110
Views
2
CrossRef citations to date
0
Altmetric
Reviews

Value of miR-21 levels as potential biomarkers in the early diagnosis of hepatocellular carcinoma:a meta-analysis

, ORCID Icon &
Pages 586-597 | Received 07 Jan 2021, Accepted 11 Jul 2021, Published online: 26 Jul 2021

References

  • Ali, H., et al., 2017. Circulating microRNAs panel as a diagnostic tool for discrimination of HCV-associated hepatocellular carcinoma. Clinics and research in hepatology and gastroenterology, 41 (4), e51–e62.
  • Amr, K.S., et al., 2016. The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma. Gene, 575 (1), 66–70.
  • Bharali, D., et al., 2019. Expression analysis of MicroRNA-21 and MicroRNA-122 in hepatocellular carcinoma. Journal of clinical and experimental hepatology, 9 (3), 294–301.
  • Biselli, M., et al., 2015. A new approach to the use of α-fetoprotein as surveillance test for hepatocellular carcinoma in patients with cirrhosis. British journal of cancer, 112 (1), 69–76.
  • Cao, L.Q., et al., 2019. Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth. Molecular cancer, 18 (1), 148.
  • Chao, Y., and Zhou, D., 2019. lncRNA-D16366 Is a Potential Biomarker for Diagnosis and prognosis of Hepatocellular Carcinoma. Medical science monitor, 25, 6581–6586.
  • Chen, S., et al., 2018. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An updated Meta-Analysis. Canadian journal of gastroenterology & hepatology, 2018, 8410195.
  • Chen, Z., et al., 2014. The changes of serum miR-21 expression level in patients with HCC before and after TACE and its clinical significance. J. Intervent. Radiol, 23, 406–410.
  • Choi, B., and Lee, J., 2010. Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments: imaging diagnosis and staging of hepatocellular carcinoma. Journal of hepato-biliary-pancreatic sciences, 17 (4), 369–373.
  • Correa, G.C., et al., 2016. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. PLoS One, 11 (9), e0163699.
  • Feng, R.M., et al., 2019. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer communications (london, England), 39 (1), 22.
  • Fukushima, Y., et al., 2015. Clinical significance of microRNA-21 as a biomarker in each Dukes' stage of colorectal cancer. Oncology reports, 33 (2), 573–582.
  • Gebert, L.F., and MacRae, I.J., 2019. Regulation of microRNA function in animals. Nature reviews. Molecular cell biology, 20 (1), 21–37.
  • Gedawy, G., et al., 2017. Circulating MiRNA-21 and programed cell death (PDCD) 4 gene expression in hepatocellular carcinoma (HCC) in Egyptian patients. Egyptian journal of medical human genetics, 18 (2), 137–145.
  • Ghosh, S., et al., 2020. The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. International journal of cancer, 147 (10), 2934–2947.
  • Guo, X., et al., 2017. Circulating miR-21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis. Oncotarget, 8 (27), 44050–44058.
  • Hong, Y., et al., 2021. MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation. Frontiers in oncology, 11, 642030.
  • Hu, L., et al., 2016. Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21. Tumour biology : the journal of the international society for oncodevelopmental biology and medicine, 37 (2), 2691–2702.
  • Hu, S., et al., 2015. MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1. Tumor biology, 36 (7), 5467–5472.
  • Huang, C.S., et al., 2015. Increased expression of miR-21 predicts poor prognosis in patients with hepatocellular carcinoma. Int J clin exp pathol, 8 (6), 7234–7238.
  • Jia, X., et al., 2014. Diagnosis accuracy of serum glypican-3 in patients with hepatocellular carcinoma: a systematic review with meta-analysis. Archives of medical research, 45 (7), 580–588.
  • Jiang, Y., et al., 2019. The Diagnostic Value of MicroRNAs as a Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. BioMed research international, 2019, 5179048.
  • Kamel, R.R., et al., 2016. Relation between microRNAs and Apoptosis in Hepatocellular Carcinoma. Open access macedonian journal of medical sciences, 4 (1), 31–37.
  • Karakas, M., et al., 2017. Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease results from the large Athero Gene study. European heart journal, 38 (7), 516–523.
  • Kishimoto, T., et al., 2013. Plasma miR-21 is a novel diagnostic biomarker for biliary tract cancer. Cancer science, 104 (12), 1626–1631.
  • Kurashige, J., et al., 2012. Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma. Journal of surgical oncology, 106 (2), 188–192.
  • Lai, C.Y., et al., 2021. MicroRNA-21 plays multiple oncometabolic roles in the process of NAFLD-related hepatocellular carcinoma via PI3K/AKT, TGF-β, and STAT3 signaling. Cancers, 13 (5), 940.
  • Lee, E., et al., 2017. High expression of lncRNA-ATB and miR-21 as a biomarker in human hepatocellular carcinoma. Cancer research, 77.
  • Li, J., 2014. Prognostic and clinicopathological significance of glypican-3 over expression in hepatocellular carcinoma: a meta-analysis. World journal of gastroenterology, 20 (20), 6336–6344.
  • Liao, Q., et al., 2015. Potential role of circulating microRNA-21 for hepatocellular carcinoma diagnosis: a meta-analysis. PLoS One, 10 (6), e0130677.
  • Lin, L., et al., 2018. Empirical comparison of publication bias tests in meta-analysis. Journal of general internal medicine, 33 (8), 1260–1267.
  • Liu, A.M., et al., 2012. Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study. BMJ open, 2 (2), e000825.
  • Lu, J., et al., 2020. Hypomethylation causes MIR21 overexpression in tumors. Molecular therapy oncolytics, 18, 47–57.
  • Lv, Z., et al., 2018. Cluster of specified microRNAs in tissues and serum as biomarkers for early diagnosis of hepatocellular carcinoma. International Journal of Clinical and Experimental Pathology, 11 (2), 990–997.
  • Marrero, J.A., et al., 2005. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma. Journal of hepatology, 43 (6), 1007–1012.
  • Marrero, J.A., et al., 2009. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology, 137 (1), 110–118.
  • Marrero, J.A., and Lok, A.S., 2004. Newer markers for hepatocellular carcinoma. Gastroenterology, 127 (5 Suppl 1), S113–S119.
  • Qu, J., et al., 2019. MicroRNA-21 as a diagnostic marker for hepatocellular carcinoma: A systematic review and meta-analysis. Pakistan journal of medical sciences, 35 (5), 1466–1471.
  • Ren, J., et al., 2017. The diagnostic and prognostic values of microRNA-21 in patients with gastric cancer: a meta-analysis. European review for medical and pharmacological sciences, 21 (1), 120–130.
  • Ronot, M., et al., 2011. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology (baltimore, Md.), 53 (4), 1182–1191.
  • Shan, L., et al., 2015. Diagnostic value of circulating miR-21 for colorectal cancer: a meta-analysis. Cancer biomarkers : section A of disease markers, 15 (1), 47–56.
  • Shang, S., et al., 2012. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology (baltimore, Md.), 55 (2), 483–490.
  • Shao, Y.Y., et al., 2010. Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma. Cancer, 116 (19), 4590–4596.
  • Sturgeon, C.M., et al.,; National Academy of Clinical Biochemistry. 2010. National academy of clinical biochemistry laboratory medicine practice guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers. Clinical chemistry, 56 (6), e1–e48.
  • Suehiro, T., et al., 2017. Significance of serum exosomal miR-122 and miR-21 as a predictive biomarker in hepatocellular carcinoma patients who underwent transarterial chemoembolization. Journal of hepatology, 66 (1), S624–S624.
  • Tian, X.P., et al., 2019. Acidic microenvironment up-regulates exosomal mir-21 and mir-10b in early-stage hepatocellular carcinoma to promote cancer cell proliferation and metastasis. Theranostics, 9 (7), 1965–1979.
  • Tomimaru, Y., et al., 2012. Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. Journal of hepatology, 56 (1), 167–175.
  • Torre, L.A., et al., 2015. Global cancer statistics, 2012. CA: a cancer journal for clinicians, 65 (2), 87–108.
  • Venazzi, A., et al., 2018. Validity of the QUADAS-2 in assessing risk of bias in alzheimer's disease diagnostic accuracy studies. Frontiers in psychiatry, 9, 221.
  • Wang, J., et al., 2019. miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5. Oncology letters, 17 (2), 2221–2227.
  • Wang, M., et al., 2018. CircRNAs as biomarkers of cancer: a meta-analysis. BMC cancer, 18 (1), 303.
  • Wang, P., et al., 2017. Application of microdrop digital PCR in detection of serum miR-21 and miR-4429 in the diagnosis of liver cancer. Zhe jiang medicine, 39 (3), 923–932.
  • Wang, W.Y., et al., 2014. miR-21 expression predicts prognosis in hepatocellular carcinoma. Clinics and research in hepatology and gastroenterology, 38 (6), 715–719.
  • Wang, X., et al., 2015. Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC): clinical analyses of patients and an HCC rat model. International Journal of Clinical and Experimental Pathology, 8 (2), 1466–1478.
  • Wang, Y.C., et al., 2014. Golgi protein 73, not glypican-3, may be a tumor marker complementary to α-fetoprotein for hepatocellular carcinoma diagnosis. Journal of gastroenterology and hepatology, 29 (3), 597–602.
  • Wang, Z., et al., 2015. MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3. Biochemical and biophysical research communications, 464 (4), 1228–1234.
  • Wong, C.H., et al., 2006. The molecular diagnosis of hepatitis B virus-associated hepatocellular carcinoma. Critical reviews in clinical laboratory sciences, 43 (1), 69–101.
  • Wu, C., et al., 2020. Micro-RNA-21 rs1292037 A > G polymorphism can predict hepatocellular carcinoma prognosis (HCC), and plays a key role in cell proliferation and ischemia-reperfusion injury (IRI) in HCC cell model of IRI. Saudi medical journal, 41 (4), 383–392.
  • Xu, F., et al., 2015. The accuracy of circulating microRNA-21 in the diagnosis of colorectal cancer: a systematic review and meta-analysis. Colorectal disease, 17 (5), O100–O107.
  • Xu, J., et al., 2011. Circulating MicroRNAs, miR-21, miR-122, and miR-223, in Patients with Hepatocellular Carcinoma or Chronic Hepatitis. Molecular carcinogenesis, 50 (2), 136–142.
  • Yoon, J.S., et al., 2018. Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. Biomarkers in medicine, 12 (10), 1105–1114.
  • Yu, Z., and Cheng, A.S., 2013. Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma. Current pharmaceutical design, 19 (7), 1192–1200.
  • Zeng, Z., et al., 2013. Potential role of microRNA-21 in the diagnosis of gastric cancer: a meta-analysis. PLoS One, 8 (9), e73278.
  • Zhang, N., et al., 2019. Circulating miR-130b- and miR-21-based diagnostic markers and therapeutic targets for hepatocellular carcinoma. Molecular genetics & genomic medicine, 7 (12), e1012.
  • Zhu, Q., et al., 2012. miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular atocellular carcinoma. Oncology reports, 27 (5), 1660–1668.
  • Zhuang, C., et al., 2016. Serum miR-21, miR-26a and miR-101 as potential biomarkers of hepatocellular carcinoma. Clinics and research in hepatology and gastroenterology, 40 (4), 386–396.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.