References
- Acquas E, Bachis A, Nosheny R L, Cernak I, Mocchetti I. Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases. Neurotoxicol Res 2004; 5: 605–615
- Adle-Biassette H, Wingertsmann L, Authier F J, Kondo H, Poron F, Hery C, Bell J, Tardieu M, Gherardi R, Gray F. Neuronal apoptosis in the central and peripheral nervous system in HIV infection. Arch Anat Cytol Pathol 1997; 45: 86–93, [PUBMED], [INFOTRIEVE], [CSA]
- Arunagiri C, Macreadie L, Hewish D, Azad A. A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes. Apoptosis 1997; 2: 69–76, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Asare E, Dunn G, Glass J, McArthur J, Luthert P, Lantos P, Everall L. Neuronal pattern correlates with the severity of human immunodeficiency virus-associated dementia complex. Usefulness of spatial pattern analysis in clinicopathological studies. Am J Pathol 1996; 148: 31–38, [PUBMED], [INFOTRIEVE], [CSA]
- Bansal A K, Mactutus C F, Nath A, Maragos W, Hauser K F, Booze R M. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum. Brain Res 2000; 879: 42–49, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Brewer G J. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 1995; 42: 674–683, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Budd S L, Tenneti L, Lishnak T, Lipton S A. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc Natl Acad Sci U S A 2000; 97: 6161–6166, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Burdo T H, Nonnemacher M, Irish B P, Choi C H, Krebs F C, Gartner S, Wigdahl B P. High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia. DNA Cell Biol 2004; 23: 261–269, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Cohen E A, Terwilliger E F, Jalinoos Y, Proulx J, Sodroski J G, Haseltine W A. Identification of HIV-1 vpr product and function. J Acquir Immune Defic Syndr 1990; 3: 11–18, [PUBMED], [INFOTRIEVE], [CSA]
- Connor R I, Chen B K, Choe S, Landau N R. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 1995; 206: 935–944, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Cornille F, Wecker K, Loffet A, Genet R, Roques B P. Efficient solid-phase synthesis of Vpr from HIV-1 using low quantities of uniformly 13C-, 15N-labeled amino acids for NMR structural studies. J Peptide Res 1999; 54: 427–435, [CROSSREF], [CSA]
- Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau N R. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. J Virol 1995; 69: 7909–7916, [PUBMED], [INFOTRIEVE], [CSA]
- Dore G J, Correll P K, Li Y, Kaldor J M, Cooper D A, Brew B J. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 1999; 13: 1249–1253, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Everall I P, Luthert P J, Lantos P L. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991; 337: 1119–1121, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Garden G A, Budd S L, Tsai E, Hanson L, Kaul M, D'emilia D M, Friedlander R M, Yuan J, Masliah E, Lipton S A. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci 2002; 22: 4015–4024, [PUBMED], [INFOTRIEVE], [CSA]
- Goh W C, Rogel M E, Kinsey C M, Michael S F, Fultz P N, Nowak M A, Hahn B H, Emerman M. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med 1998; 4: 65–71, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Gray F, Adle-Biassette H, Brion F, Ereau T, le Maner I, Levy V, Corcket G. Neuronal apoptosis in human immunodeficiency virus infection. J NeuroVirol 2000; 6: S38–S43, Suppl 1[PUBMED], [INFOTRIEVE], [CSA]
- Gummuluru S, Emerman M. Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines. J Virol 1999; 73: 5422–5430, [PUBMED], [INFOTRIEVE], [CSA]
- He J, Choe S, Walker R, Di Marzio P, Morgan D O, Landau N R. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol 1995; 69: 6705–6711, [PUBMED], [INFOTRIEVE], [CSA]
- Heinzinger N K, Bukinsky M I, Haggerty S A, Ragland A M, Kewalramani V, Lee M A, Gendelman H E, Ratner L, Stevenson M, Emerman M. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci U S A 1994; 91: 7311–7315, [PUBMED], [INFOTRIEVE], [CSA]
- Henklein P, Bruns K, Sherman M P, Tessmer U, Licha K, Kopp J, de Noronha C M, Greene W C, Wray V, Schubert U. Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest. J Biol Chem 2000; 275: 32016–32026, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Huang M B, Weeks O, Zhao L J, Saltarelli M, Bond V C. Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures. J NeuroVirol 2000; 6: 202–220, [PUBMED], [INFOTRIEVE], [CSA]
- Jacotot E, Ferri K F, El Hamel C, Brenner C, Druillennec S, Hoebeke J, Rustin P, Metivier D, Lenoir C, Geuskens M, Vieira H L, Loeffler M, Belzacq A S, Briand J P, Zamzami N, Edelman L, Xie Z H, Reed J C, Roques B P, Kroemer G. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl- 2. J Exp Med 2001; 193: 509–519, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Jacotot E, Ravagnan L, Loeffler M, Ferri K F, Vieira H L, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand J P, Irinopoulou T, Daugas E, Susin S A, Cointe D, Xie Z H, Reed J C, Roques B P, Kroemer G. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med 2000; 191: 33–46, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- James C O, Huang M B, Khan M, Garcia-Barrio M, Powell M D, Bond V C. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J Virol 2004; 78: 3099–3109, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- James H J, Sharer L R, Zhang Q, Wang H G, Epstein L G, Reed J C, Gelbard H A. Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis. Neuropathol Appl Neurobiol 1999; 25: 380–386, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Kichler A, Pages J C, Leborgne C, Druillennec S, Lenoir C, Coulaud D, Delain E, Le Cam E, Roques B P, Danos O. Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R. J Virol 2000; 74: 5424–5431, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Kolson D L, Lavi E, Gonzalez-Scarano F. The effects of human immunodeficiency virus in the central nervous system. Adv Virus Res 1998; 50: 1–47, [PUBMED], [INFOTRIEVE], [CSA]
- Krohn A J, Wahlbrink T, Prehn J H. Mitochondrial depolarization is not required for neuronal apoptosis. J Neurosci 1999; 19: 7394–7404, [PUBMED], [INFOTRIEVE], [CSA]
- Kruman I I, Nath A, Mattson M P. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 1998; 154: 276–288, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Levy D N, Refaeli Y, Mac Gregor R R, Weiner D B. Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 1994; 91: 10873–10877, [PUBMED], [INFOTRIEVE], [CSA]
- Lum J J, Cohen O J, Nie Z, Weaver J G, Gomez T S, Yao X J, Lynch D, Pilon A A, Hawley N, Kim J E, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen E A, Badley A D. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Invest 2003; 111: 1547–1454, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- MacArthur J C, Hoover D R, Bacellar H, Miller E N, Cohen B A, Becker J T, Graham N M, Mac Arthur J H, Selnes O A, Jacobson P L. Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS cohort study. Neurology 1993; 43: 2245–2252, [CSA]
- Macreadie I G, Arunagiri C K, Hewish D R, White J F, Azad A A. Extracellular addition of a domain of HIV-1 Vpr containing the amino acid sequence motif H(S/F)RIG causes cell membrane permeabilization and death. Mol Microbiol 1996; 19: 1185–1192, [PUBMED], [INFOTRIEVE], [CSA]
- Macreadie I G, Castelli L A, Hewish D R, Kirkpatrick A, Ward A C, Azad A A. A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects. Proc Natl Acad Sci U S A 1995; 92: 277–2774, [CSA]
- Morellet N, Bouaziz S, Petitjean P, Roques B P. NMR structure of the HIV-1 regulatory protein VPR. J Mol Biol 2003; 327: 215–227, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Muthumani K, Choo A Y, Hwang D S, Chattergoon M A, Dayes N N, Zhang D, Lee D M, Duvvuri D, Weiner D B. Mechanism of HIV-1 viral protein R-induced apoptosis. Biochem Biophys Res Commun 2003; 304: 583–592, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Muthumani K, Hwang D S, Desai B M, Zhang D, Dayes N S, Green D R, Weiner D B. HIV-1 Induces apoptosis through caspase 9 in T cells and PBMC's. J Biol Chem 2002a; 2: 2, [CSA]
- Muthumani K, Zhang D, Hwang D S, Kudchodkar S, Dayes N S, Desai B M, Malik A S, Yang J S, Chattergoon M A, Maguire H C, Jr, Weiner D B. Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines. Oncogene 2002b; 21: 4613–4625, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Patel C A, Mukhtar M, Harley S, Kulkosky J, Pomerantz R J. Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons. J NeuroVirol 2002; 8: 86–99, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Patel C A, Mukhtar M, Pomerantz R J. Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells. J Virol 2000; 74: 9717–9726, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Petito C K, Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995; 146: 1121–1130, [PUBMED], [INFOTRIEVE], [CSA]
- Piller S C, Ewart J D, Jans D A, Gage P W, Cox G B. The amino-terminal region of Vpr from human immunodeficiency virus type 1 forms ion channels and kills neurons. J Virol 1999; 73: 4230–4238, [PUBMED], [INFOTRIEVE], [CSA]
- Piller S C, Jans P, Gage P W, Jans D A. Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology. Proc Natl Acad Sci U S A 1998; 95: 4595–4600, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M. Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex. J Biol Chem 1998; 273: 13347–13352, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Price R W, Yiannoutsos C T, Clifford D B, Zaborski L, Tselis A, Sidtis J J, Cohen B, Hall C D, Erice A, Henry K. Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team. AIDS 1999; 13: 1677–1685, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Rausch D M, Stover E S. Neuroscience research in AIDS. Prog Neuropsychopharmacol Biol Psychiatry 2001; 25: 231–257, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Re F, Braaten D, Franke E K, Luban J. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol 1995; 69: 6859–6864, [PUBMED], [INFOTRIEVE], [CSA]
- Roumier T, Vieira H L, Castedo M, Ferri K F, Boya P, Andreau K, Druillennec S, Joza N, Penninger J M, Roques B, Kroemer G. The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death Differ 2002; 9: 1212–1219, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Sawaya B E, Khalili K, Gordon J, Srinivasan A, Richardson M, Rappaport J, Amini S. Transdominant activity of human immunodeficiency virus type 1 Vpr with a mutation at residue R73. J Virol 2000; 74: 4877–4881, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Schuler W, Wecker K, de Rocquigny H, Baudat Y, Sire J, Roques B P. NMR structure of the (52–96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions. J Mol Biol 1999; 285: 2105–2117, [PUBMED], [INFOTRIEVE], [CSA]
- Sherman M P, de Noronha C M, Heusch M I, Greene S, Greene W C. Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr. J Virol 2001; 75: 1522–1532, [PUBMED], [INFOTRIEVE], [CSA]
- Shi B, De Girolami U, He J, Wang S, Lorenzo A, Busciglio J, Gabuzda D. Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest 1996; 98: 1979–1990, [PUBMED], [INFOTRIEVE], [CSA]
- Stewart S A, Poon B, Jowett J B, Xie Y, Chen I S. Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells. Proc Natl Acad Sci U S A 1999; 96: 12039–12043, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Stewart S A, Poon B, Song J Y, Chen I S. Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation. J Virol 2000; 74: 3105–3111, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Trillo-Pazos G, McFarlane-Abdulla E, Campbell I C, Pilkington G J, Everall I P. Recombinant nef HIV-IIIB protein is toxic to human neurons in culture. Brain Res 2000; 864: 315–326, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Van d e, Bovenkamp M, Nottet H S, Pereira C F. Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia. Eur J Clin Invest 2002; 32: 619–627, [CROSSREF], [CSA]
- Vodicka M A, Koepp D M, Silver P A, Emerman M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev 1998; 12: 175–185, [PUBMED], [INFOTRIEVE], [CSA]
- Xu Y, Kulkosky J, Acheampong E, Nunnari G, Sullivan J, Pomerantz R J. HIV-1-mediated apoptosis of neuronal cells: proximal molecular mechanisms of HIV-1-induced encephalopathy. Proc Natl Acad Sci U S A 2004; 101: 7070–7075, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Yasuda J, Miyao T, Kamata M, Aida Y, Iwakura Y. T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene. Virology 2001; 285: 181–192, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]