165
Views
0
CrossRef citations to date
0
Altmetric
Patent Evaluation

Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells US2015011543 (a1): a patent evaluation

, &
Pages 1177-1181 | Received 01 Apr 2017, Accepted 24 Jul 2017, Published online: 04 Aug 2017

References

  • Liu C, Chen BJ, Deoliveira D, et al. Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. Blood. 2010;116:5518–5527.
  • Brunstein CG, Laughlin MJ. Extending cord blood transplant to adults: dealing with problems and results overall. Semin Hematol. 2010;47:86–96.
  • Murray LJ, Young JC, Osborne LJ, et al. Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34þ cells and recruit primitive CD34þ Thy-1þ cells into rapid division. Ex Hematol. 1999;27:1019–1028.
  • Heike T, Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim Biophys Acta. 2002;1592:313–321.
  • Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875–884.
  • Robinson SN, Ng J, Niu T, et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant. 2006;37:359–366.
  • Robinson SN, Simmons PJ, Yang H, et al. Mesenchymal stem cells in ex vivo cord blood expansion. Best Pract Res Clin Haematol. 2011;24:83–92.
  • Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6:1278–1281.
  • Delaney C, Heimfeld S, Brashem-Stein C, et al. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16:232–236.
  • Ratajczak MZ. Phenotypic and functional characterization of hematopoietic stem cells. Curr Opin Hematol. 2008;15:293–300.
  • Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329:1345–1348.
  • Nishino T, Wang C, Mochizuki-Kashio M, et al. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One. 2011;6:e24298.
  • Nishino T, Miyaji K, Ishiwata N, et al. Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol. 2009;37:111364–1377.e4.
  • De Lima M, McMannis J, Gee A, et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant. 2008;41:771–778.
  • Peled T, Landau E, Prus E, et al. Cellular copper content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells. Br J Haematol. 2002;116:655–661.
  • Peled T, Mandel J, Goudsmid RN, et al. Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Cytotherapy. 2004;6:344–355.
  • Saugageau G, Yves G. Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoitetic stem cells. US 2015/0011543 A1.
  • Ali S, Yu SM, Yao ZJ. Gram-scale laboratory synthesis of UM171, a potent agonist of human hematopoietic stem cell self-renewal. J Org Chem. 2016;81:10236–10241.
  • Shultz LD, Lyons BL, Burzenski LM, et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005;174:6477–6489.
  • Shultz LD, Schweitzer PA, Christianson SW, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 1995;154:180–191.
  • Caldwell J, Wang W, Zandstra PW. Proportional-integral-derivative (PID) control of secreted factors for blood stem cell culture. PLoS One. 2015;10:e0137392.
  • Saugageau G, Yves G, Rejean R, et al. Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoitetic stem cells. WO 2013/110198 A1.
  • Pabst C, Krosl J, Fares I, et al. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods. 2014;11:4:436-42.
  • Saugageau G, Hebert J, Pabst C Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation. US 2014/0343051 A1.
  • Saugageau G, Yves G, Gingras S. Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells. US 2017/0037047 A1.
  • Mora C, Serzanti M, Consiglio A, et al. Clinical potentials of human pluripotent stem cells. Cell Biology and Toxicology. 2017;33:4:351-360.
  • Cutler C, Multani P, Robbins D, et al. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013;122:3074–3081.
  • Popat U, Mehta RS, Rezvani K, et al. Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation. Blood. 2015;125:2885–2892.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.