Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons

References

• Bajetto A, Bonavia R, Barbero S, Piccioli P, Costa A, Florio T, Schettini G (1999). Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. 1 Neurochem 73: 2348–2357.
   PubMed Web of Science ®Google Scholar
• Berger JR, Arendt G (2000). HIV dementia: The role of the basal ganglia and dopaminergic systems. I Psychophar-macol 14: 214–221.
   PubMed Web of Science ®Google Scholar
• Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001). CXCR4-activated astrocyte gluta-mate release via TNFa: Amplification by microgli trig-gers neurotoxicity. Nat Neurosci 4: 702–710.
   PubMed Web of Science ®Google Scholar
• Bird P, Gething MJ, Sambrook J (1987). Translocation in yeast and mammalian cells: Not all signal sequences are functionally equivalent. I Cell Biol 105: 2905–2914.
   Google Scholar
• Epstein LG, Gendelman HE (1993). Human immunodefi-ciency virus type 1 infection of the nervous system: Pathogenic mechanisms. Ann Neurol 33: 429–436.
   PubMed Web of Science ®Google Scholar
• Gabuzd a D, Wang J (2000). Chemokine receptors and mech-anisms of cell death in HIV neuropathogenesis. I Neuro Virol 6 (Suppl. 1): S24–S32.
   Google Scholar
• Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R (1997). CD4-independent association between HIV-1 gp120 and XCR4: Functional chemokine receptors are expressed in human neurons. Curr Biol 7: 112–121.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R (1998). Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-la is mediated by the chemokine receptor CXCR4. Curr Biol 8: 595–598.
   PubMed Web of Science ®Google Scholar
• Holden CP, Haughey NJ, Nath A, Geiger JD (1999). Role of Na+/H+ exchangers, excitatory amino acid receptors and voltage-operated Ca2+ channels in human immun-odeficiency virus type 1 gp120-mediated increases in intracellular Ca2+ in human neurons and astrocytes. Neuroscience 91: 1369–1378.
   PubMed Web of Science ®Google Scholar
• Kammler S, Leurs C, Freund M, Krummheuer J, Seidel K, Tange TO, Kjems J, Scheid A, Schaal H (2001). The se-quence complementary between HIV-1 5' splice site 5D4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA. RNA 7: 421–434.
   Google Scholar
• Kaul M, Garden GA, Lipton SA (2001). Pathways to neu-ronal injury and apoptosis in HIV-associated dementia. Nature 410: 988–994.
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton SA (1999). Chemokines and activated macrophages in HIV gp120-induced neuronal apopto-sis. Proc Natl Acad Sci USA 96: 8212–8216.
   PubMed Web of Science ®Google Scholar
• Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD (2001). SDF-la induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Devel-opment 128: 1971–1981.
   Google Scholar
• Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD (1999). Chemokine receptor expression and signaling in Macaque and human fetal neurons and astrocytes: Implications for the neuropathogenesis of AIDS. J Immunol 163: 1636–1646.
   PubMed Web of Science ®Google Scholar
• Köller H, Allert N, Oel D, Stoll G, Siebler M (1998). TNFa induces a protein kinase C dependent reduction of as-troglial K+ conductance. NeuroReport 9: 1375–1378.
   Google Scholar
• Koller H, Buchholz J, Siebler M (1996a). Cerebrospinal fluid from multiple sclerosis patients inactivates neu-ronal Na+ current. Brain 119: 457–463.
   Google Scholar
• Koller H, Schaal H, Freund M, Garrido SR, von Giesen HJ, Ott M, Rosenbaum C, Arendt G (2001c). HIV-1 Tat re-duces glutamate induced intracellular Ca2+ increase in cultured cortical astrocytes. Eur I Neurosci 14: 1793–1799.
   Google Scholar
• Koller H, Thiem K, Siebler M (1996b). Tumor necrosis factor-a increases intracellular Ca2+ and induces a depo-larization in cultured astroglial cells. Brain 119: 2021–2027.
   Google Scholar
• Koller H, Trimborn M, von Giesen HJ, Schroeter M, Arendt G (2001a): TNFa reduces glutamate induced intracellu-lar Ca2+ increase in cultured cortical astrocytes. Brain Res 893: 237–243.
   Google Scholar
• Koller H, von Giesen HJ, Schaal H, Arendt G (2001b). Sol-uble cerebrospinal fluid factors induce Ca2+ dysregula-tion in rat cultured cortical astrocytes in HIV-1 associ-ated dementia complex. AIDS 15: 1789–1792.
   Google Scholar
• Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M (2000). Differ-ential signaling of the chemokine receptor CXCR4 by tromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes. Eur Neurosci 12: 117–125.
   Google Scholar
• Liu QH, Williams DA, Mmanus C, Baribaud F, Doms RW, Schols D, De Clercq E, Kotlikoff MI, Collman RG, Freedman BD (2000). HIV-1 gp120 and chemokines ac-tivate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Nat] Acad Sci USA 97: 4832–4837.
   Google Scholar
• Lo TM, Fallert CF, Piser TM, Thayer SA (1992). HIV-1 en-velope protein evokes intracellular calcium oscillations in rat hippocampal neurons. Brain Res 594: 189–196.
   Google Scholar
• Maddon PJ, Dalgleish AG, McDougal JS, Clapam PR, Weiss RA, Axel R (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333–348.
   PubMed Web of Science ®Google Scholar
• McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Selnes OA, Jacobson LP, Visscher BR, Concha M, Saah A (1993). Dementia in AIDS patients: Incidence and risk factors. Neurology 43: 2245–2252.
   PubMed Web of Science ®Google Scholar
• Medina I, Ghose S, Ben-An i Y (1999). Mobilization of intra-cellular calcium stores participates in the rise of [Ca2±1i and the toxic actions of the HIV coat protein gp120. Eur J Neurosci 11: 1167–1178.
   PubMed Web of Science ®Google Scholar
• Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Nat] Acad Sci USA 95: 14500–14505.
   PubMed Web of Science ®Google Scholar
• Nath A, Geiger J (1998). Neurobiological aspects of human immunodeficiency virus infection: Neurotoxic mecha-nisms. Prog Neurobiol 54: 19–33.
   PubMed Web of Science ®Google Scholar
• Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD (2000). Synergistic neurotoxicity by human immun-odeficiency virus proteins Tat and gp120: Protection by memantine. Ann Neurol 47: 186–194.
   PubMed Web of Science ®Google Scholar
• Nedergaard M (1994). Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 263: 1768–1771.
   PubMed Web of Science ®Google Scholar
• Neelands TR, Zhang J, Macdonald RL (1999). GABAA re-ceptors expressed in undifferentiated human teratocar-cinoma NT2 cells differ from those expressed by differ-entiated NT2-N cells. J Neurosci 19: 7057–7065.
   Google Scholar
• Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H (1997). Major histocompatibility complex (MHC) class I gene expression in single neurons of the central ner-vous system: Differential regulation by interferon (IFN)-y and tumor necrosis factor (TNF)-a. I Exp Med 185: 305–316.
   PubMed Web of Science ®Google Scholar
• Ohagen A, Ghosh S, He J, Huang K, Cheng Y, Yuan M, Osathanondh R, Gartner S, Shi B, Shaw G, Gabuzda D (1999). Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: Evidence for a role of the envelope. Virol 73: 897–906.
   Google Scholar
• Parpura V, Barsarsky TA, Liu F, Jeftinija K, Jeftinija S, Haydon PG (1994). Glutamate-mediated astrocyte-neuron signaling. Nature 369: 744–747.
   PubMed Web of Science ®Google Scholar
• Stichel CC, Muller HW (1992). Expression of inherent neu-ronal shape characteristics after transient sensitivity to epigenetic factors. Dev Brain Res 68: 149–162.
   Google Scholar
• Weydt P, Moller T, Labrakakis C, Patt S, Kettenmann H (1997). Neuroligand-triggered calcium signalling in cul-tured human glioma cells. Neurosci Lett 228: 91–94.
   Google Scholar