Clinical significance of serum hepcidin in the diagnosis and treatment of patients with anemia of chronic disease: a meta-analysis

References

• Bansal, S.S., et al., 2009. Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid communications in mass spectrometry, 23 (11), 1531–1542.
   PubMed Web of Science ®Google Scholar
• Basseri, R.J., et al., 2013. Hepcidin is a key mediator of anemia of inflammation in Crohn’s disease. Journal of crohn’s and colitis, 7 (8), e286–e291.
   PubMedGoogle Scholar
• Boshuizen, M., et al., 2020. Potential of parameters of iron metabolism for the diagnosis of anemia of inflammation in the critically ill. Transfusion medicine and hemotherapy: offizielles organ der deutschen gesellschaft fur transfusionsmedizin und immunhamatologie, 47 (1), 61–67.
   PubMed Web of Science ®Google Scholar
• Busbridge, M., et al., 2009. Development of a novel immunoassay for the iron regulatory peptide hepcidin. British journal of biomedical science, 66 (3), 150–157.
   PubMed Web of Science ®Google Scholar
• Cheng, P.P., et al., 2011. Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia. Clinical and experimental medicine, 11 (1), 33–42.
   PubMed Web of Science ®Google Scholar
• DeLoughery, T.G., 2017. Iron deficiency anemia. Medical Clinics of North America, 101 (2), 319–332.
   PubMed Web of Science ®Google Scholar
• Deschemin, J.C., et al., 2017. Pulmonary iron homeostasis in hepcidin knockout mice. Frontiers in physiology, 8, 804.
   PubMed Web of Science ®Google Scholar
• Gangat, N., and Wolanskyj, A.P., 2013. Anemia of chronic disease. Seminars in hematology, 50 (3), 232–238.
   PubMed Web of Science ®Google Scholar
• Ganz, T., 2003. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 102 (3), 783–788.
   PubMed Web of Science ®Google Scholar
• Ganz, T., and Nemeth, E., 2011. Hepcidin and disorders of iron metabolism. Annual review of medicine, 62, 347–360.
   PubMed Web of Science ®Google Scholar
• Girelli, D., Nemeth, E., and Swinkels, D.W., 2016. Hepcidin in the diagnosis of iron disorders. Blood, 127 (23), 2809–2813.
   PubMed Web of Science ®Google Scholar
• Hadziahmetovic, M., et al., 2011. Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Investigative ophthalmology & visual science, 52 (1), 109–118.
   PubMed Web of Science ®Google Scholar
• Hentze, M.W., et al., 2010. Two to tango: regulation of Mammalian iron metabolism. Cell, 142 (1), 24–38.
   PubMed Web of Science ®Google Scholar
• Joosten, E., and Lioen, P., 2015. Iron deficiency anemia and anemia of chronic disease in geriatric hospitalized patients: How frequent are comorbidities as an additional explanation for the anemia? Geriatrics & gerontology international, 15 (8), 931–935.
   PubMed Web of Science ®Google Scholar
• Kali, A., Charles, M.V., and Seetharam, R.S., 2015. Hepcidin – a novel biomarker with changing trends. Pharmacognosy reviews, 9 (17), 35–40.
   PubMedGoogle Scholar
• Kim, A., et al., 2014. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood, 123 (8), 1129–1136.
   PubMed Web of Science ®Google Scholar
• Krause, A., et al., 2000. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS letters, 480 (2–3), 147–150.
   PubMed Web of Science ®Google Scholar
• Kroot, J.J., et al., 2009. (Pre)analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies. Analytical biochemistry, 389 (2), 124–129.
   PubMed Web of Science ®Google Scholar
• Li, J., and Fine, J.P., 2011. Assessing the dependence of sensitivity and specificity on prevalence in meta-analysis. Biostatistics, 12 (4), 710–722.
   PubMed Web of Science ®Google Scholar
• Li, J., Fine, J.P., and Safdar, N., 2007. Prevalence-dependent diagnostic accuracy measures. Statistics in medicine, 26 (17), 3258–3273.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 2018. Diagnostic value and clinical significance of serum hepcidin level in iron deficiency anemia. International journal of laboratory hematology, 39 (3), 56–58.
   Google Scholar
• Lunova, M., et al., 2017. Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells. The journal of pathology, 241 (1), 104–114.
   PubMed Web of Science ®Google Scholar
• Macdougall, I.C., et al., 2010. Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clinical journal of the American society of nephrology: CJASN, 5 (9), 1681–1689.
   PubMed Web of Science ®Google Scholar
• Mahajan, G., et al., 2017. Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia. Blood research, 52 (3), 212–217.
   PubMed Web of Science ®Google Scholar
• Murawska, N., Fabisiak, A., and Fichna, J., 2016. Anemia of chronic disease and iron deficiency anemia in inflammatory bowel diseases: pathophysiology, diagnosis, and treatment. Inflammatory bowel diseases, 22 (5), 1198–1208.
   PubMed Web of Science ®Google Scholar
• Okuturlar, Y., et al., 2016. Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia. Renal failure, 38 (5), 781–786.
   PubMed Web of Science ®Google Scholar
• Pagani, A., et al., 2019. Hepcidin and Anemia: a tight relationship. Frontiers in physiology, 10, 1294.
   PubMed Web of Science ®Google Scholar
• Park, C.H., et al., 2001. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. The journal of biological chemistry, 276 (11), 7806–7810.
   PubMed Web of Science ®Google Scholar
• Przybyszewska, J., et al., 2013. Serum prohepcidin and other iron metabolism parameters in elderly patients with anemia of chronic disease and with iron deficiency anemia. Polish archives of internal medicine, 123 (3), 105–111.
   Google Scholar
• Shu, T., et al., 2015. Hepcidin in tumor-related iron deficiency anemia and tumor-related anemia of chronic disease: pathogenic mechanisms and diagnosis. European journal of haematology, 94 (1), 67–73.
   PubMed Web of Science ®Google Scholar
• Theurl, I., et al., 2011. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica, 96 (12), 1761–1769.
   PubMed Web of Science ®Google Scholar
• Wang, H., et al., 2017. Correlation between serum Hepcidin and sTfＲ in children with iron deficiency anemia and the value of the combined diagnosis. Chinese journal of health laboratory technology, 27 (3), 2778–2780.
   Google Scholar
• Wang, W.J., et al., 2015. Diagnostic value of hepcidin in elderly patients with iron deficiency anemia and anemia of chronic disease. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 23, 155–158.
   PubMedGoogle Scholar
• Zhou, B., 2015. Significance of serum hepcidin in differential diagnosis of iron deficiency anemia and Anemia of Chronic Disease. Chinese journal of control of endemic diseases, 30 (3), 77.
   Google Scholar