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Original Articles

Bioactive compounds and therapeutic role of Brassica oleracea L. seeds in rheumatoid arthritis rats via regulating inflammatory signalling pathways and antagonizing interleukin-1 receptor action

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Pages 788-807 | Received 26 Aug 2021, Accepted 23 Oct 2021, Published online: 24 Nov 2021

References

  • Aboutabl, M., and Abd El-Hamid, W., 2015. Analgesic and anti-inflammatory activities of certain 6-aryl-9-substituted-6,9-diazaspiro-[4,5]decane-8,10-diones in mice. Egyptian pharmaceutical journal, 14 (3), 196–203.
  • Aboutabl, M.E., et al., 2021. Anti-inflammatory and analgesic activities of 7-chloro-4-(piperazin-1-yl) quinoline derivative mediated by suppression of inflammatory mediators expression in both RAW 264.7 and mouse models. Pharmaceutical Sciences. 27, 326–338.
  • Abo-Zeid, M.A.M., et al., 2018. Flavonoid fraction of Cajanus cajan prohibited the mutagenic properties of cyclophosphamide in mice in vivo. Mutation research. Genetic toxicology and environmental mutagenesis, 826, 1–5.
  • Adler, I.D., 1984. Cytogenetic tests in mammals. In: S. Venitt, J.M. Parry, eds. Mutagenicity testing, a practical approach. Oxford: IRL Press, 275–306.
  • Agrawal, P.K., and Bansal, M.C., 1989. Flavanoid glycosides. In: P.K. Agrawal, Editor. 13C-NMR of flavonoids. New York: Elsevier, 283–364.
  • Ahmed, M.F., et al., 2012. Phytochemical studies and antioxidant activities of Brassica oleracea L. Var. Capitata. International journal of pharmacy and pharmaceutical sciences, 4, 374–378.
  • Ahmed, O.M., et al., 2017. Ulva lactuca hydroethanolic extract suppresses experimental arthritis via its anti-inflammatory and antioxidant activities. Beni-Suef Univ. Journal of basic applied science, 6, 394–408.
  • Akramas, L., et al., 2017. Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats. Turkish journal of veterinary and animal sciences, 41, 748–756.
  • Alam, N., Rahman, M.M., and Ibrahim Khalil, I., 2014. Nutraceuticals in arthritis management: a contemporary prospect of dietary phytochemicals. The open nutraceuticals journal, 7 (1), 1–27.
  • Alam, W., et al., 2020. Kaempferol as a dietary anti-inflammatory agent: current therapeutic standing. Molecules, 25 (18), 4073.
  • Al-Wakeel, S.A.M., El-Garf, I.A., and Saleh, N.A.M., 1988. Distribution of flavonoids in Fagonia thebaica complex. Biochemical systematics and ecology, 16 (1), 57–58.
  • Antunes-Ricardo, M., et al., 2015. Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. BioMed research international, 2015, 1–9.
  • Banu Rekha, J., Kumar, M., and Jaykar, B., 2019. Isolation and characterization of gallic acid from the ethanolic extract of leaves of Buta monosperma (LAMB). International research journal of pharmacy, 10 (2), 114–117.
  • Beck, M.-A., and Haberlein, H., 1999. Flavonol glycosides from Eschscholtzia californica. Phytochemistry, 50 (2), 329–332.
  • Bendele, A.M., et al., 2000. Combination benefit of treatment with the cytokine inhibitors interlukin-1- receptor antagonist and PE gylated soluble tumor necrosis factor type I in animal model of rheumatoid arthritis. Arthritis and rheumatism, 43 (12), 2648–2659.
  • Bhalekar, M.R., et al., 2016. A comparative study of oral and topical administration of hesperidin lipid nanoparticles in rheumatoid arthritis. Austin Arthritis, 1, 1010.
  • Bozbaş, G.T., et al., 2018. Effect of ozone in Freund’s complete adjuvant-induced arthritis. Arthritis and rheumatism, 33, 137.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitationof microgram quantities of protein utilizing the principle of protein dye binding. Analytical biochemistry, 72 (1–2), 248–254.
  • Buchs, N., et al., 2001. IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels. Genes and immunity, 2 (4), 222–228.
  • Buege, J.A., and Aust, S.D., 1978. Microsomal lipid peroxidation. Meth enzymol, 52, 302–310.
  • Burger, W., Ewald, C., and Fenner, E.-M., 1998. Increase in C-reactive protein in the serum of piglets (pCRP) following ACTH or corticosteroid administration. Zentralblatt fur veterinarmedizin. Reihe B [Journal of veterinary medicine. Series B], 45 (1), 1–6.
  • Cardoso, C.A.L., et al., 2013. Phenolic compounds and antioxidant, antimicrobial and antimycobacterial activities of Serjania erecta Radlk. (Sapindaceae). Brazilian journal of pharmaceutical sciences, 49, 776–782.
  • Dai, M.M., et al., 2014. Effects and mechanisms of geniposide on rats with adjuvant arthritis. International immunopharmacology, 20 (1), 46–53.
  • El -Alfy, N.Z.I., et al., 2016. Genotoxic effect of methotrexate on bone marrow chromosomes and DNA of male albino mice (Mus musculus). The Egyptian journal of hospital medicine, 64, 350–363.
  • Elgindi, M.R., et al., 2015. Phytochemical and biological investigation of the leaves of Ravenea rivularis (Arecaceae). Journal of pharmacognosy and phytochem, 4, 72–78.
  • Elshama, S.S., et al., 2014. Amelioration of indomethacin systemic toxicity by gum arabic administration in adult albino rats. International Journal of Medicinal Plants and Alternative Medicine, 2, 032–046.
  • El-Toumy, S.A., et al., 2010. Phytochemical and antimicrobial studies on Acacia saligna leaves. Egyptian journal of chemistry, 53, 705–717.
  • Fattahi, M.J., and Mirshafiey, A., 2012. Prostaglandins and rheumatoid arthritis. Arthritis, 2012, 239310.
  • Fikry, E.M., et al., 2019. Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis. biomedecine & pharmacotherapie [Biomedicine & pharmacotherapy], 110, 878–886.
  • Firestein, G.S., Yeo, M., and Zvaifler, N.J., 1995. Apoptosis in rheumatoid arthritis synovium. The journal of clinical investigation, 96 (3), 1631–1638.
  • Fonseca, L.J.S., et al., 2019. Oxidative stress in rheumatoid arthritis: What the future might hold regarding novel biomarkers and add-on therapies. Oxidtive medicine and cellular longevity, 2019, 1–16.
  • Franco-Ramos, R.S., et al., 2020. Evaluation of anti-cytotoxic and anti-genotoxic effects of Nigella sativa through a micronucleus test in BALB/c mice. Nutrients, 12 (5), 1317.
  • Fu, Y., et al., 2016. Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats. Acta pharmacologica sinica, 37 (11), 1467–1480.
  • García-González, A., Gaxiola-Robles, R., and Zenteno-Savín, T., 2015. Oxidative stress in patients with rheumatoid arthritis. Revista de investigacion clinica; organo del hospital de enfermedades de la nutricion, 67 (1), 46–53.
  • Georgeta, S., et al., 2016. The isolation and identification of rutin from pharmaceutical products. Analele Universitații din Oradea, Fascicula: Ecotoxicologie, Zootehnie și Tehnologii de Industrie Alimentara, 15, 2–7.
  • Gibb, R.K., et al., 1997. Apoptosis as a measure of chemosensitivity to cisplatin and taxol therapy in ovarian cancer cell lines. Gynecology and Oncology, 65, 13–22.
  • Hajizadeh, S., et al., 2003. Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis. Arthritis Research and Therapy, 5, 1–7.
  • Hallegua, D.S., and Weisman, M.H., 2002. Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases. Annals of the rheumatic diseases, 61 (11), 960–967.
  • Hamed, M.A., et al., 2012. In vitro and in vivo assessment of some functional foods against initiation of hepatocellular carcinoma. Journal of Basic and Applied Scientific Research, 2, 471–483.
  • Hassan, E.M., et al., 2016. Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities of Cajanus cajan l. Seeds cultivated in Egypt and its phytochemical composition. Pharmaceutical biology, 54 (8), 1380–1391.
  • Hawas, U.W., et al., 2009. Evaluation of Antiulcer of Chenopodium moquinianum and Kaempferol Glycosides in Rats. World journal of chemistry, 4, 73–82.
  • Hirvonen, H., et al., 2017. The effect of cryotherapy on total antioxidative capacity in patients with active seropositive rheumatoid arthritis. Rheumatology international, 37 (9), 1481–1487.
  • Huber, L.C., et al., 2006. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology, 45 (6), 669–675.
  • Joseph, B., and Raj, S.J., 2010. Pharmacognostic and phytochemical properties of aloe vera linn–an overview. International journal of pharmaceutical science review and research, 4, 106–110.
  • Kapusta-Duch, J., et al., 2012. The beneficial effects of Brassica vegetables on human health. Roczniki panstwowego zakladu higieny, 63 (4), 389–395.
  • Kay, J., and Calabrese, L., 2004. The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology, 43 (suppl_3), iii2–iii9.
  • Khalil, W.K.B., and Booles, H.F., 2011. Protective role of selenium against over-expression of cancer-related apoptotic genes induced by o-cresol in rats. Arhiv za higijenu rada i toksikologiju, 62 (2), 121–129.
  • Kinne, R.W., et al., 2001. Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis,osteoarthritis, and other inflammatory joint diseases. Arthritis research, 3 (5), 319–330.
  • Koohpeyma, H., et al., 2020. Folic acid protects rat cerebellum against oxidative damage caused by homocysteine: the expression of Bcl-2, Bax, and caspase-3 apoptotic genes. Neurotoxicity research, 37 (3), 564–577.
  • Kuligowska, M., and Odrowaz-Sypniewska, G., 2004. Role of interleukin-17 in cartilage and bone destruction in rheumatoid arthritis. Ortopedia traumatologia rehabilitacja, 6, 235–241.
  • Larsson, E., et al., 2004. Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP. Rheumatology, 43 (4), 428–434.
  • Laste, G., et al., 2014. Histopathological changes in three variations of Wistar rat adjuvant-induced arthritis model. Internationtal Journal of Pharmaceutical Research Scholar, 3, 780–790.
  • Li, Y., et al., 2019. Apoptotic effect of Aralia echinocaulis extract on fibroblast-like synoviocytes in rats with adjuvant-induced arthritis via inhibiting the Akt/Hif-1α signaling pathway in vitro. Journal of pharmacological sciences, 139 (4), 340–340e345.
  • Li, Y., et al., 2016. Quercetin, inflammation and immunity. Nutrients, 8 (3), 167.
  • Linjawi, S.A.A., Khalil, W.K.B., and Salem, L.M., 2014. Detoxified Jatrpha curcas kernel meal impact against benzene-induced genetic toxicity in male rats. International journal of pharmaceutics, 4, 57–66.
  • Liu, H., et al., 2010. Flavonoids from Halostachys caspica and their antimicrobial and antioxidant activities. Molecules, 15 (11), 7933–7945.
  • Lu, T., et al., 2002. Participation of the conventional calpains in apoptosis. Biochimica et biophysica acta, 1590 (1–3), 16–26.
  • Mabry, T.J., Markham, K.R., and Thomas, M.B., 1970. The systematic identification of flavonoids. New York, Springer, 35–109.
  • MacNaul, K.L., et al., 1990. Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization. Journal of immunology, 145 (12), 4154–4166.
  • Madhyastha, S., et al., 2008. Comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow. Clinics, 63 (6), 821–826.
  • Madrigal-Bujaidar, E., et al., 1998. In vivo and in vitro antigenotoxic effect of nordihydroguaiaretic acid against SCEs induced by methyl methanesulfonate. Mutation research/genetic toxicology and environmental mutagenesis, 419 (1–3), 163–168.
  • Makris, D.P., et al., 2008. Characterization of certain major polyphenolic antioxidants in grape (Vitis vinifera) stems by liquid chromatography-mass spectrometry. European food research and technology, 226 (5), 1075–1079.
  • Manivannan, R., and Shopna, R., 2015. Isolation of Quercetin and Isorhamnetin Derivatives and evaluation of anti-microbial and anti-inflammatory activities of Persicaria glabra. Natural product sciences, 21, 170–175.
  • Markham, K. R., and Geiger, H., 1986. 1H Nuclear magnetic resonance spectroscopy of flavonoids and their glycosides hexa deutero dimethyl sulfoxide. In: J.B. Harborne, ed. The flavonoids, advances in research since. London: Chapman & Hall, 441473.
  • Moron, M.S., Depierre, J.W., and Mannervik, B., 1979. Level of glutathione, glutathione reductase and glutathone-S-transferase activities in rat lung and liver. Biochimica et biophysica acta, 582 (1), 67–78.
  • Motawi, T.K., et al., 2020. Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model. Molecular and cellular biochemistry, 465 (1–2), 89–102.
  • Navarro-Hernandeza, R.E., et al., 2009. Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity. Association with genetic polymorphisms. Disease markers, 26 (3), 119–126.
  • Nishikimi, M., Appaji Rao, N., and Yagi, K., 1972. The occurrence of superoxide anion in the action of reduced phenazine methosulphate and molecular oxygen. Biochemical and biophysical research communications, 46 (2), 849–853.
  • Orr, C.K., et al., 2018. The utility and limitations of CRP, ESR and DAS28-CRP in appraisingdisease activity in rheumatoid arthritis. Frontiers in medicine, 5, 185.
  • Pope, J.E., and Choy, E.H., 2021. C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Seminars in arthritis and rheumatism, 51 (1), 219–229.
  • Prabowo, S., 2019. CoSCI – PBBMI, IOP Conf. Series: earth and environmental broccoli extract (Brassica oleracea) decrease periarticular malondialdehyde level and disease activity score in rats (Rattus norvegicus) with adjuvant arthritis. Science, 217, 012046.
  • Ramírez-Pérez, S., et al., 2017. High expression of interleukine-1 receptor antagonist in rheumatoid arthritis: Association with IL1RN*2/2 genotype. Autoimmunity, 50 (8), 468–475.
  • Ramos-Remus, C., Dorazco-Barragan, G., and Aceves-Avila, F.J., 2002. Genotoxicity assessment using micronuclei assay in rheumatoid arthritis patients. Clinical and experimental rheumatology, 20, 208–212.
  • Ren, S.-X., et al., 2019. Mechanistic evaluation of anti-arthritic activity of β-methylphenylalanine inexperimental rats. Biomedicine & pharmacotherapy, 113, 108730.
  • Rokayya, S., et al., 2013. Cabbage (Brassica oleracea L. var. capitata) Phytochemicals with antioxidant and anti-inflammatory potential. Asian Pac. Journal of cancer prevention, 14, 6657–6662.
  • Ross, A.D., et al., 2004. Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase. Arthritis & rheumatism, 50 (11), 3702–3711.
  • Rossi, M., et al., 2019. Acylated flavonoid glycosides are the main pigments that determine the flower colour of the Brazilian native tree Tibouchina pulchra (Cham.) Cogn. Molecules, 24, 718.
  • Ryou, S.H., et al., 2021. Brassica oleracea var. capitata L. alleviates indomethacin induced acute gastric injury by enhancing anti-inflammatory and antioxidant activity. Processes, 9 (2), 372.
  • Saleh, N.A.M., El-Hadidi, M.N., and Al-Wakeel, S.A.M., 1990. Phytochemistry and phylogenetic affinities among Egyptian species of Fagonia. Biochemical systematics and ecology, 18 (1), 49–52.
  • Schiff, M.H., 2000. Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis. Ann. Rheum. Dis, 59, i103–i108.
  • Schmid, W., 1976. The Micronucleus Test for Cytogenetic Analysis In: A. Hollaender, ed. Chemical mutagenesis, principals and methods for their detection. New York: Plenum Press, 31–53.
  • Sharma, D., Chaubey, P., and Suvarna, V., 2021. Role of natural products in alleviation of rheumatoid arthritis—a review. Journal of food biochemistry, 45 (4), e13673.
  • Silman, A.J., and Pearson, J.E., 2002. Epidemiology and genetics of rheumatoid arthritis. Arthritis research, 4 (Suppl 3), S265–S272.
  • Sims, J.E., et al., 1993. Interleukin 1 signaling occurs exclusively via the type I receptor. Proceedings of the national academy of sciences of the United States of America, 90 (13), 6155–6159.
  • Smallwood, M.J., et al., 2018. Oxidative stress in autoimmune rheumatic diseases. Free radical biology and medicine, 125, 3–14.
  • Snekhalatha, U., et al., 2013. Evaluation of complete Freund’s adjuvant-induced arthritis in a Wistar rat model comparison of thermography and histopathology. Zeitschrift für rheumatologie, 72 (4), 375–382.
  • Sucajtys-Szulc, E., et al., 2018. Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure. Molecular and cellular biochemistry, 446 (1–2), 11–23.
  • Szekanecz, Z., and Koch, A.E., 2007. Mechanisms of disease: ANGIOGENESIS in inflammatory diseases. Nature clinical practice rheumatology, 3 (11), 635–643.
  • Tak, P.P., et al., 2000. Apoptosis and p53 expression in rat adjuvant arthritis. Arthritis research, 2 (3), 229–235.
  • Tang, M.K., and Zhang, J.T., 2000. Caspase and its effects on apoptosis. Bulletin of medical research, 29, 9e13.
  • Tang, Y., et al., 2000. Flavonoid glycosides from leaves of Ginkgo biloba. Acta pharmacologica sinica, 35, 363–366.
  • Tetik, S., et al., 2010. Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarthritis patients. Indian Journal of Biochemistry and Biophysics, 47, 353–358.
  • Torres-Bugarin, O., et al., 2015. Genotoxic effect in autoimmune diseases evaluated by the micronucleus test assay; our experience and literature review. Biomed research international, 2015, 1–11.
  • Wang, J., et al., 2010. Preparative separation of phenolic compounds from Halimodendron halodendron by high-speed counter-current chromatography. Molecules, 15 (9), 5998–6007.

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