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Short Communication

Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins

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Pages 168-172 | Received 02 Aug 2006, Accepted 13 Dec 2006, Published online: 10 Jul 2009

References

  • Anderson C M, Swanson R A. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 2000; 32: 1–14
  • Bansal A K, Mactutus C F, Nath A, Maragos W, Hauser K F, Booze R M. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum. Brain Res 2000; 879: 42–49
  • Billaud J N, Selway D, Yu N, Phillips T R. Replication rate of feline immunodeficiency virus in astrocytes is envelope dependent: implications for glutamate uptake. Virology 2000; 266: 180–188
  • Chen P, Mayne M, Power C, Nath A. The Tat protein of HIV-1 induces tumor necrosis factor-α production: Implications for HIV associated neurological diseases. J Biol Chem 1997; 272: 22385–22388
  • Corasaniti M T, Bellizzi C, Russo R, Colica C, Amantea D, Di Renzo G. Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells. Toxicol Lett 2003; 139: 213–219
  • Dore G J, McDonald A, Li Y, Kaldor J M, Brew B J. Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 2003; 17: 1539–1545
  • Drejer J, Meier E, Schousboe A. Novel neuron-related regulatory mechanisms for astrocytic glutamate and GABA high affinity uptake. Neurosci Lett 1983; 37: 301–306
  • Haughey N J, Nath A, Mattson M P, Slevin J T, Geiger J D. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem 2001; 78: 457–467
  • Lafortune L, Nalbantoglu J, Antel J P. Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes. J Neuropathol Exp Neurol 1996; 55: 515–521
  • Lipton S A. AIDS related dementia and calcium homeostasis. Ann N Y Acad Sci 1994; 594: 189–196
  • Ma M, Nath A. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 1997; 71: 2495–2499
  • Magnuson D S, Knudsen B E, Geiger J D, Brownstone R M, Nath A. Human immunodeficiency virus type 1 tat activates non-N-methyl-d-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995; 37: 373–380
  • McArthur J C, Haughey N, Gartner S, Conant K, Pardo C, Nath A, Sacktor N. Human immunodeficiency virus-associated dementia: an evolving disease. J NeuroVirol 2003; 9: 205–221
  • Nath A, Haughey N J, Jones M, Anderson C, Bell J E, Geiger J D. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol 2000; 47: 186–194
  • Nath A, Psooy K, Martin C, Knudsen B, Magnuson D S, Haughey N, Geiger J D. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996; 70: 1475–1480
  • Neuenburg J K, Brodt H R, Herndier B G, Bickel M, Bacchetti P, Price R W, Grant R M, Schlote W. HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2002; 31: 171–177
  • Olsen C, Rustad A, Fonnum F, Paulsen R E, Hassel B. 3-Nitropropionic acid: an astrocyte-sparing neurotoxin in vitro. Brain Res 1999; 850: 144–149
  • Prendergast M A, Rogers D T, Mulholland P J, Littleton J M, Wilkins L H, Jr., Self R L, Nath A. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Res 2002; 954: 300–307
  • Ranki A, Nyberg M, Ovod V, Haltia M, Elovaara I, Raininko R, Haapasalo H, Krohn K. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 1995; 9: 1001–1008
  • Robinson M B. The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype. Neurochem Int 1998; 33: 479–491
  • Rosen C A, Terwilliger E, Dayton A, Sodroski J G, Haseltine W A. Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc Natl Acad Sci USA 1988; 85: 2071–2075
  • Rothstein J D, Patel S, Regan M R, Haenggeli C, Huang Y H, Bergles D E, Jin L, Dykes Hoberg M, Vidensky S, Chung D S, Toan S V, Bruijn L I, Su Z Z, Gupta P, Fisher P B. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 2005; 433: 73–77
  • Sacktor N. The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J NeuroVirol 2002; 8: 115–121, (Suppl 2)
  • Sacktor N, McDermott M P, Marder K, Schifitto G, Selnes O A, McArthur J C, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida J A, Cohen B, Epstein L. HIV-associated cognitive impairment before and after the advent of combination therapy. J NeuroVirol 2002; 8: 136–142
  • Saito Y, Sharer L R, Epstein L G, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich T A, Blumberg B M. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994; 44: 474–481
  • Scheld W M, Rocha H, Sande M A, Bryan J P. Rationale for clinical trials evaluating ceftriaxone in the therapy of bacterial meningitis. Am J Med 1984; 77: 42–49
  • Szymocha R, Akaoka H, Dutuit M, Malcus C, Didier-Bazes M, Belin M F, Giraudon P. Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol 2000; 74: 6433–6441
  • Tornatore C, Chandra R, Berger J R, Major E O. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 1994; 44: 481–487
  • Turchan J, Anderson C, Hauser K F, Sun Q, Zhang J, Liu Y, Wise P M, Kruman I, Maragos W, Mattson M P, Booze R, Nath A. Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine. BMC Neurosci 2001; 2: 3
  • Wahl L M, Corcoran M L, Pyle S W, Arthur L O, Harel-Bellan A, Farrar W L. Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proc Natl Acad Sci USA 1989; 86: 621–625
  • Wang Z, Pekarskaya O, Bencheikh M, Chao W, Gelbard H A, Ghorpade A, Rothstein J D, Volsky D J. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology 2003; 312: 60–73
  • Wang Z, Trillo-Pazos G, Kim S Y, Canki M, Morgello S, Sharer L R, Gelbard H A, Su Z Z, Kang D C, Brooks A I, Fisher P B, Volsky D J. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J NeuroVirol 2004; 10: 25–32, (Suppl 1)
  • Yu N, Billaud J N, Phillips T R. Effects of feline immunodeficiency virus on astrocyte glutamate uptake: implications for lentivirus-induced central nervous system diseases. Proc Natl Acad Sci USA 1998; 95: 2624–2629

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