Advanced search
Publication Cover
Biomarkers Volume 13, 2008 - Issue 6
Submit an article Journal homepage
176
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Zhan Xiao Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
John Xue Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Wen-Zhen Gu Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Mai Bui Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Gaoquan Li Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Zhi-Fu Tao Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Nan-Horng Lin Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
,
Thomas J. Sowin Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA,
&
Haiying Zhang Cancer Research, Abbott Laboratories, 100 Abbott Park Rd.Abbott Park, IL, 60064-6101, USA, Correspondence[email protected]
 show all
Pages 579-596 | Received 21 Aug 2007, Accepted 17 Mar 2008, Published online: 07 Nov 2008

References

  • J Bartek, and J. Lukas. (2003). Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3:421–429.
  • B Booth, and R. Zemmel. (2004). Opinion/outlook: prospects for productivity. Nature Reviews Drug Discovery 3:451–456.
  • EC Busby, DF Leistritz, RT Abraham, LM Karnitz, and JN. Sarkaria. (2000). The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Research 60:2108–2112.
  • Z Chen, Z Xiao, J Chen, SC Ng, T Sowin, H Sham, S Rosenberg, S Fesik, and H. Zhang. (2003). Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Molecular Cancer Therapeutics 2:543–548.
  • Z Chen, Z Xiao, WZ Gu, J Xue, MH Bui, P Kovar, G Li, G Wang, ZF Tao, Y Tong, NH Lin, HL Sham, JY Wang, TJ Sowin, SH Rosenberg, and H. Zhang. (2006). Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. International Journal of Cancer 119:2784–2794.
  • A Eastman, EA Kohn, MK Brown, J Rathman, M Livingstone, DH Blank, and GW. Gribble. (2002). A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01. Molecular Cancer Therapeutics 1:1067–1078.
  • RC III Edmunds, PC Ma, and CP. Tanio. (2001). Splicing a cost squeeze into the genomics revolution. McKinsey Quarterly 2:15–18.
  • SW. Fesik. (2000). Insights into programmed cell death through structural biology. Cell 103:273–282.
  • R Frank, and R. Hargreaves. (2003). Clinical biomarkers in drug discovery and development. Nature Reviews Drug Discovery 2:566–580.
  • JH Hendry, and CM. West. (1997). Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumor radiation response. International Journal of Radiation Biology 71:709–719.
  • DG Johnson, and CL. Walker. (1999). Cyclins and cell cycle checkpoints. Annual Review of Pharmacology and Toxicology 39:295–312.
  • K Koniaras, AR Cuddihy, H Christopoulos, A Hogg, and MJ. O'Connell. (2001). Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 20:7453–7463.
  • G Pascreau, Y Arlot-Bonnemains, and C. Prigent. (2003). Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis. Progress in Cell Cycle Research 5:369–374.
  • C Prigent, and S. Dimitrov. (2003). Phosphorylation of serine 10 in histone H3, what for?. Journal of Cell Science 116:3677–3685.
  • IB Roninson, EV Broude, and BD. Chang. (2001). If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resistance Updates 4:303–313.
  • A Strasser, L O'Connor, and VM. Dixit. (2000). Apoptosis signaling. Annual Review of Biochemistry 69:217–245.
  • NC. Walworth. (2000). Cell-cycle checkpoint kinases: checking in on the cell cycle. Current Opinion in Cell Biology 12:697–704.
  • L Wang, GM Sullivan, LA Hexamer, LA Hasvold, R Thalji, M Przytulinska, ZF Tao, G Li, Z Chen, Z Xiao, and WZ Gu.
  • A Wang, N Yoshimi, N Ino, T Tanaka, and H. Mori. (1997). Overexpression of cyclin B1 in human colorectal cancers. Journal of Cancer Research & Clinical Oncology 123:124–127.
  • Z Xiao, Z Chen, AH Gunasekera, TJ Sowin, SH Rosenberg, S Fesik, and H. Zhang. (2003). Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. Journal of Biological Chemistry 278:21767–21773.
  • Z Xiao, J Xue, T Sowin, S Rosenberg, and H. Zhang. (2004). A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene 24:1403–1411.
  • H Zhao, JL Watkins, and H. Piwnica-Worms. (2002). Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proceedings of the National Academy of Sciences U S A 99:14795–14800.
  • BB Zhou, and J. Bartek. (2004). Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nature Reviews Cancer 4:216–225.
  • BB Zhou, and EA. Sausville. (2003). Drug discovery targeting Chk1 and Chk2 kinases. Progress in Cell Cycle Research 5:413–421.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.