1,805
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Validation of host cerebrospinal fluid protein biomarkers for early diagnosis of tuberculous meningitis in children: a replication and new biosignature discovery study

, ORCID Icon, , ORCID Icon, , , , , , ORCID Icon, ORCID Icon & show all
Pages 549-561 | Received 03 Feb 2022, Accepted 24 Apr 2022, Published online: 12 May 2022

References

  • Ahmad, R., et al., 2019. A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough. Science translational medicine, 11 (515), eaaw8287.
  • Bahr, N.C., Nuwagira, E., et al., 2018. Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study. The lancet. Infectious diseases, 18 (1), 68–75.
  • Bahr, N.C., Halupnick, R., et al., 2018. Delta-like 1 protein, vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis. Biomarkers in medicine, 12 (7), 707–716.
  • Bahr, N.C., and Boulware, D.R., 2014. Methods of rapid diagnosis for the etiology of meningitis in adults. Biomarkers in medicine, 8 (9), 1085–1103.
  • Bahr, N.C., Meintjes, G., and Boulware, D.R., 2019. Inadequate diagnostics: the case to move beyond the bacilli for detection of meningitis due to Mycobacterium tuberculosis. Journal of medical microbiology, 68 (5), 755–760.
  • Chegou, N.N., et al., 2016. Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB. Thorax, 71 (9), 785–794.
  • Chen, Y., et al., 2016. HMGB1 level in cerebrospinal fluid as a complimentary biomarker for the diagnosis of tuberculous meningitis. SpringerPlus, 5 (1), 1775–1775.
  • Chendi, B.H., et al., 2021. A plasma 5-marker host biosignature identifies tuberculosis in high and low endemic countries. Frontiers in immunology, 12, 608846.
  • Chiang, S.S., et al., 2014. Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis. The lancet. Infectious diseases, 14 (10), 947–957.
  • Chin, J.H., et al., 2019. Xpert MTB/RIF ultra for detection of mycobacterium tuberculosis in cerebrospinal fluid. Journal of clinical microbiology, 57 (6), e00249–19.
  • Cresswell, F.V., et al., 2020. Xpert MTB/RIF ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study. The lancet infectious diseases, 20 (3), 308–317.
  • Creswell, J., et al., 2014. Results from early programmatic implementation of Xpert MTB/RIF testing in nine countries. BMC infectious diseases, 14 (1), 2.
  • Flier, M. v d., et al., 2004. Vascular endothelial growth factor and blood-brain barrier disruption in Tuberculous meningitis. The pediatric infectious disease journal, 23 (7), 608–613.
  • Fluss, R., Faraggi, D., and Reiser, B., 2005. Estimation of the Youden Index and its associated cutoff point. Biom J, 47 (4), 458–472.
  • Husain, N., et al., 2008. Vascular endothelial growth factor as a marker of disease activity in neurotuberculosis. Journal of infection, 56 (2), 114–119.
  • Ingram, G., et al., 2012. Systemic complement profiling in multiple sclerosis as a biomarker of disease state. Multiple sclerosis journal, 18 (10), 1401–1411.
  • Isaiah, S., et al., 2020. Overview of brain-to-gut axis exposed to chronic CNS Bacterial Infection(s) and a predictive urinary metabolic profile of a brain infected by Mycobacterium tuberculosis. Frontiers in neuroscience, 14, 296–296.
  • Jacobs, R., et al., 2016a. Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response. Oncotarget, 7 (36), 57581–57592.
  • Jacobs, R., et al., 2016b. Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment. Cytokine, 81, 50–56.
  • Karande, S., et al., 2005. Tuberculous meningitis and HIV. The indian journal of pediatrics, 72 (9), 755–760.
  • Kim, J., et al., 2016. Procalcitonin as a diagnostic and prognostic factor for Tuberculosis Meningitis. Journal of clinical neurology, 12 (3), 332–339.
  • Lawn, S.D., and Nicol, M.P., 2011. Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future microbiology, 6 (9), 1067–1082.
  • Li, N., et al., 2017. Association between C4, C4A, and C4B copy number variations and susceptibility to autoimmune diseases: a meta-analysis. Scientific reports, 7 (1), 42628.
  • MacLean, E., et al., 2019. A systematic review of biomarkers to detect active tuberculosis. Nature microbiology, 4 (5), 748–758.
  • Manyelo, C.M., et al., 2019a. Application of cerebrospinal fluid host protein biosignatures in the diagnosis of Tuberculous meningitis in children from a high burden setting. Mediators of inflammation, 2019, 1–11.
  • Manyelo, C.M., et al., 2019b. Potential of Host Serum Protein Biomarkers in the Diagnosis of Tuberculous Meningitis in Children. Frontiers in pediatrics, 7, 376–376.
  • Marais, S., et al., 2010. Tuberculous meningitis: a uniform case definition for use in clinical research. The lancet. Infectious diseases, 10 (11), 803–812.
  • Matsuyama, W., et al., 2001. Expression of vascular endothelial growth factor in tuberculous meningitis. Journal of the neurological sciences, 186 (1–2), 75–79.
  • Merle, N.S., et al., 2015. Complement system Part I – molecular mechanisms of activation and regulation. Frontiers in immunology, 6, 262.
  • Misra, U.K., et al., 2013. Vascular endothelial growth factor in tuberculous meningitis. Int J Neurosci, 123 (2), 128–132.
  • Misra, U.K., et al., 2010. A study of cytokines in tuberculous meningitis: clinical and MRI correlation. Neuroscience letters, 483 (1), 6–10.
  • Mutavhatsindi, H., et al., 2021. Validation and optimization of host immunological bio-signatures for a point-of-care test for TB disease. Frontiers in immunology, 12, 607827.
  • Nhu, N.T.Q., et al., 2014. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. Journal of clinical microbiology, 52 (1), 226–233.
  • Patel, V.B., et al., 2013. Diagnostic Accuracy of Quantitative PCR (Xpert MTB/RIF) for Tuberculous Meningitis in a high burden setting: a prospective study. PLoS medicine, 10 (10), e1001536.
  • Peng, T., et al., 2014. Detection of Delta-like 1 ligand for the diagnosis of tuberculous meningitis: an effective and rapid diagnostic method. J Int Med Res, 42 (3), 728–736.
  • Pormohammad, A., et al., 2019. A systematic review and meta-analysis of the diagnostic accuracy of nucleic acid amplification tests for Tuberculous meningitis. Journal of clinical microbiology, 57 (6), e01113–18.
  • Reshi, Z., et al., 2017. Cerebrospinal fluid procalcitonin as a biomarker of bacterial meningitis in neonates. Journal of perinatology, 37 (8), 927–931.
  • Seddon, J.A., and Thwaites, G.E., 2019. Tuberculous meningitis: new tools and new approaches required. Wellcome open research, 4, 181.
  • Solomons, R., et al., 2016. IMCI indicators of childhood TBM at primary health care level in the Western Cape Province of South Africa. The international journal of tuberculosis and lung disease, 20 (10), 1309–1313.
  • Solomons, R.S., et al., 2015. Chest radiograph findings in children with tuberculous meningitis. The international journal of tuberculosis and lung disease, 19 (2), 200–204.
  • Sudbury, E.L., et al., 2019. Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting. Journal of clinical tuberculosis and other mycobacterial diseases, 16, 100102.
  • Thwaites, G., et al., 2002. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. The lancet, 360 (9342), 1287–1292.
  • Visser, D.H., et al., 2015. Host immune response to tuberculous meningitis. Clin Infect Dis, 60 (2), 177–187.
  • Wang, H., and Liu, M., 2021. Complement C4, infections, and autoimmune diseases. Frontiers in immunology, 12, 694928.
  • Wei, T.-T., et al., 2016. Diagnostic accuracy of procalcitonin in bacterial meningitis versus nonbacterial meningitis: a systematic review and meta-analysis. Medicine, 95 (11), e3079.
  • World Health Organization. 2021. Global tuberculosis report 2021. Geneva: World Health Organisation.
  • World Health Organization. 2018. Roadmap towards ending TB in children and adolescents, second edition. Geneva: World Health Organization.
  • World Health Organization, 2017. Next-generation Xpert® MTB/RIF Ultra assay recommended by WHO [online]. Available from: https://www.who.int/news/item/25-03-2017-next-generation-xpert-mtb-rif-ultra-assay-recommended-by-who [Accessed 8 Jun 2021].
  • World Health Organization. 2014., High-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. Geneva, Switzerland: World Health Organization.
  • Xu, D., et al., 2015. Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics, 15 (1), 58–67.