466
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker

, , , , &
Pages 380-385 | Received 31 Oct 2017, Accepted 20 Jan 2018, Published online: 07 Feb 2018

References

  • Bae, S., et al., 2014. Plasma choline metabolites and colorectal cancer risk in the Women’s Health Initiative Observational Study. Cancer research, 74 (24), 7442–7452.
  • Barreto, F.C., et al., and European Uremic Toxin Work, G., 2009. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clinical journal of the American society of nephrology, 4 (10), 1551–1558.
  • Benedetto, U., et al., 2008. Preoperative Angiotensin-converting enzyme inhibitors and acute kidney injury after coronary artery bypass grafting. Annals of thoracic surgery, 86 (4), 1160–1165.
  • Brown, J.M. and Hazen, S.L., 2017. Targeting of microbe-derived metabolites to improve human health: the next frontier for drug discovery. The journal of biological chemistry, 292 (21), 8560–8568.
  • Caporaso, J.G., et al., 2010. QIIME allows analysis of high-throughput community sequencing data. Nature methods, 7 (5), 335–336.
  • Craciun, S. and Balskus, E.P., 2012. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proceedings of the national academy of sciences of the United States of America, 109 (52), 21307–21312.
  • Dambrova, M., et al., 2016. Diabetes is associated with higher trimethylamine N-oxide plasma levels. Experimental and clinical endocrinology & diabetes, 124 (4), 251–256.
  • Dou, L., et al., 2015. The cardiovascular effect of the uremic solute indole-3 acetic acid. Journal of the American society of nephrology, 26 (4), 876–887.
  • Evered, M.D. and Robinson, M.M., 1984. Increased or decreased thirst caused by inhibition of angiotensin-converting enzyme in the rat. The journal of physiology, 348, 573–588.
  • Ferrario, C.M. and Mullick, A.E., 2017. Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease. Pharmacological research, 125 (Pt A), 57–71.
  • Gonzalez Bosc, L., et al., 2000. Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat. American journal of hypertension, 13 (12), 1301–1307.
  • Guertin, K.A., et al., 2017. Serum trimethylamine N-oxide, carnitine, choline, and betaine in relation to colorectal cancer risk in the alpha tocopherol, beta carotene Cancer Prevention Study. Cancer epidemiology biomarkers & prevention, 26 (6), 945–952.
  • Huc, T., et al., 2017. Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats. Pharmacological research, [Epub ahead of print]. doi: 10.1016/j.phrs.2017.12.025
  • Jaworska, K., et al., 2017. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS One, 12 (12), e0189310.
  • Koeth, R.A., et al., 2013. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature medicine, 19 (5), 576–585.
  • Korner, P.I. and Bobik, A., 1995. Cardiovascular development after enalapril in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 25 (4 Pt 1), 610–619.
  • Lekawanvijit, S., et al., 2010. Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes? European heart journal, 31 (14), 1771–1779.
  • Li, X.S., et al., 2017. Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European heart journal, 38 (11), 814–824.
  • Makrecka-Kuka, M., et al., 2017. Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicology letters, 267, 32–38.
  • Mercier, K., Smith, H., and Biederman, J., 2014. Renin-angiotensin-aldosterone system inhibition: overview of the therapeutic use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists, and direct renin inhibitors. Primary care, 41 (4), 765–778.
  • Miyake, T., et al., 2017. Involvement of organic cation transporters in the kinetics of trimethylamine N-oxide. Journal of pharmaceutical sciences, 106 (9), 2542–2550.
  • Nazzal, L., et al., 2017. Microbiome perturbation by oral vancomycin reduces plasma concentration of two gut-derived uremic solutes, indoxyl sulfate and p-cresyl sulfate, in end-stage renal disease. Nephrology dialysis transplantation, 32, 1809–1817.
  • Nowinski, A. and Ufnal, M., 2018. Trimethylamine N-oxide: a harmful, protective or diagnostic marker in lifestyle diseases? Nutrition, 46, 7–12.
  • Romano, K.A., et al., 2015. Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio, 6 (2), e02481.
  • Senthong, V., et al., 2016a. Trimethylamine N-oxide and mortality risk in patients with peripheral artery disease. Journal of the American heart association, 5 (10), e004237.
  • Senthong, V., et al., 2016b. Intestinal microbiota-generated metabolite trimethylamine-N-oxide and 5-year mortality risk in stable coronary artery disease: the contributory role of intestinal microbiota in a COURAGE-like patient cohort. Journal of the American heart association, 5 (6), e002816.
  • Sikora, M., et al., 2016. Repeated restraint stress produces acute and chronic changes in hemodynamic parameters in rats. Stress, 19 (6), 621–629.
  • Somero, G.N., 1986. From dogfish to dogs: trimethylamines protect proteins from urea. Physiology, 1 (1), 9–12.
  • Tang, W.H., et al., 2017. Increased Trimethylamine N-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus. Clinical chemistry, 63 (1), 297–306.
  • Thomas, M.C., et al., 2003. Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Kidney international, 63 (6), 2152–2161.
  • Tomasova, L., et al., 2016. Intracolonic hydrogen sulfide lowers blood pressure in rats. Nitric oxide, 60, 50–58.
  • Ufnal, M., et al., 2014. Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Canadian journal of cardiology, 30 (12), 1700–1705.
  • Yancey, P.H., 2005. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Journal of experimantal biology, 208 (Pt 15), 2819–2830.
  • Yang, T., et al., 2015. Gut dysbiosis is linked to hypertension. Hypertension, 65 (6), 1331–1340.
  • Zeisel, S.H., et al., 1989. Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship. The journal of nutrition, 119 (5), 800–804.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.