Experimental Herpes Simplex Virus Encephalitis: A Combination Therapy of Acyclovir and Glucocorticoids Reduces Long-Term Magnetic Resonance Imaging Abnormalities

References

• Anderson JR, Field HJ (1983). The distribution of herpes simplex type 1 antigen in mouse central nervous system after different routes of inoculation. J Neurol Sci 60: 181–195.
   PubMed Web of Science ®Google Scholar
• Ando Y, Kimura H, Miwata H, Kudo T, Shibata M, Morishima T (1993). Quantitative analysis of herpes simplex virus DNA in cerebrospinal fluid of children with herpes simplex encephalitis. J Med Virol 41: 170–173.
   PubMedGoogle Scholar
• Aurelius E, Andersson B, Forsgren M, Skoldenberg B, Strannegard 0 (1994). Cytokines and other markers of intrathecal immune response in patients with herpes simplex encephalitis. J Infect Dis 170: 678–681.
   Google Scholar
• Aurelius E, Forsgren M, Skoldenberg B, Strannegard 0 (1993). Persistent intrathecal immune activation in pa-tients with herpes simplex encephalitis. J Infect Dis 168: 1248–1252.
   Google Scholar
• Baringer JR, Klassen T, Grumm F (1976). Experimental her-pes simplex virus encephalitis. Effect of corticosteroids and pyrimidine nucleoside. Arch Neurol 33: 442–446.
   Google Scholar
• Barthez-Carpentier MA, Rozenberg F, Dussaix E, Lebon P, Goudeau A, Billard C, Tardieu M (1995). Relapse of her-pes simplex encephalitis. J Child Neurol 10: 363–368.
   PubMed Web of Science ®Google Scholar
• Cagnin A, Myers R, Gunn RN, Lawrence AD, Stevens T, Kreutzberg GW, Jones T, Banati RB (2001). In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neu-ronal damage beyond the primary focal lesion. Brain 124: 2014–2027.
   Google Scholar
• Chan WL, Javanovic T, Lukic ML (1989). Infiltration of im-mune T cells in the brain of mice with herpes simplex virus-induced encephalitis. J Neuroimmunol 23: 195–201.
   Google Scholar
• Darai G, Scholz J, Kurz W, Koch HG (1982). Intertypic super-infection of herpes simplex virus in vivo leads to reisola-tion of latent viruses with newly acquired lymphotropic properties. Dev Biol Stand 52: 67–80.
   Google Scholar
• Demaerel P, Wilms G, Robberecht W, Johannik K, Van Hecke P, Carton H, Baert AL (1992). MRI of herpes simplex encephalitis. Neuromdio/ogy 34: 490–493.
   Google Scholar
• Dennett C, Klapper PE, Cleator GM (1996). Polymerase chain reaction in the investigation of "relapse" follow-ing herpes simplex encephalitis. J Med Virol 48: 129–132.
   Google Scholar
• Dragoje S, Tolnay M, Dalquen P, Probst A (1995). Brain irradiation and antioedematous dexamethasone treatment-risk factors for herpes simplex encephalitis? Schweiz Arch Neurol Psychiatr 146: 277–280.
   Google Scholar
• Ejercito PM, Kieff ED, Roizman B (1968). Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol 2: 357–364.
   PubMed Web of Science ®Google Scholar
• Esiri MM, Drummond CW, Morris CS (1995). Macrophages and microglia in HSV-1 infected mouse brain. J Neuroimmunol 62: 201–205.
   PubMed Web of Science ®Google Scholar
• Esiri MM, Kennedy PGE (1997). Viral diseases. In: Green-field's neuropathology. Graham DI, Lantos PL (eds). Edward Arnold: London, pp 3–63.
   Google Scholar
• Gilbert DN, Moellering RC, Sande MA (2001). The Sanford guide to antimicrobial therapy 2001. Gilbert DN, Moellering RC, Sande MA (eds). Antimicrobial Therapy, Inc.: Hyde Park, pp 101–102.
   Google Scholar
• Gold R, Buttgereit F, Toyka KV (2001). Mechanism of ac-tion of glucocorticosteroid hormones: possible impli-cations for therapy of neuroi=unological disorders. J Neuroimmunol 117: 1–8.
   PubMed Web of Science ®Google Scholar
• Haas J, Meyding-Lamade U, Fath A, Stingele K, Storch-Hagenlocher B, Wildemann B (1999). Acyclovir treat-ment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tis-sue of SJL mice. Neurosci Lett 264: 129–132.
   PubMed Web of Science ®Google Scholar
• Habel AH, Brown JK (1972). Dexamethasone in herpes-simplex encephalitis. Lancet 1: 695.
   Google Scholar
• Hayden FG (2001). Antimicrobial agents: antiviral agents (nonretroviral). In: Goodman & Gilman's the pharmaco-logical basis of therapeutics. Hardman JG, Limbird LE (eds). McGraw-Hill: New York, pp 1313–1348.
   Google Scholar
• Hisanaga K, Hosokawa M, Sato N, Mochizuki H, Itoyama Y, Iwasaki Y (1999). "Neuro-sweet disease": benign re-current encephalitis with neutrophilic dermatosis. Arch Neurol 5: 1010–1013.
   Google Scholar
• Hudson SJ, Dix RD, Streilein JW (1991). Induction of en-cephalitis in SJL mice by intranasal infection with her-pes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. J Infect Dis 163: 720–727.
   Google Scholar
• Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M, Morishima T (2000). Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Clin Infect Dis 30: 185–187.
   PubMed Web of Science ®Google Scholar
• Jacobs DH (1999). Herpes simplex virus encephali-tis following corticosteroids and cranial irradiation. Neurology 52: 1108–1109.
   Google Scholar
• Johnson RT (1996). Acute encephalitis. Clin Infect Dis 23: 219–224; quiz 225–216.
   Google Scholar
• Kapur N, Barker S, Burrows EH, Ellison D, Brice J, Illis LS, Scholey K, Colbourn C, Wilson B, Loates M (1994). Herpes simplex encephalitis: long-term magnetic reso-nance imaging and neuropsychological profile. J Neurol Neurosurg Psychiatry 57: 1334–1342.
   Google Scholar
• Kimura H, Aso K, Kuzushima K, Hanada N, Shibata M, Morishima T (1992). Relapse of herpes simplex en-cephalitis in children. Pediatrics 89: 891–894.
   PubMed Web of Science ®Google Scholar
• Koprowski H, Zheng YM, Heber-Katz E, Fraser N, Rorke L, Fu ZF, Hanlon C, Dietzschold B (1993). In vivo expres-sion of inducible nitric oxide synthase in experimen-tally induced neurologic diseases. Proc Nail Acad Sci USA 90: 3024–3027.
   PubMed Web of Science ®Google Scholar
• Lahat E, Barr J, Barkai G, Paret G, Brand N, Barzilai A (1999). Long term neurological outcome of herpes encephalitis. Arch Dis Child 80: 69–71.
   Google Scholar
• Lamadé UM, Lamadé W, Hess T, Gosztonyi G, Kehm R, Sartor K, Hacke W (1996). A mouse model of her-pes simplex virus encephalitis: diagnostic brain imaging by magnetic resonance imaging. In Vivo 10: 563–568.
   Google Scholar
• Lellouch-Tubiana A, Fohlen M, Robain O, Rozenberg F (2000). Immunocytochemical characterization of long-term persistent immune activation in human brain after herpes simplex encephalitis. Neuropathol Appl Neurobiol 26: 285–294.
   PubMed Web of Science ®Google Scholar
• Longson M, Beswick TS (1971). Dexamethasone treatment in herpes-simplex encephalitis. Lancet 1: 749–750.
   Google Scholar
• Longson M, Juel-Jensen BE, Liversedge LA (1975). Systemic corticosteroids in treatment of herpes simplex encephalitis. BMJ 4: 578.
   Google Scholar
• McFarland DJ, Hotchin J (1983). Host genetics and the be-havioral sequelae to herpes encephalitis in mice. Physiol Behav 30: 881–884.
   Google Scholar
• McFarland DJ, Sikora E, Hotchin J (1986). The production of focal herpes encephalitis in mice by stereotaxic in-oculation of virus. Anatomical and behavioral effects. J Neurol Sci 72: 307–318.
   Google Scholar
• McGrath N, Anderson NE, Croxson MC, Powell KF (1997). Herpes simplex encephalitis treated with acyclovir: di-agnosis and long term outcome. J Neurol Neurosurg Psychiatry 63: 321–326.
   PubMed Web of Science ®Google Scholar
• Meyding-Lamadé U, Haas J, Lamadé W, Stingele K, Kehm R, Fath A, Heinrich K, Storch Hagenlocher B, Wildemann B (1998a). Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue. Neurosci Lett 244: 9–12.
   PubMed Web of Science ®Google Scholar
• Meyding-Lamadé U, Lamadé W, Kehm R, Knopf KW, Hess T, Gosztonyi G, Degen O, Hacke W (1998b). Her-pes simplex virus encephalitis: cranial magnetic reso-nance imaging and neuropathology in a mouse model. Neurosci Lett 248: 13–16.
   Google Scholar
• Meyding-Lamadé U, Lamadé W, Kehm R, Oberlinner C, Fath A, Wildemann B, Haas J, Hacke W (1999a). Herpes simplex virus encephalitis: chronic progressive cerebral MRI changes despite good clinical recovery and low vi-ral load-an experimental mouse study. Eur j Neurol 6: 531–538.
   PubMed Web of Science ®Google Scholar
• Meyding-Lamadé UK, Lamadé WR, Wildemann BT, Sartor K, Hacke W (1999b). Herpes simplex virus encephalitis: chronic progressive cerebral magnetic resonance imag-ing abnormalities in patients despite good clinical re-covery. Clin Infect Dis 28: 148–149.
   PubMed Web of Science ®Google Scholar
• Meyding-Lamadé U, Seyfer S, Haas J, Dvorak F, Kehm R, Lamadé W, Hacke W, Wildemann B (2002). Experimen-tal herpes simplex virus encephalitis: inhibition of the expression of inducible nitric oxide synthase in mouse brain tissue. Neurosci Lett 318: 21–24.
   PubMed Web of Science ®Google Scholar
• Molloy S, Allcutt D, Brennan P, Farrell MA, Perryman R, Brett FM (2000). Herpes simplex encephalitis occurring after chemotherapy, surgery, and stereotactic radiother-apy for medulloblastoma. Arch Pathol Lab Med 124: 1809–1812.
   Google Scholar
• Nahmias AJ, Whitley RJ, Visintine AN, Takei Y, Alford CA Jr (1982). Herpes simplex virus encephalitis: laboratory evaluations and their diagnostic significance. J Infect Dis 145: 829–836.
   PubMed Web of Science ®Google Scholar
• Paillard C, Vanhulle C, Devaux AM, Ensel P, Monroc-Morval M, Blanc T (1999). [Recurrence of herpes sim-plex encephalitis.] Arch Pediatr 6: 1081–1085.
   Google Scholar
• Pike MG, Kennedy CR, Neville BG, Levin M (1991). Herpes simplex encephalitis with relapse. Arch Dis Child 66: 1242–1244.
   Google Scholar
• Plantinga EG, Vanneste JA (2001). Mild herpes simplex encephalitis worsening despite acyclovir treatment. J Neurol 248: 237–238.
   PubMed Web of Science ®Google Scholar
• Rau P, Heiland S, Sellner J, Sartor K, Hacke W, Meyding-Lamadé U (2002). Experimental herpes simplex virus encephalitis: sequential diffusion-weighted magnetic resonance imaging. J Neurol 249 (Suppl 1): 168.
   Google Scholar
• Sartor K (1991). Viral infections. In: MR imaging of the skull and brain. Sartor K (ed). Springer: Berlin, Heidelberg, New York, pp 645–648.
   Google Scholar
• Schiff D, Rosenblum MK (1998). Herpes simplex encephali-tis (HSE) and the immunocompromised: a clinical and autopsy study of HSE in the settings of cancer and human immunodeficiency virus-type 1 infection. Hum Pathol 29: 215–222.
   PubMed Web of Science ®Google Scholar
• Schimmer BP, Parker KL (2001). Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Goodman & Gilmans The pharmacological basis of therapeutics. Hardman JG, Limbird LE (eds). McGraw-Hill: New York, pp 1649–1778.
   Google Scholar
• Skoldenberg B (1991). Herpes simplex encephalitis. Scand J Infect Dis Suppl 80: 40–46.
   Google Scholar
• Skoldenberg B, ForsgrenM, Alestig K, Bergstrom T, Burman L, Dahlqvist E, Forkman A, Fryden A, Lovgren K, Norlin K, et al (1984). Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet 2: 707–711.
   Google Scholar
• Smith CC (1975). Diseases of the central nervous system. Meningitis and encephalitis. BMJ 4: 335–337.
   Google Scholar
• Sobel RA, Collins AB, Colvin RB, Bhan AK (1986). The in situ cellular immune response in acute herpes simplex encephalitis. Am J Pathol 125: 332–338.
   PubMed Web of Science ®Google Scholar
• Soto-Hernandez JL (2000). Follow-up in herpes simplex virus encephalitis. Clin Infect Dis 31: 206–207.
   Google Scholar
• Steiner I, Kennedy PG (1995). Herpes simplex virus latent infection in the nervous system. J NeuroVirol 1: 19-29. Straub J, Chofflon M, Delavelle J (1997). Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery. Neurology 49: 1145–1147.
   Google Scholar
• Thompson KA, Blessing WW, Wesselingh SL (2000). Her-pes simplex replication and dissemination is not in-creased by corticosteroid treatment in a rat model of focal Herpes encephalitis. J NeuroVirol 6: 25–32.
   Web of Science ®Google Scholar
• Tyler KL, Tedder DG, Yamamoto LJ, Klapper JA, Ashley R, Lichtenstein KA, Levin MJ (1995). Recurrent brain-stem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology 45: 2246–2250.
   PubMed Web of Science ®Google Scholar
• Upton AR, Barwick DD, Foster JB (1971a). Dexametha-sone treatment in herpes-simplex encephalitis. Lancet 1: 290–291.
   Google Scholar
• Upton AR, Foster JB, Barwick DD (1971b). Dexamethasone treatment in herpes-simplex encephalitis. Lancet 1: 861.
   Google Scholar
• Vantandingham KE, Marsteller HB, Ross GW, Hayden FG (1988). Relapse of herpes simplex encephalitis af-ter conventional acyclovir therapy. JAMA 259: 1051–1053.
   Google Scholar
• Whitley RJ (1991). Herpes simplex virus infections of the central nervous system. Encephalitis and neonatal herpes. Drugs 42: 406–427.
   Google Scholar
• Whitley RJ (1997). Herpes simplex virus. In: Infections of the central nervous system. Scheld WM, Whitley RJ, Durack DT (eds). Lippincott-Raven Publishers: Philadelphia, New York, pp 73–90.
   Google Scholar
• Whitley RJ, Alford CA, Hirsch MS, Schooley RT, Luby JP, Aoki FY, Hanley D, Nahmias AJ, Soong SJ (1986). Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 314: 144–149.
   PubMed Web of Science ®Google Scholar
• Wildemann B, Ehrhart K, Storch-Hagenlocher B, Meyding-Lamade U, Steinvorth S, Hacke W, Haas J (1997). Quan-titation of herpes simplex virus type 1 DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis. Neurology 4: 1341–1346.
   Google Scholar
• Yamamoto K, Chiba HO, Ishitobi M, Nakagawa H, Ogawa T, Ishii K (1997). Acute encephalopathy with bilateral striatal necrosis: favourable response to corticosteroid therapy. Eur Paediatr Neurol 1:41–45.
   Google Scholar