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Biomarkers Volume 8, 2003 - Issue 1
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Research Article

Use of biochemical markers to monitor changes in bone turnover in cynomolgus monkeys

Jean-Jacques Legrand Beaufour-Ipsen Pharma, Paris, France
,
Cecile Fisch CIT, Evreux, France
,
Pierre-Olivier Guillaumat CIT, Evreux, France
,
Jean-Marc Pavard CIT, Evreux, France
,
Mahmoud Attia CIT, Evreux, France
,
Stephane De Jouffrey CIT, Evreux, France
&
Jean-Roger Claude Faculty of Pharmacy, Paris, France
 show all
Pages 63-77 | Published online: 29 Sep 2008

  • BALENA, R., TOOLAN, B. C., SHEA, M., MARKATOS, A., MYERS, E. R., LEE, S. C., OPAS, E. E., SEEDOR, J. G., KLEIN, H., FRANKENFIELD, D., QUARTUCCIO, H., FIORAVATNI, C., CLAIR, J., BROWN, E., HAYES, W. C. and RODAN, G. A. 1993. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metubolism, bone histomorpometry, and bone strength in ovariectomized nonhuman primates. Journal of Clinical Investigation, 92, 2577-2586.
  • BLACK, D. A., DUNCAN, A. and ROBINS, S. 1988, Quantitative analysis of the pyridinium crosslinks of urine using ion paired reverse phase HPLC. Analytical biochemistry, 169, 197-203.
  • BOLOTIN, H. H. 1998, A new perspective on the cuasal influence of soft tissue compsition on DXA-measured in vivo bone mineral density. Journal of Bone and Mineral Research, 13, 1739-1746.
  • BOUVIER, M. and HYLANDER, W. L. 1996. The mechanical ormetabolic function of secondary osteonal bone in the monkey Macaea fascincularis. Archives of Oral Biology, 41 941-950.
  • BROMMAGE, R. 2001, Perspectives on using nonhuman primates to understand the etiology and treatment of postmenopausal osteoporosis. Journal of Musculoskeletal and Neuronal Interaction, 1. 307-325.
  • BROMMAGE, R., ALLISON, C., STAVISKI, R. and KAPLAN, J. 1999a. Measurement of serum bone-specific alkaline phosphatase activity in cynomolgus macaques. Journal of Medical Primatology, 28, 329-333.
  • BROMMAGE, R., HOTCHKLISS, C. E., LEES, C. J., STANCILL, M. W., HOCK, J. M. and JEROME, C. P.1999h, Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increase bone mass in ovariectomized monkeys. Journal of Clinical Endocrinology and Metabolism, 84, 3757-3763.
  • BURR, D. B., HIRANO, T., TURNER, C. H., HORCHKISS, C. E., BROMMAGE, R. and HOCK, J. M. 2001. Intermittently bone turnover and porosity without reducing bone strentgth in the humerus of ovariectomized cynomolgus monkeys. Journal of Bone and Mineral Research, 16, 157-165.
  • CAHOON, S., BODNE, S. D., GOULD, K. G. and VAILAS, A. C. 1996, Noninasive markers of bone metabolism in the rhesus monkey: normal effects of age and gender. Journal of Medical Primatology, 25, 333-338.
  • CALVO, M. S., EYRE, D. R. and Gundberg, C. M. 1996, Molecular basis and clinicla application of biological markers of bone turnover. Endocrine Reivews, 17, 333-368.
  • CARLSON, C. S., TULLI, H. M., JAYO, M. J., LOESER, R. F., TRACY, R. P., MANK, K. G. and ADAMS, M. R. 1993, Immunolocalization of noncollagenous bone matrix proteins in lumbar vertebrae from intact and surgically menopausal cynomolgue monkeys. Journal of Bone and Mineral Research, 8, 71-81.
  • CHENG, J-C., SHER, H. L., GUO, X., HUNG, V. W. and CHEUNG, A. Y. 2001, The effect of vertebral rotation of the lumbar spine on dual energy X-ray aobsorptiometry measurements: observational study. Hong Kong Med Journal, 7, 241-245.
  • DELMAS, P. D. 1993, Biochemical markers of bone turnover for the clinical investigation of osteoporosis. Osteoporosis International, 3, Supplement1, S81-S86.
  • DELMAS, P. D. 2001, Bone marker nomenclature. Bone, 28, 575-576.
  • DELMAS. P. D., CHRISTIANSEN, C., MANN, K. G. and PRICE, P. A. 1990, Bone gla protein (osteocalcin) assay standardization report. Journal of Bone and Mineral Research, 5, 5-10.
  • FISCH,C. and FORSTER, R. 1998a, Bone mineral density assessent by DXA to assess efficacy and safety of new drugs in rats and monkeys. Toxicology Letters, 95, Supplement 1, P3G167(abstract).
  • FISCH, C., LE BIGOT, J. F. and FORSTER, R. 1998b, Bone studies in the ovariectomised rat. Effect of overiectomy and therapeutic treatments on bone in aged ovariectomised rats. Toxicological Sciences, 42, Supplement 1, S828(abstract).
  • GARNERO, P., SHIH, W. J., GINEYTS, E., KARPF, D. B. and DELMAS, P. d. 1994, Comparisons of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. Journal of Clinical Endocrinology and Metabolism, 79, 1693-1700.
  • GOODWIN, B.T. and JEROME, C. P. 1987, Iliac biopsy for histomorphometric analysis of trabecular bone in cynomolgus monkeys and baboons, Laboratory Animal Science, 37, 213-216.
  • Hanson, D. A., WEIS, M. A., BOLLEN, A. M., MASLAN, S. L., SINGER, F. R. and EYRE, D. R. 1992, A specific immunoassay for monitoring human bone resorption: quantification of type I collagen cross-linked N-telopeptides in urine. Journal of Bone and Mineral Research, 7, 1251-1258.
  • HASSAGER, C., JENSEN, L., JOHANSEN, J., RUS, B., MELKKO, J., PODENPHANT, J., RISTELL, L., CHRISTIANSEN, C. and RISTELI, J. 1991, The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism, 40, 205-208.
  • HOTCHKISS, C. E. 1999, Use of peripheral quantitative computed tomography for densitometry of the femoral neck and spine in cynomologus monkeys(Macaca fascicularis). Bone, 24, 101-107
  • HOTCHKISS, C. E. and BROMMAGE, R. 2000, Changes in bone turnover during the menstrual cycle in cynomolgus monkeys. Calcified Tissue International, 66, 224-228.
  • HOTCHKISS, C. E. STAVISI, R., NOWRA, J., BROMMAGE, R., LEE, C. J. and KAPLAN, J. 2001, Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolugus monkeys. Bone, 29, 7-15.
  • HRESCHCHYSHYN, M. M., HOPKINS, A., ZYLSTRA, S. and ANBAR, M. 1988. Effects of natural menopuse, hysterectomy, and oophorectomy on lumbar spine and femoral neck bone densities, Obstetrics and Cynecology, 72, 631-638.
  • IROH, F., KOHMA, M., FURIHATA-KOMATSU, H., AOYAGI, S., KUSAMA, H., KOMATSU, H. and NAKAMURA, T. 2002, Reductions in bone mass, structure and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate. Journal of Bone and Mineral Reaserch, 17, 534-543.
  • JAYO, M. J., RANKEIN, S. E., WEAVER, D. S., CARLSON, C. S. and CLARKSON, T. B. 1991. Accuracy and precision of lumber mineral content by dual-energy X-ray absorptiometry in live female monkeys. Calcified Tissue Internatinal, 49, 438-440.
  • JEROME, C. P. and LLES, C. J. 1996. Raloxifene increases bone mass and reduces bone turnover in ovariectomized cynomolgus monkeys. Journal of Bone and Mineral Research, 11, Supplementary I, S445(abstract).
  • JEROME, C. P., CARLSON, C. S., REGISTER, T. C., BAIN, F. T., JAYO, M. J., WEAVVER, D. C. and ADAMS, M. R. 1994, Bone functional changes in intact, ovariectomized, and ovariectomized, hormone-supplemented adult cynomolgus monkeys (Macaca fascicularis) evaluated by serum markers and dynamic histomorphometry. Journal of Bons and Mineral Research, 9, 527-540.
  • JEROME, C. P., LEES, C. J. and WEAVER D. S. 1995, Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fasciularis). Bone, 17, Supplement 1, 403S-408S.
  • JEROME, C. P., VAFAI, H. T., KAPLN, M. and KAPLAN, K. 1997a, Structural histomorphometric analysis of cortical, transitional and cancellous vertebral bone in intact, ovariectomized, and nandrolonetreated cynomolgus monkeys (Macaca fascicularis). Journal of Histotechnology, 20, 191-198.
  • JEROME, C. P., TURNER, C. H. and LEES, C. J. 1997b. Decresed bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis). Calcified Tissue International, 60, 265-270.
  • JEROME, C. P., JOHNSON, C. S. VAFAI, H.T., KAPLAN, K. C., BAILEY, J., CAPWELL, B.,FRASER, F., HANSEN, L., RAMSAY, H., SHADOAN, M., LEES, C. J., THOMSEN, J. S. and MOSEKILDE, L. 1999, Effects of treatment for 6 months with human parathyroid hormoen (1-34) peptide in ovariectomized cynomolgus monkeys (Macaca fascicularis). Bone, 25, 310-319.
  • KHOSLA, S. and KLEEREKOPER, M. 1999, Biochemical markers of bone turnover. In: Primer on the Metabolic Bone Diseases and Disordrs of Mineral Metabolism, 4th edition, edited by M. J. Favus (Lippincott Williams & Wilkins), Philadelphia, pp. 128-133.
  • KROLNER, B. and NIELSEN, S. P. 1982. Bone mineral content of lumbar spine in normal and osteoporatic women: cross-sectional and longitudinal studies. Clinical Science, 62, 329-336.
  • MANN, D. R., RUDMAN, C. G., AKINBAMI, M. A. and GOULD, K. G. 1992, Preservation of bone mass in bypogonadal female monkeys with recombinant human growth hormone administration. Journal of Clinical Endocrinology and Metabolism, 74, 1263-1269.
  • PANTEGHINI, M. and PAGANI, F. 1995. Biological variation in bone-derived biochemical markers in serum. Scandinavian Journal of Clinical and Laboratory Investigation, 55, 609-616.
  • PARFITT, A. M. 1980, Morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis. Mineral and Electrolyte Metabolism, 4, 273-287.
  • PRICE, C. P. 1993, Multiple forms of human serum alkaline phosphatase: detection and quantification. Annals of Clinical Biochemistry, 30, 355-372.
  • PRICE, P., OTSUKA, A., POSER, J., KRISTANPONIS, J. and RAMAN, N. 1976, Characterization of a gammacarboxyglutamic acid-containing protein from bone. Proceedings of the National Academy of Sciences of the USA, 73, 1447-1451.
  • REGISTER, T. C. and JEROME, C. P. 1996, Increased urinary markers of collagen degradation accompany ovariectomy in skeletally mature cynomolgus monkeys. Journal of Bone and Mineral Research, 11, Supplement 1, S196(abstract).
  • ROBINS, S. P., WOITGE, H., HESLEY, R., JU, J., SEYEDIN, S. and SEIBEL, M. J. 1994, Direct enzyme-linked immunoassay for urine deoxypyridinoline as a specific marker for measuring bone resorption. Journal of Bone and Mineral Research 9, 1643-1649.
  • SEYEDIN, S. M., KUNG, V. T., DANILOFF, Y. N., HESLEY, R. P., GOMEZ, B., NIELSEN, L. A., ROSEN, H. N. and ZUR, R. F. 1993, Immunoassay for urinary pyridinoline: the new marker of bone resorption. Journal of Bone and Mineral Research, 8, 635-641.
  • STEPAN, J. J., POSPICHAL, J., PRESL, J. and PACOVSKY, V. 1987. Bone loss and biochemical indices of bone remodelling in surgically induced postmenopausal women, Bone, 8, 279-284.
  • TRACY, R. P., ANDRIANORIVO, A., RIGGS, B. L. and MANN, K. G. 1990. Comparison of monoclonal and polyclonal antibody-based immunoassay osteocalcin: a study of source of variation in assay results. Journal of Bone and Mineral Research, 5, 451-461.
  • VAN HOOF, V. O. and DE BROE, M. E. 1994, Interpretaion and clinical significance of alkaline phosphatase isoenzyme patters. Critical Reviews in Clinical Laboratory Sciences, 31, 197-293.
  • WEAVER, D. S., POWER, R. A., JEROME, C. P., PHIFER, B. M. and REGISTER, T. C. 1994. Ther effects of immediate and delayed treatment of ovariectomized cynomolgue monkeys with nandrolone decanoate on densitometry, bone biomarkers, sex steroids and body weight. Journal of Bane and Miner Research, 9, Supplement 1, S393(abstract).

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