MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/β-catenin axis

References

• Abuna, R.P.F., et al., 2019. The Wnt/β-catenin signaling pathway is regulated by titanium with nanotopography to induce osteoblast differentiation. Colloids and surfaces. B, biointerfaces, 184, 110513.
   PubMed Web of Science ®Google Scholar
• Arora, S., et al., 2019. Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction. Circulation, 139 (8), 1047–1056.
   PubMed Web of Science ®Google Scholar
• Bebensee, D.F., Can, K., and Müller, M., 2017. Increased mitochondrial mass and cytosolic redox imbalance in hippocampal astrocytes of a mouse model of rett syndrome: subcellular changes revealed by ratiometric imaging of JC-1 and roGFP1 fluorescence. Oxidative medicine and cellular longevity, 2017, 3064016.
   PubMed Web of Science ®Google Scholar
• Beltran, C., et al., 2020. Enhancing glycolysis protects against ischemia-reperfusion injury by reducing ROS production. Metabolites, 10 (4), 132.
   Web of Science ®Google Scholar
• Brade, T., Männer, J., and Kühl, M., 2006. The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart. Cardiovascular research, 72 (2), 198–209.
   PubMed Web of Science ®Google Scholar
• Can, K., et al., 2019. Neuronal redox-imbalance in Rett syndrome affects mitochondria as well as cytosol, and is accompanied by intensified mitochondrial O2 consumption and ROS release. Frontiers in physiology, 10, 479.
   PubMed Web of Science ®Google Scholar
• Fasolino, M., and Zhou, Z.J.G., 2017. The crucial role of DNA methylation and MeCP2 in neuronal function. Genes (basel), 8 (5), 141.
   Web of Science ®Google Scholar
• Filosa, S., et al., 2015. Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome. Free radical biology & medicine, 88 (Pt A), 81–90.
   PubMed Web of Science ®Google Scholar
• Gay, D., et al., 2020. Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing. Science advances, 6 (12), eaay3704.
   PubMed Web of Science ®Google Scholar
• Hu, X., et al., 2020. LncRNA Oprm1 overexpression attenuates myocardial ischemia/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1/miR-30b-5p/CSE axis. Life sciences, 254, 117699.
   PubMed Web of Science ®Google Scholar
• Huang, J., et al., 2021. MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2. Journal of receptor and signal transduction research, 41 (1), 6–14.
   PubMed Web of Science ®Google Scholar
• Ji, H., et al., 2021. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology, 236 (2), 1228–1236.
   PubMed Web of Science ®Google Scholar
• Jin, Q., et al., 2020. Wenxin granule ameliorates hypoxia/reoxygenation-induced oxidative stress in mitochondria via the PKC-δ/NOX2/ROS pathway in H9c2 cells. Oxidative medicine and cellular longevity, 2020, 3245483.
   PubMed Web of Science ®Google Scholar
• Johnson, B.S., et al., 2017. Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome. Nature medicine, 23 (10), 1203–1214.
   PubMed Web of Science ®Google Scholar
• Lagger, S., et al., 2017. MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain. PLoS genetics, 13 (5), e1006793.
   PubMed Web of Science ®Google Scholar
• Lee, W., et al., 2020. MeCP2 regulates gene expression through recognition of H3K27me3. Nature communications, 11 (1), 3140.
   PubMed Web of Science ®Google Scholar
• Li, J.H., et al., 2019. MiR-34a regulates cell apoptosis after myocardial infarction in rats through the Wnt/β-catenin signaling pathway. European review for medical and pharmacological sciences, 23 (6), 2555.
   PubMed Web of Science ®Google Scholar
• Liao, B., et al., 2020. LncRNA Kcnq1ot1 renders cardiomyocytes apoptosis in acute myocardial infarction model by up-regulating Tead1. Life sciences, 256, 117811.
   PubMed Web of Science ®Google Scholar
• Lin, J., et al., 2020. Overexpression of MECP2 attenuates cigarette smoke extracts induced lung epithelial cell injury by promoting CYP1B1 methylation. The journal of toxicological sciences, 45 (3), 177–186.
   PubMed Web of Science ®Google Scholar
• Liu, C., et al., 2020. Knockdown of miR-665 protects against cardiomyocyte ischemia/reperfusion injury-induced ROS accumulation and apoptosis through the activation of Pak1/Akt signaling in myocardial infarction. International heart journal, 61 (2), 347–354.
   PubMed Web of Science ®Google Scholar
• Ma, R., et al., 2020. MiR-129-5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion. The Kaohsiung journal of medical sciences, 36 (8), 599–606.
   PubMed Web of Science ®Google Scholar
• Mellios, N., et al., 2018. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Molecular psychiatry, 23 (4), 1051–1065.
   PubMed Web of Science ®Google Scholar
• Meng, G., et al., 2014. Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells. Tumor biology, 35 (12), 11819–11827.
   PubMedGoogle Scholar
• Miao, C., et al., 2013. MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats. Cellular signalling, 25 (3), 598–608.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., et al., 2016. Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia/reperfusion injury. The journal of biological chemistry, 291 (6), 2566–2575.
   PubMed Web of Science ®Google Scholar
• Ong, S.B., et al., 2018. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacology & therapeutics, 186, 73–87.
   PubMed Web of Science ®Google Scholar
• Shao, Z., et al., 2020. Circ_0003789 facilitates gastric cancer progression by inducing the epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway. Cancer biotherapy and radiopharmaceuticals.
   Web of Science ®Google Scholar
  doi:10.1089/cbr.2020.4044
   Google Scholar
• Shi, C.C., et al., 2020. MicroRNA-323-3p inhibits oxidative stress and apoptosis after myocardial infarction by targeting TGF-β2/JNK pathway. European review for medical and pharmacological sciences, 24 (12), 6961–6970.
   PubMed Web of Science ®Google Scholar
• Signorini, C., et al., 2016. MECP2 duplication syndrome: evidence of enhanced oxidative stress. A comparison with Rett syndrome. PLoS one, 11 (3), e0150101.
   PubMed Web of Science ®Google Scholar
• Su, G., et al., 2020. Prokineticin 2 relieves hypoxia/reoxygenation-induced injury through activation of Akt/mTOR pathway in H9c2 cardiomyocytes. Artificial cells, nanomedicine, and biotechnology, 48 (1), 345–352.
   PubMed Web of Science ®Google Scholar
• Tao, H., et al., 2016a. MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5. International journal of biological macromolecules, 82, 68–75.
   PubMed Web of Science ®Google Scholar
• Tao, J., et al., 2016b. Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway. Lipids in health and disease, 15, 72.
   PubMed Web of Science ®Google Scholar
• Thirunavukkarasu, M., et al., 2015. Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway. Journal of physiology and biochemistry, 71 (4), 623–633.
   PubMed Web of Science ®Google Scholar
• Tsai, K.L., et al., 2020. IL-20 promotes hypoxia/reoxygenation-induced mitochondrial dysfunction and apoptosis in cardiomyocytes by upregulating oxidative stress by activating the PKC/NADPH oxidase pathway. Biochimica et biophysica acta. Molecular basis of disease, 1866 (5), 165684.
   PubMed Web of Science ®Google Scholar
• Wang, C., et al., 2018. The effect of Mecp2 on heart failure. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 47 (6), 2380–2387.
   PubMedGoogle Scholar
• Wang, H., et al., 2020. Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells. Oncogenesis, 9 (8), 76.
   PubMed Web of Science ®Google Scholar
• Yang, M., Kong, D., and Chen, J.C., 2019. Inhibition of miR-148b ameliorates myocardial ischemia/reperfusion injury via regulation of Wnt/β-catenin signaling pathway. Journal of cellular physiology, 234 (10), 17757–17766.
   PubMed Web of Science ®Google Scholar
• Zeng, W., et al., 2019. Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury. Journal of pharmacological sciences, 140 (1), 14–19.
   PubMed Web of Science ®Google Scholar
• Zhang, X.Y., Xu, Y.Y., and Chen, W.Y., 2020a. MicroRNA-1324 inhibits cell proliferative ability and invasiveness by targeting MECP2 in gastric cancer. European review for medical and pharmacological sciences, 24 (9), 4766–4774.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., et al., 2020b. Effects of SFRP4 overexpression on the production of adipokines in transgenic mice. Adipocyte, 9 (1), 374–383.
   PubMed Web of Science ®Google Scholar
• Zhao, L.Y., et al., 2017. MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1. Oncogenesis, 6 (7), e368.
   PubMedGoogle Scholar
• Zhu, X., and Lu, XJJoCP., 2019. MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and mitochondrial dysfunction caused by hypoxia/reoxygenation through activation of the wnt/β-catenin signaling pathway via targeting MYBL2. Journal of cellular physiology, 234 (12), 22034–22043.
   PubMed Web of Science ®Google Scholar
• Zouein, F.A., and Booz, G.W., 2020. Targeting mitochondria to protect the heart: a matter of balance? Clinical science (London, England), 134 (7), 885–888.
   Google Scholar