Advanced search
Publication Cover
Biomarkers Volume 7, 2002 - Issue 2
Submit an article Journal homepage
172
Views
48
CrossRef citations to date
0
Altmetric
Research Article

Cytogenetic analysis of buccal cells from shoeworkers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde

Sema Burgaz Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey
,
Onur Erdem Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey
,
Gonca Çakmak Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey
,
Nurten Erdem National Institute of Occupational Safety and Health, Etimesgut, Ankara, Turkey
,
Asuman Karakaya Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandog an, Ankara, Turkey
&
Ali Esat Karakaya Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey
Pages 151-161 | Published online: 29 Sep 2008

  • ACGIH. 1999, Threshold Limit Values and Biological Exposure Indices for 1999-2000. (Cincinnati:American Conference of Governmental Industrial Hygienists).
  • BLAIR, A., STEWART, P. A. and HOOVER, R. N. 1990, Mortality from lung cancer among workers employed in formaldehyde industries. American Journal of Industrial Medicine, 17, 683-699.
  • BURGAZ, S., ISCAN, A., BUYUKBINGOL, Z. K., BOZKURT, A. and KARAKAYA, A. E. 1995, Evaluation of micronuclei in exfoliated urothelial cells and urinary thioether excretion of smokers. Mutation Research, 335, 163-169.
  • BURGAZ, S., COK, I., ULUSOY, L., TARHAN, U., AYGUN, N. and KARAKAYA, A. E. 1997, Biological monitoring of n-hexane exposure in shoe workers. Biomarkers, 2, 25-28.
  • BURGAZ, S., KARAHALIL, B., BAYRAK, P., TASKIN, L., YAVUZASIAN, F., BÖKESOY, I., ANZION, R. B. M., Bos, R. P. and PLATIN, N. 1999, Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and in exfoliated buccal epithelial cells of nurses handling antineoplastics. Mutation Research, 439, 97-104.
  • BURGAK, S., COK, I., UYSAL TECIMER, B. and KARAKAYA, A. E. 2000, Monitoring of genotoxic damage in smokeless tobacco (Maras powder) consumers using micronucleated exfoliated oral cells. Biomarkers, 5(3), 219-224.
  • BURGAZ, S., CAKMAK, G., ERDEM, O., YILMAZ, M. and KARAKAYA, A. E. 2001, Micronuclei frequencies in exfoliated nasal mucosa cells from pathology and anatomy laboratory workers exposed to formaldehyde. Neoplasma, 48, 144-147.
  • CAUARTELLI, G., BONATTI, S., DE FERRARI, M., SCAIA, M., MEREU, P., MARGARINO, G. and ABBONDANDOIX), A. 2000, Micronucleus frequencies in exfoliated buccal cells in normal mucosa, precancerous lesions and squamous cell carcinoma. Analytical and Quantitative Cytology and Histology, 22, 486-492.
  • DIAZ, S., FONSECA, G. and FERNANDEZ, I. 1990, Analysis of lymphocyte and oral mucosa cell micronuclei in Cuban paint industry workers. Hereditas, 113, 77-80.
  • FENECH, M., HOLIAND, N., CHANG, W. P., ZEIGER, E. and BONASSI, S. 1999, The human micronucleus project - an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutation Research, 428, 271-283.
  • FUNES-CRAVIOIO, F., KOLMODIN-HEDMAN, B., LINDSTEN, J., NORDENSKJOLD, M., ZAPATA-GAYON, C., LAMBERT, B., NORBERG, R., OLIN, R. and SWENSSON, A. 1977, Chromosome aberrations and sister-chromatid exchanges in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers. Lancet, ii, 322-325.
  • GONSEBATT, M. E., VEGA, L., SAIAKAR, A. M., MONTERO, R., GUZMAN, P., BIAS, J., DEL RAKO, L. M., GARCIA-VARGAS, G., ALBORES, A., CEBRIAN, M. E., KELSH, M. and OSTROSKY-WEGMAN, P. 1997, Cytogenetic effects in human exposure to arsenic. Mutation Research, 386, 219-228.
  • HE, J. L., JIN, L. F. and JIN, H. Y. 1998, Detection of cytogenetic effects in peripheral lymphocytes of students exposed to formaldehyde with cytokinesis-blocked micronucleus assay. Biomedical and Environmental Sciences, 11(1), 87-92.
  • HECK, H. A., CASANOVA, M. and STARR, T. B. 1990, Formaldehyde toxichy -- new understanding. Toxicology, 20, 397-426.
  • HOLZ, O., SCHERER, G., BRODTMEIER, S., KOOPS, F., WARNCKE, K., KRAUSE, T., AUSTEN, A., ANGERER, J., TRICKER. A. R., ADLKOFER, F. and RUDIGER, H. W. 1995, Determination of low level exposure to volatile aromatic hydrocarbons and genotoxic effects in workers at a styrene plant. Occupational and Environmental Medicine, 52(6), 420-428.
  • ICHIHARA, G., SAIIO, I., KAMIJIMA, M., Yu, X., SHIBATA, E., TOIDA, M. and TAKECJCHI, Y. 1998, Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n-hexane and methyl ethyl ketone. International Archives of Occupational and Environmental Health, 71, 100-104.
  • IARC. 1987, IARC monographs on evaluation of carcinogenic risks to humans. Supplement 7. Overall Evaluations of Carcinogenicity. An Updating of IARC Monographs Volumes 1 to 42 (Lyon: International Agency for Research on Cancer).
  • IARC. 1995, IARC monographs on evaluation of carcinogenic risks to humans. Volume 62. Wood Dust and Formaldehyde (Lyon: International Agency for Research on Cancer).
  • KARAHALIL, B., KARAKAYA, A. E. and BURGAZ, S. 1999, The micronucleus assay in exfoliated buccal cells: application to occupational exposure to polycyclic aromatic hydrocarbons. Mutation Research, 442, 29-35.
  • LEHUCHER-MICHEL, M. P., FAVRE-ELO, G., DEVICTOR, B., DUFFAUD, F. and BOITA, A. 1997, Effect of smoking on micronucleated epithelial cells in smears from the uterine cervix. Carcinogenesis, 18, 749-753.
  • LEMASTERS, G. K., LOCKEY, J. E., OLSEN, D. M., SELEVAN, S. G., TABOR, M. W., LIVINGSION, G. K. and NEW, G. K. 1999. Comparison of internal dose measures of solvents in breath, blood and urine and genotoxic changes in aircraft maintenance personnel. Drug and Chemical Toxicology, 22(1), 181-200.
  • MACHADO-SANTELLI, G. M., CERQUEIRA, E. M., OLIVEIRA, C. T. and DE BRAGANCA PEREIRA, C. A. A. 1994, Biomonitoring of nurses handling antineoplastic drugs. Mutation Research, 322, 203-208.
  • MAKI-PAKKANEN, J., HUSGAFVEL-PURSIAINEN, K., KALLIOMAKII, P.-L., TUOMINEN, J. and SORSA, M. 1980, Toluene-exposed workers and chromosome aberrations. Journal of Toxicology and Environmental Health, 6, 775-781.
  • MAYER, V. W. and GOIN, C.J.I 994, Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones. Mutation Research, 341(2), 83-91.
  • MCCARROLL, N. E., KEECH, B. H. and PIPER, C. E. 198 la, A microsuspension adaptation of the Bacillus subtiSs 'rec' assay. Environmental Mutagenesis, 3(6), 607-616.
  • MCCARROLL, N. E., PIPER, C. E. and KEECH, B. H. 1981b, An E. colt microsuspension assay for the detection of DNA damage induced by direct-acting agents and promutagens. Environmental Mutagenesis, 3(4), 429-444.
  • MCGREGOR, D. 1994, The genetic toxicology of toluene. Mutation Research, 317, 213-228.
  • MORTELMANS, K., HAWORTH, S., LAWIXIR, S., SPECK, W., TRAINER, B. and ZEIGER, E. 1986, Salmonella mutagenicity tests II. Results from the testing of 270 chemicals. Environmental Mutagenesis, 8(7), 1-119.
  • NAROD, S. A., NERI, L., RISCH, H. A. and RAMAN, S. 1988, Lymphocyte micronuclei and sister chromatid exchange among Canadian federal laboratory employees. American Journal of Industrial Medicine, 14(4), 449-456.
  • NISE, G., HOGSTEDT, B., BRAIT, I. and SKERFVING, S. 1991, Cytogenetic effects in rotogravure printers exposed to toluene (and benzene). Mutation Research, 261, 217-223.
  • NORPPA, H., LUOMAHAARA, S., HEIKANEN, H., ROTH, S., SORSA, M., RENZI, L. and LINDHOLM, C. 1993, Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidogens and clastogens. Environmental Health Perspectives, 101, supplement, 519-525.
  • OGATA, M. and TAGUCHI, T. 1987, Quantrtation of urinary metabolites of toluene, xylene, styrène, ethylbenzene, benzene and phenol by automated high performance liquid chromatography. International Archives of Occupational and Environmental Health, 59, 263-272.
  • PELCOVA, P., ROSSNER, P. and PICKOVA, J. 1990, Chromosome aberrations in rotogravure printing plant workers. Mutation Research, 245, 299-303.
  • PELCOVA, P., CERNA, M., PASTORKOVA, A., VRBIKOVA, V., PROCHAZKA, B., HURYCHOVA, D., DLASKOVA, Z. and HORNYCHOVA, M. 2000, Study of the genotoxicity of toluene. Archives of Environmental Health, 55(4), 268-273.
  • PERBELLINI, L., AMOROS, D. M., LORENS, A. C., GIULIARI, C. and BRUGNONE, F. 1990, An improved method of analysing 2,5-hexanedione in urine. British Journal of Industrial Medicine, 47, 421-424.
  • PITARQUE, M., VAGLENOV, A., NOSKO, M., HIRVONEN, A., NORPPA, H., CREUS, A. and MARCOS, R. 1999, Evaluation of DNA damage by the Comet assay in shoe workers exposed to toluene and other organic solvents. Mutation Research, 441, 115-127.
  • PIYATHILAKE, C. J., MACALUSO, M., HINE, R. J., VINTER, D. W., RICHARAS, E. W. and KRUMDIECK, C. I. 1995, Cigarette smoking, vitamin deficiency, and occurrence of micronuclei in the epithelial cells of buccal mucosa. Cancer Epidemiology, Biomarkers and Prevention, 4, 751-758.
  • POPP, W., VAHRENHOIJ;, C., YAMAN, S., MULLER, C., MULLER, G., SCHMIEDING, W., NORPOTH, K. and FAHNERT, R. 1992, Investigations of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchange frequency in the lymphocytes of female workers exposed to benzene and toluene. Carcinogenesis, 13(1), 57-61.
  • RICHER, C. I., CHAKRABARII, S., SENECAL-QUEVILLON, M., DUHR, M. A., ZHANC, X. X. and TARDIF, R. 1993, Cytogenetic effects of low-level exposure to toluene, xylene, and their mixture on human blood lymphocytes. Occupational and Environmental Health, 64, 581-585.
  • SALAMA, A. S., SERRANO, M. and Au, W. W. 1999, Biomonitoring using accessible human cells for exposure and health risk assessment. Mutation Research, 436, 99-112.
  • SARTO, F., FINOTTO, S., GIACOMELLI, L., MAZZETLI, D., TOMANIN, R. and LEVIN A. G. 1987, The micronucleus assay in exfoliated cells of the human buccal mucosa. Mutagenesis, 2, 11-17.
  • SARTO, F., TOMANIN, R., GIACOMELLI, L., IANNINI, G. and CUPIRAGGI, A. R. 1990, The micronucleus assay in human exfoliated cells of the nose and mouth: application to occupational exposures to chromic acid and ethylene oxide. Mutation Research, 244, 345-351.
  • SHAHAM, J., BOMSTEIN, Y., MELZER, A. and RIBAK, J. 1997, DNA-protein crosslinks and sister chromatid exchanges as biomarkers of exposure to formaldehyde. International Journal of Occupational and Environmental Health, 3(2), 95-104.
  • STICH, H. F. 1987, Micronucleated exfoliated cells as indicators for genotoxic damage and as markers in chemoprevention trials. Journal of Nutrition, Growth and Cancer, 4, 9-18.
  • STICH, H. F. and ROSIN, M. P. 1983, Micronuclei in exfoliated human cells as an internal dosimeter for exposures to carcinogens. In Carcinogens and Mutagens in the Environment, volume II. Naturally Occurring Compounds, Endogenous Formation and Modulation, edited by H. F. Stich (Florida: CRC Press), pp. 17-25.
  • STONE, J. G., JONES, N. J., MCGRECOR, A. D. and WATERS, R. 1995, Development of a human biomonitoring assay using buccal mucosa: comparison of smoking-related DNA adducts in mucosa versus biopsies. Cancer Research, 55, 1267-1270.
  • SURRALLES, J., AUTIO, K., NYLUND, L., JARVENSTAUS, H., NORPPA, H., VEIDEBAUM, T., SORSA, M. and PELKONEN, K. 1997, Molecular cytogenetic analysis of buccal cells and lymphocytes from benzene-exposed workers. Carcinogenesis, 18(4), 817-823.
  • SURUDA, A., SCHULTE, P., BOENIGER, M., HAVES, R. B., LIVINGSTON, G. K., STEENLAND, K., STEWART, P., HERRICK, R., DOUTHIT, D. and FINGERHUT, M. A. 1993, Cytogenetic effects of formaldehyde exposure in students of mortuary science. Cancer Epidemiology, Biomarkers and Prevention, 2(5), 453-460.
  • TAKEUCHI, Y., HISANAGA, N., ONO, Y., SHIBATA, E., SAITO, I. and IWATA, M. 1993, Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene. International Archives of Occupational and Environmental Health, 65, S227-S230.
  • THOMPSON, E. J., SHACKLEKON, S. and HARRINGION, J. M. 1984, Chromosome aberrations and sister-chromatid exchange frequencies in pathology staff occupationally exposed to formaldehyde. Mutation Research, 141, 89-93.
  • TlTENKO-HOLLAND, N., LEVINE, A. J., SMITH, M. T., QUINTANA, P. J. E., BOENIGER, M., HAVES, R., SURUDA, A. and SCHULTE, P. 1996, Quantification of epithelial cell micronuclei by fluorescence in situ hybridization (FISH) in mortuary science students exposed to formaldehyde. Mutation Research, 371, 237-248.
  • VALVERDE, M., DEL CARMEN LOPEZ, M., LOPEZ, I., SANCHEZ, I., FORTOUL, T. I., OSTROSKY-WEGMAN, P. and ROJAS, E. 1997, DNA damage in leukocytes and buccal and nasal epithelial cells of individual exposed to air pollution in Mexico city. Environmental and Molecular Mutagenesis, 30, 147-152.
  • YING, C. J., YAN, W. S., ZHAO, M. Y., YE, X. L., XIE, H., YIN, S. Y. and ZHU, X. S. 1997, Micronuclei in nasal mucosa, oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class. Biomedical and Environmental Sciences, 10(4), 451-455.
  • ZHANG, L. and MOCK, D. 1989, Gamma-glutamyl transpeptidase activity in superficial exfoliated cells during hamster buccal pouch carcinogenesis. Carcinogenesis, 10, 857-860.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.