Microneedles as an alternative technology for transdermal drug delivery systems: a patent review

References

• Cheung K, Das DB. Microneedles for drug delivery: trends and progress. Drug Deliv. 2016;7:2338–2354.
   Google Scholar
• Waghule T, Singhvi G, Dubey SK, et al. Microneedles: a smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019;109:1249–1258.
   PubMed Web of Science ®Google Scholar
• Sharma S, Hatware K, Bhadane P, et al. Recent advances in microneedle composites for biomedical applications: advanced drug delivery technologies. Mater Sci Eng C. 2019;103:109717.
   Web of Science ®Google Scholar
• Larraneta E, Lutton REM, Woolfson AD, et al. Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Mater Sci Eng R. 2016;104:1–32.
   Web of Science ®Google Scholar
• Lin Y-H, Lee I-C, Hsu W-C, et al. Rapid fabrication method of a microneedle mold with controllable needle height and width. Biomed Microdevices. 2016;18(5):85–95.
   PubMed Web of Science ®Google Scholar
• Jeong H-R, Lee H-S, Choi I-J, et al. Considerations in the use of microneedles: pain, convenience, anxiety and safety. J Drug Target. 2017;25(1):29–40.
   PubMed Web of Science ®Google Scholar
• Sabri AH, Ogilvie J, Abdulhamid K, et al. Expanding the applications of microneedles in dermatology. Eur J Pharm Biopharm. 2019;140:121–140.
   PubMed Web of Science ®Google Scholar
• Bhatnagar S, Dave K, Vamsi V, et al. Microneedles in the clinic. J Control Release. 2017;260:164–182.
   PubMed Web of Science ®Google Scholar
• Moffat K, Wang Y, Singh TRR, et al. Microneedles for enhanced transdermal and intraocular drug delivery. Curr Opin Pharmacol. 2017;36:14–21.
   PubMed Web of Science ®Google Scholar
• Ma G, Wu C. Microneedle, bio-microneedle and bio-inspired microneedle: A review. J Control Release. 2017;251:11–23.
   PubMed Web of Science ®Google Scholar
• Larraneta E, Stewart S, Fallows SJ, et al. A facile system to evaluate in vitro drug release from dissolving microneedle arrays. Int J Pharm. 2016;497(1–2):62–69.
   PubMedGoogle Scholar
• Vora LK, Donnelly RF, Larraneta E, et al. Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: proof of concept. J Control Release. 2017;265:93–101.
   PubMed Web of Science ®Google Scholar
• Shakya AK, Lee CH, Gill HS. Cutaneous vaccination with coated microneedles prevents development of airway allergy. J Control Release. 2017;265:75–82.
   PubMed Web of Science ®Google Scholar
• Schipper P, Van der Maaden K, Groeneveld V, et al. Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice. J Control Release. 2017;262:28–36.
   PubMed Web of Science ®Google Scholar
• Donnelly RF, Morrow DI, McCrudden MTC, et al. Hydrogel-forming and dissolving microneedles for enhanced delivery of photosensitizers and precursors. Photochem Photobiol. 2014;90(3):641–647.
   PubMed Web of Science ®Google Scholar
• Hardy JG, Larraneta E, Donnelly RF, et al. Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Mol Pharm. 2016;13(3):907–914.
   PubMedGoogle Scholar
• Li QY, Zhang JN, Chen BZ, et al. A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin. RSC Adv. 2017;7(25):15408–15415.
   Web of Science ®Google Scholar
• Omolu A, Bailly M, Day RM. Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity. Drug Deliv. 2017;24(1):942–951.
   PubMed Web of Science ®Google Scholar
• Du G, Hathout RM, Nasr M, et al. Intradermal vaccination with hollow microneedles: a comparative study of various protein antigen and adjuvant encapsulated nanoparticles. J Control Release. 2017;266:109–118.
   PubMed Web of Science ®Google Scholar
• Yang J, Liu X, Fu Y, et al. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharm Sin B. 2019;9(3):469–483.
   PubMed Web of Science ®Google Scholar
• Indermun S, Luttge R, Choonara YE, et al. Current advances in the fabrication of microneedles for transdermal delivery. J Control Release. 2014;185:130–138.
   PubMed Web of Science ®Google Scholar
• Tuan-Mahmood T-M, McCrudden MTC, Torrisi BM, et al. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci. 2013;50(5):623–637.
   PubMed Web of Science ®Google Scholar
• Wang M, Hu L, Xu C. Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing. Lab Chip. 2017;17(8):1373–1387.
   PubMed Web of Science ®Google Scholar
• Li Y, Xianfeng C. Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery. US20140142541. 2014.
   Google Scholar
• Prausnitz MR, Kim YC, Edelhauser HF. Formulations and methods for targeted ocular delivery of therapeutic agents. WO2015095772. 2015
   Google Scholar
• Jung HII, Yang HS. Microstructure-based drug delivery system comprising microporous structure. US20150328443. 2015.
   Google Scholar
• Mistilis MJ, Edens WC, Bommarius AS, et al. Thermally stable vaccine formulations and microneedles. WO2015034924. 2015.
   Google Scholar
• Kosuda KM, Stinson JA, Boopathy AV, et al. Microneedle comprising silk fibroin applied to a dissolvable base. WO2019195350. 2019.
   Google Scholar
• Qinying Y, Zhenghan Z, Gensheng Y, et al. Drug-loaded soluble microneedle patch and preparation method thereof. CN109701152. 2019.
   Google Scholar
• Lim CY, Tey HL. Dissolving microneedle patches comprising corticosteroid. WO2019135717. 2019.
   Google Scholar
• Zvezdin VN, Kasatkin IA, Akafeva TI. A microneedle patch for transdermal injections. WO2019231360 2019.
   Google Scholar
• Donnelly R, Woolfson D. Drug delivery device. WO2017191457. 2017.
   Google Scholar
• Narayan R, Hall R, Zhang Y. Devices and methods for transdermal treatment of basal cell carcinoma. WO2017117133. 2017.
   Google Scholar
• Falo LD, Erdos GJR. Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices. 20180304062. 2018.
   Google Scholar
• Nejad HR, Sadeqi A, Sonkusale S. System and method for making microneedles. WO2019203888. 2019.
   Google Scholar
• Gu Z, Zhang Y. Ros-responsive microneedle patch for acne vulgaris treatment. WO2019200081. 2019.
   Google Scholar
• Chen P, Wang XM, Xu C, et al. Self-implantable micro-drug-reservoirs for localized and controlled ocular drug delivery. WO2019143293. 2019.
   Google Scholar
• Gu Z, Ye Y. Methods and compositions related to physiologically responsive microneedle delivery systems. WO2017143153. 2017.
   Google Scholar
• Cho D-Y, Lim D-J, Woodworth BA. Sustained intratonsillar drug delivery with needle array. WO2018140800. 2018.
   Google Scholar
• Liu F, Yu X, Lu GW, et al. Microneedle array with active ingredient. WO2018151832. 2018.
   Google Scholar
• Falo LD Jr, Erdos G, Ozdoganlar OB. Tip-loaded microneedle arrays for transdermal insertion. WO2013166162. 2013.
   Google Scholar
• Jaklenec A, McHugh KJ, Langer RS, et al. Microneedle tattoo patches and use thereof. US20190015650. 2019. WO2019018301.
   Google Scholar
• Lim CY. Pyramidal microneedles with enhanced drug loading capacity and method for manufacturing. WO2018208222. 2018.
   Google Scholar
• Baker AT, Ross RF, Gadsby ED, et al. Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure. WO2017189258. 2017.
   Google Scholar
• Burton K. Microneedle delivery system with anchor. WO2019136033. 2019.
   Google Scholar
• Kalluri H, Banga AK. Microneedles and transdermal drug delivery. J Drug Delivery Sci Technol. 2009;19(5):303–310.
   Web of Science ®Google Scholar
• Van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans) dermal drug and vaccine delivery. J Control Release. 2012;161(2):645–655.
   PubMed Web of Science ®Google Scholar
• Ross RF Transdermal patch containing microneedles. WO2012117302. 2012.
   Google Scholar
• Stinchcomb A, Ghosh P. Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery. WO2014176325. 2014.
   Google Scholar
• Stinchcomb AL, Banks SL, Golinski MJ, et al. Use of cannabidiol prodrugs in topical and transdermal administration with microneedles. US20150197484. 2015.
   Google Scholar
• Ross RF. Device for delivery of rheumatoid arthritis medication. US2017157380. 2017.
   Google Scholar
• Ross RF Drug delivery methods targeting the lymphatic system. WO2019232265. 2019.
   Google Scholar
• Ying Z, Kristen JH, Amy SD. Microneedle devices and methods. US20180344631. 2018.
   Google Scholar
• Prausnitz MR, Terry RN, Li W. Separable microneedle arrays for sustained release of drug. WO2019075275. 2019.
   Google Scholar
• Gill HS, Shakya AK. Methods and devices for the treatment of food allergies. WO2018222874. 2018.
   Google Scholar
• Alary M, Hopson P, Liu JJ, et al. Microneedle arrays and methods for making and using. WO2018119174. 2018.
   Google Scholar
• Chowdhury DFH. Microneedle Transdermal Delivery Device. US20170312488. 2017.
   Google Scholar
• Kulkarni G. Transdermal microneedle drug delivery device and method. WO2017113011. 2017.
   Google Scholar
• Prausnitz MR, Edelhauser HF, Patel SR. Methods and devices for drug delivery to ocular tissue using microneedle. US2018028357. 2018.
   Google Scholar
• D’Souza MJ. Microneedle-based transdermal delivery system and method of making same. WO2018089918. 2018.
   Google Scholar
• Burton K. Wearable device with microneedle array delivery system. WO2019139827. 2019.
   Google Scholar
• Ross FR. Increased bioavailability of transdermally delivered agents. US20170246439. 2017.
   Google Scholar
• Ramakrishnan V. Microneedle arrays, and methods and systems of producing microneedle arrays having a branched material. WO2019207528. 2019.
   Google Scholar
• Chandrashekhar P. Methods, compositions, and devices for drug/live cell microarrays. WO 2018017674. 2018.
   Google Scholar
• Heuser K, Spilgies H. Microneedle system for administering liquid formulations. US20180099133. 2018.
   Google Scholar
• Choi HH, Knutson GP, David MM. Method of contact coating a microneedle array. US20130216694. 2013.
   Google Scholar
• Determan AS, Johnson PR, Moseman JT, et al. Aqueous formulations for coating microneedle arrays. US20130123707. 2013.
   Google Scholar
• Douroumis D. Method of coating microneedle devices. US20140350457. 2014.
   Google Scholar
• Ishibashi M, Hamamoto H, Tanaka T, et al. Microneedle array coated with drug composition. US20150216796. 2015.
   Google Scholar
• Johnson PR Alum-containing coating formulations for microneedle vaccine patch. WO2016122915. 2016.
   Google Scholar
• Cosmed Pharmaceutical Co., Ltd. Coating liquid for microneedles, microneedle-coating substance, and microneedle array. AU2017215012. 2017.
   Google Scholar
• Brown K, Dohmeier DM, Mosemant JT, et al. Zinc compositions for coated microneedle arrays. WO2017062727. 2017.
   Google Scholar