiety conjugates. WO2010/040188.
  • University College Cardiff Consultants Limited. Therapeutic conjugates. WO2012/035310.
  • Nektar Therapeutics. Polymer-based compositions and conjugates of antimicrobial agents. US8420068; 2013.
  • Oregon Health Sciences University. Covalent polar lipid conjugates with antimicrobial and antineoplastic drugs for targeting to biological protected sites. WO2000/033883.
  • University of Manitoba. Guanidinylated aminoglycoside-lipid conjugates. WO2012/004684.
  • University of South Florida. Surfactant-free nanoparticles for drug delivery. WO2008/085556.
  • Matera Lda. Antimicrobial nanoparticle conjugates. WO2012/025514.
  • Vyome Biosciences. Conjugate-based antifungal and antibacterial prodrugs. WO2012/177986.
  • William Marsh Rice University. Fullerene (C60) vancomycin conjugates as improved antibiotics. US2004/0241173.
  • University of Manitoba. Triazole-based aminoglycoside-peptide conjugates and methods of use. WO2009/037592.
  • Newsouth Innovations PTY Ltd. Dual action nitric oxide donors and their use as antimicrobial agents. WO2014/071457.
  • Czaplewski L, Bax R, Clokie M, et al. Alternatives to antibiotics—a pipeline portfolio review. Lancet Infect Dis. 2016;16(2):239–251.
  • Liu R, Wang R, Wang F. Antibody-drug conjugates for non-oncological indications. Exp Opin Biol Ther. 2016;16(5):591–593.
  • Miles Laboratories Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation. US4226978; 1978.
  • Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor. US7635685; 2009.
  • MicroCarb Inc. Receptor conjugates for targeting penicillin antibiotics to bacteria. US5466681; 1994.
  • Sense Therapeutic Ltd. Uses of ble proteins and antibiotics from the bleomycin family. WO2004/046730.
  • Los Alamos National Security, LLC. Synthetic analogs of bacterial quorum sensors. US8350061; 2011.
  • University of Notre Dame Du Lac. Anti-bacterial siderophore-aminopenicillin conjugates. US2013/0281424.
  • Burnet M, Guse J-H, Kim G. Antibiotic conjugates. US2006/0069047.
  • Oregon Health Sciences University. Covalent polar lipid conjugates with antimicrobial and antineoplastic drugs for targeting to biological protected sites. WO2000/033883.
  • Ramot U, Yacoby I, Ron EZ et al. Targeted drug-carrying viruses. WO/2006/095345.
  • Glycovaxyn Ag. Capsular Gram-positive bacteria bioconjugate vaccines. WO2011/138361.
  • Gmbh FKD Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate. WO2003/000738.
  • Emory University. Oligosaccharide conjugates for targeting bacteria and uses related thereto. WO2012/097223.
  • Yale University. Antibiotics improved by conjugation with stereospecific carbohydrtes and methods for carbohydrate stereoselectivity. WO1992/007862.
  • University of Manitoba. Triazole-based aminoglycoside-peptide conjugates and methods of use. WO2009/037592.
  • Wang H Targeted antibiotic and antimicrobial treatments for personalized administration. US2013/0183323.
  • Genentech Inc. Anti-wall teichoic antibodies and conjugates. US2015/0366985.
  • Research Corporation NY. Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections. US4427660; 1982.
  • Allergan Inc. Peptide therapeutic conjugates and uses thereof. WO2010/063124.
  • National Institute of Immunology. Novel bioconjugates as therapeutic agent and synthesis thereof. WO2007/108013.
  • Allergan Inc. Antibiotic Conjugates. US2014/0256658.
  • Allergan Inc. Antibiotic conjugates directly linked with steroid drugs. WO2014/138350.
  • Allergan Inc. Steroid antibiotic conjugates. WO2014/138359.
  • Allergan Inc. Antibiotic conjugates linked with steroid drugs. WO2014/138375.
  • Lehigh University. Methods for the manufacture and use of antimicrobial sterol conjugates. US5834453; 1997.
  • Ophidian Pharmaceuticals Inc. Prevention and treatment of sepsis. WO1994/014437.
  • Pono Corporation. Prevention and treatment of sepsis. US6660267; 1994.
  • Plc CLS Method for the production of antigenic protein-hapten conjugates, and antibodies corresponding thereto. WO1989/003040.
  • Aktiebolag RBL A pharmaceutical preparation and a conjugate of a bactericide and an antibody directed against plaque forming or caries-inducing bacteria. WO1989/011866.
  • Kim S Anti-bacterial antibodies and methods of use. US6322788; 1999.
  • Kim S Antibody-conjugated antibodies. US2002/0168368.
  • Strox Biopharmaceuticals LCC. Anti-staphylococcus aureus antibodies. US2009/0274704.
  • Strox Biopharmaceuticals LLC. Anti-bacterial antibodies. US2010/0322944.
  • Strox Biopharmaceuticals LLC. Antibiotic-conjugated antibodies. US7,569,677; 2002.
  • Strox Biopharmaceuticals LLC. Anti-Staphylococcus aureus antibodies. US7795402; 2010.
  • Strox Biopharmaceuticals LLC. Anti-bacterial antibodies. US8142780; 2010.
  • Genentech Inc. Anti-wall teichoic antibodies and conjugates. WO2014/194247.
  • Genentech Inc. Anti-wall teichoic antibodies and conjugates. WO2014/193722.
  • Genentech Inc. Anti-wall teichoic antibodies and conjugates. US2015/0366985.
  • Lehar S, Pillow T, Xu M, et al. Novel antibody-antibiotic conjugate eliminates intracellular S aureus. Nature. 2015;527(7578):323–328.
  • Keener A. First QIDP drug approved, but designation may fail urgent needs. Nature Med. 2014;20:690–691.
  • Mullard A. FDA drug approvals. Nature Rev Drug Discov. 2014;2015(14):77–81.
  • Mullard A. FDA drug approvals. Nature Rev Drug Discov. 2015;2016(15):73–76.
  • Coates A, Halls G, Hu Y. Novel classes of antibiotics or more of the same. Brit J Pharmacol. 2011;163:184–194.
  • Nichols DCN, Trakhtenberg E, Pham L, et al. Use of Ichip for high-throughput in situ cultivation of “uncultivable” microbial species. App Env Microb. 2010;76(8):2445–2450.
  • Ling LL, Schneider T, Peoples A, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015;517:455–459.
  • Hegde SS, Okusanya OO, Skinner R, et al. Pharmacodynamics of TD-1792, a novel glycopeptide-cephalosporin heterodimer antibiotic used against Gram-positive bacteria, in a neutropenic murine thigh model. Antimicrob Agents Chemother. 2012;56(3):1578–1583.
  • Stryjewski ME, Potgieter PD, Li Y-P, et al. TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections. Antimicrob Agents Chemother. 2012;56(11):5476–5483.
  • Poolman J, Frasch C, Nurkka A, et al. Impact of the conjugation method on the immunogenicity of Streptococcus pneumoniae serotype 19F polysaccharide in conjugate vaccines. Clin Vaccine Immunol. 2011;18:327–336.
  • Adamo R, Nilo A, Castagner B, et al. Synthetically defined glycoprotein vaccines: current status and future directions. Chem Sci. 2013;4:2995–3008.
  • Hedari CP, Khinkarly RW, Dbaibo GS. Meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine: a new conjugate vaccine against invasive meningococcal disease. Infect Drug Resist. 2014;7:85–99.

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