Chemokine Receptors and Neural Function

References

• Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA (1996). CC CKR5: RANTES, MIP-1/3 receptor as a fusion cofactor for macrophage-tropic-HIV-1. Science 272: 1955–1958. Andrews PW (1984). Retinoic acid induces neuronal differ-entiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 103: 285–293.
   Google Scholar
• Araujo DM, Cotman CW (1993). Trophic effects of interleukin-4, -7, and -8 on hippocampal neurons cul-tures: potential involvement of glial-derived factors. Brain Res 600: 49–55.
   PubMed Web of Science ®Google Scholar
• Ascensio VC, Campbell IL (1999). Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci 22: 504–512.
   Google Scholar
• Axmann A, Seidel D, Reimann T, Hempel U, Wenzel KW (1998). Transforming growth factor-beta1-induced ac-tivation of the Raf-MEK-MAPK signaling pathway in rat lung fibroblasts via a PKC-dependent mechanism. Biochem Biophys Res Commun 249: 456–460.
   Google Scholar
• Baggiolini M (1998). Chemokines and leukocyte traffic. Nature 392: 565–568.
   PubMed Web of Science ®Google Scholar
• Baggiolini M, Dewald B, Moser B (1997). Human chemo-kines: an update. Annu Rev Immunol 15: 675–705.
   PubMed Web of Science ®Google Scholar
• Bais C, Santomasso B, Coso O, Arvanitakis L, Geras Raaka E, Gutkind JS, Asch AS, Cesarman E, Gershengom E, Mesri EA (1998). G-protein coupled receptor of Kaposi's sarcoma-associated herpesvirus is a vial oncogene and angiognesis activator. Nature 392: 86–89.
   Google Scholar
• Bajetto A, Bonavia R, Barbero S, Piccioli P, Costa A, Florio T, Schettini G (1999). Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. J Neurochem 73: 2348–2357.
   PubMed Web of Science ®Google Scholar
• Bajetto A, Bonavia R, Barbero S, Florio T, Schettini G (2001). Chemokines and their receptors in the central nervous system. Front Neuroendocrinol 22: 147–184.
   PubMed Web of Science ®Google Scholar
• Barnes DA, Tse J, Kaufhold M, Owen M, Hesselgesser J, Streiter R, Horuk R, Perez H (1998). Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J Clin Invest 101: 2910–2919.
   PubMed Web of Science ®Google Scholar
• Berger EA (1997). HIV entry and tropism: the chemokine receptor connection. AIDS 11 (Suppl A): S3–S16.
   Google Scholar
• Berger EA, Murphy PM, Farber JM (1999). Chemokine receptors as HIV-1 coreceptors: roles in viral en-try, tropism, and disease. Annu Rev Immunol 17: 657–700.
   PubMed Web of Science ®Google Scholar
• Berson JF, Doms RW (1998). Structure-function studies of the HIV-1 coreceptors. Semin Immunol 10: 237–248.
   PubMed Web of Science ®Google Scholar
• Bolin LM, Murray R, Lukacs NW, Streiter RM, Kunkel SL, Schall TJ, Bacon KB (1998). Primary sensory neurons migrate in response to the chemokine RANTES. J Neu-roimmunol 81: 49–57.
   Google Scholar
• Bonnachi A, Romagnani P, Romanelli RG, Efsen E, Annunziato F, Lasagni L, Francalanci M, Serio M, Laffi G, Pinzani M, Gentilini P, Marra F (2001). Signal trans-duction by the chemokine receptor CXCR3. J Biol Chem 276: 9945–9954.
   Google Scholar
• Boring L, Gosling J, Cleary M, Charo IF (1998). Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894–897.
   PubMed Web of Science ®Google Scholar
• Boutet A, Salim H, Leclerc P, Tardieu M (2001). Cellular expression of functional chemokine receptor CCR5 and CXCR4 in human embryonic neurons. Neurosci Lett 311: 105–108.
   Google Scholar
• Brack-Werner R (1999). Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 13: 1–22.
   PubMed Web of Science ®Google Scholar
• Brown Z, Robson RL, Westwick J (1996). Regulation and expression of chemokines: potential role in glomeru-lonephritis. J Leukoc Biol 59: 75–80.
   PubMed Web of Science ®Google Scholar
• Ca=arota M, Bevilaqua LR, Dunkley PR, Rostas JA (2001). Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism. J Neurochem 79: 1122–1128.
   Google Scholar
• Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (1996). The /3-chemokine receptors CCR3 and CCR5 facilitate infection by HIV-1 primary isolates. Cell 85: 1135–1148.
   PubMed Web of Science ®Google Scholar
• Choi DW, Rothman SM (1990). The role of glutamate neuro-toxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13: 171–182.
   PubMed Web of Science ®Google Scholar
• Cocchi F, De Vico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-1 suppressive factors produced by CD8+ T cells. Science 270: 1811–1815.
   PubMed Web of Science ®Google Scholar
• Colamussi ML, Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Zauli G (2000). Stromal derived factor-1alpha induces apoptosis in activated primary CD4+ T cells. AIDS 14: 748–750.
   Google Scholar
• Coughlan CM, McManus CM, Sharron M, Gao Z, Murphy D, Jaffer S, Choe W, Chen W, Hesselgesser J, Gaylord H, Kalyuzhny A, Lee VM, Wolf B, Doms RW, Kolson DL (2000). Expression of multiple functional chemokine re-ceptors and monocyte chemoattractant protein-1 in hu-man neurons. Neuroscience 97: 591–600.
   Google Scholar
• Damaj BB, McColl SR, Neote K, Hebert CA, Naccache PH (1996). Diverging signal transduction pathways ac-tivated by interleukin 8 (IL-8) and related chemokines in human neutrophils. IL-8 and Gro-alpha differentially stimulate calcium influx through IL-8 receptors A and B. J Biol Chem 271: 20540–20544.
   Google Scholar
• Del Como M, Liu Q-H, Schols D, de Clercq E, Gessani S, Freedman BD, Collman RG (2001). HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages medi-ated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood 98: 2909–2916.
   Google Scholar
• Deng HK, Liu R, Ellmeier W, Choe S, Unutrnaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR (1996). Identification of a major HIV-1 co-receptor for primary isolates of HIV-1. Nature 381: 661–666.
   PubMed Web of Science ®Google Scholar
• Dhanasekaran N, Gutkind JS (2001). Signaling by G pro-tein coupled receptors and G proteins: a perspective. Oncogene 20: 1530–1531.
   Google Scholar
• Digicaylioglu M, Lipton SA (2001). Erythrop olefin-mediated neuroprotection involves cross-talk between Jak2 and NF-KB signalling cascades. Nature 412: 641–647.
   PubMed Web of Science ®Google Scholar
• Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J (1996). A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383: 547–550.
   PubMedGoogle Scholar
• Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW (1996). A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors. Cell 85: 1149–1158.
   PubMed Web of Science ®Google Scholar
• Dragic T, Litwin V, Allaway GP, Martin SR, Huang YX, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA (1996). HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381: 667–673.
   PubMed Web of Science ®Google Scholar
• Feng Y, Broder CC, Kennedy PE, Berger EA (1996). HIV-entry cofactor: functional cDNA cloning of a seven-transmembrane, G-protein-coupled receptor. Science 272: 872–877.
   PubMed Web of Science ®Google Scholar
• Flores-Morales A, Pircher TJ, Silvemnoinen O, Gustafsson JA, Sanchez-Gomez M, Norstedt G, Haldosen LA, Wood TJ (1998). In vitro interaction between STAT 5 and JAK 2; dependence upon phosphorylation status of STAT 5 and JAK 2. Mol Cell Endocrinol 138: 1–10.
   PubMed Web of Science ®Google Scholar
• Gabuzda D, He J, Ohagen A, Vallat A-V (1998). Chemokine receptors in HIV-1 infection of the central nervous sys-tem. Semin Immuno110: 203–213.
   Google Scholar
• Gabuzda D, Wang J (2000). Chemokine receptors and mech-anisms of cell death in HIV neuropathogenesis. J Neuro-Virol 6 (Suppl 1): S24–S32.
   Google Scholar
• Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, Qin S, Newman W, Groopman JE (1998). The a-chemokine, stromal cell-derived factor-1a, binds to the transmem-brane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. JBiol Chem 273: 23169–23175.
   PubMed Web of Science ®Google Scholar
• Gelbard HA, Dzenko K, Diloreto D, Delcerro C, Delcerro M, Epstein LG (1994a). Neurotoxic effects of tumor necro-sis factor in primary human neuronal cultures are medi-ated by activation of the AMPA receptor subtype: impli-cations for AIDS neuropathogenesis. Dev Neurosci 15: 418–422.
   Google Scholar
• Gelbard HA, Nottet HSLM, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton SA, Tourtellotte WW, Epstein LG, Gendelman HE (1994b). Platelet activating factor: a candidate HIV-1 in-duced neurotoxin. J Virol 68: 4628–4635.
   PubMed Web of Science ®Google Scholar
• Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, Epstein LG (1992). Cytokines and arachidonic metabo-lites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: im-plications for the neuropathogenesis of HIV disease. J Exp Med 176: 1703–1718.
   Google Scholar
• Gether U (2000). Uncovering molecular mechanisms in-volved in activation of G-protein-coupled receptors. Endocr Rev 21: 90–113.
   PubMed Web of Science ®Google Scholar
• Gether U, Kobilka BK (1998). G-protein coupled recep-tors: mechanism of agonist activation. J Biol Chem 273: 17979–17982.
   PubMed Web of Science ®Google Scholar
• Gillard SE, Lu M, Mastracci RM, Miller RJ (2002). Expres-sion of functional chemokine receptors by rat cerebellar neurons. J Neuroimmunol 124: 16–28.
   PubMed Web of Science ®Google Scholar
• Giovannelli A, Limatola C, Ragozzino D, Mileo AM, Ruggieri A, Ciotti MT, Mercanti D, Santoni A, Eusebi F (1998). CXC chemokines interleukin-8 (IL-8) and growth-related gene product alpha (GROalpha) mod-ulate Purkinje neuron activity in mouse cerebellum. J Neuroimmunol 92: 122–132.
   Google Scholar
• Giulian D, Vaca K, Noonan CA (1990). Secretion of neuro-toxins by mononuclear phagocytes infected with HIV-1. Science 250: 1593–1596.
   PubMed Web of Science ®Google Scholar
• Goslin J, Slymaker S, Gu L, Tseng S, Zlot CH, Young SG, Rollins BJ, Charo IF (1999). MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J Clin Invest 103: 773–778.
   Google Scholar
• Grammer TC, Blenis J (1997). Evidence for MEK-independent pathways regulating the prolonged activa-tion of the ERK-MAP kinases. Oncogene 14: 1635–1642.
   PubMed Web of Science ®Google Scholar
• Griffiths-Johnson DA, Collins PD, Jose PJ, Williams TJ (1997). Animal models of asthma: role of chemokines. Methods Enzymol 288: 241–266.
   Google Scholar
• Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ (1998). Absence of monocyte chemoattrac-tant protein-1 reduces atherosclerosis in low density lipoprotein receptor deficient mice. Mol Cell 2: 275–281.
   PubMed Web of Science ®Google Scholar
• Guerrini L, Blasi F, Denis-Donini S (1995). Synaptic activa-tion of NF-KB by glutamate in cerebellar granule neurons in vitro. Proc Natl Acad Sci USA 92: 9077–9081.
   PubMedGoogle Scholar
• Guinamard R, Signoret N, Masamichi I, Marsh M, Krosaki T, Ravetch JV (1999). B cell antigen receptor en-gagement inhibits stromal cell-derived factor (SDF)-1 alpha chemotaxis and promotes proteine kinase C (PKC)-induced internalization of CXCR4. JExp Med 189: 1461–1466.
   Google Scholar
• Hartley RS, Margulis M, Fishman PS, Lee VM, Tang CM (1999). Functional synapses are formed between hu-man NTera2 (NT2N, hNT) neurons grown on astrocytes. J Comp Neurol 407: 1–10.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R (1997). CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 7: 112–121.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Horuk R (1999). Chemokine and chemo-kine receptor expression in the central nervous system. J NeuroVirol 5: 13–26.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R (1998). Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is me-diated by the chemokine receptor CXCR4. Curr Biol 8: 595–598.
   PubMed Web of Science ®Google Scholar
• Horuk R, Martin AW, Wang Z, Schweitzer L, Gerassimides A, Guo H, Lu Z, Hesselgesser J, Perez HD, Kim J, Parker J, Hadley TJ, Peiper SC (1997). Expression of chemokine receptors in subsets of neurons in the central nervous system. J Immunol 158: 2882–2890.
   PubMed Web of Science ®Google Scholar
• Jazin EE, Soderstrom S, Ebendal T, Larha=ar D (1997). Embryonic expression of the mRNA for the rat homo-logue of the fusin/CXCR-4 HIV-1 co-receptor. J Neuroim-munol 79: 148–154.
   Google Scholar
• Ji TH, Grossman M, Ji 1(1998). G-protein coupled receptors: diversity of receptor-ligand interactions. J Biol Chem 273: 17299–17302.
   Google Scholar
• Kaiser E, Forster R, Wolf I, Ebensperger C, Kuehl WM, Lipp M (1993). The G protein-coupled receptor BLR1 is in-volved in murine B cell differentiation and is also ex-pressed in neuronal tissues. Eur J Immunol 23: 2532–2539.
   Google Scholar
• Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA (1994). Constitutive NF-KB activity in neu-rons. Mol Cell Biol 14: 3981–3992.
   PubMed Web of Science ®Google Scholar
• Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R (2000). Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95: 1911–1917.
   Google Scholar
• Katsuta T, Lim C, Shimoda K, Shibuta K, Mitra P, Banner BF, Mori M, Barnard GF (2000). Interleukin-8 and SDF1-alpha mRNA expression in colonic biopsies from pa-tients with inflammatory bowel disease. Am J Gastroen-tero195: 3157–3164.
   Google Scholar
• Kaul M, Garden G, Lipton SA (2001). Pathways to neu-ronal injury and apoptosis in HIV-associated dementia. Nature 410: 988–994.
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton SA (1999). Chemokines and activated macrophages in HIV gp120-induced neuronal apopto-sis. Proc Nati Acad Sci USA 96: 8212–8216.
   PubMed Web of Science ®Google Scholar
• Kijowski J, Baj-Krzworzeka M, Majka M, Reca R, Marquez LA, Christofidou-Solomidou M, Janowska-Wieczorek A, Ratajcak MZ (2001). The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not af-fect proliferation and survival in lymphohematopoietic cells. Stem Cells 19: 453–466.
   PubMed Web of Science ®Google Scholar
• Kita H, Gleich GJ (1996). Chemokines active on eosinophils: potential roles in allergic inflammation. J Exp Med 183: 2421–2426.
   PubMed Web of Science ®Google Scholar
• Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD (2001). SDF-1a induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Devel-opment 128: 1971–1981.
   Google Scholar
• Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD (1999). Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J Immuno1163: 1636–1646.
   Google Scholar
• Koenig S, Gendelman HE, Orenstein JM, Canto MCD, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233: 1089–1093.
   PubMed Web of Science ®Google Scholar
• Kouba M, Vanetti M, Wang X, Schafer M, Hollt V (1993). Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue. FEBS Lett 321: 173–178.
   Google Scholar
• Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC (1998). Evidence of zeta protein kinase C in-volvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem 46: 30306–30315.
   Google Scholar
• Lavi E, Kolson DL, Ulrich AM, Fu L, Gonzalez-Scarano F (1998). Chemokine receptors in the human brain and their relationship to HIV infection. J NeuroVirol 4: 301–311.
   PubMed Web of Science ®Google Scholar
• Lavi E, Strizki JM, Ulrich AM, Zhang W, Fu L, Wang Q, O'Connor M, Hoxie JA, Gonzales-Scarano F (1997). CXCR-4 (Fusin), a co-receptor for the type 1 human im-munodeficiency virus (HIV-1), is expressed in the hu-man brain in a variety of cell types, including microglia and neurons. Am J Pathol 151: 1035–1042.
   PubMed Web of Science ®Google Scholar
• Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M (2000). Differ-ential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes. Eur J Neurosci 12: 117–125.
   Google Scholar
• Lee SC, Hatch WC, Liu W, Kress Y, Lyman WD, Dickson DW (1993). Productive infection of human fetal microglia by HIV-1. Am J Pathol 143: 1032–1039.
   PubMedGoogle Scholar
• Lee VM-Y, Andrew PW (1986). Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neu-rons involves the induction of all three neurofilment proteins. J Neurosci 6: 514–521.
   PubMed Web of Science ®Google Scholar
• Lefkowitz RJ (1998). G protein coupled receptors: new roles for receptor kinases and /3-arrestins in receptor signaling and desensitization. J Biol Chem 273: 18677–18680.
   PubMed Web of Science ®Google Scholar
• Limatola C, Ciotti MT, Mercanti D, Vacca F, Ragozzino D, Giovannelli A, Santoni A, Eusebi F, Mildedi R (2000a). The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methy1-4-isoxazolepropionate receptors. Proc Nati Acad Sci USA 97: 6197–6201.
   PubMedGoogle Scholar
• Limatola C, Giovannelli A, Maggi L, Ragozzino D, Castellani L, Ciotti MT, Mercanti D, Santoni A, Eusebi F (2000b). SDF-1alpha-mediated modulation of synap-tic transmission in rat cerebellum. Eur J Neurosci 12: 2497–2504.
   PubMed Web of Science ®Google Scholar
• Limatola C, Mileo AM, Giovannelli A, Vacca F, Ciotti MT, Mercanti D, Santoni A, Eusebi F (1999). The growth-related gene product beta induces sphingomyelin hy-drolysis and activation of c-Jun N-terminal kinase in rat cerebellar granule neurones. J Biol Chem 274: 36537–36543.
   Google Scholar
• Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, De Clercq E, Kotlikoff MI, Collman RG, Freedman BD (2000). HIV-1 gp120 and chemokines ac-tivate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Nati Acad Sci USA 97: 4832–4837.
   Google Scholar
• Llanes C, Collman RG, Hrin R, Kolson DL (1995). Acetyl-cholinesterease expression in NTera 2 human neuronal cells: a model for developmental expression in the ner-vous system. J Neurosci Res 42: 791–802.
   Google Scholar
• Lukacs NW, Streiter RM, Chensue SW, Kunkel SW (1996). Activation and regulation of chemokines in allergic air-way inflammation. J Leukoc Biol 59: 13–17.
   PubMedGoogle Scholar
• Luster A (1998). Chemokines-chemotactic cytokines that mediate inflammation. N Engl j Med 338: 436–445.
   PubMed Web of Science ®Google Scholar
• Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA (1998). Imaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Nati Acad Sci USA 95: 9448–9453.
   PubMed Web of Science ®Google Scholar
• Madani N, Kozak SL, Kavanaugh MP, Kabat D (1998). gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by corecep-tors CXCR4 and CCR5. Proc Nati Acad Sci USA 95: 8005–8010.
   Google Scholar
• Mattson M, Culmsee C, Yu Z, Camandola S (2000). Roles of nuclear factor kappaB in neuronal survival and plastic-ity. J Neurochem 74: 443–456.
   PubMed Web of Science ®Google Scholar
• McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Nunez G (2001). Bimp1, a MAGUK family member linking protein kinase C activation to Bc110-mediated NF-kappaB induction. J Biol Chem 276: 30589–30597.
   PubMedGoogle Scholar
• McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J (1999). Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol 213: 442–456.
   PubMed Web of Science ®Google Scholar
• Mehler MF, Kessler JA (1997). Hematolymphopoietic and inflammatory cytokines in neural development. Trends Neurosci 20: 357–365.
   PubMed Web of Science ®Google Scholar
• Mellado M, Rodriguez-Frade JM, Vila-Coro AJ, Fernandez S, de Ana AM, Jones DR, Toran JL, Martinez AC (2001). Chemokine receptor homo- or heterodimerization ac-tivates distinct signaling pathways. EMBO J 20: 2497–2507.
   PubMed Web of Science ®Google Scholar
• Mennicken F, Maki R, de Souza EB, Quirion R (1999). Chemokines and chemokine receptors in the CNS: a pos-sible role in neuroinfla=ation and patterning. Trends Pharmacol Sci 20: 73–78.
   PubMed Web of Science ®Google Scholar
• Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Nati Acad Sci USA 95: 8075–8080.
   Google Scholar
• Meucci O, Fatatis A, Simen AA, Miller RJ (2000). Expres-sion of CX3CR1 chemokine receptors on neurons and their role in neuronal surivival. Proc Nati Acad Sci USA 97: 8075–8080.
   Google Scholar
• Miller RJ (1998). Presynaptic receptors. Annu Rev Pharma-col Toxicol 38: 201–227.
   PubMed Web of Science ®Google Scholar
• Miller RJ, Meucci 0 (1999). AIDS and the brain: is there a chemokine connection? Trends Neurosci 22: 471–479.
   Google Scholar
• Murphy PM (1994). The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 12: 593–633.
   PubMed Web of Science ®Google Scholar
• Murphy PM (1996). Chemokine receptors: structure, func-tion and role in microbial pathogenesis. Cytokine Growth Factor Rev 7: 47–64.
   PubMedGoogle Scholar
• Murphy PM, Baggiolini M, Charo IF, Herbert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ (2000). International union of pharmacology. XXII. Nomen-clature for chemokine receptors. Pharmacol Rev 52: 145–176.
   Google Scholar
• Nuovo GJ, Gallery F, MacConnell P, Braun A (1994). In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-a RNA in the central nervous system. Am J Pathol 144: 659–666.
   PubMedGoogle Scholar
• Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzara-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B (1996). The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382: 833–835.
   PubMed Web of Science ®Google Scholar
• Oh SB, Endoh T, Simen AA, Ren D, Miller RJ (2002). Reg-ulation of calcium currents by chemokines and their re-ceptors. J Neuroimmunol 123: 66–75.
   PubMed Web of Science ®Google Scholar
• Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ (2001). Chemokines and glycoprotein120 pro-duce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci 21: 5027–5035.
   PubMed Web of Science ®Google Scholar
• O'Neill LAJ, Kaltschmidt C (1997). NF-KB: a crucial tran-scription factor for glial and neuronal cell function. Trends Neurosci 20: 252–258.
   Google Scholar
• Pandey V, Bolsover SR (2000). Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 recep-tor. Biochem Biophys Res Commun 274: 212–215.
   Google Scholar
• Pati S, Cavrois M, Guo HG, Foulke J, Kim J, Feldman RA, Reitz M (2001). Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor 0RF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Viro118: 8660–8673.
   Google Scholar
• Pircher TJ, Flores-Morales A, Mui AL, Saltiel AR, Norstedt G, Gustafsson JA, Haldosen LA (1997). Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5. Mol Cell Endocrinol 133: 169–176.
   PubMedGoogle Scholar
• Pircher TJ, Petersen H, Gustafsson JA, Haldosen LA (1999). Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT)5a. Mo/ Endocrino/ 13: 555–565.
   PubMed Web of Science ®Google Scholar
• Pleasure SJ, Lee VM (1993). NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. I Neurosci Res 90: 2174–2178.
   Google Scholar
• Pleasure SJ, Page C, Lee VM-Y (1992). Pure, postmitotic polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 12: 1802–1815.
   PubMed Web of Science ®Google Scholar
• Premack BA, Schall TJ (1996). Chemokine receptors: gate-ways to inflammation and infection. Nat Med 2: 1174–1178.
   PubMed Web of Science ®Google Scholar
• Pulliam L, Herndier BG, Tang NM, McGrath MS (1991). HIV-1 infected macrophages produce soluble factors that cause histological and neurochemical alterations in cul-tured human brains. J Clin Invest 87: 503–512.
   PubMedGoogle Scholar
• Puma C, Danick M, Quirion R, Ramon F, Williams S (2001). The chemokine interlukin-8 acutely reduces Ca2+ cur-rents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs. J Neurochem 78: 960–971.
   PubMedGoogle Scholar
• Quesenberry PJ, Hulspas R, Joly M, Benoit B, Engstrom C, Rielly J, Savarese T, Pang L, Recht L, Ross A, Stein G, Stewart M (1999). Correlates between hematopoiesis and neuropoiesis: neural stem cells. J Neurotrauma 16: 661–666.
   Google Scholar
• Rodriguez-Frade JM, Mellado M, Martinez AC (2001). Chemokine receptor dimerization: two are better than one. Trends Immunol 22: 612–617.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Frade JM, Vila-Coro AJ, De Ana AM, Albar AJ, Martinez AC, Mellado M (1999a). The chemokine mono-cyte chemoattractant protein-1 induces functional re-sponses through dimerization of its receptor CCR2. Proc Natl Acad Sci USA 96: 3628–3633.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Frade JM, Vila-Coro AJ, Martin A, Nieto M, Sanchez-Madrid F, Proudfoot AE, Wells TN, Martinez AC, Mellado M (1999b). Similarities and differences in RANTES- and (A0P)-RANTES-triggered signals: implications for chemotaxis. J Cell Biol 144: 755–765.
   PubMed Web of Science ®Google Scholar
• Rollins BJ (1997). Chemokines. Blood 90: 909–928.
   PubMed Web of Science ®Google Scholar
• Rottman J, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ (1997). Cellular localization of the chemokine receptor CCR5. Am J Pathol 151: 1341–1351.
   PubMed Web of Science ®Google Scholar
• Rucker J, Edinger AL, Sharron M, Samson M, Lee B, Berson JF, Yi Y, Margulies B, Collman RG, Doranz BJ, Parmentier M, Doms RW (1997). Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency virus. J Virol 71: 8999–9007.
   PubMed Web of Science ®Google Scholar
• Ruland J, Dunca GS, Eila A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW (2001). Bc110 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104: 33–42.
   PubMed Web of Science ®Google Scholar
• Sabri F, Tresoldi E, Di Stefano M, Polo S, Monaco MC, Verani A, Fiore JR, Lusso P, Major E, Chiodi F, Scarlatti G (1999). Nonproductive human immunodeficiency virus type 1 infection of human fetal astroyctes: independence from CD4 and major chemokine receptors. Virology 264: 370–384.
   Web of Science ®Google Scholar
• Saharinen P, Takaluoma K, Silvennoinen 0 (2000). Regu-lation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol 20: 3387–3395.
   Google Scholar
• Saito M, Sato R, Hisatome I, Narahashi T (1996). RANTES and platelet-activating factor open Ca2±-activated K± channels in eosinophils. FASEB J10: 792–798.
   Google Scholar
• Saito Y, Sharer LR, Epstein LG, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich TA, Blumberg BM (1994). Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous system. Neurology 44: 474–481.
   PubMed Web of Science ®Google Scholar
• Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL (1998). Chemokines and receptors in HIV en-cephalitis. AIDS 12: 1021–1026.
   PubMed Web of Science ®Google Scholar
• Saporta S, Willing AE, Colina LO, Zigova T, Milliken M, Daadi MM, Sanberg PR (2000). In vitro and in vivo characterization of hNT neuron neurotransmitter phe-notypes. Brain Res Bull 53: 263–268.
   Google Scholar
• Sato K, Kawasaki H, Nagayama H, Enomoto M, Morimoto C, Tadokoro K, Juji T, Takahashi TA (2001). Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages. Int Im-munol 13: 167–179.
   Google Scholar
• Sato N, Kamino K, Tateishi K, Satoh T, Nishiwaki Y, Yoshiiwa A, Miki T, Ogihara T (1997). Elevated amy-loid beta protein(1–40) level induces CREB phosphory-lation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun 232: 637–642.
   Google Scholar
• Schorr W, Swandulla D, Zeilhofer HU (1999). Mechanisms of IL-8-induced Ca2+ signaling in human neutrophil granulocytes. Eur J Immunol 29: 897–904.
   Google Scholar
• Schutze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, Kronke M (1992). TNF activates NF-KB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphinogmyelin breakdown. Cell 71: 765–776.
   Google Scholar
• Segerer S, Regele H, Mack M, Kain R, Carton JP, Colin Y, Kerjaschki D, Schlondorff D (2000). The Duffy antigen receptor for chemokines is up-regulated during acute re-nal transplant rejection and crescentic glomerulonephri-tis. Kidney Int 58: 1546–1556.
   Google Scholar
• Shaywitz AJ, Greenberg ME (1999). CREB: a stimulus in-duced transcription factor induced by a diverse array of extracellular signals. Annu Rev Biochem 68: 821–861.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Rahman M, Mitsuya H (2001). Diverse transcrip-tional response of CD4 (±) T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming ef-fects of SDF-1 on CD4(±) T cells. J Immunol 167: 3064–3073.
   PubMedGoogle Scholar
• Takahashi K, Wesselingh SL, Griffin DE, McArthur JE, Johnson RT, Glass JD (1996). Localization of HIV-1 in the brain using polymerase chain reaction/in situ hy-bridization and i=unocytochemistry. Ann Neurol 39: 705–711.
   PubMedGoogle Scholar
• Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL (2001). From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Nati Acad Sci USA 98: 7934–7939.
   Google Scholar
• Ueda Y, Hirai S, Osada S, Suzuki A, Mizuno K, Ohno S (1996). Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem 271: 23512–23519.
   PubMed Web of Science ®Google Scholar
• Vallat AV, De Girolami U, He J, Mhashilkar A, Marasco W, Shi B, Gray F, Bell J, Keohane C, Smith TW, Gabuzda D (1998). Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol 152: 167–178.
   PubMed Web of Science ®Google Scholar
• Venkatakrishnan G, Salgia R, Groopman JE (2000). Chemokine receptors CXCR-1/2 activate mitogen acti-vated protein kinase via the epidermal growth factor re-ceptor in ovarian cancer cells. J Biol Chem 275: 6868–6875.
   PubMed Web of Science ®Google Scholar
• Vila-Coro AJ, Rodriguez-Frade JM, De Ana AM, Moreno-Ortiz MC, Martinez AC, Mellado M (1999). The chemokine SDF-1alpha triggers CXCR4 receptor dimer-ization and activates the JAK/STAT pathway. FASEB J13: 1699–1710.
   PubMed Web of Science ®Google Scholar
• Wang J, Crawford K, Menglan Y, Wang H, Gorry PR, Gabuzda D (2002). Regulation of CC chemokine recep-tor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and mi-croglia by T-helper type 2 cytokines. J Infect Dis 185: 885–897.
   Google Scholar
• Ward SG, Westwick J (1998). Chemokines: understanding their role in T-lymphocyte biology. Biochem J333: 457–470.
   PubMed Web of Science ®Google Scholar
• Watkins BA, Dorn HH, Kelly WB, Armstrong RC, Potts BJ, Michaels F, Kufta CV, Dubois-Dalcq M (1990). Specific tropism of HIV-1 for microglial cells in primary human brain cultures. Science 249: 549–553.
   Google Scholar
• Way KJ, Chou E, King GL (2000). Identification of PKC-isoform-specific biological actions using phar-macological approaches. Trends Pharmacol Sci 21: 181–187.
   PubMed Web of Science ®Google Scholar
• Westmoreland SV, Alvarez X, deBakker C, Aye P, Wilson ML, Williams KC, Lackner AA (2002). Developmental expression patterns of CCR5 and CXCR4 in the rhesus macaque brain. J Neuroimmunology 122: 146–158.
   Google Scholar
• Westmoreland SV, Rottman JB, Williams KC, Lackner AA, Sasseville VG (1998). Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis. Am J Pathol 152: 659–665.
   PubMed Web of Science ®Google Scholar
• Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA (1986). Cellular localization of human immunod-eficiency virus within the brains of acquired immunod-eficiency patients. Proc Natl Acad Sci USA 83: 7089–7093.
   PubMed Web of Science ®Google Scholar
• Wong M, Fish E (1998). RANTES and MIP-1a activate STAT's in T cells. J Biol Chem 273: 309–314.
   PubMed Web of Science ®Google Scholar
• Wong M, Uddin S, Majchrzak B, Huynh T, Proudfoot AEI, Platanias LC, Fish EN (2001). RANTES activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells. J Biol Chem 276: 11427–11431.
   PubMed Web of Science ®Google Scholar
• Wong ML, Xin WW, Dumas RS (1996). Rat LCR1: cloning and cellular distribution of a putative chemokine recep-tor in brain. Mo/ Psychiatr 1: 133–140.
   Google Scholar
• Xia M, Bacskai BJ, Knowles RB, Qin SX, Hyman BT (2000). Expression of the chemokine receptor CXCR3 on neu-rons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. J Neuroimmunol 108: 227–235.
   PubMed Web of Science ®Google Scholar
• Xia M, Hyman BT (2002). Groa/KC, a chemokine re-ceptor CXCR2 ligand, can be a potent trigger for neuronal ERK 1/2 and PI-3K pathways and for tau hyperphosphorylation-a role in Alzheimer's disease? J Neuroimmunol 122: 55–64.
   Google Scholar
• Yang Y-M, Hatch WC, Liu Z-Y, Du B, Groopman JE (2001). /3-Chemokine induction of activation protein-1 and cyclic AMP responsive element activation in human myeloid cells. Cell Growth Differ 12: 211–221.
   Google Scholar
• Ye RD (2001). Regulation of nuclear factor KB activation by G-protein coupled receptors. JLeukoc Biol 70: 839–848.
   PubMed Web of Science ®Google Scholar
• Zhang L, He T, Talal A, Wang G, Frankel SS, Ho DD (1998). In vivo distribution of the human immunode-ficiency virus/simian immunodeficiency virus corecep-tors: CXCR4, CCR3, and CCR5. J Virol 72: 5035–5045.
   Google Scholar
• Zheng J, Ghorpade A, Niemann D, Cotter RL, Thylin MR, Epstein L, Swartz JM, Shepard RB, Liu X, Nukuna A, Gendelman HE (1999a). Lymphotropic virions af-fect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J Virol 73: 8256–8267.
   PubMed Web of Science ®Google Scholar
• Zheng J, Thylin MR, Ghorpade A, Xiong H, Persidsky Y, Cotter R, Niemann D, Che M, Zheng Y-C, Gelbard HA, Shepard RB, Swartz JM, Gendelman HE (1999b). Intra-cellular CXCR4 signaling, neuronal apoptosis and neu-ropathogenic mechanisms of HIV-1-associated demen-tia. J Neuroimmunol 98: 185–200.
   PubMed Web of Science ®Google Scholar
• Zlotnik A, Yoshie 0 (2000). Chemokines: a new classifica-tion system and their role in immunity. Immunity 12: 121–127.
   PubMed Web of Science ®Google Scholar
• Zou YR, Kottrnan AH, Kuroda M, Taniuchi I, Littman DR (1998). Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595–599.
   PubMed Web of Science ®Google Scholar