References
- Antoine, D.J., et al., 2013. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology, 58, 777–787.
- Bala. S., et al., 2012. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology, 56, 1946–1957.
- Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry, 72, 248–254.
- Church, R.J., et al., 2016. Beyond miR-122: Identification of microRNA alterations in blood during a time course of hepatobiliary injury and biliary hyperplasia in rats. Toxicological sciences, 150, 3–14.
- Duchesne, L., et al., 2012. Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate. PLoS-Biology, 10, 1427.
- Eakins, R., et al., 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. Scientific reports, 5, 16423.
- Giesen, P., et al., 1989. Greater than expected alanine aminotransferase activities in plasma and in hearts of patients with acute myocardial infarction. Clinical chemistry, 35, 279–283.
- Hanley AJ, et al., 2004. Elevations in markers of liver injury and risk of type 2 diabetes the insulin resistance atherosclerosis study. Diabetes, 53, 2623–2632.
- Harrill, A.H., et al., 2012. The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clinical pharmacology & therapeutics, 92, 214–220.
- Jaeschke, H. and Mcgill, M.R., 2013. Serum glutamate dehydrogenase-biomarker for liver cell death or mitochondrial dysfunction? Toxicological Sciences, 134, 221–222.
- Jaeschke, H., Xie, Y., and McGill, M.R., 2014. Acetaminophen-induced liver injury: from animal models to humans. Journal of clinical and translational hepatology, 2, 153–161.
- Koberle, V., et al., 2013. Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers. PLoS One, 8, e75184.
- Koutedakis, Y., et al., 1993. Serum enzyme activities in individuals with different levels of physical fitness. The journal of sports medicine and physical fitness, 33, 252.
- Krauskopf, J., et al., 2015. Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury. Toxicological sciences, 143, 268–276.
- Kubo, M., et al., 2007. Liver enzymes as a predictor for incident diabetes in a Japanese population: the Hisayama study. Obesity (Silver Spring), 15, 1841–1850.
- Ladue, J.S. and Wroblewski, F., 1955. The significance of the serum glutamic oxalacetic transaminase activity following acute myocardial infarction. Circulation, 11, 871–877.
- Lagos-Quintana M, et al., 2002. Identification of tissue-specific microRNAs from mouse. Current biology, 12, 735–739.
- Laterza, O.F., et al., 2009. Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clinical chemistry, 55, 1977–1983.
- Lee, K.L. and Kenney, F.T., 1970. Induction of alanine transaminase by adrenal steroids in cultured hepatoma cells. Biochemical and biophysical research communications, 40, 469–475.
- Lindena, J., et al., 1986. Catalytic enzyme activity concentration in tissues of man, dog, rabbit, guinea pig, rat and mouse. Approach to a quantitative diagnostic enzymology, III. Communication. Clinical chemistry and laboratory medicine, 24, 35–48.
- Lowry, O.H., et al., 1951. Protein measurement with the Folin phenol reagent. Journal of biological chemistry, 193:265–275.
- Matheis, K., et al., 2011. A generic operational strategy to qualify translational safety biomarkers. Drug discovery today, 16, 600–608.
- McGill, M.R., et al., 2012a. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. The journal of clinical investigation, 122, 1574–1583.
- McGill, M.R., et al., 2012b. Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicology and applied pharmacology, 264, 387–394.
- Mitchell, P.S., et al., 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences, 105, 10513–10518.
- Momen-Heravi, F., et al., 2015. Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Scientific reports, 5, 19991.
- Murphy, S.L., Xu, J., Kochanek, K.D., 2013. Deaths: final data for 2010. National vital statistics reports, 61, 1–117.
- O'brien, P.J., et al., 2002. Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats. Laboratory animals, 36, 313–321.
- Olson, H., et al., 2000. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory toxicology and pharmacology, 32, 56–67.
- Ozer, J., et al., 2008. The current state of serum biomarkers of hepatotoxicity. Toxicology, 245, 194–205.
- Park, H.K., et al., 2016. Time-course changes in the expression levels of miR-122,-155, and-21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats. Journal of veterinary science, 17, 45–51.
- Rafter, I., et al., 2012. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. International journal of molecular medicine, 30, 1241.
- Sattar, N., et al., 2004. Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes, 53, 2855–2860.
- Schmidt, E.S. and Schmidt F.W., 1988. Glutamate dehydrogenase: biochemical and clinical aspects of an interesting enzyme. Clinica chimica acta, 173, 43–55.
- Schomaker, S., et al., 2013. Assessment of emerging biomarkers of liver injury in human subjects. Toxicological science, 132, 276–283.
- Starckx, S., et al., 2013. Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats. Toxicological pathology, 41, 795–804.
- Starkey Lewis, P.J., et al., 2011. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology, 54, 1767–1776.
- Thulin, P., et al., 2014. Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver international, 34, 367–378.
- Thulin, P., et al., 2008. PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicology and applied pharmacology, 231, 1–9.
- Vliegenthart, A., Antoine, D.J., Dear, J.W., 2015. Target biomarker profile for the clinical management of paracetamol overdose. British journal of clinical pharmacology, 80, 351–362.
- Wang, K., et al., 2009. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proceedings of the National Academy of Sciences, 106, 4402–4407.
- Wilke, R.A., et al., 2007. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nature reviews drug discovery, 6, 904–916.
- Zhang. Y., et al., 2010. Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clinical chemistry, 56, 1830–1838.