Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats

References

• Ademuyiwa, A., et al., 2014. Protective effects of cyclohexyl methyl di-thiocarbamates sodium salt on diclofenac induced reproductive toxicity in male albino rats. Biochemical pharmacology, 4 (1), 1–5.
   Google Scholar
• Aebi, H., 1984. Catalase in vitro. Methods in enzymology, 105, 121–126.
   PubMed Web of Science ®Google Scholar
• Ahmad, S., et al., 2012. Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicology letters, 208 (2), 149–161.
   PubMed Web of Science ®Google Scholar
• Ajarem, J., et al., 2016. Oral administration of potassium bromated induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of Swiss mice. Behavioural and brain function, 12 (14), 2–10.
   PubMedGoogle Scholar
• Al-Aboud, M., 2018. Effect of red beetroot (Beta vulgaris L.) intake on the level of some hematological tests in a group of female volunteers. Journal of food and agriculture science, 8 (2), 10–17.
   Google Scholar
• Appasamy, M., et al., 2007. Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reproduction BioMedicine, 14 (2), 159–165.
   PubMed Web of Science ®Google Scholar
• Aprioku, J., and Uche, F., 2013. Renal effects of non-steroidal anti-inflammatory drugs in albino rats. British journal of pharmaceutical research, 3 (3), 314–325.
   Google Scholar
• Assmaa, O., et al., 2012. Effect of sodium fluoride on the thyroid gland of growing male albino rats: histological and biochemical study. The Egyptian journal of histology, 35, 470–482.
   Google Scholar
• Bahadir, A., et al., 2014. The protective effects of erdosteine and N-acetyl cysteine in rats with paracetamol induced hippocampal tissue damage. Journal of physical chemistry and biophysics, 5, 1–5.
   PubMedGoogle Scholar
• Bancroft, J., et al., 1996. Theory and practice of histological techniques. 4th ed. New York, NY: Churchill Livingstone.
   Google Scholar
• Bao, S., et al., 2017. Effects of diclofenac on the expression of Nrf2 and its downstream target genes in mosquito fish (Gambusia affnis). Aquatic toxicology, 188, 43–53.
   PubMed Web of Science ®Google Scholar
• Beutler, E., et al., 1963. Improved method for the determination of blood glutathione. The journal of laboratory and clinical medicine, 61, 882–888.
   PubMed Web of Science ®Google Scholar
• Beytut, F., et al., 2018. The possible protective effects of vitamin E and selenium administration in oxidative stress caused by high doses of glucocorticoid administration in the brain of rats. Journal of trace elements in medicine and biology, 45, 131–135.
   PubMed Web of Science ®Google Scholar
• Caraci, F., et al., 2011. Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. Current drug metabolism, 12 (6), 570–578.
   PubMed Web of Science ®Google Scholar
• da Silva, et al., 2019. Betanin, a natural food additive: stability, bioavailability, antioxidant and preservative ability assessments. Molecules, 24, 458.
   Web of Science ®Google Scholar
• Das, D., and Roy, C., 2012. The protective role of Benincasa hispida on diclofenac sodium induced hepatotoxicity in albino rat model. IJPRD, 3 (11), 171–179.
   Google Scholar
• Deshmukh, A., et al., 2011. Cerebroprotective effects of extract of Beta vulgaris (C.) in middle cerebral artery occlusion (MCAO)-induced cerebral ischemia. Phytopharmacology, 1 (5), 138–147.
   Google Scholar
• El-Gamal, A., et al., 2014. Beetroot (L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators of inflammation, 2014, 983952.
   PubMedGoogle Scholar
• El-Maddawy, Z., and El-Sayed, Y., 2018. Comparative analysis of the protective effects of curcumin and N-acetyl cysteine against paracetamol-induced hepatic, renal, and testicular toxicity in Wistar rats. Environmental science and pollution research, 25 (4), 3468–3479.
   PubMed Web of Science ®Google Scholar
• Esatbeyoglu, T., et al., 2015. Betanin-A food colorant with biological activity. Molecular nutrition and food research, 59 (1), 36–47.
   PubMed Web of Science ®Google Scholar
• González-Ponce, H., et al., 2018. Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrition, 10 (2), 117–156.
   Google Scholar
• Guiloski, I., et al., 2015. Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish. Ecotoxicology and environmental safety, 114, 204–211.
   PubMed Web of Science ®Google Scholar
• Gum, S., and Cho, M., 2013. Recent updates on acetaminophen hepatotoxicity: the role of Nrf2 in hepatoprotection. Toxicological research, 29 (3), 165–172.
   PubMedGoogle Scholar
• Han, J., et al., 2014. Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.). Fish physiology and biochemistry, 40 (3), 865–874.
   PubMed Web of Science ®Google Scholar
• Han, J., et al., 2015. Betanin reduces the accumulation and cross-links of collagen in high fructose fed rat heart through inhibiting non-enzymatic glycation. Chemico-Biological interactions, 227, 37–44.
   PubMed Web of Science ®Google Scholar
• Hfaiedh, M., et al., 2014. Protective role of Cactus cladodes extract on sodium dichromate-induced testicular injury and oxidative stress in rats. Biological trace element research, 159 (1–3), 304–311.
   PubMed Web of Science ®Google Scholar
• Hirschler, V., et al., 2018. Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude. Redox report, 23 (1), 35–40.
   PubMed Web of Science ®Google Scholar
• Ibrahim, M., et al., 2018. Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. Biomedicine pharmacotherapy, 100, 267–274.
   PubMed Web of Science ®Google Scholar
• Ilic, S., et al., 2011. Pentadecapeptide BPC157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. Life science, 88 (11–12), 535–542.
   PubMed Web of Science ®Google Scholar
• Indumathi, D., et al., 2017. Protective effect of betanin against streptozotocin - nicotinamide induced liver, kidney and pancreas damage by attenuating lipid by products and improving renal biomarkers in Wistar rats. International journal of advanced research in biological sciences, 4, 160–170.
   Google Scholar
• John, S., et al., 2017. Antioxidant and antibacterial activities of Beta vulgaris L. peel extracts. International Journal of pharma research and health sciences, 5 (6), 1974–1979.
   Google Scholar
• Kapadia, J., et al., 2011. Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines, anticancer agent. Medicinal chemistry, 11, 280–284.
   Web of Science ®Google Scholar
• Karimi, M., et al., 2012. Effect of acute toxicity of cadmium mice kidney cells. Iran Journal of toxicology, 6, 691–798.
   Google Scholar
• Klopčič, I., et al., 2018. Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol. Toxicology letters, 294, 95–104.
   PubMed Web of Science ®Google Scholar
• Lanza, F., et al., 2018. Endoscopic comparison of gastroduodenal injury with over-the-counter doses of new fast-dissolving ibuprofen and paracetamol formulations: a randomized, placebo-controlled, 4-way crossover clinical trial. Clinical and experimental gastroenterology, 11, 169–177.
   PubMed Web of Science ®Google Scholar
• Lis, M., et al., 2006. Effect of paracetamol injection in ovo in the course of hatching thyroid hormone levels in chicken embryos. Bulletin of the veterinary institute in Pulawy, 50, 537–542.
   Google Scholar
• Livrea, A., and Tesoriere, L., 2012. Lipoperoxyl radical scavenging and antioxidative effects of red beet pigments. Red beet biotechnology, 9, 105–124.
   Google Scholar
• Lopez-Doval, S., et al., 2015. Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate. Toxicology letter, 233, 138–147.
   PubMed Web of Science ®Google Scholar
• Lu, X., et al., 2009. Radio protective activity of betalains from red beets in mice exposed to gamma irradiation. European journal of pharmacology, 615 (1–3), 223–227.
   PubMed Web of Science ®Google Scholar
• Mironczuk-Chodakowska, L., et al., 2018. Endogenous non-enzymatic antioxidants in the human body. Advances in medical sciences, 63, 68–78.
   PubMed Web of Science ®Google Scholar
• Mohan, D., and Sharma, A., 2017. Biochemical changes of the liver of mice after exposure to different doses of diclofenac sodium. International Journal of animal and veterinary science, 11 (5), 375–384.
   Google Scholar
• Nishikimi, M., et al., 1972. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochemical biophysical research communications, 46 (2), 849–854.,
   PubMed Web of Science ®Google Scholar
• Ohkawa, H., et al., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry, 95 (2), 351–358.
   PubMed Web of Science ®Google Scholar
• Oliveira, M., et al., 2018. Carnosic acid induces anti-inflammatory effects in paraquat-treated SH-SY5Y cells through a mechanism involving a crosstalk between the Nrf2/HO-1 axis and NF-κB. Molecular neurobiology, 55, 890–897.
   PubMed Web of Science ®Google Scholar
• Onaolapo, O., et al., 2017. L-methionine and silymarin: a comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex. Biomedicine & pharmacotherapy, 85, 323–333.
   PubMed Web of Science ®Google Scholar
• Patricia, R., et al., 2018. SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress. Antioxidant redox signal, 28 (13), 1187–1208.
   PubMed Web of Science ®Google Scholar
• Peter, J., and Prince, S., 2018. Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation. Biomedicine and pharmacotherapy, 98, 45–51.
   PubMed Web of Science ®Google Scholar
• Saravanan, M., et al., 2014. Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures. Environmental toxicology and pharmacology, 38 (3), 948–958.
   PubMed Web of Science ®Google Scholar
• Soares, A., et al., 2013. Effect of an Agaricus blazei aqueous extract pretreatment on paracetamol- induced brain and liver injury in rats. BioMed research international, 2013, 469180.
   PubMedGoogle Scholar
• Sulakhiya, K., et al., 2016. Effect of Beta vulgaris Linn. leaves extract on anxiety- and depressive-like behavior and oxidative stress in mice after acute restraint stress. Pharmacognosy research, 8 (1), 1–7.
   PubMed Web of Science ®Google Scholar
• Syed, M., et al., 2016. Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: possible role in drug induced liver injury (DILI). Toxicology in vitro, 31, 93–102.
   PubMed Web of Science ®Google Scholar
• Venkatachalam, U., and Muthukrishnan, S., 2013. Hepatoprotective activity of desmodium gangeticum in paracetamol induced liver damage in rats. Biomedicine and preventive nutrition, 3, 273–277.
   Google Scholar
• Yurt, K., et al., 2018. The neuroprotective effect of melatonin on the hippocampus exposed to diclofenac sodium during the prenatal period. Journal of chemical neuroanatomy, 87, 37–48.
   PubMed Web of Science ®Google Scholar