References
- Siegel RL , Miller KD , Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30.
- Queralto N , Berliner AN , Goldsmith B , et al. Detecting cancer by breath volatile organic compound analysis: a review of array-based sensors. J Breath Res. 2014;8:027112.
- Torre LA , Siegel RL , Jemal A. Lung cancer statistics, lung cancer and personalized medicine. Springer; 2016. p. 1–19.
- Baker LH. Breast cancer detection demonstration project: five‐year summary report. CA Cancer J Clin. 1982;32:194–225.
- Cooner WH , Mosley B , Rutherford CL , et al. Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen. J Urol. 1990;143:1146–1152.
- Taivans I , Bukovskis M , Strazda G , et al. Breath testing as a method for detecting lung cancer. Expert Rev Anticancer Ther. 2014;14:121–123.
- Haick H , Broza YY , Mochalski P , et al. Assessment, origin, and implementation of breath volatile cancer markers. Chem Soc Rev. 2014;43:1423–1449.
- Jun Y-W , Huh Y-M , Choi J-S , et al. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc. 2005;127:5732–5733.
- Kuhl CK , Schrading S , Leutner CC , et al. Mammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancer. J Clin Oncol. 2005;23:8469–8476.
- Sone S , Takashima S , Li F , et al. Mass screening for lung cancer with mobile spiral computed tomography scanner. The Lancet. 1998;351:1242–1245.
- Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002;2:683.
- Pieterman RM , Van Putten JW , Meuzelaar JJ , et al. Preoperative staging of non–small-cell lung cancer with positron-emission tomography. New England J Med. 2000;343:254–261.
- Rangayyan RM , Suri JS . Recent advances in breast imaging, mammography, and computer-aided diagnosis of breast cancer. SPIE Publications; 2006.
- Klemi PJ , Parvinen I , Pylkkänen L , et al. Significant improvement in breast cancer survival through population-based mammography screening. Breast. 2003;12:308–313.
- Khullar S , DiSario J . Colon cancer screening. Sigmoidoscopy Colonoscopy, Gastrointest Endosc Clin N Am. 1997;7:365–386.
- Grossman S , Milos ML , Tekawa IS , et al. Colonoscopic screening of persons with suspected risk factors far colon, cancer: ii. past history of colorectal neoplasms. Gastroenterology. 1989;96:299–306.
- Van Rossum LG , Van Rijn AF , Laheij RJ , et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology. 2008;135:82–90.
- Smith-Bindman R , Lipson J , Marcus R , et al. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009;169:2078–2086.
- Einstein AJ , Henzlova MJ , Rajagopalan S . Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA. 2007;298:317–323.
- Haick H , Peled N , Breath analysis of pulmonary nodules, patent US 9528979 B2. 2016.
- Kubáň P , Foret F . Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. A review. Analytica Chim Acta. 2013;805:1–18.
- Paschke KM , Mashir A , Dweik RA . Clinical applications of breath testing. F1000 Med Rep. 2010;2:56.
- de Boer NK , de Meij TG , Oort FA , et al. The scent of colorectal cancer: detection by volatile organic compound analysis. Clin Gastroenterol Hepatol. 2014;12:1085–1089.
- Dweik RA , Amann A . Exhaled breath analysis: the new frontier in medical testing. J Breath Res. 2008;2:030301.
- Phillips M , Basa-Dalay V , Blais J , et al. Point-of-care breath test for biomarkers of active pulmonary tuberculosis. Tuberculosis. 2012;92:314–320.
- Mashir A , Dweik RA . Exhaled breath analysis: the new interface between medicine and engineering. Adv Powder Technol. 2009;20: 420. Japan.
- Mürtz M . Breath diagnostics using laser spectroscopy. Opt Photonics News. 2005;16:30–35.
- Altomare DF . Breath analysis for colorectal cancer screening. Colorectal Dis. 2016;18:1127–1128.
- Eng K , Alkhouri N , Cikach F , et al. Analysis of breath volatile organic compounds in children with chronic liver disease compared to healthy controls. J Breath Res. 2015;9:026002.
- Adiguzel Y , Kulah H . Breath sensors for lung cancer diagnosis. Biosens Bioelectron. 2015;65:121–138.
- Phillips M , Method and apparatus for identification of biomarkers in breath and methods of usng same for prediction of lung cancer, Patent US 20160363581 A1. 2017.
- Capone S , Tufariello M , Forleo A , et al. Breath analysis by a GC/MS coupled to a gas sensor detector, Convegno Nazionale Sensori. Springer; 2016. p. 267–275.
- Szabó AH , Podolec P , Ferenczy V , et al. The analysis of linear and monomethylalkanes in exhaled breath samples by GC× GC-FID and GC–MS/MS. J Chromatogr B. 2015;978:62–69.
- Del Río RF , O’Hara M , Pemberton P , et al. Elimination characteristics of post-operative isoflurane levels in alveolar exhaled breath via PTR-MS analysis. J Breath Res. 2016;10:046006.
- Aprea E , Cappellin L , Gasperi F , et al. Application of PTR-TOF-MS to investigate metabolites in exhaled breath of patients affected by coeliac disease under gluten free diet. J Chromatogr B. 2014;966:208–213.
- Kumar S , Huang J , Abbassi-Ghadi N , et al. Selected ion flow tube mass spectrometry analysis of exhaled breath for volatile organic compound profiling of esophago-gastric cancer. Anal Chem. 2013;85:6121–6128.
- Fink T , Wolf A , Maurer F , et al. Volatile organic compounds during Inflammation and sepsis in ratsa potential breath test using ion-mobility spectrometry. Anesthesiology: J Am Soc Anesthesiologists. 2015;122:117–126.
- Fink T , Baumbach JI , Kreuer S . Ion mobility spectrometry in breath research. J Breath Res. 2014;8:027104.
- Selyanchyn R , Wakamatsu S , Hayashi K , et al. A nano-thin film-based prototype QCM sensor array for monitoring human breath and respiratory patterns. Sensors. 2015;15:18834–18850.
- Ogimoto Y , Selyanchyn R , Takahara N , et al. Detection of ammonia in human breath using quartz crystal microbalance sensors with functionalized mesoporous SiO2 nanoparticle films. Sens Actuators B Chem. 2015;215:428–436.
- Zhang X , Zou Y , An C , et al. Sensitive detection of carcinoembryonic antigen in exhaled breath condensate using surface acoustic wave immunosensor. Sens Actuators B Chem. 2015;217:100–106.
- Groves WA , Zellers ET , Frye GC . Analyzing organic vapors in exhaled breath using a surface acoustic wave sensor array with preconcentration: selection and characterization of the preconcentrator adsorbent. Anal Chim Acta. 1998;371:131–143.
- Scarlata S , Pennazza G , Santonico M , et al. Exhaled breath analysis by electronic nose in respiratory diseases. Expert Rev Mol Diagn. 2015;15:933–956.
- Phillips M , Cataneo RN , Ditkoff BA , et al. Prediction of breast cancer using volatile biomarkers in the breath. Breast Cancer Res Treat. 2006;99:19–21.
- Phillips M , Gleeson K , Hughes JMB , et al. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. The Lancet. 1999;353:1930–1933.
- Dragonieri S , Annema JT , Schot R , et al. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer. 2009;64:166–170.
- Fu X-A , Li M , Knipp RJ , et al. Noninvasive detection of lung cancer using exhaled breath. Cancer Med. 2014;3:174–181.
- Peled N , Hakim M , Bunn PA , et al. Non-invasive breath analysis of pulmonary nodules. J Thorac Oncol. 2012;7:1528–1533.
- Rovira NL , Fuentes AH , Escorza JAV , et al., Optoelectronic Device for The Detection of Uterine Cervical Cancer, Comprising A Self-Positioning Attachment, Patent US 20120253202 A1. 2015.
- Phillips M , Altorki N , Austin JH , et al. Detection of lung cancer using weighted digital analysis of breath biomarkers. Clinica Chimica Acta. 2008;393:76–84.
- Zhou J , Huang Z-A , Kumar U , et al. Review of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis. Anal Chim Acta. 2017;996:1–9.
- Krilaviciute A , Heiss JA , Leja M , et al. Detection of cancer through exhaled breath: a systematic review. Oncotarget. 2015;6:38643.
- Dragonieri S , Pennazza G , Carratu P , et al. Electronic nose technology in respiratory diseases. Lung. 2017;195:157–165.
- Bikov A , Lázár Z , Horvath I . Established methodological issues in electronic nose research: how far are we from using these instruments in clinical settings of breath analysis? J Breath Res. 2015;9:034001.
- van der Schee M , Fens N , Brinkman P , et al. Effect of transportation and storage using sorbent tubes of exhaled breath samples on diagnostic accuracy of electronic nose analysis. J Breath Res. 2012;7:016002.
- Phillips M , Herrera J , Krishnan S , et al. Variation in volatile organic compounds in the breath of normal humans. J Chromatogr B: Biomed Sci Appl. 1999;729:75–88.
- Poli D , Goldoni M , Corradi M , et al. Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME–GC/MS. J Chromatogr B. 2010;878:2643–2651.
- Peng G , Tisch U , Adams O , et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat Nanotechnol. 2009;4:669–673.
- Valentine J , Bryant PJ , Gutshall PL , et al. Detection of Δ9-tetrahydrocannabinol in human breath following marijuana smoking. Anal Lett. 1979;12:867–880.
- Ochiai N , Takino M , Daishima S , et al. Analysis of volatile sulphur compounds in breath by gas chromatography–mass spectrometry using a three-stage cryogenic trapping preconcentration system. J Chromatogr B: Biomed Sci Appl. 2001;762:67–75.
- Fu X , Nantz M , Bousamra M , et al., Noninvasive detection of cancer originating in tissue outside of the lung using exhaled breath, patent WO 2017023768 A1. 2017.
- Fu X , Nantz M , Bousamra M , Noninvasive detection of lung cancer using exhaled breath, patent US 9638695 B2. 2017.
- Abdel-Rehim M , Method and device for analyte sampling and analyte concentration determination from exhaled breath, patent US2016159863 A1. 2016.
- Horváth I , Barnes PJ , Loukides S , et al. A European Respiratory Society technical standard: exhaled biomarkers in lung disease. Eur Respir J. 2017;49:1600965.
- Haick H , Hakim M , Volatile organic compounds as diagnostic markers for various types of cancer, patent WO 2011083473 A1. 2017.
- Dumlao MC , Xiao D , Zhang D , et al. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry. J Am Soc Mass Spectrom. 2017;28:575–578.
- Dumlao M , Khairallah GN , Donald WA . Internal energy deposition in dielectric barrier discharge ionization is significantly lower than in direct analysis in real-time mass spectrometry. Aust J Chem. 2017;70:1219–1226.
- Dumlao MC , Jeffress LE , Gooding JJ , et al. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures. Analyst. 2016;141:3714–3721.
- Stephens ER , Dumlao M , Xiao D , et al. Benzylammonium thermometer ions: internal energies of ions formed by low temperature plasma and atmospheric pressure chemical ionization. J Am Soc Mass Spectrom. 2015;26:2081–2084.
- Kabir KMM , Donald WA . Microscale differential ion mobility spectrometry for field deployable chemical analysis. TrAC Trends Anal Chem. 2017;97:399–427.
- Phillips M , Breath collection apparatus, patent US 6726637 B2. 2004.
- Indelicato S , Bongiorno D , Indelicato S , et al. Halogenated anesthetics determination in urine by SPME/GC/MS and urine levels relationship evaluation with surgical theatres contamination. J Anal Methods Chem. 2014;2014. doi: 10.1155/2014/753237.
- Li M , Biswas S , Nantz MH , et al. Preconcentration and analysis of trace volatile carbonyl compounds. Anal Chem. 2012;84:1288–1293.
- Hansel A , Jordan A , Holzinger R , et al. Proton transfer reaction mass spectrometry: on-line trace gas analysis at the ppb level. Int J Mass Spectrom Ion Process. 1995;149:609–619.
- Deng C , Zhang J , Yu X , et al. Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization. J Chromatogr B. 2004;810:269–275.
- Buszewski B , Ulanowska A , Ligor T , et al. Analysis of exhaled breath from smokers, passive smokers and non‐smokers by solid‐phase microextraction gas chromatography/mass spectrometry. Biomed Chromatogr. 2009;23:551–556.
- Benoit FM , Davidson W , Lovett A , et al. Breath analysis by atmospheric pressure ionization mass spectrometry. Anal Chem. 1983;55:805–807.
- Wehinger A , Schmid A , Mechtcheriakov S , et al. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas. Int J Mass Spectrom. 2007;265:49–59.
- Saraoglu HM , Kocan M . Determination of blood glucose level-based breath analysis by a quartz crystal microbalance sensor array. IEEE Sens J. 2010;10:104–109.
- Buszewski B , Grzywinski D , Ligor T , et al. Detection of volatile organic compounds as biomarkers in breath analysis by different analytical techniques. Bioanalysis. 2013;5:2287–2306.
- Dragonieri S , Schot R , Mertens BJ , et al. An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol. 2007;120:856–862.
- Di Natale C , Macagnano A , Martinelli E , et al. Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors. Biosens Bioelectron. 2003;18:1209–1218.
- Zilberman Y , Ionescu R , Feng X , et al. Nanoarray of polycyclic aromatic hydrocarbons and carbon nanotubes for accurate and predictive detection in real-world environmental humidity. ACS Nano 2011;5:6743–6753.
- Ahmad LM , Smith Z , Satterfield BC , et al., Method and apparatus for rapid quantification of an analyte in breath, patent US 9689864 B2. 2017.
- Haick H , Peled N , Volatile organic compounds for detecting cell dysplasia and genetic alterations associated with lung cancer, patent US 9315848 B2. 2016.
- Meyer MR , Peters FT , Maurer HH . Automated mass spectral deconvolution and identification system for GC-MS screening for drugs. Poisons, and Metabolites in Urine, Clin Chem. 2010;56:575–584.
- Leopold JH , Bos LD , Sterk PJ , et al. Comparison of classification methods in breath analysis by electronic nose. J Breath Res. 2015;9:046002.
- Peng G , Hakim M , Broza YY , et al. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br J Cancer. 2010;103:542–551.
- Sood AK , Nick AM , Felix EA , Detection of Cancer by Volatile Organic Compounds From Breath, patent US 20140127326 A1. 2014.
- Milton DK , White IM , Human exhaled aerosol droplet biomarker system and method, patent US 20170184609 A1. 2017.
- Zhang Y , Cui D , Volatile Compound Fingerprint Atlas-Spectrum Model Used for Early Gastric Cancer Diagnosis/Warning, patent US 20140244229 A1. 2014.
- Bikov A , Hernadi M , Korosi BZ , et al. Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer. BMC Pulm Med. 2014;14:202.