Assessment of titanium dioxide nanoparticles toxicity via oral exposure in mice: effect of dose and particle size

References

• Abdel Halim, M.A.K., 2012. The influence of size and exposure duration of gold nanoparticles on gold nanoparticles levels in several rat organs in vivo. Journal of cell science and therapy, 4, 1–5.
   Google Scholar
• Abdelazim, S.A., et al., 2015. Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitamin E in nano-sized titanium dioxide-induced liver injury. Cellular physiology and biochemistry, 35(6), 2402–2411.
   PubMedGoogle Scholar
• Armand, L., et al., 2013. Titanium dioxide nanoparticles induce matrix metalloprotease 1 in human pulmonary fibroblasts partly via an interleukin-1β-dependent mechanism. American journal of respiratory cell and molecular biology, 48(3), 354–363.
   PubMed Web of Science ®Google Scholar
• Banchroft, J.D., Stevens, A., and Turner, D.R., 1996. Theory and practice of histological techniques. 4th ed. New York, London, San Francisco, Tokyo: Churchill Livingstone.
   Google Scholar
• Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry, 72, 248–254.
   PubMed Web of Science ®Google Scholar
• Brun, E., et al., 2014. Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Particle and fibre toxicology, 11, 1–16.
   PubMed Web of Science ®Google Scholar
• Buege, J.A. and Aust, S.D., 1978. Microsomal lipid peroxidation. Methods in enzymology, 52, 302–310.
   PubMedGoogle Scholar
• Cho, W.S., et al., 2013. Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Particle and fibre toxicology, 10(1), 9.
   PubMed Web of Science ®Google Scholar
• Colvin, V.L., 2003. The potential environmental impact of engineered nanomaterials. Nature biotechnology, 21(10), 1166–1170.
   PubMed Web of Science ®Google Scholar
• Dorier, M., et al., 2015. Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells. Nanoscale, 7(16), 7352–7360.
   PubMed Web of Science ®Google Scholar
• Engin, A.B., et al., 2017. Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system. Particle and fibre toxicology, 14, 22.
   PubMed Web of Science ®Google Scholar
• Fabian, E., et al., 2008. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Archives of toxicology, 82(3), 151–157.
   PubMed Web of Science ®Google Scholar
• Geraets, L., et al., 2014. Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Particle and fibre toxicology, 30, 1–21.
   Google Scholar
• Gunnar, M., et al., 2009. Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance. European heart journal, 30, 116–124.
   PubMed Web of Science ®Google Scholar
• Helfenstein, M., et al., 2008. Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Toxicology, 253(1–3), 70–78.
   PubMed Web of Science ®Google Scholar
• Hong, J. and Zhang, Y.Q., 2016. Murine liver damage caused by exposure to nano-titanium dioxide. Nanotechnology, 18(27), 112001.
   Google Scholar
• Hu, H., et al., 2015. Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. Journal of applied toxicology, 35(10), 1122–1132.
   PubMed Web of Science ®Google Scholar
• Jemec, A., et al., 2012. Antioxidant responses and whole-organism changes in Daphnia magna acutely and chronically exposed to endocrine disruptor bisphenol A. Ecotoxicology and environmental safety, 86, 213–218.
   PubMed Web of Science ®Google Scholar
• Jia, X., et al., 2017. The potential liver, brain, and embryo toxicity of titanium dioxide nanoparticles on mice. Nanoscale research letters, 12, 478.
   PubMed Web of Science ®Google Scholar
• Kamat, P.V., 2002. Photophysical, photochemical and photocatalytic aspects of metal nanoparticles. The journal of physical chemistry B, 106(32), 7729–7744.
   Web of Science ®Google Scholar
• Kang, S.J., et al., 2008. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environmental and molecular mutagenesis, 49(5), 399–405.
   PubMed Web of Science ®Google Scholar
• Kirkali, G., Gezer, S., and Umur, N., 2000. Nitric oxide in chronic liver disease. Turkish journal of medical sciences, 30, 511–515.
   Google Scholar
• Kogan, M.J., et al., 2006. Nanoparticle-mediated local and remote manipulation of protein aggregation. Nano letters, 6(1), 110–115.
   PubMed Web of Science ®Google Scholar
• Kogan, M.J., et al., 2007. Peptides and metallic nanoparticles for biomedical applications. Nanomedicine, 2(3), 287–306.
   PubMed Web of Science ®Google Scholar
• Li, S., et al., 2008. Impact and mechanism of TiO2 nanoparticles on DNA synthesis in vitro. Science in China series B: chemistry, 51(4), 367–372.
   Google Scholar
• Liu, H.T., et al., 2009. Biochemical toxicity of mice caused by nano-anatase TiO2 particles. Biological trace element research, 129(1–3), 170–180.
   PubMed Web of Science ®Google Scholar
• Long, T.C., et al., 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environmental science & technology, 40(14), 4346–4352.
   PubMed Web of Science ®Google Scholar
• Lubinsky, S. and Bewley, G.C., 1979. Genetics of catalase in Drosophila melanogaster rates of synthesis and degradation of the enzyme in flies aneuploid and cuploid for the structural gene. Genetics, 19, 723–749.
   Google Scholar
• Minigalieva, I.A., et al., 2018. Combined subchronic toxicity of aluminum (III), titanium (IV) and silicon (IV) oxide nanoparticles and its alleviation with a complex of bio protectors. International journal of molecular sciences, 19(3), 837.
   Web of Science ®Google Scholar
• Moron, M.S., Depierre, J.W., and Mannervik, B., 1979. Level of glutathione: glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochimica et biophysica acta, 582(1), 67–78.
   PubMed Web of Science ®Google Scholar
• Moshage, H., et al., 1995. Nitrite and nitrate determination in plasma: a critical evaluation. Clinical chemistry, 41(6 Pt 1), 892–896.
   PubMed Web of Science ®Google Scholar
• Oberdorster, G., Ferin, J., and Lehnert, B.E., 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environmental health perspectives, 102, 173–179.
   PubMed Web of Science ®Google Scholar
• Park, S., et al., 2007. Cellular toxicity of various inhalable metal nanoparticles on human alveolar epithelial cells. Inhalation toxicology, 19(Suppl. 1), 59–65.
   PubMed Web of Science ®Google Scholar
• Reitman, S. and Frankel, S., 1957. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. American journal of clinical pathology, 28(1), 56–63.
   PubMed Web of Science ®Google Scholar
• Rindler, P.M., et al., 2013. High dietary fat selectively increases catalase expression within cardiac mitochondria. Journal of biological chemistry, 18(288), 1979–1990.
   Google Scholar
• Rizk, M.Z., et al., 2017. Toxicity of titanium dioxide nanoparticles: effect of dose and time on biochemical disturbance, oxidative stress and genotoxicity in mice. Biomedicine & pharmacotherapy, 90, 466–472.
   PubMed Web of Science ®Google Scholar
• Röhrdanz, E., et al., 2001. The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes. Brain research, 900(1), 128–136.
   PubMed Web of Science ®Google Scholar
• Serdar, O., et al., 2018. Antioxidant biomarkers in Gammarus pulex to evaluate the efficiency of electrocoagulation process in landfill leachate treatment. Environmental science and pollution research, 25, 12538–12544.
   PubMed Web of Science ®Google Scholar
• Sha, B., et al., 2013. Nano-titanium dioxide induced cardiac injury in rat under oxidative stress. Food and chemical toxicology, 58, 280–288.
   PubMed Web of Science ®Google Scholar
• Shi, H., et al., 2013. Titanium dioxide nanoparticles: a review of current toxicological data. Particle and fibre toxicology, 10, 1–33.
   PubMed Web of Science ®Google Scholar
• Shukla, R.K., et al., 2014. Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine, 9(9), 1423–1434.
   PubMed Web of Science ®Google Scholar
• Tassinari, R., et al., 2014. Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology, 8(6), 654–662.
   PubMed Web of Science ®Google Scholar
• Trouiller, B., et al., 2009. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer research, 69 (22), 8784–8789.
   PubMed Web of Science ®Google Scholar
• Turkez, H. and Geyikoglu, F., 2007. An in vitro blood culture for evaluating the genotoxicity of titanium dioxide: the responses of antioxidant enzymes. Toxicology and industrial health, 23, 19–23.
   PubMed Web of Science ®Google Scholar
• Valavanidis, A., et al., 2006. Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicology and environmental safety, 64(2), 178–189.
   PubMed Web of Science ®Google Scholar
• Wang, J.X., et al., 2007. Acute toxicity and bio distribution of different sized titanium dioxide particles in mice after oral administration. Toxicology letters, 168(2), 176–185.
   PubMed Web of Science ®Google Scholar
• Wu, J.H., et al., 2009. Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicology letters, 191(1), 1–8.
   PubMed Web of Science ®Google Scholar
• Yildirim, N.C., et al., 2018. Biochemical responses of Gammarus pulex to malachite green solutions decolorized by Coriolus versicolor as a biosorbent under batch adsorption conditions optimized with response surface methodology. Ecotoxicology and environmental safety, 156, 41–47.
   PubMed Web of Science ®Google Scholar
• Yosida, T.H. and Amano, K., 1965. Autosomal polymorphism in laboratory bred and wild Norway rats, Rattus norvegicus. Chromosoma, 16(6), 658–667.
   PubMed Web of Science ®Google Scholar
• Zhao, X., et al., 2013. Nano-sized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS one, 8, 2.
   Web of Science ®Google Scholar
• Zhu, R.R., et al., 2007. A novel toxicological evaluation of TiO2 nanoparticles on DNA structure. Chinese journal of chemistry, 25(7), 958–961.
   Web of Science ®Google Scholar