Natural and synthetic products used for the treatment of smoke inhalation: a patent review

References

• Parsons M, Murphy J, Alani S, et al. Thermal burns and smoke inhalation: a simulation session. Cureus. 2015;7(10):e360.
   PubMedGoogle Scholar
• Murakami K, Traber D. Pathophysiological basis of smoke inhalation injury. News Physiolo Sci. 2003;18:125–129.
   PubMedGoogle Scholar
• Li H, Yao Z, Tan J, et al. Epidemiology and outcome analysis of 6325 burn patients: a five-year retrospective study in a major burn center in Southwest China. Sci Rep. 2017 Apr 6;7:46066.
   PubMedGoogle Scholar
• Traber MG, Shimoda K, Murakami K, et al. Burn and smoke inhalation injury in sheep depletes vitamin E: kinetic studies using deuterated tocopherols. Free Radic Biol Med. 2007 May 1;42(9):1421–1429.
   PubMed Web of Science ®Google Scholar
• Iqbal T, Saaiq M, Ali Z. Epidemiology and outcome of burns: early experience at the country’s first national burns centre. Burns. 2013;39(2):358–362.
   PubMed Web of Science ®Google Scholar
• Souza R, Jardim C, Salge J, et al. Lesão por inalação de fumaça. J Bras Pneumol. 2004;30(6):557–565.
   Google Scholar
• Heimbach DM, Waeckerle JF. Inhalation injuries. Ann Emerg Med. 1988;17(12):1316–1320.
   PubMed Web of Science ®Google Scholar
• Rivero C, Rivera J, Cabezas MC, et al. Manejo de quemados. Gustavo Pradilla and Basil A. Pruitt, JR, (editors). In: Guias de practica clinica basadas en la evidencia (Proyecto ISS - ASCOFAME). 2006. p. p14–69.
   Google Scholar
• Demling R, Lalonde C, Youn YK, et al. Effect of graded increases in smoke inhalation injury on the early systemic response to a body burn. Crit Care Med. 1995 Jan;23(1):171–178.
   PubMed Web of Science ®Google Scholar
• Ward PA, Till GO. Pathophysiologic events related to thermal injury of skin. J Trauma. 1990;30(12 Suppl):S75–9.
   PubMedGoogle Scholar
• Cardoso EK, Fernandes AM, Rieder MM. Physical therapy treatment for the victims of nightclub kiss: the experience of an Emergency Hospital. Rev Bras Queimaduras. 2014;13(3):136–141.
   Google Scholar
• Peters W. Inhalation injury caused by the products of combustion. CMA Journal. 1981;125:249–252.
   PubMed Web of Science ®Google Scholar
• Pantet O, Faouzi M, Brusselaers N, et al. Comparison of mortality prediction models and validation of SAPS II in critically ill burns patients. Ann Burns Fire Disasters. 2016 Jun 30;29(2):123–129.
   PubMedGoogle Scholar
• Musch G, Winkler T, Harris RS, et al. Lung [18F]fluorodeoxyglucose uptake and ventilation-perfusion mismatch in the early stage of experimental acute smoke inhalation. Anesthesiology. 2014 March;120(3):683–693.
   PubMed Web of Science ®Google Scholar
• Rajpura A. The epidemiology of burns and smoke inhalation in secondary care: a population-based study covering Lancashire and South Cumbria. Burns. 2002 Mar;28(2):121–130.
   PubMed Web of Science ®Google Scholar
• Mosier MJ, Pham TN, Park DR, et al. Predictive value of bronchoscopy in assessing the severity of inhalation injury. J Burn Care Res. 2012 Jan-Feb;33(1):65–73.
   PubMed Web of Science ®Google Scholar
• Silva L, Garcia L, Oliveira B, et al. Acute respiratory distress syndrome in burn patients: incidence and risk factor analysis. Ann Burns Fire Disasters. 2016 Sep 30;29(3):178–182.
   PubMedGoogle Scholar
• Boateng JS, Matthews KH, Stevens HNE, et al. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008 Aug;97(8):2892–2923.
   PubMed Web of Science ®Google Scholar
• Carvalho FO, Felipe FA, Costa ACSM, et al. Inflammatory mediators and oxidative stress in animals subjected to smoke inhalation: a systematic review. Lung. 2016;Aug;194(4):487–499.
   PubMed Web of Science ®Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.WO2005081816. 2005.
   Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.US20050192226. 2005.
   Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.US20110070167. 2011.
   Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.CA2557411. 2005.
   Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.EP1725244. 2006.
   Google Scholar
• Enkhbaatar P, Murakami K, Traber DL Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants.EP2322189. 2011.
   Google Scholar
• Keith JC, Vlasuk GP Use of estrogen receptor beta selective ligands for treating acute lung injuries.WO2008094976. 2008.
   Google Scholar
• Keith JC, Vlasuk GP Use of ER.beta. selective ligands for treating acute lung injuries.US20080182872. 2008.
   Google Scholar
• Keith JC, Vlasuk GP Use of ER.beta. selective ligands for treating acute lung injuries.CA2676553. 2008.
   Google Scholar
• Keith JC, Vlasuk GP Use of estrogen receptor beta selective ligands for treating acute lung injuries.EP2112926. 2009.
   Google Scholar
• Keith JC, Vlasuk GP Use of ERβ selective ligands for treating acute lung injuries.mxMX/a/2009/008121. 2009.
   Google Scholar
• Schmalstieg FC, Traber D Therapies for smoke and/or burn induced lung injury.US20020044934. 2002.
   Google Scholar
• Brands R Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases.WO2009106368. 2009.
   Google Scholar
• Brands R Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases.US20110052560 (2011).
   Google Scholar
• Brands R Alkaline phosphatase for increasing the activity of the immune system of a mammal at risk of inflammatory diseases.EP2252324. 2010.
   Google Scholar
• Brands R Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases.CA2716400. 2009.
   Google Scholar
• Brands R Fosfatasa alcalina para aumentar la actividad del sistema inmune en un mamífero con riesgo de enfermedades inflamatorias.ES2421717. 2013.
   Google Scholar
• Saifer MG, Berkeley LDW, Menlo Park WH, et al. Reduction of superoxide accumulation on caused by smoke.US4022224. 1977.
   Google Scholar
• Colman RW, Scott CF, Pixley RA, et al. Effect of heparin on the inhibition of the contact system enzymes. Ann N Y Acad Sci. 1989;556(1):95–103.
   PubMedGoogle Scholar
• Idell S. Anticoagulants for acute respiratory distress syndrome: can they work? Am J Respir Crit Care Med. 2001;164(4):517–520.
   PubMed Web of Science ®Google Scholar
• Tuinman PR, Dixon B, Levi M, et al. Nebulized anti-coagulants for acute lung injury – a systematic review of pre-clinical and clinical investigations. Crit Care. 2012;16(2):R70.
   PubMed Web of Science ®Google Scholar
• Murakami K, Bjertnaes LJ, Schmalstieg FC, et al. A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med. 2002;30(9):2083–2090.
   PubMed Web of Science ®Google Scholar
• Enkhbaatar P, Esechie A, Wang J, et al. Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation. Clinical Science. 2008;114:321–329.
   PubMed Web of Science ®Google Scholar
• Moggs JG, Orphanides G. Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Rep. 2001 Sep;2(9):775–781.
   PubMed Web of Science ®Google Scholar
• Levin ER. Cell localization, physiology, and nongenomic actions of estrogen receptors. J Appl Physiol. 1985 Oct;91(4):1860–1867.
   Google Scholar
• Quaedackers ME, van den Brink CE, Wissink S, et al. 4-hydroxytamoxifen trans-represses nuclear factor-kappa B activity in human osteoblastic U2-OS cells through estrogen receptor (ER)alpha, and not through ER beta. Endocrinology. 2001 Mar;142(3):1156–1166.
   PubMed Web of Science ®Google Scholar
• Tzagarakis-Foster C, Geleziunas R, Lomri A, et al. Estradiol represses human T-cell leukemia virus type 1 Tax activation of tumor necrosis factor-alpha gene transcription. J Biol Chem. 2002 Nov 22;277(47):44772–44777.
   PubMed Web of Science ®Google Scholar
• Green S, Walter P, Kumar V, et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature. 1986 Mar 13-19;320(6058):134–139.
   PubMed Web of Science ®Google Scholar
• Kuiper GG, Enmark E, Pelto-Huikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5925–5930.
   PubMed Web of Science ®Google Scholar
• Välimaa H, Savolainen S, Soukka T, et al. Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. J Endocrinol. 2004 Jan;180(1):55–62.
   PubMed Web of Science ®Google Scholar
• Fasco MJ, Hurteau GJ, Spivack SD. Expressão de receptores de estrogénio alfa e beta dependentes do gênero tecido não tumoral e tumoral pulmonar desumano. Mol Cell Endocrinol. 2002;188:125–140.
   PubMed Web of Science ®Google Scholar
• Cristofaro PA, Opal SM, Palardy JE, et al. WAY-202196, um receptor selectivo de beta-agonista de estrogênio, contra a morte em choque séptico experimental. Crit Care Med. 2006;34:2188–2193.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick SL, Funkhouser JM, Sindoni DM, et al. Expression of estrogen receptor-beta protein in rodent ovary. Endocrinology. 1999 Jun;140(6):2581–2591.
   PubMed Web of Science ®Google Scholar
• Cowley SM, Hoare S, Mosselman S, et al. Estrogen receptors alpha and beta form heterodimers on DNA. J Biol Chem. 1997 Aug 8;272(32):19858–19862.
   PubMed Web of Science ®Google Scholar
• McDonnell DP. Selective estrogen receptor modulators (SERMs): a first step in the development of perfect hormone replacement therapy regimen. J Soc Gynecol Investig. 2000 Jan-Feb;7(1 Suppl):S10–5.
   PubMedGoogle Scholar
• Paige LA, Christensen DJ, Grøn H, et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3999–4004.
   PubMed Web of Science ®Google Scholar
• Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301–314.
   PubMed Web of Science ®Google Scholar
• Brenner B, Gulbins E, Schlottmann K, et al. L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci USA. 1996;93:15376–15381.
   PubMed Web of Science ®Google Scholar
• Brenner B, Weinmann S, Grassmé H, et al. L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac. Immunology. 1997;92:214–219.
   PubMed Web of Science ®Google Scholar
• Smolen JE, Petersen TK, Koch C, et al. L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinase. J Biol Chem. 2000;275:15876–15884.
   PubMed Web of Science ®Google Scholar
• Laudanna C, Constantin G, Baron P, et al. Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-α and interleukin-8 mRNA in human neutrophils: evidence for a role of L-selectin as a signaling molecule. J Biol Chem. 1994;269:4021–4026.
   PubMed Web of Science ®Google Scholar
• Brenner B, Grassmé HUC, Müller C, et al. L-selectin stimulates the neutral sphingomyelinase and induces release of ceramide. Exp Cell Res. 1998;243:123–128.
   PubMed Web of Science ®Google Scholar
• Nishijima K, Ando M, Sano S, et al. Costimulation of T-cell proliferation by anti-l-selectin antibody is associated with the reduction of a cdk inhibitor p27. Immunology. 2005 Nov;116(3):347–353.
   PubMed Web of Science ®Google Scholar
• Smith CW, Kishimoto TK, Abbassi O, et al. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cell in vitro. J Clin Invest. 1991;87:609–618.
   PubMed Web of Science ®Google Scholar
• Smith WB, Gamble JR, Clark-Lewis I, et al. Chemotactic desensitization of neutrophils demonstrates interleukin-8 (IL-8)-dependent and IL-8-independent mechanisms of transmigration through cytokine-activated endothelium. Immunology. 1993 Mar;78(3):491–497.
   PubMed Web of Science ®Google Scholar
• Cohen P. The origins of protein phosphorylation. Nat Cell Biol. 2002 May;4(5):E127–30.
   PubMed Web of Science ®Google Scholar
• Gomes MT, Lopes AH, Meyer-Fernandes JR. Possible roles of ectophosphatases in host-parasite interactions. J Parasitol Res. 2011;2011:1–7.
   Google Scholar
• Andrews PD, Stark MJ. Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci. 2000;113(3):507–520.
   PubMed Web of Science ®Google Scholar
• Justino A, Nozawa SR, Maccheroni W, et al. The Aspergillus nidulans pyrG89 mutation alters glycosylation of secreted acid phosphatase. Fungal Genet Biol. 2001;32(2):113–120.
   PubMed Web of Science ®Google Scholar
• Freitas-Mesquita AL, Meyer-Fernandes JR. Biochemical properties and possible roles of ectophosphatase activities in fungi. Int J Mol Sci. 2014;15(2):2289–2304.
   PubMed Web of Science ®Google Scholar
• Szöör B. Trypanosomatid protein phosphatases. Mol Biochem Parasitol. 2010;173(2):53–63.
   PubMed Web of Science ®Google Scholar
• Thomas C, Rajagopal A, Windsor B, et al. A role for ectophosphatase in xenobiotic resistance. Plant Cell. 2000;12(4):519–533.
   PubMed Web of Science ®Google Scholar
• Forgiarini Junior LA, Kretzmann NA, Tieppo J, et al. Lung alterations in a rat model of diabetes mellitus: effects of antioxidant therapy. J Bras Pneumol. 2010;36(5):579–587.
   PubMed Web of Science ®Google Scholar
• Domínguez A. Modificación de la superóxido dismutasa para mejorar sus propriedades biofarmacéuticas. Biotecnología Aplicada. 2006;23:1:11-16 .
   Google Scholar
• Villalonga R, Villalonga ML, Gomez L. Preparação e propriedades funcionais de tripsina modificada por celulose carboximetilo. J Mol Catal Enzimática B. 2002;10:483–490.
   Google Scholar
• Beckman JS, Minor RL, White CW, et al. Superoxide dismutase and catalasa conjugated to polyethylene glycol increase endothelial enzyme activity oxidant resistance. J Biol Chem. 1988;263:6884–6892.
   PubMed Web of Science ®Google Scholar
• Mehvar R. Modulation of the pharmacokinetic and pharmacodynamic of proteins by polyethylene glycol conjugation. J Pharm Pharmaceut Sci. 2000;3:125–136.
   PubMed Web of Science ®Google Scholar
• Esechie A, Enkhbaatar P, Traber DL, et al. Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury. Br J Pharmacol. 2009 Nov;158(6):1442–1453.
   PubMed Web of Science ®Google Scholar
• Nieman GF, Paskanik AM, Fluck RR, et al. Comparison of exogenous surfactants in the treatment of wood smoke inhalation. Am J Respir Crit Care Med. 1995;152:597–602.
   PubMed Web of Science ®Google Scholar
• Miskolci V, Rollins J, Vu HY, et al. NFκB is persistently activated in continuously stimulated human neutrophils. Mol Med. 2007;13:134–142.
   PubMed Web of Science ®Google Scholar
• Andrew CM, Elamin ME, Anthony FS. Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: a systematic review. Crit Care Med. 2014 Feb;42(2):413–419.
   PubMed Web of Science ®Google Scholar
• Umar S, Iorga A, Matori H, et al. Estrogen rescues preexisting severe pulmonary hypertension in rats. Am J Respir Crit Care Med. 2011;184:715–723.
   PubMed Web of Science ®Google Scholar
• Yu HP, Hsieh YC, Suzuki T, et al. Salutary effects of estrogen receptor-b agonist on lung injury after trauma–hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1004–L1009.
   PubMed Web of Science ®Google Scholar
• Sakurai H, Schmalstieg FC, Traber LD, et al. Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. J Appl Physiol. 1999;86:1151–1159.
   PubMed Web of Science ®Google Scholar
• Poelstra K, Bakker WW, Klok PA, et al. A physiologic function for alkaline phosphatase: endotoxin detoxification. Lab Invest. 1997 Mar;76(3):319–327.
   PubMed Web of Science ®Google Scholar
• Eckle T, Füllbier L, Wehrmann M, et al. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15;178(12):8127–8137.
   PubMed Web of Science ®Google Scholar
• Menander-Huber KB, Edsmyr F, Huber W. Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo-controlled study in patients with bladder tumours. Urol Res. 1978;6(4):255–257.
   PubMedGoogle Scholar