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Article

The rs9939609 polymorphism in the fat mass and obesity associated (FTO) gene is associated with obesity in Tunisian population

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Pages 787-792 | Received 01 Apr 2018, Accepted 07 Jul 2018, Published online: 23 Aug 2018

References

  • Abdelmajed, S.S., et al., 2017. Association analysis of FTOgene polymorphisms and obesity risk among Egyptian children and adolescents. Genes and diseases, 4 (3), 170–175.
  • Binh, T.Q., et al., 2013. Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population. Gene, 513 (1), 31–35.
  • Carlos, F.F., et al., 2013. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. Diabetes, metabolic syndrome and obesity : targets and therapy, 6, 241–245.
  • Cheung, W.W. and Mao, P., 2012. Recent advances in obesity: genetics and beyond. ISRN endocrinology, 2012, 536905.
  • Chu, X., et al., 2008. Association of morbid obesity with FTO and INSIG2 allelic variants. Archives of surgery, 143, 235–240.
  • Corella, D., et al., 2012. Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population. Nutrition, metabolism, and cardiovascular diseases: NMCD, 22 (8), 651–658.
  • Cornes, B.K., et al., 2009. Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G × E) interaction. International journal of obesity, 33 (1), 75–79.
  • de Luis, D.A., et al., 2012. Effects of RS9939609 gene variant in FTO gene on weight loss and cardiovascular risk factors after biliopancreatic diversion surgery. Journal of gastrointestinal surgery: official journal of the society for surgery of the alimentary tract, 16 (6), 1194–1198.
  • Dina, C., et al., 2007. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature genetics, 39 (6), 724–726.
  • Do, R., et al., 2008. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes, 57 (4), 1147–1150.
  • Doney, A.S., et al., 2009. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: A Go-DARTS study. Circulation cardiovascular genetics, 2 (3), 255–259.
  • Elouej, S., et al., 2016. Association of rs9939609 polymorphism with metabolic parameters and fto risk haplotype among Tunisian metabolic syndrome. Metabolic syndrome and related disorders 14, 1–8.
  • Fang, H., et al., 2010. Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. BMC medical genetics, 11, 136.
  • Frayling, T.M., et al., 2007. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 884–889.
  • Freathy, R.M., et al., 2008. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57 (5), 1419–1426.
  • Friedewald, W.T., Levy, R.I., and Fredrickson, D.S., 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry, 18 (6), 499–502.
  • Gu, H.V., Alvarsson, A., and Brismar, K., 2010. The common FTO Genetic polymorphism rs9939609 is associated with increased BMI in type 1 diabetes but not with diabetic nephropathy. Biomarker insights, 5, 29–32.
  • Hallman, D.M., et al., 2012. The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents. International journal of obesity, 36 (1), 61–68.
  • Hotta, K., et al., 2008. Variations in the FTO gene are associated with severe obesity in the Japanese. Journal of human genetics, 53 (6), 546–553.
  • Jacobsson, J.A., et al., 2008. Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochemical and biophysical research communications, 368 (3), 476–482.
  • Jacobsson, J.A., et al., 2009. The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920–1924. BMC medical genetics, 10, 131.
  • Labayen, I., et al., 2011. Association between the FTO rs9939609 polymorphism and leptin in European adolescent: a possible link with energy balance control. The HELENA study. International journal of obesity, 35, 66–71.
  • Legry, V., et al., 2009. Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA study. Metabolism: clinical and experimental, 58 (7), 971–975.
  • Li, H., et al., 2012. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia, 55 (4), 981–995.
  • López-Bermejo, A., et al., 2008. The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. The journal of clinical endocrinology and metabolism, 93 (4), 1501–1505.
  • Marcadet, A., O’Connel, P., and Cohen, D., 1987. Standardized southern blot workshop techniques. In: B. Dupont, ed. Histocompatibility testing. New York: Springer, 587–590.
  • Marvelle, A.F., et al., 2008. Association of FTO with Obesity-Related traits in the cebu longitudinal health and nutrition survey (CLHNS) cohort. Diabetes, 57 (7), 1987–1991.
  • Matthews, D.R., et al., 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28 (7), 412–419.
  • Muller, T.D., et al., 2008. Fat mass and obesity associated gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC medical genetics, 9, 85.
  • NCD Risk Factor Collaboration (NCD-RisC) – Africa Working Group 2017. Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies. International Journal of epidemiology, 46 (5), 1421–1432.
  • Price, R.A., Li, W.D., and Zhao, H., 2008. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC medical genetics, 9, 4.
  • Qi, L., et al., 2008. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes, 57 (11), 3145–3151.
  • Rauhio, A., et al., 2013. Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women. Maturitas, 76 (2), 165–171.
  • Razquin, C., et al., 2009. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. International Journal of obesity, 34 (2), 266–272.
  • Rodrigues, G.K., et al., 2015. A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population who underwent bariatric surgery. Nutrition, 31 (11–12), 1344–1350.
  • Rodriguez-Lopez, R., et al., 2010. de polimorfismos en el gen FTO con la obesidad morbida en la poblacion extremena. Endocrinologia y nutricion, 57 (5), 203–209.
  • Shimaoka, I., et al., 2010. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertension research: official journal of the Japanese society of hypertension, 33 (3), 214–218.
  • Speakman, J.R., Rance, K.A., and Johnstone, A.M., 2008. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring), 16 (8), 1961–1965.
  • Villalobos-Comparán, M., et al., 2008. The FTO gene is associated with adulthood obesity in the Mexican population. Obesity, 16 (10), 2296–2301.
  • Wåhlén, K., Sjölin, E., and Hoffstedt, J., 2008. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. Journal of lipid research, 49 (3), 607–611.
  • Woehning, A., et al., 2013. The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients. International journal of obesity, 37 (1), 135–139.
  • World Health Organization, 2000. WHO Technical Report Series, no. 894. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. Geneva, Switzerland: WHO.
  • Zavattari, P., et al., 2011. RS9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children. Annals of human genetics, 75 (6), 648–654.
  • Zhao, X., et al., 2014. An obesity genetic risk score is associated with metabolic syndrome in Chinese children. Gene, 535 (2), 299–302.

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