1
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Human Immunodeficiency Virus Type 1 Tat Protein Directly Activates Neuronal N -methyl- D -aspartate Receptors at an Allosteric Zinc-Sensitive Site

, , , &
Pages 399-403 | Published online: 10 Jul 2009

References

  • Allavena C, Dousset B, May T, Dubois F, Canton P, Belleville F (1995). Relationship of trace element, immunologi-cal markers, and HIV1 infection progression. Biol Trace Elem Res 47: 133–138.
  • Baron BM, Harrison BL, Miller FP, McDonald IA, Salituro FG, Schmidt CJ, Sorensen SM, White HS, Palfreyman MG (1990). Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-b-aspartate receptor-associated glycine binding site. Mol Pharmaco138: 554–561.
  • Bonavia R, Bajetto A, Barbero S, Albini A, Noonan DM, Schettini G (2001). HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun 288: 301–308.
  • Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997). HIV-1 Tat protein exits from cells via a leader-less secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its ba-sic region. AIDS 11: 1421–1431.
  • Chen N, Moshaver A, Raymond LA (1997). Differential sen-sitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol 51: 1015–1023.
  • Chen P, Mayne M, Power C, Nath A (1997). The Tat pro-tein of HIV-1 induces tumor necrosis factor-alpha pro-duction. Implications for HIV-1-associated neurological diseases. J Biol Chem 272: 22385–22388.
  • Cheng J, Nath A, Knudsen B, Hochman S, Geiger JD, Ma M, Magnuson DS (1998). Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience 82: 97–106.
  • Davies J, Francis AA, Jones AW, Watkins JC (1981). 2-Amino-5-phosphonovalerate (2APV), a potent and se-lective antagonist of amino acid-induced and synaptic excitation. Neurosci Lett 21: 77–81.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). Involve-ment of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neu-ron cell death caused by HIV-1 protein tat. J Neurochem 73: 1363–1374.
  • Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD (2001). HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neu-rochem 78: 457–467.
  • Hayman M, Arbuthnott G, Harkiss G, Brace H, Filippi P, Philippon V, Thomson D, Vigne R, Wright A (1993). Neurotoxicity of peptide analogues of the transactivat-ing protein tat from Maedi-Visna virus and human im-munodeficiency virus. Neuroscience 53: 1–6.
  • Hofrnan FM, Dohadwala MM, Wright AD, Hinton DR, Walker SM (1994). Exogenous tat protein activates cen-tral nervous system-derived endothelial cells. J Neu-roimmunol 54: 19–28.
  • Hudson L, Liu J, Nath A, Jones M, Raghavan R, Narayan O, Male D, Everall 1(2000). Detection of the human immun-odeficiency virus regulatory protein tat in CNS tissues. J NeuroVirol 6: 145–155.
  • Kruman II, Nath A, Mattson MP (1998). HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mech-anism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 154: 276–288.
  • Legendre P, Westbrook GL (1990). The Inhibition of single N-methyl-b-aspartate activated channels by zinc ions on cultured rat neurones. J Physiol (Lond) 429: 429–449.
  • Ma M, Nath A (1997). Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 71: 2495–2499.
  • MacDonald JF, Bartlett MC, Mody I, Pahapill P, Reynolds JN, Salter MW, Schneiderman JH, Pennefather PS (1991). Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocam-pal neurones. J Physiol (Lond) 432: 483–508.
  • Magnuson DSK, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). Human immunodeficiency virus type 1 Tat activates non-N-methyl-b-aspartate excita-tory amino acid receptors and causes neurotoxicity. Ann Neurol 37: 373–380.
  • Mayer ML, Vyklicky L, Jr. (1989). The action of zinc on synaptic transmission and neuronal excitability in
  • Mayer ML, Westbrook GL, Guthrie PB (1984). Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309: 261–263.
  • Monaghan DT, Buller AL (1994). Anatomical, pharmaco-logical, and molecular diversity of native NMDA recep-tor subtypes. In: The NMDA receptor. Collingridge GL, Watkins JC (eds). New York: Oxford University Press, DD. 158–176.pp. 156-1/b.
  • Nath A, Conant K, Chen P, Scott C, Major EO (1999). Tran-sient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon. J Biol Chem 274: 17098–17102.
  • Nath A, Geiger J (1998). Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mecha-nisms. Prog Neurobiol 54: 19–33.
  • Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD (1996). Identification of a human immunodeficiency virus type 1 Tat epitope that is neu-roexcitatory and neurotoxic. J Virol 70: 1475–1480.
  • New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998). HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-b-aspartate receptors by a NFkappaB- independent mech-anism. J Biol Chem 273: 17852–17858.
  • Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984). Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462.
  • Rogers SW, Andrews PI, Gahring LC, Whisenand T, Cauley K, Crain B, Hughes TE, Heinemann SF, McNamara JO (1994). Autoantibodies to glutamate receptor G1uR3 in Rasmussen's encephalitis. Science 265: 648–651.
  • Shi B, Raina J, Lorenzo A, Busciglio J, Gabuzda D (1998). Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J NeuroVirol 4: 281–290.
  • Starling I, Wright A, Arbuthnott G, Harkiss G (1999). Acute in vivo neurotoxicity of peptides from Maedi Visna virus transactivating protein Tat. Brain Res 830: 285–291.
  • Strijbos PJ, Zamani MR, Rothwell NJ, Arbuthnott G, Harkiss G(1995). Neurotoxic mechanisms of transactivating pro-tein Tat of Maedi-Visna virus. Neurosci Lett 197: 215–218.
  • Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL (1998). Control of voltage-independent zinc inhibi-tion of NMDA receptors by the NR1 subunit. J Neurosci 18: 6163–6175.
  • Twyman RE, Gahring LC, Spiess J, Rogers SW (1995). Glutamate receptor antibodies activate a subset of re-ceptors and reveal an agonist binding site. Neuron 14: 755–762.
  • Wesselingh SL, Power C, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE (1993). Intracerebral cy-tokine messenger RNA expression in acquired immun-odeficiency syndrome dementia. Ann Neurol 33: 576–582.
  • Wiley CA, Baldwin M, Achim CL (1996). Expression of HIV regulatory and structural mRNA in the central nervous system. AIDS 10: 843–847.cultures of mouse hippocampus. J Physiol 415: 351–365.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.