Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat

References

• Albini A, Soldi R, Giunciuglio D, Giraudo E, Benelli R, Primo L, Noonan D, Salio M, Camussi G, Rockl W, Bussolino F. 1996. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nat Med. 2: 1371–1375. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Alessi D R, Caudwell F B, Andjelkovic M, Hemmings B A, Cohen P. 1996. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399: 333–338. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Amara A, Gall S L, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier J L, Arenzana-Seisdedos F. 1997. HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med. 186: 139–146. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Arenzana-Seisdedos F, Virelizier J L, Rousset D, Clark-Lewis I, Loetscher P, Moser B, Baggiolini M. 1996. HIV blocked by chemokine antagonist. Nature. 383: 400, [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Barillari G, Gendelman R, Gallo R C, Ensoli B. 1993. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci U S A. 90: 7941–7945. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Benelli R, Mortarini R, Anichini A, Giunciuglio D, Noonan D M, Montalti S, Tacchetti C, Albini A. 1998. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides. AIDS. 12: 261–268. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Berger J R, Moskowitz L, Fischl M, Kelley R E. 1987. Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome. South Med J. 80: 683–686. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Bonwetsch R, Croul S, Richardson M W, Lorenzana C, Valle L D, Sverstiuk A E, Amini S, Morgello S, Khalili K, Rappaport J. 1999. Role of HIV-1 Tat and CC chemokine MIP-1alpha in the pathogenesis of HIV associated central nervous system disorders. J NeuroVirol. 5: 685–694. [PUBMED], [INFOTRIEVE]
   Web of Science ®Google Scholar
• Borgatti P, Zauli G, Colamussi M L, Gibellini D, Previati M, Cantley L L, Capitani S. 1997. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Eur J Immunol. 27: 2805–2811. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Bornemann M A, Verhoef J, Peterson P K. 1997. Macrophages, cytokines, and HIV. J Lab Clin Med. 129: 10–16. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Bruce-Keller A J, Barger S W, Moss N I, Pham J T, Keller J N, Nath A. 2001. Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol. J Neurochem. 78: 1315–1324. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Budka H, Wiley C A, Kleihues P, Artigas J, Asbury A K, Cho E S, Cornblath D R, Dal, Canto M C, De, Girolami U, Dickson D, et al, 1991. HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol. 1: 143–152. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cheeran M C, Hu S, Yager S L, Gekker G, Peterson P K, Lokensgard J R. 2001. Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implications. J Neuro-Virol. 7: 135–147
   Google Scholar
• Chen P, Mayne M, Power C, Nath A. 1997. The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. J Biol Chem. 272: 22385–22388. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Chirmule N, Than S, Khan S A, Pahwa S. 1995. Human immunodeficiency virus Tat induces functional unresponsiveness in T cells. J Virol. 69: 492–498. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cinque P, Vago L, Mengozzi M, Torri V, Ceresa D, Vicenzi E, Transidico P, Vagani A, Sozzani S, Mantovani A, Lazzarin A, Poli G. 1998. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS. 12: 1327–1332. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cocchi F, De, Vico A L, Garzino-Demo A, Arya S K, Gallo R C, Lusso P. 1995. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 270: 1811–1815. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Conant K, Garzino-Demo A, Nath A, McArthur J C, Halliday W, Power C, Gallo R C, Major E O. 1998. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A. 95: 3117–3121. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• D'Aversa T G, Weidenheim K M, Berman J W. 2002. CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosis. Am J Pathol. 160: 559–567. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Deregibus M C, Cantaluppi V, Doublier S, Brizzi M F, Deambrosis I, Albini A, Camussi G. 2002. HIV-1-Tat protein activates phosphatidylinositol 3-kinase/AKT-dependent survival pathways in Kaposi's sarcoma cells. J Biol Chem. 277: 25195–25202. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Dewhurst S, Sakai K, Bresser J, Stevenson M, Evinger-Hodges M J, Volsky D J. 1987. Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV. J Virol. 61: 3774–3782. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Dickson D W, Mattiace L A, Kure K, Hutchins K, Lyman W D, Brosnan C F. 1991. Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab Invest. 64: 135–156. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Ehrlich L C, Hu S, Sheng W S, Sutton R L, Rockswold G L, Peterson P K, Chao C C. 1998. Cytokine regulation of human microglial cell IL-8 production. J Immunol. 160: 1944–1948. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Ensoli B, Buonaguro L, Barillari G, Fiorelli V, Gendelman R, Morgan R A, Wingfield P, Gallo R C. 1993. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol. 67: 277–287. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Epstein L G, Sharer L R, Oleske J M, Connor E M, Goudsmit J, Bagdon L, Robert-Guroff M, Koenigsberger M R. 1986. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics. 78: 678–687. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Esser R, Glienke W, von, Briesen H, Rubsamen-Waigmann H, Andreesen R. 1996. Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus. Blood. 88: 3474–3481. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Eugenin E A, D'Aversa T G, Lopez L, Calderon T M, Berman J W. 2003. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem. 85: 1299–1311. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Ganju R K, Munshi N, Nair B C, Liu Z Y, Gill P, Groopman J E. 1998. Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells. J Virol. 72: 6131–6137. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Gerszten R E, Garcia-Zepeda E A, Lim Y C, Yoshida M, Ding H A, Gimbrone M A, Jr, Luster A D, Luscinskas F W, Rosenzweig A. 1999. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 398: 718–723. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Glass J D, Fedor H, Wesselingh S L, McArthur J C. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol. 38: 755–762. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Glass J D, Wesselingh S L, Selnes O A, McArthur J C. 1993. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology. 43: 2230–2237. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Gordon C J, Muesing M A, Proudfoot A E, Power C A, Moore J P, Trkola A. 1999. Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion. J Virol. 73: 684–694. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Grant I, Atkinson J H, Hesselink J R, Kennedy C J, Richman D D, Spector S A, McCutchan J A. 1987. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging. Ann Intern Med. 107: 828–836. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Gray F, Adle-Biassette H, Brion F, Ereau T, le, Maner I, Levy V, Corcket G. 2000. Neuronal apoptosis in human immunodeficiency virus infection. J NeuroVirol. 6(Suppl 1)S38–S43. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Haseltine W A, Wong-Staal F. 1988. The molecular biology of the AIDS virus. Sci Am. 259: 52–62. [PUBMED], [INFOTRIEVE]
   Web of Science ®Google Scholar
• Helland D E, Welles J L, Caputo A, Haseltine W A. 1991. Transcellular transactivation by the human immunodeficiency virus type 1 tat protein. J Virol. 65: 4547–4549. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Hemmings B A. 1997. Akt signaling: linking membrane events to life and death decisions. Science. 275: 628–630. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Horuk R. 1999. Chemokine and chemokine receptor expression in the central nervous system. J NeuroVirol. 5: 13–26. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hofman F M, Dohadwala M M, Wright A D, Hinton D R, Walker S M. 1994. Exogenous tat protein activates central nervous system-derived endothelial cells. J Neuroimmunol. 54: 19–28. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kelder W, McArthur J C, Nance-Sproson T, McClernon D, Griffin D E. 1998. Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus- associated dementia. Ann Neurol. 44: 831–835. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kelly M D, Naif H M, Adams S L, Cunningham A L, Lloyd A R. 1998. Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages. J Immunol. 160: 3091–3095. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Kim B O, Liu Y, Ruan Y, Xu Z C, Schantz L, He J J. 2003. Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol. 162: 1693–1707. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kinter A, Catanzaro A, Monaco J, Ruiz M, Justement J, Moir S, Arthos J, Oliva A, Ehler L, Mizell S, Jackson R, Ostrowski M, Hoxie J, Offord R, Fauci A S. 1998. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction. Proc Natl Acad Sci U S A. 95: 11880–11885. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kolson D L, Lavi E, Gonzalez-Scarano F. 1998. The effects of human immunodeficiency virus in the central nervous system. Adv Virus Res. 50: 1–47. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kruman I I, Nath A, Maragos W F, Chan S L, Jones M, Rangnekar V M, Jakel R J, Mattson M P. 1999. Evidence that Par-4 participates in the pathogenesis of HIV encephalitis. Am J Pathol. 155: 39–46. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Kruman, II, Nath A, Mattson M P. 1998. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol. 154: 276–288. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kutsch O, Oh J, Nath A, Benveniste E N. 2000. Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes. J Virol. 74: 9214–9221. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Lafrenie R M, Wahl L M, Epstein J S, Hewlett I K, Yamada K M, Dhawan S. 1996a. HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis. J Immunol. 156: 1638–1645. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lafrenie R M, Wahl L M, Epstein J S, Hewlett I K, Yamada K M, Dhawan S. 1996b. HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. J Immunol. 157: 974–977. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lane B R, Lore K, Bock P J, Andersson J, Coffey M J, Strieter R M, Markovitz D M. 2001. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J Virol. 75: 8195–8202. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Larsen C G, Anderson A O, Appella E, Oppenheim J J, Matsushima K. 1989. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science. 243: 1464–1466. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lipton S A, Gendelman H E. 1995. Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med. 332: 934–940. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Liu Y, Jones M, Hingtgen C M, Bu G, Laribee N, Tanzi R E, Moir R D, Nath A, He J J. 2000. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med. 6: 1380–1387. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Luo Y, Fischer F R, Hancock W W, Dorf M E. 2000. Macrophage inflammatory protein-2 and KC induce chemokine production by mouse astrocytes. J Immunol. 165: 4015–4023. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Ma M, Nath A. 1997. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol. 71: 2495–2499. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Marcuzzi A, Weinberger J, Weinberger O K. 1992. Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in cocultured lymphocytes. J Virol. 66: 4228–4232. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Marder K, Albert S, Dooneief G, Stern Y, Ramachandran G, Epstein L. 1996. Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders. Neurology. 47: 1247–1253
   PubMedGoogle Scholar
• Marzolo M P, von, Bernhardi R, Bu G, Inestrosa N C. 2000. Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells. J Neurosci Res. 60: 401–411. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A. 2000. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry. 69: 376–380. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Masliah E, Ge N, Achim C L, Hansen L A, Wiley C A. 1992. Selective neuronal vulnerability in HIV encephalitis. J Neuropathol Exp Neurol. 51: 585–593. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Masliah E, Heaton R K, Marcotte T D, Ellis R J, Wiley C A, Mallory M, Achim C L, McCutchan J A, Nelson J A, Atkinson J H, Grant I. 1997. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol. 42: 963–972. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Miike T, Nelson R P, Trudeau W L, Lockey R F, Yodoi J. 1993. Elevated serum levels of IL-8 in patients with HIV infection. Clin Exp Immunol. 93: 149–151. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Mayne M, Holden C P, Nath A, Geiger J D. 2000. Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. J Immunol. 164: 6538–6542. [PUBMED], [INFOTRIEVE]
   Google Scholar
• McArthur J C, Hoover D R, Bacellar H, Miller E N, Cohen B A, Becker J T, Graham N M, McArthur J H, Selnes O A, Jacobson L P, et al, 1993. Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology. 43: 2245–2252. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• McManus C M, Weidenheim K, Woodman S E, Nunez J, Hesselgesser J, Nath A, Berman J W. 2000. Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation. Am J Pathol. 156: 1441–1453. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Mengozzi M, De, Filippi C, Transidico P, Biswas P, Cota M, Ghezzi S, Vicenzi E, Mantovani A, Sozzani S, Poli G. 1999. Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells. Blood. 93: 1851–1857. [PUBMED], [INFOTRIEVE]
   Web of Science ®Google Scholar
• Mitola S, Sozzani S, Luini W, Primo L, Borsatti A, Weich H, Bussolino F. 1997. Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1. Blood. 90: 1365–1372. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Moestrup S K, Gliemann J, Pallesen G. 1992. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res. 269: 375–382. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Morini M, Benelli R, Giunciuglio D, Carlone S, Arena G, Noonan D M, Albini A. 2000. Kaposi's sarcoma cells of different etiologic origins respond to HIV- Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology. Biochem Biophys Res Commun. 273: 267–271. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nath A, Hartloper V, Furer M, Fowke K R. 1995. Infection of human fetal astrocytes with HIV-1: viral tropism and the role of cell to cell contact in viral transmission. J Neuropathol Exp Neurol. 54: 320–330. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nath A, Haughey N J, Jones M, Anderson C, Bell J E, Geiger J D. 2000. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol. 47: 186–194. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nath A, Psooy K, Martin C, Knudsen B, Magnuson D S, Haughey N, Geiger J D. 1996. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol. 70: 1475–1480. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• New D R, Maggirwar S B, Epstein L G, Dewhurst S, Gelbard H A. 1998. HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-d-aspartate receptors by a NFkappaB-independent mechanism. J Biol Chem. 273: 17852–17858. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nicolini A, Ajmone-Cat M A, Bernardo A, Levi G, Minghetti L. 2001. Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-kappaB activation and oxidative stress in microglial cultures by independent mechanisms. J Neurochem. 79: 713–716. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Polazzi E, Levi G, Minghetti L. 1999. Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures. J Neuropathol Exp Neurol. 58: 825–831. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Prendergast M A, Rogers D T, Mulholland P J, Littleton J M, Wilkins L H, Jr, Self R L, Nath A. 2002. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-d-aspartate receptor. Brain Res. 954: 300–307. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Web of Science ®Google Scholar
• Price R W, Brew B, Sidtis J, Rosenblum M, Scheck A C, Cleary P. 1988. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science. 239: 586–592. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Rezaie P, Trillo-Pazos G, Greenwood J, Everall I P, Male D K. 2002. Motility and ramification of human fetal microglia in culture: an investigation using time-lapse video microscopy and image analysis. Exp Cell Res. 274: 68–82. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Rollins B J. 1997. Chemokines. Blood. 90: 909–928. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sacktor N, McDermott M P, Marder K, Schifitto G, Selnes O A, McArthur J C, Stern Y, Albert S, Palumbo D, Kieburtz K, De, Marcaida J A, Cohen B, Epstein L. 2002. HIV-associated cognitive impairment before and after the advent of combination therapy. J NeuroVirol. 8: 136–142. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sanders V J, Pittman C A, White M G, Wang G, Wiley C A, Achim C L. 1998. Chemokines and receptors in HIV encephalitis. AIDS. 12: 1021–1026. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sasseville V G, Smith M M, Mackay C R, Pauley D R, Mansfield K G, Ringler D J, Lackner A A. 1996. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol. 149: 1459–1467. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Schmidtmayerova H, Nottet H S, Nuovo G, Raabe T, Flanagan C R, Dubrovsky L, Gendelman H E, Cerami A, Bukrinsky M, Sherry B. 1996. Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci U S A. 93: 700–704. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Schroder J M, Mrowietz U, Morita E, Christophers E. 1987. Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J Immunol. 139: 3474–3483. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sheng W S, Hu S, Hegg C C, Thayer S A, Peterson P K. 2000. Activation of human microglial cells by HIV-1 gp41 and Tat proteins. Clin Immunol. 96: 243–251. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Sopper S, Demuth M, Stahl-Hennig C, Hunsmann G, Plesker R, Coulibaly C, Czub S, Ceska M, Koutsilieri E, Riederer P, Brinkmann R, Katz M, ter, Meulen V. 1996. The effect of simian immunodeficiency virus infection in vitro and in vivo on the cytokine production of isolated microglia and peripheral macrophages from rhesus monkey. Virology. 220: 320–329. [CROSSREF], [PUBMED], [INFOTRIEVE]
   Google Scholar
• Spencer D C, Price R W. 1992. Human immunodeficiency virus and the central nervous system. Annu Rev Microbiol. 46: 655–693. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Stoll G, Jander S. 1999. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol. 58: 233–247. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tarzami S T, Cheng R, Miao W, Kitsis R N, Berman J W. 2002. Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death. J Mol Cell Cardiol. 34: 209–221. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Taub D D, Lloyd A R, Conlon K, Wang J M, Ortaldo J R, Harada A, Matsushima K, Kelvin D J, Oppenheim J J. 1993. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med. 177: 1809–1814. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Thomas C A, Dobkin J, Weinberger O K. 1994. TAT-mediated transcellular activation of HIV-1 long terminal repeat directed gene expression by HIV-1-infected peripheral blood mononuclear cells. J Immunol. 153: 3831–3839. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Tong L, Pav S, White D M, Rogers S, Crane K M, Cywin C L, Brown M L, Pargellis C A. 1997. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat Struct Biol. 4: 311–316. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Trkola A, Dragic T, Arthos J, Binley J M, Olson W C, Allaway G P, Cheng-Mayer C, Robinson J, Maddon P J, Moore J P. 1996. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature. 384: 184–187. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Trkola A, Gordon C, Matthews J, Maxwell E, Ketas T, Czaplewski L, Proudfoot A E, Moore J P. 1999. The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivity. J Virol. 73: 6370–6379. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tyor W R, Power C, Gendelman H E, Markham R B. 1993. A model of human immunodeficiency virus encephalitis in scid mice. Proc Natl Acad Sci U S A. 90: 8658–8662. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Walz A, Peveri P, Aschauer H, Baggiolini M. 1987. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun. 149: 755–761. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Weeks B S, Lieberman D M, Johnson B, Roque E, Green M, Loewenstein P, Oldfield E H, Kleinman H K. 1995. Neurotoxicity of the human immunodeficiency virus type 1 tat transactivator to PC12 cells requires the Tat amino acid 49–58 basic domain. J Neurosci Res. 42: 34–40. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Weiss J M, Downie S A, Lyman W D, Berman J W. 1998. Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. J Immunol. 161: 6896–6903. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Weiss J M, Nath A, Major E O, Berman J W. 1999. HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J Immunol. 163: 2953–2959. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Westendorp M O, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin K M, Krammer P H. 1995. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature. 375: 497–500. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Westmoreland S V, Rottman J B, Williams K C, Lackner A A, Sasseville V G. 1998. Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis. Am J Pathol. 152: 659–665. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wiley C A, Baldwin M, Achim C L. 1996. Expression of HIV regulatory and structural mRNA in the central nervous system. AIDS. 10: 843–847. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wiley C A, Masliah E, Morey M, Lemere C, De, Teresa R, Grafe M, Hansen L, Terry R. 1991. Neocortical damage during HIV infection. Ann Neurol. 29: 651–657. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wiley C A, Schrier R D, Nelson J A, Lampert P W, Oldstone M B. 1986. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A. 83: 7089–7093. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wolf B B, Lopes M B, Vanden, Berg S R, Gonias S L. 1992. Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am J Pathol. 141: 37–42. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Xiong H, Boyle J, Winkelbauer M, Gorantla S, Zheng J, Ghorpade A, Persidsky Y, Carlson K A, Gendelman H E. 2003. Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia. J Neurosci Res. 71: 600–607. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Yoshimura T, Robinson E A, Appella E, Matsushima K, Showalter S D, Skeel A, Leonard E J. 1989. Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence. Mol Immunol. 26: 87–93. [CROSSREF], [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar