249
Views
0
CrossRef citations to date
0
Altmetric
Review

Arginine-lowering enzymes against cancer: a technocommercial analysis through patent landscape

, , &
Pages 603-614 | Received 26 Apr 2018, Accepted 01 Aug 2018, Published online: 23 Aug 2018

References

  • Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget. 2010;1:246–251.
  • Kelloff GJ, Hoffman JM, Johnson B, et al. Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clin Cancer Res. 2005;11:2785–2808.
  • Patil MD, Bhaumik J, Babykutty S, et al. Arginine dependence of tumor cells: targeting a chink in cancer’s armor. Oncogene. 2016;35:4957-4972.
  • Pasut G, Anti-Cancer SM. PEG-enzymes: 30 years old, but still a current approach. Adv Drug Deliv Rev. 2008;60:69–78.
  • Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 2003;55:1293–1302.
  • Delage B, Fennell DA, Nicholson L, et al. Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer. 2010;126:2762–2772.
  • Xiong L, Teng JLL, Botelho MG, et al. Arginine metabolism in bacterial pathogenesis and cancer therapy. Int J Mol Sci. 2016;17:363–381.
  • Feun L, You M, Wu CJ, et al. Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des. 2008;14:1049–1057.
  • Bragg J, Rajkovic A, Anderson C, et al. Identification and characterization of a putative arginine kinase homolog from Myxococcus xanthus Required for fruiting body formation and cell differentiation. J Bacteriol. 2012;194:2668–2676.
  • Fukumura D, Kashiwagi SJR. The role of nitric oxide in tumor progression. Nat Rev Cancer. 2006;6:521–534.
  • Takaku H, Takase M, Abe S, et al. In vivo anti-tumor activity of arginine deiminase purified. Int J Cancer. 1992;51:244–249.
  • Cheng PN-M, Lam T-L, Lam W-M, et al. Pegylated Recombinant Human Arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res. 2007;67:309–317.
  • Tommasi S, Elliot DJ, Da BM, et al. Homoarginine and inhibition of human arginase activity : kinetic characterization and biological relevance. Sci Rep. 2018;8:3697.
  • Li L, Wang Y, Chen J, et al. An engineered arginase FC protein inhibits tumor growth in vitro and in vivo. evidence-based complement. Evid Based Complement Alternat Med. 2013;2013.
  • Stone EM, Glazer ES, Chantranupong L, et al. Replacing Mn2+ with Co2+ in human arginase i enhances cytotoxicity toward L-arginine auxotrophic cancer cell lines. ACS Chem Biol. 2010;5:333–342.
  • Wheatley DN, Campbell E. Arginine catabolism, liver extracts, and cancer. Pathol Oncol Res. 2002;8:18–25.
  • Han RZ, Xu GC, Dong JJ, et al. Arginine deiminase : recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug. Appl Microbiol Biotechnol. 2016;4747–4760.
  • Miyazaki K, Takaku H, Umeda M, et al. Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a mycoplasma-infected cell line. Cancer Res. 1990;50:4522–4527.
  • Agency of Ind Science & Technol. Arginine deiminase and use thereof. JP2035081. 1988.
  • Nippon Mining Company Limited, Tokyo. Arginine deiminase from a mycoplasma arginini strain. US5474928. 1995.
  • Enzon I, Piscataway NJU Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same. US6132713. 1997.
  • Phoenix Pharmacologics Inc., Lexington K Modified arginine deiminase. US6737259. 2004.
  • Coriell Institute for Medical Research. Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent. US5372942A. 1992.
  • Cancer Treatments International. Therapeutic composition for treatment of cancer by arginine depletion. EP1499342. 2005.
  • Tepic S, Pyk P. Arginine decomposing enzyme therapeutic composition. US6261557. 2001.
  • Shanghai Institute of Pharmaceutical Industry, CN, China Head Institute Of Pharmaceutical Industrial Research. Arginine deiminase mutant from arthritis-type mycoplasma and application thereof. CN104130996. 2014.
  • Ikemoto M, Tabata M, Miyake T, et al. Expression of human liver arginase in Escherichia coli. Purification and properties of the product. Biochem J. 1990;270:697–703.
  • Zhang X, Liu J, Yu X, et al. High-level expression of human arginase I in Pichia pastoris and its immobilization on chitosan to produce L-ornithine. BMC Biotechnol. 2015;15:66.
  • The University of Taxas System. Compositions and methods for engineered human arginine deiminases. US20090238813. 2009.
  • Jiangsu T-Mab Biopharma Co. Ltd. Arginine deiminase mutant and preparation and application thereof. US 8663967. 2011.
  • RWTH Aachen University, Jacob’s University Bremen GmbH. Directed evolution of arginine deiminase for increased activity at physiological pH. EP2295560. 2011.
  • Vision Global Holdings Ltd., Sheung WH. Albumin-binding arginine deiminase and the use thereof. US9255262. 2016.
  • Fernandes HS, Teixeira CSS, Fernandes P, et al. Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections. Expert Opin Ther Pat. 2017;27:283–297.
  • Long Y, Tsai W, Wangpaichitr M, et al. Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence and glutamine addiction. Mol Cancer Ther. 2013;12:2581–2590.
  • Huang H, Wu W, Wang Y, et al. ASS1 as a novel tumor suppressor gene in myxo fibrosarcomas : aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance. Clin Cancer Res. 2013;19:2861-2872.
  • Aerase Inc. Compositions of engineered human arginases and methods for treating cancer. US9050340. 2015.
  • Jiangsu Simcere Pharmaceutical Research Company Ltd. Recombinant human arginase fusion protein and application thereof. CN101781369. 2010.
  • R The Board of Regents of The University of Texas System. Compositions of engineered human arginases and methods for treating cancer. WO2010051533A2. 2008.
  • Turecek PL, Bossard MJ, Schoetens F, et al. PEGylation of biopharmaceuticals: a review of chemistry and nonclinical safety information of approved drugs. J Pharm. 2016;105:460–475.
  • Takaku H, Misawa S, Hideya Hayashi KM. Chemical modification by polyethylene glycol of the anti-tumor enzyme arginine deiminase from Mycoplasma arginini. Jpn J Cancer Res. 1993;84:1195–1200.
  • Enzon Pharmaceuticals Inc. Modified arginine deiminase. AU1998074798. 1999.
  • Shanghai Fudan Zhangjiang Biol. Modified arginine deiminase. CN1536079. 2003.
  • Tsinghua University Protgen Ltd. Novel compound for the treatment of tumor. US20100303893. 2010.
  • Jiangnan University C. PEG (polyethylene glycol) modified recombinant arginine deiminase (ADI) as well as preparation method and application thereof. CN103923898. 2014.
  • Bio-Cancer Treatment International Ltd. Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation. US7951366. 2002.
  • The Hong Kong Polytechnic University. Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents. US8507245. 2013.
  • Beijing Shuanglu Pharmaceutical Co. Ltd. Sulfhydryl modified recombinant human arginase I, as well as preparation method and application thereof. CN103571814. 2012.
  • Bio-Cancer Treatment International Limited. Use of arginase in combination with 5FU and other compounds for treatment of human malignancies. WO2006058486. 2006.
  • Polaris Group. Methods of treatment with arginine deiminase. US9333268. 2016.
  • Srl M. Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria. US20030215429. 1998.
  • Pharma E. Erythrocytes containing arginine deiminase. US9125876. 2015.
  • Jiangsu T-Mab Biopharma Co. Ltd. Arginine deiminase mutant and preparation and application thereof. CN101812438. 2010.
  • Phoenix Pharmacologics Inc. Methods for inhibiting viral replication in vivo. US7204980. 2007.
  • AngioLab Inc. Pharmaceutical composition comprising arginine deiminasa for inhibiting angio-genesis. US20040096437. 2004.
  • US Department of Health and Human Services, National Institute of Health, Division of Extramural Inventions and Technology Resources. Methods for treatment of ocular diseases. US8877183. 2014.
  • Foster TP, Rodriguez PC, Hill JM, et al. Methods for treatment of ocular diseases. WO2014003850. 2014.
  • Louisiana State University and Agricultural and Mechanical College. Methods for treatment of ocular diseases. US20130344049. 2014.
  • Bio cancer Treatment International. Methods and compositions for modulating the immune system with arginase. WO2015165374. 2014.
  • Wells JW, Evans CH, Scott MC, et al. Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. PLoS One. 2013;8:1.
  • Feun L, Savaraj N. Pegylated arginine deiminase: a novel anticancer enzyme agent. Expert Opin Investig Drugs. 2006;15:815–822.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.