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Research Article

MGMT hypomethylation is associated with DNA damage in workers exposed to low-dose benzene

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Pages 470-475 | Received 21 Jul 2016, Accepted 07 Dec 2016, Published online: 12 Jan 2017

References

  • Argos, M., et al., 2015. Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ health perspect, 123, 64–71.
  • Arnold, S.M., et al., 2013. The use of biomonitoring data in exposure and human health risk assessment: benzene case study. Critical reviews in toxicology, 43, 119–153.
  • Beall, H.D. and Winski, S.I. 2000. Mechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug development. Frontiers in bioscience, 5, D639–648.
  • Bollati, V., et al., 2007. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer research, 67, 876–880.
  • Byun, H.M., et al., 2013. Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants. Particle and fibre toxicology, 10, 28.
  • Carugno, M., et al., 2012. Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure. Environmental health perspectives, 120, 210–215.
  • Casale, T., et al., 2016. Workers exposed to low levels of benzene present in urban air: assessment of peripheral blood count variations. Chemosphere, 152, 392–398.
  • Collins, A.R., 2004. The comet assay for DNA damage and repair: principles, applications, and limitations. Molecular biotechnology, 26, 249–261.
  • Costello, J.F., et al., 1994. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. The Journal of biological chemistry, 269, 17228–17237.
  • Duan, H., et al., 2013. Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon. Archives of toxicology, 87, 2013–2022.
  • Esteller, M., et al., 1999. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer research, 59, 793–797.
  • Everhard, S., et al., 2009. Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas. Neuro-oncology, 11, 348–56.
  • Fracasso, M.E., et al., 2010. Low air levels of benzene: correlation between biomarkers of exposure and genotoxic effects. Toxicology letters, 192, 22–28.
  • Huang, Y., et al., 2010. The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing. PLos One, 5, e8888.
  • IARC (International Agency for Research on Cancer). 2012. IARC monographs onthe evaluation of the carcinogenic risk of chemicals to humans. Benzene. In: Chemical agents and related occupations. 100 F, Lyon, France: World Health Organisation, 1–46.
  • Johnson, E.S., Langard, S., and Lin, Y.S. 2007. A critique of benzene exposure in the general population. Science of the Total environment, 374, 183–198.
  • Koestler, D.C., et al. (2013). Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environmental health perspectives, 121, 971–977.
  • Koh, D.H., et al., 2015. The relationship between low-level benzene exposure and blood cell counts in Korean workers. Occupational and environmental medicine, 72, 421–427.
  • Koturbash, I., Beland, F.A., and Pogribny, I.P. 2011. Role of epigenetic events in chemical carcinogenesis – a justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicology mechanisms and methods, 21, 289–297.
  • Lan, Q., et al., 2004. Hematotoxicity in workers exposed to low levels of benzene. Science, 306, 1774–1776.
  • Li, Y., et al., 2006. Determination of S-phenylmercapturic acid in human urine using an automated sample extraction and fast liquid chromatography-tandem mass spectrometric method. Biomedical chromatography, 20, 597–604.
  • Liu, L. and Gerson, S.L. 2006. Targeted modulation of MGMT: clinical implications. Clinical cancer research, 12, 328–331.
  • Qian, X., Von Wronski, M.A., and Brent, T.P. 1995. Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression. Carcinogenesis, 16, 1385–1390.
  • Schettgen, T., et al., 2008. Fast determination of urinary S-phenylmercapturic acid (S-PMA) and S-benzylmercapturic acid (S-BMA) by column-switching liquid chromatography-tandem mass spectrometry. Journal of Chromatography B analytical technologies in the biomedical and life sciences, 863, 283–292.
  • Schnatter, A.R., et al. 2012. Myelodysplastic syndrome and benzene exposure among petroleum workers: an international pooled analysis. Journal of the national cancer institute, 104, 1724–1737.
  • Seow, W.J., et al. 2012. Urinary benzene biomarkers and DNA methylation in Bulgarian petrochemical workers: study findings and comparison of linear and beta regression models. PLoS One, 7, e50471.
  • Subrahmanyam, V.V., Ross, D., Eastmond, D.A., Smith, M.T. 1991. Potential role of free radicals in benzene-induced myelotoxicity and leukemia. Free radical biology and medicine, 11, 495–515.
  • Tudor, G., et al., 2003. Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression. Biochemical pharmacology, 65, 1061–1075.
  • Xing, C., et al., 2013. Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers. Environmental and molecular mutagenesis, 54, 397–405.
  • Yager, J.W., et al., 1990. Characterization of micronuclei induced in human lymphocytes by benzene metabolites. Cancer research, 50, 393–399.
  • Yu, M., et al., 2012. Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nature protocols, 7, 2159–2170.
  • Zhang, L., et al., 2007. Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environmental and molecular mutagenesis, 48, 467–474.
  • Zhang, X, et al., 2016. Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers. Archives of toxicology, 90, 1997–2008.

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