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Research Article

Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic model

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Pages 331-348 | Received 08 Aug 2006, Published online: 08 Oct 2008

References

  • Amberg A, Rosner E, Dekant W. Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans. Toxicological Science 1999; 51: 1–8
  • Amberg A, Rosner E, Dekant W. Toxicokinetics of methyl tert-butyl ether and its metabolites in humans after oral exposure. Toxicological Science 2001; 61: 62–7
  • Ashley D, Bonin M, Cardinali F, McCraw J, Holler J, Needham L, Patterson D. Determining volatile organic compounds in human blood from a large sample population by using purge and trap gas chromatography/mass spectrometry. Analytical Chemistry 1992; 64: 1021–1029
  • ATSDR. 2006. Agency for Toxic Substances and Disease Registry (available at http://www.atsdr.cdc.gov/toxprofiles/tp91.html).
  • Boroujerdi M. Pharmacokinetics: Principle and Applications. McGraw Hill, New York 2002
  • Buckley TJ, Prah JD, Ashley D, Zweidinger RA, Wallace LA. Body burden measurements and models to assess inhalation exposure to methyl tertiary-butyl ether (MTBE). Journal of the Air and Waste Management Association 1997; 47: 739–752
  • CalEPA. 1998. Draft public health goal for methyl tertiary butyl ether (MTBE) in drinking water. Sacramento, CA: Office of Environmental Health Hazard Assessment, California Environmental Protection Agency.
  • CARB. 1997. Toxic air contaminant identification list summaries: Methyl Tert.-Butyl Ether. Sacramento, CA: Air Resources Board, Stationary Source Division, California Environmental Protection Agency.
  • Castell JV, Donato MT, Gomez-Lechon MJ. Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Experimental and Toxicological Pathology 2005; 57(Suppl. 1)189–204
  • Clewell HJ, Gentry PR, Kester JE, Andersen ME. Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene. Critical Reviews in Toxicology 2005; 35: 413–433
  • CRS. 2001. MTBE in Gasoline: Clean Air and Drinking Water Issues. McCarthy, JS Tiernan M. Congressional Research Service, Library of Congress, OC 98-290 ENR.
  • Dekant W, Bernauer U, Rosner E, Amberg A. Toxicokinetics of ethers used as fuel oxygenates. Toxicology Letters 2001; 124: 37–45
  • Ding X, Kaminski LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Reviews in Pharmacological Toxicology 2003; 43: 149–173
  • EPA. 2001. Methyl Tertiary Butyl Ether (available at http://www.epa.gov/mtbe/).
  • Furtaw EJ. An overview of human exposure modeling activities at the USEPAs National Exposure Laboratory. Toxicology and Environmental Health 2001; 17: 302–314
  • Hakkola M, Saarinen L. Exposure of tanker drivers to gasoline and some of its components. Annals of Occupational Hygiene 2000; 40: 1–10
  • HEI. 2004. Program Summary: Research on Oxygenates Added to Gasoline. Cambridge, MA: Health Effects Institute.
  • Imbriani M, Ghittori S. Gases and organic solvents in urine as biomarkers of occupational exposure: a review. International Archives of Environmental Health 2005; 78: 1–19
  • Johnson ML. 1998. Exposure of humans to MTBE from drinking water. Report to the Governor and Legislature of the State of California as Sponsored by SB521 (available at http://tsrtp.ucdavis.edu/mtberpt/vol5_1.pdf).
  • Jones K, Cocker J. A human exposure study to investigate biological monitoring methods for 2-butoxyethanol. Biomarkers 2003; 8: 360–370
  • Licata AC, Dekant W, Smith CE, Borghoff SJ. A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: implementing sensitivity and variability analyses. Toxicological Science 2001; 62: 191–204
  • Lindstrom AB, Pleil JD. Alveolar breath sampling and analysis to assess exposures to methyl tertiary butyl ether (MTBE) during motor vehicle refueling. Journal of the Air and Waste Management Association 1996; 46: 676–682
  • Lindstrom AB, Pleil JD. A review of the USEPAs single breath canister (SBC) method for exhaled volatile organic biomarkers. Biomarkers 2002; 7: 189–208
  • McKone TE. Human exposure to volatile organic compounds in household tap water: the indoor pollution pathway. Environmental Science and Technology 1987; 21: 1194–1201
  • Pleil JD, Lindstrom AB. Collection of a single alveolar exhaled breath for volatile organic compounds analysis Journal of Industrial Medicine 1995a; 28: 109–121
  • Pleil JD, Lindstrom AB. Measurement of volatile organic compounds in exhaled breath as collected in SUMMA canisters. Journal of Chromatography B 1995b; 665: 271–279
  • Pleil JD, Lindstrom AB. Sample timing and mathematical considerations for modeling breath elimination of volatile organic compounds. Risk Analysis 1998; 18: 585–602
  • Pleil JD, Kim D, Prah JD, Ashley DL, Rappaport SM. 2005. The unique value of breath biomarkers for estimating pharmacokinetic rate constants and body burden from environmental exposures. In: Anton Amann, David SmithBreath Gas Analysis for Medical Diagnostics. Singapore: World Scientific Publishers. p. 347–360.
  • Prah JD, Ashley DA, Blount B, Case M, Leavens T, Pleil JD, Cardinali F. Dermal, oral and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers. Toxicological Sciences 2004; 77: 195–205
  • Prah JD, Goldstein GM, Devlin R, Otto D, Ashley D, House D, Willingham F, Cohen KL, Gerrity T. Sensory, symptomatic, inflammatory, and ocular responses to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment. Inhalation Toxicology 1994; 6: 521–538
  • Rappaport SM. Smoothing of exposure variability at the receptor: implication for health standards. Annals of Occupational Hygiene 1985; 29: 201–214
  • Rappaport SM, Spear RC. Physiological damping of exposure variability during brief periods. Annals of Occupational Hygiene 1988; 32: 21–33
  • Rappaport SM, Symanski E, Yager JW, Kupper LL. The relationship between environmental monitoring and biological markers in exposure assessment. Environmental Health Perspectives 1995; 103(Suppl. 3)49–53
  • Tsai PJ, Lee CC, Chen MR, Shih TS, Lai CH, Liou HH. Predicting the contents of BTEX and MTBE for the three types of tollbooth at a highway toll station via the direct and indirect approaches. Atmospheric Environment 2002; 36: 5961–5969
  • USGS. 2001. National Survey of MTBE and other VOCs in Community Drinking Water Sources. Clawges R, Rowe B, Zogorski J. US Geological Survey FS-064-01, October 2001.
  • Wallace LA, Nelson WC, Pellizzari ED, Raymer JH. Uptake and decay of volatile organic compounds at environmental concentrations: application of a four compartment model to a chamber study of five human subjects. Journal of Exposure Analysis and Environmental Epidemiology 1997; 7: 141–163
  • Watson WP, Mutti A. Role of biomarkers in monitoring exposures to chemicals: present position, future prospects. Biomarkers 2004; 9: 211–242

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