477
Views
8
CrossRef citations to date
0
Altmetric
Drug Evaluation

Prucalopride for the treatment of ileus

&
Pages 489-493 | Received 24 Jul 2016, Accepted 27 Feb 2017, Published online: 10 Mar 2017

References

  • Asgeirsson T, El-Badawi KI, Mahmood A, et al. Postoperative ileus: it costs more than you expect. J Am Coll Surg. 2010 Feb;210(2):228–231.
  • Delaney CP. Clinical perspective on postoperative ileus and the effect of opiates. Neurogastroenterol Motil. 2004 Oct;16(Suppl 2):61–66.
  • Parvizi J, Han S-B, Tarity TD, et al. Postoperative ileus after total joint arthroplasty. J Arthroplasty. 2008 Apr;23(3):360–365.
  • Greenwood-Van Meerveld B. Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007;12(4):619–626.
  • Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm. 2007 Oct 15;64(20 Suppl 13):S3–S7.
  • Delaney CP, Senagore AJ, Viscusi ER, et al. Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials. Am J Surgery. 2006;191(3):315–319.
  • Saclarides T. Postoperative ileus: strategies for reduction. Ther Clin Risk Manag. 2008;4(5):913–917.
  • Miedema BW, Johnson JO, Pritts T, et al. Methods for decreasing postoperative gut dysmotility. Lancet Oncol. 2003 Jun;4(6):365–372.
  • Van Bree SHW, Bemelman WA, Hollmann MW, et al. Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperative ileus. Ann Surg. 2014 Apr;259(4):708–714.
  • Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterology Motil. 2004;16(S2):54–60.
  • Van Bree S, Vlug M, Bemelman W, et al. Faster recovery of gastrointestinal transit after laparoscopy and fast-track care in patients undergoing colonic surgery. Gastroenterology. 2011;141(3):872–880.
  • Topcu SY, Oztekin SD, Kafali H, et al. Effect of gum chewing on reducing postoperative ileus and recovery after colorectal surgery: a randomised controlled trial. Complement Ther Clin Pract. 2016 May [cited 2016 Jul 23];23:21–25.
  • Kruse C, Müller SA, Warschkow R, et al. Does caffeine reduce postoperative bowel paralysis after elective laparoscopic colectomy? (CaCo trial): study protocol for a randomized controlled trial. Trials. 2016;17:186.
  • Vather R, Bissett I. Management of prolonged post-operative ileus: evidence-based recommendations. ANZ J Surg. 2013 May;83(5):319–324.
  • Biondo S, Miquel J, Espin-Basany E, et al. A double-blinded randomized clinical study on the therapeutic effect of gastrografin in prolonged postoperative ileus after elective colorectal surgery. World J Surg. 2016;40(1):206–214.
  • Vather R, Josephson R, Jaung R, et al. Gastrografin in prolonged postoperative ileus: a double-blinded randomized controlled trial. Ann Surg. 2015 Jul;262(1):23–30.
  • Ludwig K, Viscusi ER, Wolff BG, et al. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J Surg. 2010;34(9):2185–2190.
  • Xu -L-L, Zhou X-Q, Yi P-S, et al. Alvimopan combined with enhanced recovery strategy for managing postoperative ileus after open abdominal surgery: a systematic review and meta-analysis. J Surg Res. 2016 Jun;203(1):211–221.
  • Earnshaw SR, Kauf TL, McDade C, et al. Economic impact of alvimopan considering varying definitions of postoperative ileus. J Am Coll Surg. Elsevier. 2015;221(5):941–950.
  • De Winter BY, Boeckxstaens GE, De Man JG, et al. Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats. Gut. 1999 Nov;45(5):713–718.
  • Appel S, Kumle A, Hubert M, et al. First pharmacokinetic-pharmacodynamic study in humans with a selective 5-hydroxytryptamine4 receptor agonist. J Clin Pharmacol. 1997;37:229–237.
  • Emmanuel AV, Roy AJ, Nicholls TJ, et al. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther. 2002;16(7):1347–1356.
  • Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. 2002;71(4):533–554.
  • Kim DY, Camilleri M. Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol. 2000;95(10):2698–2709.
  • Bouras EP, Camilleri M, Burton DD, et al. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology. 2001;120(2):354–360.
  • Bouras EP, Camilleri M, Burton DD, et al. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999;44(5):682–686.
  • Flach S, Scarfe G, Dragone J, et al. A phase 1 study to investigate the absorption, pharmacokinetics and excretion of (14C) pruclaopride after a single dose in healthy volunteers. Clin Ther. 2016;38(9):2106–2115.
  • Ford AC, Suares NC. Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. Gut. 2011;60(2):209–218.
  • Camilleri M, Piessevaux H, Yiannakou Y, et al. Efficacy and safety of prucalopride in chronic constipation: an integrated analysis of six randomized, controlled clinical trials. Dig Dis Sci. 2016;61(8):2357–2372.
  • Krobert KA, Brattelid T, Levy FO, et al. Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants. Naunyn Schmiedebergs Arch Pharmacol. 2005;371(6):473–479.
  • De Maeyer JH, Lefebvre RA, Schuurkes JAJ. 5-HT4 receptor agonists: similar but not the same. Neurogastroenterology Motil. 2008;20(2):99–112.
  • Chapman H, Pasternack M. The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph. Eur J Pharmacol. 2007;554(2–3):98–105.
  • Smart CJ, Ramesh AN. The successful treatment of acute refractory pseudo-obstruction with prucalopride. Colorectal Dis. 2012 Aug;14(8):e508.
  • Emmanuel AV, Kamm MA, Roy AJ, et al. Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction – a double-blind, placebo-controlled, cross-over, multiple n = 1 study. Aliment Pharmacol Ther. 2012;35(1):48–55.
  • Park SJ, Choi EJ, Yoon YH, et al. The effects of prucalopride on postoperative ileus in guinea pigs. Yonsei Med J. 2013;54(4):845–853.
  • Gomez-Pinilla PJ, Di Giovangiulio M, Nemethova A, et al. 416 prucalopride activates the intestinal cholinergic anti-inflammatory pathway and prevents postoperative ileus. Gastroenterology. 2014 May;146(5):S–89.
  • Galandiuk S, Beyens G, Ausma J, et al. 934 evaluation of the efficacy, safety and tolerability of prucalopride (Resolor®) given subcutaneously in patients undergoing elective partial colectomies. Gastroenterology. 2008 Apr;134(4):A–138.
  • Gong J, Xie Z, Zhang T, et al. Randomised clinical trial: prucalopride, a colonic pro-motility agent, reduces the duration of post-operative ileus after elective gastrointestinal surgery. Aliment Pharmacol Ther. 2016;43(7):778–789.
  • Tiernan J, Cook A, Geh I, et al. Use of a modified Delphi approach to develop research priorities for the Association of Coloproctology of Great Britain and Ireland. Colorectal Dis. 2014;16(12):965–970.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.