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Research Article

Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate

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Pages 204-217 | Published online: 29 Sep 2008

References

  • BAUR, X., MAREK, W., AMMON, J., CZUPPON, A. B., MARCZYNSKI, B., RAUTT-HEIMSOTH, M., ROEMMEI-T, H. and FRUHMANN, G. 1994, Respiratory and other hazards of isocyanates. International Archives of Occupational and Environmental Health, 66, 141–152.
  • BRORSON, T, SKARPING, G. and SANGG, C. 1991, Biological monitoring of isocyanates and related amines — Part IV: 2,4- and 2,6-toluenediamine in plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate. International Archives of Occupational and Environmental Health, 63, 253–259.
  • DAY, B. W, JIN, R and KAROL., M. H. 1996, In vivo and in vitro reactions of toluene diisocyanate isomers with guinea pig haemoglobin. Chemical Research in Toxicology, 9, 568–573.
  • DAY, B. W, JIN, R, BASAI-YGA, D. M., KRAMARIK, J. A. and KAROL., M. H. 1997, Formation, solvolysis and transcarbamoylation reactions of bis (S-glutathionyl) adducts of 2,4- and 2,6-diisocyanato-toluene. Chemical Research in Toxicology, 10, 424–431.
  • KAARIA, K, HIRVONEN, A., NORPPA, H., PIIRILA, P., VAINIO, H. and ROSENBERG, C. 2001, Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). Analyst, 126, 1025–1031.
  • KLEES, J. E. and OTT, M. G. 1999, Dfisocyanates in polyurethane plastics applications. Occupational Medicine: State of the Art Reviews, 14, 759–776.
  • LIND, P., DAI-ENE, M., SKARPING, G. and HAGMAR, L 1996, Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6-toluene diisocyanate. Occupational and Environmental Medicine, 53, 94–99.
  • LIND, P., DAI-ENE, M. and SKARPING, G. 1996, Biomarkers of toluene diisocyanate and thermal degradation products of polyurethane, with special reference to the sample preparation. Analytica Chimica Acta, 333, 277–283.
  • LIND, P., DAI-ENE, M., TINNERBERG, H. and SKARPING, G. 1997, Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam. Analyst, 122, 51–56.
  • LIND, P., DAI-ENE, M., LINDSTROM, V, GRUBB, A. and SKARPING, G. 1997, Albumin adducts in plasma from workers exposed to toluene diisocyanate. Analyst, 122, 151–154.
  • MAITRE, A., BERODE, M., PERDRix, A., ROMAZINI, S. and SAVOLAINEN, H. 1993, Biological monitoring of occupational exposure to toluene diisocyanate. International Archives of Occupational and Environmental Health, 65, 97–100.
  • PURNELL, C. J. and WALKER, R. F 1985, Methods for the determination of atmospheric organic isocyanates. A review. Analyst, 110, 893–905.
  • SABBIONI, G., LAMB, J. H., FARMER, P. B. and SEPAL O. 1997, Reactions of 4-methylphenyl isocyanate with amino acids. Biomarkers, 2, 223–232.
  • SABBIONI, G., HARTLEY, R and SCHNEIDER, S. 2001, Synthesis of adducts with amino acids as potential dosimeters for the biomonitoring of humans exposed to toluenediisocyanate. Chemical Research in Toxicology, 14, 1573–1583.
  • SCHIDTZE, D., SEPAL O., LEWALTER, J., MLKSCHE, L., HENSCHLER, D. and SABBIONI, G. 1995, Biomonitoring of workers exposed to 4,4'-methylenedianiline or 4,4'-methylenediphenyl diiso-cyanate. Carcinogenesis, 16, 573–582.
  • SEPAL O., HENSCHLER, D. and SABBIONI, G. 1995, Albumin adducts, haemoglobin adducts and urinary metabolites in workers exposed to 4,4'-methylenediphenyl diisocyanate. Carcinogenesis, 16, 2583–2587.
  • SKARPING, G., DAI-ENE, M. and LIND, P. 1994, Determination of toluenediamine isomers by capillary gas chromatography and chemical ionisation mass spectrometry with special reference to the biological monitoring of 2,4- and 2,6-toluene diisocyanate. Journal of Chromatography A, 663, 199–210.
  • STRETCHER, R. P., KENNEDY, E. R. and LORBERAU, C. D. 1994, Strategies for the simultaneous collection of vapours and aerosols with emphasis on isocyanate sampling. Analyst, 119, 89–97.
  • STRETCHER, R. P., REH, C. M., KEY-SCHWARTZ, R. J., SCHLECHT, P. C., CASSINEILL M. E. and O'CONNOR, P. F 2000, Determination of airborne isocyanate exposure: considerations in method selection. American Industrial Hygiene Association Journal, 61, 544–556.
  • VANDENPLAS, O., MAI-0, J.-L., SAErrA, M., MAPP, C. E. and FABBRL L. M. 1993, Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. British Journal of Industrial Medicine, 50, 213–228.

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