References
- Adle-Biassette H, Chretien F, Wingertsmann L, Hery C, Ereau T, Scaravilli F, Tardieu M, Gray F. 1999. Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage. Neuropathol Appl Neurobiol. 25: 123–133. [PUBMED], [INFOTRIEVE]
- Agarwal S, Sohal R S. 1994. Aging and proteolysis of oxidized proteins. Arch Biochem Biophys. 309: 24–28. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Ageta H, Kato A, Fukazawa Y, Inokuchi K, Sugiyama H. 2001. Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Brain Res Mol Brain Res. 97: 186–189. [CROSSREF], [PUBMED], [INFOTRIEVE]
- An S F, Giometto B, Groves M, Miller R F, Beckett A A, Gray F, Tavolato B, Scaravilli F. 1997. Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS. J Neuropathol Exp Neurol. 56: 1262–1268. [PUBMED], [INFOTRIEVE]
- Anderson J P, Esch F S, Keim P S, Sambamurti K, Lieberburg I, Robakis N K. 1991. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett. 128: 126–128. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Baker R T, Tobias J W, Varshavsky A. 1992. Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem. 267: 23364–23375. [PUBMED], [INFOTRIEVE]
- Band G P, Ridderinkhof K R, Segalowitz S. 2002. Explaining neurocognitive aging: is one factor enough?. Brain Cogn. 49: 259–267. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Bence N F, Sampat R M, Kopito R R. 2001. Impairment of the ubiquitin-proteasome system by protein aggregation. Science. 292: 1552–1555. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Bennett M C, Bishop J F, Leng Y, Chock P B, Chase T N, Mouradian M M. 1999. Degradation of alpha-synuclein by proteasome. J Biol Chem. 274: 33855–33858. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Bulteau A L, Szweda L I, Friguet B. 2002. Age-dependent declines in proteasome activity in the heart. Arch Biochem Biophys. 397: 298–304. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Burbea M, Dreier L, Dittman J S, Grunwald M E, Kaplan J M. 2002. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in. C. elegans. Neuron. 35: 107–120. [CROSSREF]
- Buttner C, Sadtler S, Leyendecker A, Laube B, Griffon N, Betz H, Schmalzing G. 2001. Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. J Biol Chem. 276: 42978–42985. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Carrard G, Bulteau A L, Petropoulos I, Friguet B. 2002. Impairment of proteasome structure and function in aging. Int J Biochem Cell Biol. 34: 1461–1474. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Chang L, Ernst T, Leonido-Yee M, Witt M, Speck O, Walot I, Miller E N. 1999. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia. Neurology. 53: 782–789. [PUBMED], [INFOTRIEVE]
- Chapman A P, Courtney S C, Smith S J, Rider C C, Beesley P W. 1992. Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranes. Biochem Soc Trans. 20: 155S, [PUBMED], [INFOTRIEVE]
- Chapman A P, Smith S J, Rider C C, Beesley P W. 1994. Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities. Neurosci Lett. 168: 238–242. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Chung K K, Dawson V L, Dawson T M. 2001. The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci. 24: S7–S14. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Davies K J. 2001. Degradation of oxidized proteins by the 20S proteasome. Biochimie. 83: 301–310. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Di, Antonio A, Haghighi A P, Portman S L, Lee J D, Amaranto A M, Goodman C S. 2001. Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature. 412: 449–452. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Dickson D W. 1997. The pathogenesis of senile plaques. J Neuropathol Exp Neurol. 56: 321–339. [PUBMED], [INFOTRIEVE]
- Dickson D W, Wertkin A, Kress Y, Ksiezak-Reding H, Yen S H. 1990. Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest. 63: 87–99. [PUBMED], [INFOTRIEVE]
- Dimakopoulos A C, Mayer R J. 2002. Aspects of neurodegeneration in the canine brain. J Nutr. 132: 1579S–1582S. [PUBMED], [INFOTRIEVE]
- Dore G J, Correll P K, Li Y, Kaldor J M, Cooper D A, Brew B J. 1999. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS. 13: 1249–1253. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Dougherty R H, Skolasky R L, Jr, McArthur J C. 2002. Progression of HIV-associated dementia treated with HAART. AIDS Read. 12: 69–74. [PUBMED], [INFOTRIEVE]
- Ehlers M D. 2003. Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease. Trends Neurosci. 26: 4–7. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Esiri M M, Biddolph S C, Morris C S. 1998. Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry. 65: 29–33. [PUBMED], [INFOTRIEVE]
- Figueiredo-Pereira M E, Li Z, Jansen M, Rockwell P. 2002. N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells. J Biol Chem. 277: 25283–25289. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Gelman B B, Wolf D A, Olano J P, Linthicum L C. 1996. Incarceration and the acquired immunodeficiency syndrome: autopsy results in Texas prison inmates. Hum Pathol. 27: 1282–1287. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Glass J D, Fedor H, Wesselingh S L, McArthur J C. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol. 38: 755–762. [PUBMED], [INFOTRIEVE]
- Goto S, Takahashi R, Araki S, Nakamoto H. 2002. Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism. Ann N Y Acad Sci. 959: 50–56. [PUBMED], [INFOTRIEVE]
- Goto S, Takahashi R, Kumiyama A A, Radak Z, Hayashi T, Takenouchi M, Abe R. 2001. Implications of protein degradation in aging. Ann N Y Acad Sci. 928: 54–64. [PUBMED], [INFOTRIEVE]
- Gray F, Chretien F, Vallat-Decouvelaere A V, Scaravilli F. 2003. The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol. 62: 429–440. [PUBMED], [INFOTRIEVE]
- Grune T. 2000. Oxidative stress, aging and the proteasomal system. Biogerontology. 1: 31–40. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Hegde A N, Di, Antonio A. 2002. Ubiquitin and the synapse. Nat Rev Neurosci. 3: 854–861. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Hogg R S, O'Shaughnessy M V, Gataric N, Yip B, Craib K, Schechter M T, Montaner J S. 1997. Decline in deaths from AIDS due to new antiretrovirals. Lancet. 349: 1294, [PUBMED], [INFOTRIEVE]
- Izycka-Swieszewska E, Zoltowska A, Rzepko R, Gross M, Borowska-Lehman J. 2000. Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS). Folia Neuropathol. 38: 175–182. [PUBMED], [INFOTRIEVE]
- Jellinger K A, Setinek U, Drlicek M, Bohm G, Steurer A, Lintner F. 2000. Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol (Berl). 100: 213–220. [CROSSREF]
- Jiang Y H, Armstrong D, Albrecht U, Atkins C M, Noebels J L, Eichele G, Sweatt J D, Beaudet A L. 1998. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 21: 799–811. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Kanemaru K, Meckelein B, Marshall D C, Sipe J D, Abraham C R. 1996. Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiol Aging. 17: 767–771. [PUBMED], [INFOTRIEVE]
- Keck S, Nitsch R, Grune T, Ullrich O. 2003. Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem. 85: 115–122. [PUBMED], [INFOTRIEVE]
- Keller J N, Gee J, Ding Q. 2002. The proteasome in brain aging. Ageing Res Rev. 1: 279–293. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Keller J N, Hanni K B, Kindy M S. 2000a. Oxidized high-density lipoprotein induces neuron death. Exp Neurol. 161: 621–630. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Keller J N, Hanni K B, Markesbery W R. 2000b. Impaired proteasome function in Alzheimer's disease. J Neurochem. 75: 436–439. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Keller J N, Hanni K B, Markesbery W R. 2000c. Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev. 113: 61–70. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Keller J N, Huang F F, Markesbery W R. 2000d. Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience. 98: 149–156. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Keller J N, Markesbery W R. 2000. Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death. J Neurosci Res. 61: 436–442. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Klimaschewski L. 2003. Ubiquitin-dependent proteolysis in neurons. News Physiol Sci. 18: 29–33. [PUBMED], [INFOTRIEVE]
- Lennox G, Lowe J, Morrell K, Landon M, Mayer R J. 1988. Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases. Neurosci Lett. 94: 211–217. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Li Z, Jansen M, Pierre S R, Figueiredo-Pereira M E. 2003. Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation. Int J Biochem Cell Biol. 35: 547–552. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Licastro F, Campbell I L, Kincaid C, Veinbergs I, Van, Uden E, Rockenstein E, Mallory M, Gilbert J R, Masliah E. 1999. A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. Am J Pathol. 155: 869–875. [PUBMED], [INFOTRIEVE]
- Lopez-Salon M, Alonso M, Vianna M R, Viola H, Mello e Souza T, Izquierdo I, Pasquini J M, Medina J H. 2001. The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Eur J Neurosci. 14: 1820–1826. [PUBMED], [INFOTRIEVE]
- Lowe J, Blanchard A, Morrell K, Lennox G, Reynolds L, Billett M, Landon M, Mayer R J. 1988. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J Pathol. 155: 9–15. [PUBMED], [INFOTRIEVE]
- Lowe J, Mayer J, Landon M, Layfield R. 2001. Ubiquitin and the molecular pathology of neurodegenerative diseases. Adv Exp Med Biol. 487: 169–186. [PUBMED], [INFOTRIEVE]
- Ma J, Wollmann R, Lindquist S. 2002. Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science. 298: 1781–1785. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Mahler H R. 1969. Protein turnover and synthesis: relation to synaptic function. Adv Biochem Psychopharmacol. 1: 49–69. [PUBMED], [INFOTRIEVE]
- Marzban G, Grillari J, Reisinger E, Hemetsberger T, Grabherr R, Katinger H. 2002. Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries. Exp Gerontol. 37: 1451–1460. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Masliah E, De, Teresa R M, Mallory M E, Hansen L A. 2000. Changes in pathological findings at autopsy in AIDS cases for the last 15 years. AIDS. 14: 69–74. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Masliah E, Heaton R K, Marcotte T D, Ellis R J, Wiley C A, Mallory M, Achim C L, McCutchan J A, Nelson J A, Atkinson J H, Grant I. 1997. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol. 42: 963–972. [PUBMED], [INFOTRIEVE]
- McGeer P L, McGeer E G. 2001. Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging. 22: 799–809. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Merker K, Grune T. 2000. Proteolysis of oxidised proteins and cellular senescence. Exp Gerontol. 35: 779–786. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Merker K, Stolzing A, Grune T. 2001. Proteolysis, caloric restriction and aging. Mech Ageing Dev. 122: 595–615. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Merrill J E, Koyanagi Y, Zack J, Thomas L, Martin F, Chen I S. 1992. Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol. 66: 2217–2225. [PUBMED], [INFOTRIEVE]
- Mezey E, Dehejia A, Harta G, Papp M I, Polymeropoulos M H, Brownstein M J. 1998. Alpha synuclein in neurodegenerative disorders: murderer or accomplice?. Nat Med. 4: 755–757. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Mirra S S, Hart M N, Terry R D. 1993. Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. Arch Pathol Lab Med. 117: 132–144. [PUBMED], [INFOTRIEVE]
- Mizuno Y, Hattori N, Matsumine H. 1998. Neurochemical and neurogenetic correlates of Parkinson's disease. J Neurochem. 71: 893–902. [PUBMED], [INFOTRIEVE]
- Morgello S, Mahboob R, Yakoushina T, Khan S, Hague K. 2002. Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time. Arch Pathol Lab Med. 126: 182–190. [PUBMED], [INFOTRIEVE]
- Navia B A, Cho E S, Petito C K, Price R W. 1986. The AIDS dementia complex: II. Neuropathology. Ann Neurol. 19: 525–535. [PUBMED], [INFOTRIEVE]
- Ohtsuka H, Takahashi R, Goto S. 1995. Age-related accumulation of high-molecular-weight ubiquitin protein conjugates in mouse brains. J Gerontol A Biol Sci Med Sci. 50: B277–B281. [PUBMED], [INFOTRIEVE]
- Pappolla M A, Omar R, Saran B. 1989. The “normal” brain. “Abnormal” ubiquitinilated deposits highlight an age-related protein change. Am J Pathol. 135: 585–591. [PUBMED], [INFOTRIEVE]
- Petito C K. 1993. Neuropathology of Acquired Immunodeficiency Syndrome. Principles and practice of neuropathology, Nelson J S, Parisi J E, Schochet S S, St. Louis, Mosby–Year Book. pp 88–108
- Raasi S, Schmidtke G, de, Giuli R, Groettrup M. 1999. A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol. 29: 4030–4036. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Roberts E S, Zandonatti M A, Watry D D, Madden L J, Henriksen S J, Taffe M A, Fox H S. 2003. Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol. 162: 2041–2057. [PUBMED], [INFOTRIEVE]
- Ryazanov A G, Nefsky B S. 2002. Protein turnover plays a key role in aging. Mech Ageing Dev. 123: 207–213. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Sacktor N, Lyles R H, Skolasky R, Kleeberger C, Selnes O A, Miller E N, Becker J T, Cohen B, McArthur J C. 2001. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998. Neurology. 56: 257–260. [PUBMED], [INFOTRIEVE]
- Sacktor N C, Lyles R H, Skolasky R L, Anderson D E, McArthur J C, McFarlane G, Selnes O A, Becker J T, Cohen B, Wesch J, Miller E N. 1999. Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology. 52: 1640–1647. [PUBMED], [INFOTRIEVE]
- Sacktor N C, Skolasky R L, Lyles R H, Esposito D, Selnes O A, McArthur J C. 2000. Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors. J NeuroVirol. 6: 84–88. [PUBMED], [INFOTRIEVE]
- Schreiber G, Aldred A R. 1993. Extrahepatic synthesis of acute phase proteins. Acute phase proteins: molecular biology, biochemistry, and clinical applications, Mackiewicz A, Kushner I, Baumann H, Boca Raton, CRC Press. pp 39–76
- Sherman M Y, Goldberg A L. 2001. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 29: 15–32. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T. 2000. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet. 25: 302–305. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Stolzing A, Grune T. 2001. The proteasome and its function in the ageing process. Clin Exp Dermatol. 26: 566–572. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Taylor J P, Tanaka F, Robitschek J, Sandoval C M, Taye A, Markovic-Plese S, Fischbeck K H. 2003. Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet. 12: 749–757. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Terry R D, Masliah E, Salmon D P, Butters N, De, Teresa R, Hill R, Hansen L A, Katzman R. 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 30: 572–580. [PUBMED], [INFOTRIEVE]
- Thal D R, Rub U, Schultz C, Sassin I, Ghebremedhin E, Del, Tredici K, Braak E, Braak H. 2000. Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol. 59: 733–748. [PUBMED], [INFOTRIEVE]
- Tozzi V, Balestra P, Galgani S, Narciso P, Sampaolesi A, Antinori A, Giulianelli M, Serraino D, Ippolito G. 2001. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years. J Acquir Immune Defic Syndr. 28: 19–27. [PUBMED], [INFOTRIEVE]
- Tsuji T, Shimohama S. 2002. Protein degradation in Alzheimer's disease and aging of the brain. Prog Mol Subcell Biol. 29: 43–60. [PUBMED], [INFOTRIEVE]
- Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer H K, Siegmund W, Kunert-Keil C, Walker L C, Warzok R W. 2002. Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics. 12: 535–541. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Walker D G, Kim S U, McGeer P L. 1995. Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J Neurosci Res. 40: 478–493. [PUBMED], [INFOTRIEVE]
- Ward W F. 2000. The relentless effects of the aging process on protein turnover. Biogerontology. 1: 195–199. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Wiley C A, Achim C. 1994. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol. 36: 673–676. [PUBMED], [INFOTRIEVE]
- Williams K C, Hickey W F. 2002. Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu Rev Neurosci. 25: 537–562. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Wilson S M, Bhattacharyya B, Rachel R A, Coppola V, Tessarollo L, Householder D B, Fletcher C F, Miller R J, Copeland N G, Jenkins N A. 2002. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet. 32: 420–425. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Wolf D A, Dholakia S R, Keherly M J, Rodriguez-Wolf M G, Cloyd M W, Gelman B B. 1997. Proteolysis in the myelopathy of acquired immunodeficiency syndrome: preferential loss of the C-8 component of myelin basic protein. Lab Invest. 77: 513–523. [PUBMED], [INFOTRIEVE]
- Wyss-Coray T, Mucke L. 2002. Inflammation in neurodegenerative disease—a double-edged sword. Neuron. 35: 419–432. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y. 2001. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. J Neuropathol Exp Neurol. 60: 731–739. [PUBMED], [INFOTRIEVE]