Downregulation of fibrosis and inflammatory signalling pathways in rats liver viaPulicaria crispa aerial parts ethanol extract

References

• Abd-Alla, H.I., et al., 2016. Phytochemical composition, protective and therapeutic effect on gastric ulcer and α-amylase inhibitory activity of Achillea biebersteinii Afan. Archives of pharmacal research, 39 (1), 10–20.
   PubMed Web of Science ®Google Scholar
• Abdel-Moneim, A.M., et al., 2015. Free radical-scavenging, anti-inflammatory/anti-fibrotic and hepatoprotective actions of taurine and silymarin against CCl4 induced rat liver damage. PLoS one, 10 (12), e0144509.
   PubMed Web of Science ®Google Scholar
• Abdou, E.M., et al., 2019. Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl4 induced hepatotoxicity in rats. Scientific reports, 9 (1), 19779.
   PubMedGoogle Scholar
• Abiri, R., et al., 2018. Towards a better understanding of Artemisia vulgaris: botany, phytochemistry, pharmacological and biotechnological potential. Food research international, 109, 403–415.
   PubMed Web of Science ®Google Scholar
• Alam, M.F., et al., 2018. Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice. Experimental and molecular pathology, 105 (1), 81–88.
   PubMed Web of Science ®Google Scholar
• Al-Sayed, E., et al., 2014. Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice. Pharmaceutical biology, 52 (12), 1581–1590.
   PubMed Web of Science ®Google Scholar
• Bao, Y-l., et al., 2021. Animal and organoid models of liver fibrosis. Frontiers in physiology, 12, 666138.
   PubMed Web of Science ®Google Scholar
• Boulos, L., 2002. Flora of Egypt VII. [ISBN-13: 9789775429223]. Cairo, Egypt: Al Hadara Publishing.
   Google Scholar
• Bradford, M.M., 1976. A rapid and sensitivemethod for the quantitation ofmicrogram quantities of protein utilizingthe principle of protein-dye binding. Analytical biochemistry, 72, 248–254.
   PubMed Web of Science ®Google Scholar
• Brautbar, N. and Williams, J., 2002. Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. International journal of hygiene and environmental health, 205 (6), 479–491.
   PubMed Web of Science ®Google Scholar
• Buege, J.A. and Aust, S.D., 1978. Microsomal lipid peroxidation. Meth enzymol, 52, 302–310.
   PubMedGoogle Scholar
• Cho, J.Y., et al., 2000. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. European journal of pharmacology, 398 (3), 399–407.
   PubMed Web of Science ®Google Scholar
• Dogra, N.K., Kumar, S. and Kumar, D., 2020. Vernonia anthelmintica (L.) Willd.: an ethnomedicinal, phytochemical, pharmacological and toxicological review. Journal of ethnopharmacology, 256, 112777.
   PubMed Web of Science ®Google Scholar
• El Gibali, M. A., 1988. Studies on the flora of northern Sinai. Thesis (M.Sc.). Cairo University.
   Google Scholar
• Emam, M.A., Khattab, H.I. and Hegazy, M.G., 2019. Assessment of anticancer activity of Pulicaria undulata on hepatocellular carcinoma HepG2 cell line. Tumour biology, 41 (10), 1010428319880080.
   Google Scholar
• Evans, W. C., 2006. Trease and Evans pharmacognosy. 15th ed. New Delhi: Rajkamal Electric Press.
   Google Scholar
• Fahmi, A.A., et al., 2019a. Pulicaria crispa mitigates gastric ulcer induced by ethanol in rats: role of treatment and auto healing. Biomarkers, 24 (3), 286–289.
   PubMed Web of Science ®Google Scholar
• Fahmi, A.A., et al., 2019b. Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats. Heliyon, 5 (3), e01359.
   PubMed Web of Science ®Google Scholar
• Fattori, V., et al., 2018. Budlein, A. sesquiterpene lactone from Viguiera robusta, alleviates pain and inflammation in a model of acute gout arthritis in mice. Frontiers in pharmacology, 9, 1076.
   PubMed Web of Science ®Google Scholar
• Goodman, Z.D., 2007. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. Journal of hepatology, 47 (4), 598–607.
   PubMed Web of Science ®Google Scholar
• Hamid, M., et al., 2017. Amelioration of CCl4-induced liver injury in rats by selenizing Astragalus polysaccharides: role of proinflammatory cytokines, oxidative stress and hepatic stellate cells. Research in veterinary science, 114, 202–211.
   PubMed Web of Science ®Google Scholar
• Han, H., et al., 2019. Plant sterol ester of α-linolenic acid attenuates nonalcoholic fatty liver disease by rescuing the adaption to endoplasmic reticulum stress and enhancing mitochondrial biogenesis. Oxidative medicine and cellular longevity, 2019, 8294141.
   PubMed Web of Science ®Google Scholar
• Harborne, J. B., 1998. Phytochemical methods – a guide to modern techniques of plant analysis. London: Chapman and Hall.
   Google Scholar
• Helal, N.M., Ibrahim, N.A. and Khattab, H., 2019. Phytochemical analysis and antifungal bioactivity of Pulicaria undulata (L.) methanolic extract and essential oil. Egyptian journal of botany, 59 (3), 827–844.
   Web of Science ®Google Scholar
• Hind, D.J.N., and Boulos, L., 2002. Four new combinations in Pulicaria (Compositae: Inuleae). Kew bulletin, 57 (2), 495–498.
   Google Scholar
• Huang, C.C., et al., 2013. Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis. Journal of nutritional biochemistry, 24 (3), 516–530.
   PubMed Web of Science ®Google Scholar
• Hussain, T., et al., 2016. Oxidative stress and inflammation: what polyphenols can do for us? Oxidative medicine and cellular longevity, 2016, 7432797.
   PubMed Web of Science ®Google Scholar
• Hussein, S.R., et al., 2017. Phenolic constituents of Pulicaria undulata (L.) C.A. Mey. sub sp. undulata (Asteraceae): antioxidant protective effects and chemosystematic significances. Journal of food and drug analysis, 25 (2), 333–339.
   PubMed Web of Science ®Google Scholar
• Iwai, M., et al., 2000. Biological significance of AFP expression in liver injury induced by CCl4. Acta histochemica ET cytochemica, 33 (1), 17–22.
   Web of Science ®Google Scholar
• James, L.P., et al., 2003. Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free radical research, 37 (12), 1289–1297.
   PubMed Web of Science ®Google Scholar
• Kreczko, S., Lipska, A. and Wysocka, J., 2000. Alpha-fetoprotein: diagnostic value in hepatic disorders. Polski merkuriusz lekarski, 8 (48), 420–423.
   PubMedGoogle Scholar
• Lamia, S.S., et al., 2021. Coenzyme Q10 and silymarin reduce CCl4-induced oxidative stress and liver and kidney injury in ovariectomized rats – implications for protective therapy in chronic liver and kidney diseases. Pathophysiology, 28 (1), 50–63.
   Google Scholar
• Li, F., et al., 2018. Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors. Food and chemical toxicology, 120, 104–111.
   PubMed Web of Science ®Google Scholar
• Maghraby, A.S., et al., 2010. Immunostimulatory effects of extract of Pulicaria crispa before and after Schistosoma mansoni infection. Acta pol pharm, 67 (1), 75–79.
   PubMed Web of Science ®Google Scholar
• Mahmoodzadeh, Y., Mazani, M. and Rezagholizadeh, L., 2017. Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in rats. Toxicology reports, 4, 455–462.
   PubMed Web of Science ®Google Scholar
• Mannaa, F.A. and Abdel-Wahhab, K.G., 2016. Physiological potential of cytokines and liver damages. Hepatoma research, 2 (6), 131–143.
   Google Scholar
• Marsillach, J., et al., 2009. Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. BMC gastroenterology, 9 (1), 3.
   PubMedGoogle Scholar
• Mohamed, E.A., Muddathir, A.M. and Osman, M.A., 2020. Antimicrobial activity, phytochemical screening of crude extracts, and essential oils constituents of two Pulicaria spp. growing in Sudan. Scientific reports, 10 (1), 17148.
   PubMed Web of Science ®Google Scholar
• Mohamed, N.M., et al., 2014. CCl4-induced hepatonephrotoxicity: protective effect of nutraceuticals on inflammatory factors and antioxidative status in rat. Journal of applied pharmaceutical science, 4 (02), 087–100.
   Google Scholar
• Morio, L.A., et al., 2001. Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicology and applied pharmacology, 172 (1), 44–51.
   PubMed Web of Science ®Google Scholar
• Moron, M.S., Depierre, J.W. and Mannervik, B., 1979. Level of glutathione, glutathione reductase and glutathone-S-transferase activities in rat lung and liver. Biochimica et biophysica acta, 582 (1), 67–78.
   PubMed Web of Science ®Google Scholar
• Moshage, H., et al., 1995. Nitrite and nitrate determination in plasma: a criticalevaluyation. Clinical chemistry, 41 (6 Pt 1), 892–896.
   PubMed Web of Science ®Google Scholar
• Motawi, T.K., et al., 2011. Zingiber officinale acts as a nutraceutical agent against liver fibrosis. Nutrition & metabolism, 8, 40–50.
   PubMed Web of Science ®Google Scholar
• Nishikimi, M., Appaji Rao, N. and Yagi, K., 1972. The occurrence of superoxide anion in the action of reducedphenazine methosulphate and molecular oxygen. Biochemical and biophysical research communications, 46 (2), 849–853.
   PubMed Web of Science ®Google Scholar
• Razavi, B.M. and Karimi, G., 2016. Protective effect of silymarin against chemical induced cardiotoxicity. Iranian journal of basic medical sciences, 19, 916–923.
   PubMed Web of Science ®Google Scholar
• Sang, R., et al., 2019. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artificial cells, nanomedicine, and biotechnology, 47 (1), 3929–3937.
   PubMed Web of Science ®Google Scholar
• Shah, M.D., et al., 2015. Antioxidative and chemopreventive effects of Nephrolepis biserrata against carbon tetrachloride (CCl4)-induced oxidative stress and hepatic dysfunction in rats. Pharmaceutical biology, 53 (1), 31–39.
   PubMed Web of Science ®Google Scholar
• Siedle, B., et al., 2003. The effect of sesquiterpene lactones on the release of human neutrophil elastase. Biochemical pharmacology, 65 (5), 897–903.
   PubMed Web of Science ®Google Scholar
• Sülsen, V.P., et al., 2017. Potential of terpenoids and flavonoids from asteraceae as anti-inflammatory, antitumor, and antiparasitic agents. Evidence-based complementary and alternative medicine 2017, 6196198.
   PubMed Web of Science ®Google Scholar
• Suzuki, H., and Suzuki, K., 1998. Rat hypoplastic kidney (hpk/hpk) induces renal anemia, hyperparathyroidism, and osteodystrophy at the end stage of renal failure. The journal of veterinary medical science, 60 (10), 1051–1058.
   PubMed Web of Science ®Google Scholar
• Tochukwu, N., et al., 2018. Curative and protective efficacy of Cassia occidentalis ethanolic leaf extract on carbon tetrachloride induced liver damage of female albino Wistar rats. EC clinical & experimental anatomy, 2 (2018), 48–61.
   Google Scholar
• Wang, C., Geng, Q., and Wang, Y., 2012. Protective effect of atractylenolide I on immunological liver injury. Zhongguo zhong yao Za zhi, 37 (12), 1809–1813.
   PubMedGoogle Scholar
• Wang, X., et al., 2018. Alpha-fetoprotein as a predictive marker for patients with hepatitis B-related acute-on-chronic liver failure. Canadian journal of gastroenterology & hepatology, 2018, 1232785.
   PubMed Web of Science ®Google Scholar
• Yusufoglu, H.S., 2014. Analgesic, antipyretic, anti-inflammatory, hepatoprotective and nephritic effects of the aerial parts of Pulicaria arabica (Family: Compositae) on rats. Asian pacific journal of tropical medicine, 7, S583–S590.
   Web of Science ®Google Scholar
• Yuvaraj, P. and Subramoniam, A., 2009. Hepatoprotective property of Thespesia populnea against carbon tetrachloride inducedliver damage in rats. Journal of basic and clinical physiology and pharmacology, 20 (2), 169–177.
   PubMedGoogle Scholar
• Zhou, D., et al., 2010. Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. Journal of ethnopharmacology, 129 (2), 232–237.
   PubMed Web of Science ®Google Scholar