A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)

References

• MY L, Chen D, Shiloh A, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002;416:648–653.
   PubMed Web of Science ®Google Scholar
• Li MY, Brooks CL, Kon N, et al. A dynamic role of HAUSP in the p53-MDM2 pathway. Mol Cell. 2004;13:879–886.
   PubMed Web of Science ®Google Scholar
• Ovaa H, Kessler BM, Rolen U, et al. Activity-based ubiquitin-specific protease(USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A. 2004;101:2253–2258.
   PubMed Web of Science ®Google Scholar
• Loosdregt JV, Fleskens V, Fu J, et al. Stabilization of the transcription factor FOXP3 by the deubiquitinase USP7 increases Treg-Cell-Suppressive capacity. Immunity. 2013;39:259–271.
   PubMed Web of Science ®Google Scholar
• Riquelme PP, Worboys JD, Green J, et al. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. EMBO Rep. 2018;19:e44766.
   PubMed Web of Science ®Google Scholar
• Cai J, Chen HY, Peng SJ, et al. USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling. FASEB J. 2018;32:5238–5249.
   PubMed Web of Science ®Google Scholar
• Xiang QW, Ju H, Li Q, et al. Human herpesvirus 8 interferon regulatory factors 1 and 3 mediate replication and latency activities via interactions with USP7 deubiquitinase. J Virol. 2018;92:e02003–e02017.
   PubMed Web of Science ®Google Scholar
• Sanders SJ, Sencicek GE, Hus V, et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with Autism. Neuron. 2011;70:863–885.
   PubMed Web of Science ®Google Scholar
• Zhang P, Wei YK, Wang L, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16:864–875.
   PubMed Web of Science ®Google Scholar
• Zhan MX, Sun XH, Liu JX, et al. USP7 promotes medulloblastoma cell survival and metastasis by activating Shh pathway. Biochem Biophys Res Commun. 2017;484:429–434.
   PubMed Web of Science ®Google Scholar
• Sun J, Lin L, Zhang JH, et al. The prognostic value of USP7 and p53 in advanced hypopharyngeal carcinoma. Ann Diagn Pathol. 2021;51:151695.
   PubMed Web of Science ®Google Scholar
• Zr W, WT K, OW L, et al. Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing. Acta Pharm Sin B. 2021;11(3):694–707.
   PubMed Web of Science ®Google Scholar
• Holowaty MN, Sheng Y, Nguyen T, et al. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. J Biol Chem. 2003;278:47753–47761.
   PubMed Web of Science ®Google Scholar
• Hu M, Pw L, MY L, et al. Crystal structure of a UBP-Family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell. 2002;111:1041–1054.
   PubMed Web of Science ®Google Scholar
• Chauhan D, Tian Z, Nicholson B, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes Bortezomib resistance. Cancer Cell. 2012;22:345–358.
   PubMed Web of Science ®Google Scholar
• Fan YH, Vasudevan SA, Dou J, et al. USP7 inhibitors P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013;4:e867.
   PubMed Web of Science ®Google Scholar
• Pozhidaeva A, Valles G, Wang F, et al. USP7-specific inhibitors target and modified the enzyme’s active site via distinct chemical mechanisms. Cell Chem Biol. 2017;24:1501–1512.
   PubMed Web of Science ®Google Scholar
• Setz C, Friedrich M, Rauch P, et al. Inhibitors of deubiquitinating enzymes block HIV-1 replication and augment the presentation of Gag-derived MHC-I epitopes. Viruses. 2017;9:222.
   PubMed Web of Science ®Google Scholar
• Altun M, Kramer HB, Willems LI, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol. 2011;18:1401–1412.
   PubMedGoogle Scholar
• Weinstock J, Wu J, Cao P, et al. Selective dual inhibitors of the cancer-related deubiquitylating protease USP7 and USP47. ACS Med Chem Lett. 2012;3:789–792.
   PubMed Web of Science ®Google Scholar
• Chen C, Song JM, Wang JZ, et al. Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors. Bioorg Med Chem Lett. 2017;27:845–849.
   PubMed Web of Science ®Google Scholar
• Reverdy C, Conrath S, Lopez R, et al. Discovery of specific inhibitors of Human USP7/HAUSP deubiquitinating enzyme. Chem Biol. 2012;19:467–477.
   PubMedGoogle Scholar
• Colombo M, Vallese S, Peretto I, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010;5:552–558.
   PubMed Web of Science ®Google Scholar
• Colland F, Formstecher E, Jacq X, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009;8:2286–2295.
   PubMed Web of Science ®Google Scholar
• Kategaya L, Lello PD, Rouge L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017;550:534–538.
   PubMed Web of Science ®Google Scholar
• Lello PD, Pastor R, Murray JM, et al. Discovery of small-molecule inhibitors of ubiquitin specific protease 7(USP7) using integrated NMR and in silico techniques. J Med Chem. 2017;60:10056–10070.
   PubMed Web of Science ®Google Scholar
• Lamberto I, Liu XX, Seo HS, et al. Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7. Cell Chem Biol. 2017;24:1490–1500.
   PubMed Web of Science ®Google Scholar
• Gavory G, Dowd CRO, Helm MD, et al. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol. 2018;14:118–125.
   PubMed Web of Science ®Google Scholar
• Dowd CRO, Helm MD, Rountree JSS, et al. Identification and structure-guided development of pyrimidinone based USP7 inhibitors. ACS Med Chem Lett. 2018;9:238–243.
   PubMed Web of Science ®Google Scholar
• Turnbull AP, Ioannidis S, Krajewski WW, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitor. Nature. 2017;550:481–486.
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Miyazaki M, Kodrasov MP, et al. Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as USP7 inhibitor. Bioorg Med Chem Lett. 2013;23:3884–3886.
   PubMed Web of Science ®Google Scholar
• Tanokashira N, Kukita S, Kato H, et al. Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani. Tetrahedron. 2016;72:5530–5540.
   Web of Science ®Google Scholar
• Afifi AH, Kagiyama I, Desoky AHE, et al. Sulawesins A-C, furanosesterterpene tetronic acids that inhibit USP7, from a Psammocinia sp. Marine sponge. J Nat Prod. 2017;80:2045–2050.
   PubMed Web of Science ®Google Scholar
• Jing B, Liu M, Yang L, et al. Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro. Acta Pharmocol Sin. 2018;39:492–498.
   PubMed Web of Science ®Google Scholar
• Colland F, inventor. Selective and reversible inhibitors of ubiquitin specific protease 7. World Patent WO2013030218A4. 2013 Mar 7.
   Google Scholar
• Ioannidis S, inventor. Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors. Faming Zhuanli Shenqing. CN107406451A. 2017.
   Google Scholar
• Ioannidis S, inventor. Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors. United States patent US10000495B2. 2018 Jun 19.
   Google Scholar
• Ioannidis S, inventor. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors. United States patent US10377767B2. 2019 Aug 13.
   Google Scholar
• Ioannidis S, inventor. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors. United States patent US10377773B2. 2019 Aug 13.
   Google Scholar
• Ioannidis S, inventor. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors. United States patent US10508098B2. 2019 Dec 17.
   Google Scholar
• András K, inventor. New (hetero) aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them. World Patent WO2017212010A1. 2017 Dec 14.
   Google Scholar
• András K, inventor. New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them. World Patent WO2017212012A1. 2017 Dec 14.
   Google Scholar
• Colin OD, inventor. Piperidine derivatives as inhibitors of ubiquitin specific protease 7. World Patent WO2018073602A1. 2018 Apr 26.
   Google Scholar
• Sara B, inventor. Novel USP7 inhibitors for treating multiple myeloma. World Patent WO2019067503A1. 2019 Apr 04.
   Google Scholar
• Sara B, inventor. USP7 inhibition. World Patent WO2020086595A8. 2020 Apr 30.
   Google Scholar
• Chen SJ, inventor. Pyrimidinopyrazole compound containing fused ring group, and preparation method and application of pyrimidinopyrazole compound. Faming Zhuanli Shenqing. CN111808105. 2020.
   Google Scholar
• Chen SJ, inventor. Thienopyrimidinone compound and medical application thereof. Faming Zhuanli Shenqing. CN113087718. 2021
   Google Scholar
• Chen SJ, inventor. Triazine benzimidazole compounds and medical use thereof. Faming Zhuanli Shenqing. CN113423709. 2021.
   Google Scholar
• Wen XA, inventor. Piperidine compound and preparation method and medical application thereof. Faming Zhuanli Shenqing. CN112608320. 2021.
   Google Scholar
• Blake R, inventor. USP7 inhibitor compounds and methods of use. Faming Zhuanli Shenqing. CN107531683. 2018.
   Google Scholar
• Jones A, inventor. 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carbonitrile derivatives for treating cancer. Faming Zhuanli Shenqing. CN108473502. 2018.
   Google Scholar
• Gibson KR, inventor. 2-cyanoisoindoline derivatives for treating cancer. Faming Zhuanli Shenqing. CN108698992. 2018.
   Google Scholar
• Sun HB, inventor. Benzothiazole compounds and medical application. Faming Zhuanli Shenqing. CN111763201. 2020.
   Google Scholar
• Weinstock J, inventor. Covalent irreversible inhibitors of USP7 as anti-cancer agents. United States patent US10292973B2. 2019 May 21.
   Google Scholar
• Wang H, inventor. Azole compounds as ubiquitin-specific protease USP7 inhibitors. United States patent US20200016140A1. 2020 Jan 16.
   Google Scholar
• Xu QL, inventor. Thiophene compounds and applications of thiophene compounds serving as USP7 inhibitors and antitumor drugs. Faming Zhuanli Shenqing. CN109096271. 2018.
   Google Scholar
• Biannic B, inventor. Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof. United States patent US10722514B2. 2020 Jul 28.
   Google Scholar
• Pepe A, inventor. 6-amino-2,4-dihydropyrano[2,3-c]pyrazoles and methods of use. United States patent US10980781B2. 2021 Apr 20.
   Google Scholar
• Wang WW, inventor. Application of pentacyclic triterpenoid in preparing USP7 inhibitor. Faming Zhuanli Shenqing. CN105534991. 2016.
   Google Scholar
• Ruadhri, inventor. Treatment of inflammation. European patent EP2446883A1. 2012 May 2.
   Google Scholar
• Wang LW, inventor. Methods and materials for treating cancer. United States patent US20210283101. 2021 Sep 16.
   Google Scholar
• Li B, inventor. Application of ubiquitination pathway related factor in regulating and controlling functions of regulatory T cell. Faming Zhuanli Shenqing. CN108144049. 2018.
   Google Scholar
• Liu JP, inventor. Medical application of ubiquitin-specific proteases USP7 to treating aging and related diseases. Faming Zhuanli Shenqing. CN108144050. 2018.
   Google Scholar
• Meng D, inventor. Modified Bach1 gene and application thereof. Faming Zhuanli Shenqing. CN109517826. 2019.
   Google Scholar
• YY W, inventor. Application of USP7 inhibitor in medicine for treating ABC-DLBCL. Faming Zhuanli Shenqing. CN111840562. 2020.
   Google Scholar
• Baek KH, inventor. Vector library for yeast two hybrid screening and method for identifying deubiquitinating enzyme binding to target protein using same. United States patent US20210032619. 2021 Feb 4.
   Google Scholar
• Zhang HZ, inventor. Mammary-cancer-susceptible-gene detection chip and preparation method thereof. Faming Zhuanli Shenqing. CN105969859. 2016.
   Google Scholar