REFERENCES
- Balzarini J, Naesens L, De Clercq E. Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered. Int J Cancer 1990; 46: 337–340, [PUBMED], [INFOTRIEVE]
- Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 1999; 13: 1–22, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chun T W, Carruth L, Finzi D, Shen X, DiGiuseppe J A, Taylor H, Hermankova M, Chadwick K, Margolick J, Quinn T C, Kuo Y H, Brookmeyer R, Zeiger M A, Barditch-Crovo P, Siliciano R F. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997a; 387: 183–188, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chun T W, Stuyver L, Mizell S B, Ehler L A, Mican J A, Baseler M, Lloyd A L, Nowak M A, Fauci A S. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A 1997b; 94: 13193–13197, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Cinque P, Bestetti A, Morelli P, Presi S. Molecular analysis of cerebrospinal fluid: potential for the study of HIV-1 infection of the central nervous system. J NeuroVirol 2000; 6(Suppl 1)S95–S102, [PUBMED], [INFOTRIEVE]
- Cinque P, Presi S, Bestetti A, Pierotti C, Racca S, Boeri E, Morelli P, Carrera P, Ferrari M, Lazzarin A. Effect of genotypic resistance on the virological response to highly active antiretroviral therapy in cerebrospinal fluid. AIDS Res Hum Retroviruses 2001; 17: 377–383, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Clements J E, Babas T, Mankowski J L, Suryanarayana K, Piatak M, Jr., Tarwater P M, Lifson J D, Zink M C. The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis 2002; 186: 905–913, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Crowe S M, McGrath M S, Elbeik T, Kirihara J, Mills J. Comparative assessment of antiretrovirals in human monocyte-macrophages and lymphoid cell lines acutely and chronically infected with the human immunodeficiency virus. J Med Virol 1989; 29: 176–180, [PUBMED], [INFOTRIEVE], [CSA]
- Crowe S M, Sonza S. HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: a further obstacle to eradication. J Leukoc Biol 2000; 68: 345–350, [PUBMED], [INFOTRIEVE], [CSA]
- Cserr H F, Knopf P M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol Today 1992; 13: 507–512, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Dore G J, Correll P K, Li Y, Kaldor J M, Cooper D A, Brew B J. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. Aids 1999; 13: 1249–1253, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ellis R J, Gamst A C, Capparelli E, Spector S A, Hsia K, Wolfson T, Abramson I, Grant I, McCutchan J A. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Neurology 2000; 54: 927–936, [PUBMED], [INFOTRIEVE], [CSA]
- Finzi D, Blankson J, Siliciano J D, Margolick J B, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn T C, Chaisson R E, Rosenberg E, Walker B, Gange S, Gallant J, Siliciano R F. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999; 5: 512–517, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Finzi D, Hermankova M, Pierson T, Carruth L M, Buck C, Chaisson R E, Quinn T C, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho D D, Richman D D, Siliciano R F. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278: 1295–1300, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Flaherty M T, Hauer D A, Mankowski J L, Zink M C, Clements J E. Molecular and biological characterization of a neurovirulent molecular clone of SIV. J Virol 1997; 71: 5790–5798, [PUBMED], [INFOTRIEVE], [CSA]
- Fox H S, Weed M R, Huitron-Resendiz S, Baig J, Horn T F, Dailey P J, Bischofberger N, Henriksen S J. Antiviral treatment normalizes neurophysiological but not movement abnormalities in simian immunodeficiency virus-infected monkeys. J Clin Invest 2000; 106: 37–45, [PUBMED], [INFOTRIEVE], [CSA]
- Furtado M R, Callaway D S, Phair J P, Kunstman K J, Stanton J L, Macken C A, Perelson A S, Wolinsky S M. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999; 340: 1614–1622, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Gisolf E H, Enting R H, Jurriaans S, deWolf F, vanderEnde M E, Hoetelmans R M, Portegies P, Danner S A. Cerebrospinal fluid HIV-1 RNA during treatment with ritonavir/saquinavir or ritonavir/saquinavir/stavudine. AIDS 2000; 14: 1583–1589, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Glynn S L, Yazdanian M. In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J Pharm Sci 1998; 87: 306–310, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Gray F, Chretien F, Vallat-Decouvelaere A V, Scaravilli F. The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 2003; 62: 429–440, [PUBMED], [INFOTRIEVE], [CSA]
- Hickey W F. Basic principles of immunological surveillance of the normal central nervous system. Glia 2001; 36: 118–124, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Hirsch V M, Fuerst T R, Sutter G, Carroll M W, Yang L C, Goldstein S, Piatak M, Elkins W R, Alvord W G, Montefiori D C, Moss B, Lifson J D. Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol 1996; 70: 3741–3752, [PUBMED], [INFOTRIEVE], [CSA]
- Jellinger K A, Setinek U, Drlicek M, Bohm G, Steurer A, Lintner F. Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol (Berl) 2000; 100: 213–220, [CROSSREF]
- Kelder W, McArthur J C, Nance-Sproson T, McClernon D, Griffin D E. B-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann Neurol 1998; 44: 831–835, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Kim R B, Fromm M F, Wandel C, Leake B, Wood A J, Roden D M, Wilkinson G R. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101: 289–294, [PUBMED], [INFOTRIEVE], [CSA]
- Lambotte O, Taoufik Y, deGoer M G, Wallon C, Goujard C, Delfraissy J F. Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2000; 23: 114–119, [PUBMED], [INFOTRIEVE]
- Langford T D, Letendre S L, Larrea G J, Masliah E. Changing patterns in the neuropathogenesis of HIV during the HAART era. Brain Pathol 2003; 13: 195–210, [PUBMED], [INFOTRIEVE]
- Mankowski J L, Clements J E, Zink M C. Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model. J Infect Dis 2002; 186(Suppl 2)S199–S208, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mankowski J L, Flaherty M T, Spelman J P, Hauer D A, Didier P J, Martin Amedee A, Murphey-Corb M, Kirstein L M, Munoz A, Clements J E, Zink M C. Pathogenesis of simian immunodeficiency virus encephalitis: Viral determinants of neurovirulence. J Virol 1997; 71: 6055–6060, [PUBMED], [INFOTRIEVE], [CSA]
- Masliah E, DeTeresa R M, Mallory M E, Hansen L A. Changes in pathological findings at autopsy in AIDS cases for the last 15 years. AIDS 2000; 14: 69–74, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Neuenburg J K, Brodt H R, Herndier B G, Bickel M, Bacchetti P, Price R W, Grant R M, Schlote W. HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2002; 31: 171–177, [PUBMED], [INFOTRIEVE]
- Perno C F, Aquaro S, Rosenwirth B, Balestra E, Peichl P, Billich A, Villani N, Calio R. In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages. J Leukoc Biol 1994; 56: 381–386, [PUBMED], [INFOTRIEVE], [CSA]
- Perno C F, Newcomb F M, Davis D A, Aquaro S, Humphrey R W, Calio R, Yarchoan R. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis 1998; 178: 413–422, [PUBMED], [INFOTRIEVE]
- Ranki A, Lagerstedt A, Ovod V, Aavik E, Krohn K JE. Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid cell lines. Arch Virol 1994; 139: 365–378, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Saito Y, Sharer L R, Epstein L G, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich T A, Blumberg B M. Overexpressionof nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous system. Neurology 1994; 44: 474–481, [PUBMED], [INFOTRIEVE], [CSA]
- Sawchuk R J, Yang Z. Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system. Adv Drug Deliv Rev 1999; 39: 5–31, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Schinazi R F, Boudinot F D, Ibrahim S S, Manning C, McClure H M, Liotta D C. Pharmacokinetics and metabolism of racemic 2′,3′-dideoxy-5-fluoro-3′-thiacytidine in rhesus monkeys. Antimicrob Agents Chemother 1992; 36: 2432–2438, [PUBMED], [INFOTRIEVE], [CSA]
- Shen A, Zink M C, Mankowski J L, Chadwick K, Margolick J B, Carruth L M, Li M, Clements J E, Siliciano R F. Resting CD4(+) T Lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy. J Virol 2003; 77: 4938–4949, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Sonza S, Crowe S M. Reservoirs for HIV infection and their persistence in the face of undetectable viral load. AIDS Patient Care STDS 2001; 15: 511–518, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Sonza S, Mutimer H P, Oelrichs R, Jardine D, Harvey K, Dunne A, Purcell D F, Birch C, Crowe S M. Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy. AIDS 2001; 15: 17–22, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Staprans S, Marlowe N, Glidden D, Novakovic-Agopian T, Grant R M, Heyes M, Aweeka F, Deeks S, Price R W. Time course of cerebrospinal fluid responses to antiretroviral therapy: evidence for variable compartmentalization of infection. AIDS 1999; 13: 1051–1061, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Suryanarayana K, Wiltrout T A, Vasquez G M, Hirsch V M, Lifson J D. Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res Hum Retroviruses 1998; 14: 183–189, [PUBMED], [INFOTRIEVE], [CSA]
- Tornatore C, Chandra R, Berger J R, Major E O. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 1994; 44: 481–487, [PUBMED], [INFOTRIEVE], [CSA]
- Wong J K, Hezareh M, Gunthard H F, Havlir D V, Ignacio C C, Spina C A, Richman D D. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278: 1291–1295, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Zhang L, Ramratnam B, Tenner-Racz K, He Y, Vesanen M, Lewin S, Talal A, Racz P, Perelson A S, Korber B T, Markowitz M, Ho D D. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340: 1605–1613, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Zhu T, Muthui D, Holte S, Nickle D, Feng F, Brodie S, Hwangbo Y, Mullins J I, Corey L. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J Virol 2002; 76: 707–716, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Zink M C, Clements J E. A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. J NeuroVirol 2002; 8(Suppl 2)42–48, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Zink M C, Coleman G D, Mankowski J L, Adams R J, Tarwater P M, Fox K, Clements J E. Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. J Infect Dis 2001; 184: 1015–1021, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Zink M C, Suryanarayana K, Mankowski J L, Shen A, Piatak J, Spelman J P, Carter D L, Adams R J, Lifson J D, Clements J E. High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis. J Virol 1999; 73: 10480–10488, [PUBMED], [INFOTRIEVE], [CSA]