Cognitive and motor deficits associated with HIV-2₂₈₇ infection in infant pigtailed macaques: A nonhuman primate model of pediatric neuro–AIDS

REFERENCES

• Abrams E J, Matheson P B, Thomas P A, Thea D M, Krasinski K, Lambert G, Shaffer N, Bamji M, Hutson D, Grimm K, et al. Neonatal predictors of infection status and early death among 332 infants at risk of HIV-1 infection monitored prospectively from birth. New York City Perinatal HIV Transmission Collaborative Study Group. Pediatrics 1995; 96: 451–458, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Angelini L, Zibordi F, Triulzi F, Cinque P, Giudici B, Pinzani R, Plebani A. Age-dependent neurologic manifestations of HIV infection in childhood. Neurol Sci 2000; 21: 135–142, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Aylward E H, Butz A M, Hutton N, Joyner M L, Vogelhut J W. Cognitive and motor development in infants at risk for human immunodeficiency virus. Am J Dis Child 1992; 146: 218–222, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Belman A L. AIDS and pediatric neurology. Neurol Clin 1990; 8: 571–603, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Belman A L. Acquired immunodeficiency syndrome and the child's central nervous system. Pediatr Clin N Am 1992; 39: 691–714
   PubMed Web of Science ®Google Scholar
• Belman A L, Diamond G, Dickson D, Horoupian D, Llena J, Lantos G, Rubinstein A. Pediatric acquired immunodeficiency syndrome: neurologic syndromes. Am J Dis Child 1988; 142: 29–35, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Belman A L, Muenz L R, Marcus J C, Goedert J J, Landesman S, Rubinstein A, Goodwin S, Durako S, Willoughby A. Neurologic status of human immunodeficiency virus 1-infected infants and their controls: a prospective study from birth to 2 years. Pediatrics 1996; 98: 1109–1118, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Boivin M J, Davies A G, Mokili J KL, Green S DR, Giordani B, Cutting W AM. A preliminary evaluation of cognitive and motor effects of pediatric HIV infection in Zairian children. Health Psychol 1995; 14: 13–21, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Brouwers P, DeCarli C, Tudor-Williams G, Civitello L, Moss H, Pizzo P. Interrelations among patterns of change in neurocognitive, CT brain imaging and CD4 measures associated with anti-retroviral therapy in children with symptomatic HIV infection. Adv Neuroimmuno 1994; 4: 223–231, [CSA]
   PubMedGoogle Scholar
• Brouwers P, Tudor-Williams G, DeCarli C, Moss H A, Wolters P L, Civitello L A, Pizzo P A. Relation between stage of disease and neurobehavioral measures in children with symptomatic HIV disease. AIDS 1995; 9: 713–720, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bruck I, Tahan T T, Rodrigues da Cruz C, Martins L TF, Antoniuk S A, Rodrigues M, Mara de Souza S, Regina de Bruyn L. Developmental milestones of vertically HIV infected and seroreverters Children: follow up of 83 children. Arq Neuropsiquiatr 2001; 59: 691–695, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Burbacher T M, Grant K S, Mottet N K. Retarded object permanence development in methylmercury exposed macaca-fascicularis infants. Dev Psychol 1986; 22: 771–776, [CROSSREF]
   Google Scholar
• Chase C, Vibbert M, Pelton S I, Coulter D L, Cabral H. Early neurodevelopmental growth in children with vertically transmitted human immunodeficiency virus infection. Arch Pediatr Adolesc Med 1995; 149: 850–855, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Chase C, Ware J, Hittelman J, Blasini I, Smith R, Llorente A, Anisfeld E, Diaz C, Fowler M G, Moye J, Kaligh L I. Early cognitive and motor development among infants born to women infected with human immunodeficiency virus. Pediatrics 2000; 106: e25, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chougnet C, Kovacs A, Baker R, Mueller B U, Luban N LC, Liewehr D J, Steinberg S M, Thomas E K, Shearer G M. Influence of human immunodeficiency virus-infected maternal environment on development of infant interleukin-12 production. J Infect Dis 2000; 181: 1590–1597, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Clerici M, Saresella M, Colombo F, Fossati S, Sala N, Bricalli D, Villa M L, Ferrante P, Dally L, vigano A. T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV. Blood 2000; 96: 3866–3871, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cooper E R, Hanson C, Diaz C, Mendez H, Abboud R, Nugent R, Pitt J, Rich K, Rodrigues E M, Smeriglio V. Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. J Pediatr 1998; 132: 808–812, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Coplan J, Contello K A, Cunningham C K, Weiner L B, Dye T D, Roberge L, Wojtowycz M A, Kirkwood K. Early language development in children exposed to or infected with human immunodeficiency virus. Pediatr Electronic 1998; 102: e8, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Coscia J M, Christensen B K, Henry R R, Wallston K, Radcliffe J, Rutstein R. Effects of home environment, socioeconomic status, and health status on cognitive functioning in children with HIV-1 infection. J Pediatr Psychiatry 2001; 26: 321–329, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• DeMaria M A, Casto M, O'Connell M, Johnson R P, Rosenzweig M. Characterization of lymphocyte subsets in rhesus macaques during the first year of life. Eur J Haematol 2000; 65: 245–257, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Diamond G W. Developmental problems in children with HIV infection. Mental Retard 1989; 27: 213–217
   PubMedGoogle Scholar
• Diamond G W, Kaufman J, Belman A L, Cohen L, Cohen H J, Rubinstein A. Characterization of cognitive functioning in a subgroup of children with congenital HIV infection. Arch Clin Neuropsychol 1987; 2: 245–256, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Diamond G W, Gurdin P, Wiznia A A, Bleman A L, Rubenstein A, Cohen H J. Effects of congenital HIV infection on neurodevelopmental status of babies in foster care. Dev Med Child Neurol 1990; 32: 999–1005, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Drotar D, Olness K, Wiznitzer M, Guay L, Marum L, Svilar G, Hom D, Fagan J F, Ndugwa C, Kiziri-Mayengo R. Neurodevelopmental outcomes of Ugandan infants with human immunodeficiency virus type 1 infection. Pediatrics 1997; 100: E5, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Drotar D, Olness K, Wiznitzer M, Schatschneider C, Marum L, Guay L, Fagan J, Hom D, Svilar G, Ndugwa C, Mayengo R K. Neurodevelopmental outcomes of Ugandan infants with HIV infection: an application of growth curve analysis. Health Psychol 1999; 18: 114–121, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Eiden L E, Rausch D M, da Cunha A, Murray E A, Heyes M, Sharer L, Nohr D, Weihe E. Aids and the central nervous system. Ann N Y Acad Sci 1993; 693: 229–244, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Englund J A, Baker C J, Raskino C, McKinney R E, Lifschitz M H, Petrie B, Fowler M G, Connor J D, Mendez H, O'Donnell K, Wara D W. The Aids Clinical Trials Group Protocol 152 Study Team. Clinical and laboratory characteristics of a large cohort of symptomatic, human immunodeficiency virus-infected infants and children. Pediatr Infect Dis J 1996; 15: 1025–1036, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Epstein L G. HIV infection in the newborn and child: Specific effects on the nervous system. AIDS in children, adolescents, and heterosexual adults, R F Schinazi, A J Nahmias. Elsevier Science, New York 1988
   Google Scholar
• Epstein L G, Sharer L R, Joshi V V, Fojas M R, Koenigsberger M R, Oleske J W. Progressive encephalopathy in children with acquired immunodeficiency syndrome. Ann Neurol 1984; 17: 488–496, [CROSSREF]
   Google Scholar
• Epstein L G, Sharer L R, Oleske J M, Connor E M, Goudsmit J, Bagdon L, Robert-Guroff M, Koenigsberger M R. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatr 1986; 78: 678–687
   PubMed Web of Science ®Google Scholar
• Esposito S, Musetti L, Musetti M C, Tornaghi R, Corbella S, Massironi E, Marchisio P, Guareschi A, Principi N. Behavioral and psychological disorders in uninfected children aged 6 to 11 years born to human immunoedeficiency virus-seropositive mothers. J Dev Behav Pediatr 1999; 20: 411–417, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Fox H S, Buchmeier M J, Lane T E, Stenglein S, Nelson J, Prospero-Garcia O, Henriksen S J, Gold L H, Bloom F E. Infection of rhesus macaques with neuro-pathogenic SIV induces cognitive and electrophysiologic abnormalities: viral and host factors lead to CNS dysfunction. J NeuroVirol 1996; 2: 13
   Google Scholar
• Fox H S, Gold L H, Henriksen S J, Bloom F E. Simian immunodeficiency virus: a model for neuroAIDS. Neurobiol Dis 1997; 4: 265–274, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Gesner M, Papaevangelou V, Kim M, Chen S H, Moore T, Krasinski K, Borkowsky W. Alteration in the proportion of CD4 T lymphocytes in a subgroup of human immunodeficiency-virus-exposed-uninfected children. Pediatr 1994; 93: 624–630
   PubMedGoogle Scholar
• Gold L H, Fox H S, Henriksen S J, Buchmeier M J, Weed M R, Taffe M A, Huitron-Resendiz S, Horn T F, Bloom F E. Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys. J Med Primatol 1998; 27: 104–112, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Gurbindo D, Resino S, Sanchez-Ramon S, Leon J A, Munoz-Fernandez M A. Correlation of viral load and CD8 T-lymphocytes with development of neurological manifestations in vertically HIV-1-infected infants. A prospective longitudinal study. Neuropediatrics 1999; 30: 197–204, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Herz A M, Robertson M N, Lynch J B, Schmidt A, Rabin M, Sherbert C, Agy M B, Anderson D, Hu S L, Greenberg P D, Morton W R. Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission. J Med Primatol 2002; 31: 29–39, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Ho R JY, Agy M B, Morton W R, Scheibel M, McClure J, Watson A, Hu S L, Nosbisch C, Dorofeeva N, Unadkat J D. Development of a chronically catheterized maternal-fetal macaque model to study in utero mother-to-fetus HIV transmission: a preliminary report. J Med Primatol 1996; 25: 218–224, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Ho R J, Larsen K, Kinman L, Sherbert C, Wang X Y, Finn E, Nosbisch C, Schmidt A, Anderson D, Hu S L, Agy M, Ochs H, Morton W R, Unadkat J D. Characterization of a maternal-fetal HIV transmission model using pregnant macaques infected with HIV-2 (287). J Med Primatol 2001; 30: 131–140, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Holterman L, Niphuis H, Koornstra W, Dubbes R, ten Haaft P, Heeney J L. The rate of progression to AIDS is independent of virus dose in simian immunodeficiency virus-infected macaques. J Gen Virol 2000; 81: 1719–1726, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Horn T F, Huitron-Resendiz S, Weed M R, Henriksen S J. Early physiological abnormalities after simian immunodeficiency virus infection. Proc Nat Acad Sci USA 1998; 95: 15072–15077, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Knight W G, Mellins C A, Levenson R L, Jr., Arpadi S M, Kairam R. Brief report: effects of pediatric HIV infection on mental and psychomotor development. J Pediatr Psychol 2000; 25: 583–587, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Kuhn L, Coutsoudis A, Moodley D, Mngqundaniso N, Trabattoni D, Shearer G M, Clerici M, Coovadia H M. Interferon-gamma and interleukin-10 production among HIV-1-infected and uninfected infants of HIV-1-infected mothers. Pediatr Res 2001; 50: 412–416, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Kuhn L, Meddows-Taylor S, Gray G, Tiemessen C. Human immunodeficiency virus (HIV)-specific cellular immune responses in newborns exposed to HIV in utero. CID 2002; 34: 267–276, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lifschitz M, Hanson C, Wilson G, Shearer W T. Behavioral changes in children with human immunodeficiency virus (HIV) infection. International Conference on AIDS. 1989. 5: 316
   Google Scholar
• Lindsey J C, Hughes M D, McKinney R E, Cowles M K, Englund J A, Baker C J, Burchett S K, Kline M W, Kovacs A, Moye J. Treatment-mediated changes in human immunodeficiency virus (HIV) type 1 RNA and CD4 cell counts as predictors of weight growth failure, cognitive decline, and survival in HIV-infected children. J Infect Dis 2000; 182: 1385–1393, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lobato M N, Caldwell M B, Ng P, Oxtoby M J. Pediatric Spectrum of Disease Clinical Consortium Encephalopathy in children with perinatally acquired human immunodeficiency virus infection. J Pediatr 1995; 126: 710–715, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Looney D J, McClure J, Kent S J, Radaelli A, Kraus G, Schmidt A, Steffy K, Greenberg P, Hu S L, Morton W R, Wong-Stall F. A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2(287) challenge. Virology 1998; 242: 150–160, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Lucas S B, Hounnou A, Peacock C, Beaumel A, Djomand G, N'Gbichi J M, Yeboue K, Honde M, Diomande M, Giordano C, Doorly R, Brattegaard K, Kestens L, Smithwick R, Kadio A, Ezani N, Yapi A, De Cock K M. The mortality and pathology of HIV infection in a West African city. AIDS 1993; 7: 1569–1579, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Macmillan C, Magder L S, Brouwers P, Chase C, Hittelman J, Lasky T, Malee K, Mellins C A, Velez-Borras. Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women. J Neurol 2001; 57: 1402–1411
   Google Scholar
• Marcario J K, Raymond L AM, McKiernan B J, Foresman L L, Joag S V, Raghavan R, Narayan O, Cheney P D. Motor skill impairment in SIV-infected rhesus macaques with rapidly and slowly progressing disease. J Med Primatol 1999; 28: 105–117, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• McClure J, Schmidt A M, Rey-Cuille M-A, Bannick J, Misher L, Tsai C C, Anderson D M, Morton W R, Hu S L. Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina. J Med Primatol 2000; 29: 114–126, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Mellins C A, Levenson R L, Jr, Zawadzki R, Kairam R, Weston M. Effects of pediatric HIV infection and prenatal drug exposure on mental and psychomotor development. J Pediatr Psychol 1994; 19: 617–628, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Mintz M. Clinical comparison of adult and pediatric NeuroAIDS. Adv Neuroimmunol 1994; 4: 207–221, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Mintz M. Clinical features of HIV infection in children. The neurology of AIDS, H E Gendelman, S A Liption, L Epstein, S Swindells. Chapman & Hall, New York 1998; pp 385–407
   Google Scholar
• Moss H A, Brouwers P L, Wolters P L, Wiener L, Hersh S, Pizzo P A. The development of a Q-sort behavioral rating procedure for pediatric HIV patients. J Pediatr Psychol 1994; 19: 27–46, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Moss H A, Wolters P L, Brouwers P, Hendricks M L, Pizzo P A. Impairment of expressive behavior in pediatric HIV-infected patients with evidence of CNS disease. J Pediatr Psychol 1996; 21: 379–400, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Moss H A, Wolters P L, Eddy J, Weiner L, Pizzo P, Brouwers P. The effects of encephalopathy and AZT treatment on the social and emotional behavior in pediatric AIDS. V International Conference on AIDS. 1989. 5: 328
   Google Scholar
• Moss H A, Wolters P L, El-Amin D, Butler K, Brouwers P, Pizzo P. The use of videotaped behavior samples of pediatric AIDS patients to evaluate psychosocial changes associated with encephalopathy before and after treatment. VI International Conference on AIDS. 1990. 6: 131
   Google Scholar
• Murray E A, Rausch D M, Lendvay J, Sharer L R, Eiden L E. Cognitive and motor impairments associated with SIV infection in Rhesus monkeys. Science 1992; 255: 1246–1249, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nielsen S D, Jeppesen D L, Kolte L, Clark D R, Sorensen T U, Dreves A M, Ersboll A K, Ryder L P, Valerius N H, Nielsen J O. Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts. Blood 2001; 98: 398–404, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Nozyce M, Hittelman J, Muenz L, Duraki S J, Fischer M L, Willoughby A. Effect of perinatally acquired human immunodeficiency virus infection on neurodevelopment in children during the first two years of life. Pediatr 1994; 94: 883–891
   PubMed Web of Science ®Google Scholar
• Pearson D A, McGrath N M, Nozyce M, Nichols S L, Raskino C, Brouwers P, Lifschitz M C, Baker C J, Englund J A. Predicting HIV disease progression in children using measures of neuropsychological and neurological functioning. Pediatrics 2000; 106: e76, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Web of Science ®Google Scholar
• Pollack H, Kuchuk A, Cowan L, Hacimamutoglu S, Glasberg H, David R, Krasinski K, Borkowsky W, Oberfield S. Neurodevelopment, growth, and viral load in HIV-infected infants. Brain Behav Immun 1996; 10: 298–312, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Pratt R D, Nichols S, McKinney N, Kwok S, Danker W M, Spector S A. Virologic markers of Human Immunodeficiency Virus Type 1 in cerebrospinal fluid of infected children. J Infect Dis 1996; 174: 288–293, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Price R W, Brew B, Sidtis J J, Rosenblum M, Scheck A, Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988; 239: 586–592, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Prospero-Garcia O, Gold L H, Fox H S, Polis I, Koob G F, Bloom F E, Henriksen S J. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys. Proc Nat Acad Sci USA 1996; 93: 14158–14163, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Rausch D M, Heyes M P, Eiden L E. Effects of chronic zidovudine administration on CNS function and virus burden after perinatal SIV infection in rhesus monkeys. Adv Neuroimmunol 1994a; 4: 233–237, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Rausch D M, Heyes M P, Murray E A, Eiden L E. Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of Rhesus macaques infected perinatally with simian immunodeficiency virus. J Infect Dis 1995; 172: 59–69, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Rausch D M, Heyes M P, Murray E A, Lendvay J, Sharer L R, Ward J M, Rehm S, Nohr D, Weibe E, Eiden L E. Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys. J Neuropathol Exp Neurol 1994b; 53: 165–175, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Raymond L AM, Wallace D, Marcario J K, Raghavan R, Narayan O, Foresman L L, Berman N EJ, Cheney P D. Motor evoked potentials in a rhesus macaque model of neuro-AIDS. J NeuroVirol 1999; 5: 217–231, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ruppenthal G C, Sackett G P. Research protocol and technician's manual: a guide to the care, feeding and evaluation of infant monkeys. The Infant Primate Research Laboratory, Seattle, WA 1992
   Google Scholar
• Schwarcz S K, Rutherford G W. Acquired immunodeficiency syndrome in infants, children and adolescents. J Drug Issues 1989; 19: 75–92, [CSA]
   Google Scholar
• Scott G B, Hutto C, Makuch R W, Mastrucci M T, O'Conner T, Mitchell C D, Trapido E J, Parks W P. Survival in children with perinatally acquired human immunodeficiency virus type I infection. NE J Med 1989; 321: 1791–1796
   PubMed Web of Science ®Google Scholar
• Sharer L R, Epstein L G, Cho E S, Joshi V V, Meyenhofer M F, Rankin L F, Petito C K. Pathologic features of AIDS encephalopathy in children: Evidence for LAV/HTLV-III infection of the brain. Human Pathol 1986; 17: 271–284
   PubMed Web of Science ®Google Scholar
• Sharer L R, Saito Y, Blumberg B M. Neuropathology of Human Immunodeficiency Virus-1 infection of the brain. Aids and the nervous system2nd ed., J R Berger, R M Levy. Lippincott-Raven Publishers, Philadelphia 1997; 461–479
   Google Scholar
• Smith R, Malee K, Charurat M, Magder L, Mellins C, MacMillan C, Hittleman J, Lasky T, Llorente A, Moye J. Timing of perinatal human immunodeficiency virus type 1 infection and rate of neurodevelopment. Pediatr Infect Dis J 2001; 19: 862–871, [CSA]
   Google Scholar
• Tardieu M, Mayaux M J, Seibel N, Funck-Brentano I, Straub E, Teglas J P, Blanche S. Cognitive assessment of school-age children infected with maternally transmitted human immunodeficiency virus type 1. J Pediatr 1995; 126: 375–379, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tardieu M, Chenadec J L, Persoz A, Meyer L, Blanche S, Mayaux M J. Hiv-1-related encephalopathy in infants compared with children and adults. Neurol 2000; 54: 1089–1095, [CSA]
   PubMed Web of Science ®Google Scholar
• Terao K, Rose L M, Sackett G P, Clark E A. Development of lymphocyte subsets in pigtailed macaques. Human Immunol 1988; 21: 33–48, [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Tovo P A, de Martino M, Gabiano C, Cappello N, D'Elia R, Loy A, Plebani A, Zuccotti G V, Dallacasa P, Ferraris G, Caselli D, Fundaro' C, D'Argenio P, Galli L, Principi N, Stegagno M, Ruga E, Palomba E. The Italian Register for HIV Infection in Children Prognostic factors and survival in children with perinatal HIV-1 infection. Lancet 1992; 339: 1249–1253, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Watson A, McClure J, Ranchalix J, Scheibel M, Schmidt A, Kennedy B, Morton W R, Haigwood N L, Hu S L. Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2-infected macaques. AIDS Res Hum Retroviruses 1997; 13: 1375–1381, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Westmoreland S V, Williams K C, Simon M A, Bahn M E, Rullkoetter A E, Elliott M W, deBakker C D, Knight H L, Lackner A A. Neuropathogenesis of simian immunodeficiency virus in neonatal rhesus macaques. Am J Pathol 1999; 155: 1217–1228, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Wilkins J W, Robertson K R, van der Horst C, Robertson W T, Fryer J G, Hall C D. The importance of confounding factors in the evaluation of neuropsychological changes in patients infected with human immunodeficiency virus. J Acquir Immune Defic Synd 1990; 3: 938–942
   PubMed Web of Science ®Google Scholar
• Wolters P L, Brouwers P, Moss H A, Pizzo P A. Adaptive behavior of children with symptomatic HIV infection before and after Zidovudine therapy. J Pediatr Psychol 1994; 19: 47–61, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Worlein J M, Ha J C, Harris C, Leigh J, Stratton K, Ho J R. Special challenges of rearing infant macaques infected with lentivirus (SIV, HIV, SHIV). Developments in primatology: progress and prospects., G P Sackett, G P Sackett, G Ruppenthal, in press
   Google Scholar
• Worlein J M, Sackett G P. Social development in nursery-reared infant pigtailed macaques (Macaca nemestrina). Am J Primatol 1997; 41: 23–35, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar