18
Views
4
CrossRef citations to date
0
Altmetric
Papers

The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery

, , , , , , & show all
Pages 328-337 | Received 20 Feb 2007, Accepted 20 Mar 2007, Published online: 10 Jul 2009

References

  • Aguzzi A, Heikenwalder M. Prions, cytokines, and chemokines: a meeting in lymphoid organs. Immunity 2005; 22: 145–154
  • Blattler T, Brandner S, Raeber A J, Klein M A, Voigtlander T, Weissmann C, Aguzzi A. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 1997; 389: 69–73
  • Brain J, Saksena A, Laneuville P. The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190(Bcr-Abl) transgenic mice. Leuk Res 2002; 26: 1011–1016
  • Buday L. Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins. Biochim Biophys Acta 1999; 1422: 187–204
  • Budka H. Neuropathology of prion diseases. Br Med Bull 2003; 66: 121–130
  • Bueler H, Aguzzi A, Sailer A, Greiner R A, Autenried P, Aguet M, Weissmann C. Mice devoid of PrP are resistant to scrapie. Cell 1993; 73: 1339–1347
  • Bujassoum S, Rifkind J, Lipton J H. Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy. Leuk Lymphoma 2004; 45: 401–403
  • Capdeville R, Buchdunger E, Zimmermann J, Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 2002; 1: 493–502
  • Cashman N R, Caughey B. Prion diseases—close to effective therapy?. Nat Rev Drug Discov 2004; 3: 874–884
  • Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, La Casse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 2005; 308: 1435–1439
  • Criado J R, Sanchez-Alavez M, Conti B, Giacchino J L, Wills D N, Henriksen S J, Race R, Manson J C, Chesebro B, Oldstone M B. Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons. Neurobiol Dis 2005; 19: 255–265
  • Crossman L C, Druker B J, Deininger M W, Pirmohamed M, Wang L, Clark R E. hOCT 1 and resistance to imatinib. Blood 2005; 106: 1133–1134
  • Dai H, Marbach P, Lemaire M, Hayes M, Elmquist W F. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 2003; 304: 1085–1092
  • Decaudin D, de Cremoux P, Sastre X, Judde J G, Nemati F, Tran-Perennou C, Freneaux P, Livartowski A, Pouillart P, Poupon M F. In vivo efficacy of STI571 in xenografted human small cell lung cancer alone or combined with chemotherapy. Int J Cancer 2005; 113: 849–856
  • Doh-ura K, Ishikawa K, Murakami-Kubo I, Sasaki K, Mohri S, Race R, Iwaki T. Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models. J Virol 2004; 78: 4999–5006
  • Ertmer A, Gilch S, Yun S W, Flechsig E, Klebl B, Stein-Gerlach M, Klein M A, Schatzl H M. The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells. J Biol Chem 2004; 279: 41918–41927
  • Glatzel M, Heppner F L, Albers K M, Aguzzi A. Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron 2001; 31: 25–34
  • Green R M, Lo K, Sterritt C, Beier D R. Cloning and functional expression of a mouse liver organic cation transporter. Hepatology 1999; 29: 1556–1562
  • Heikenwalder M, Zeller N, Seeger H, Prinz M, Klohn P C, Schwarz P, Ruddle N H, Weissmann C, Aguzzi A. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science 2005; 307: 1107–1110
  • Honey K, Rudensky A Y. Lysosomal cysteine proteases regulate antigen presentation. Nat Rev Immunol 2003; 3: 472–482
  • Jones S B, Lu H Y, Lu Q. Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons. J Neurosci 2004; 24: 8510–8521
  • Jonker J W, Schinkel A H. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 2004; 308: 2–9
  • Kaeser P S, Klein M A, Schwarz P, Aguzzi A. Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. J Virol 2001; 75: 7097–7106
  • Kimberlin R H, Walker C A. Incubation periods in six models of intraperitoneally injected scrapie depend mainly on the dynamics of agent replication within the nervous system and not the lymphoreticular system. J Gen Virol 1988; 69: 2953–2960, (Pt 12)
  • Klein M A, Kaeser P S, Schwarz P, Weyd H, Xenarios I, Zinkernagel R M, Carroll M C, Verbeek J S, Botto M, Walport M J, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A. Complement facilitates early prion pathogenesis. Nat Med 2001; 7: 488–492
  • Leis J F, Stepan D E, Curtin P T, Ford J M, Peng B, Schubach S, Druker B J, Maziarz R T. Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI–571). Leuk Lymphoma 2004; 45: 695–698
  • Li A, Harris D A. Mammalian prion protein suppresses Bax-induced cell death in yeast. J Biol Chem 2005; 280: 17430–17434
  • Luhr K M, Nordstrom E K, Low P, Ljunggren H G, Taraboulos A, Kristensson K. Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells. J Virol 2004; 78: 4776–4782
  • Mahon F X, Belloc F, Lagarde V, Chollet C, Moreau-Gaudry F, Reiffers J, Goldman J M, Melo J V. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003; 101: 2368–2373
  • Montrasio F, Frigg R, Glatzel M, Klein M A, Mackay F, Aguzzi A, Weissmann C. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 2000; 288: 1257–1259
  • Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche J L, Lehmann S, Launay J M, Kellermann O. Signal transduction through prion protein. Science 2000; 289: 1925–1928
  • Netzer W J, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann W G, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A 2003; 100: 12444–12449
  • Nico P B, de-Paris F, Vinade E R, Amaral O B, Rockenbach I, Soares B L, Guarnieri R, Wichert-Ana L, Calvo F, Walz R, Izquierdo I, Sakamoto A C, Brentani R, Martins V R, Bianchin M M. Altered behavioural response to acute stress in mice lacking cellular prion protein. Behav Brain Res 2005; 162: 173–181
  • Peretz D, Williamson R A, Kaneko K, Vergara J, Leclerc E, Schmitt-Ulms G, Mehlhorn I R, Legname G, Wormald M R, Rudd P M, Dwek R A, Burton D R, Prusiner S B. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 2001; 412: 739–743
  • Prinz M, Heikenwalder M, Junt T, Schwarz P, Glatzel M, Heppner F L, Fu Y X, Lipp M, Aguzzi A. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature 2003; 425: 957–962
  • Prusiner S B. Prions. Proc Natl Acad Sci U S A 1998; 95: 13363–13383
  • Roucou X, Gains M, LeBlanc A C. Neuroprotective functions of prion protein. J Neurosci Res 2004; 75: 153–161
  • Safar J G, DeArmond S J, Kociuba K, Deering C, Didorenko S, Bouzamondo-Bernstein E, Prusiner S B, Tremblay P. Prion clearance in bigenic mice. J Gen Virol 2005; 86: 2913–2923
  • Schmitt A, Mossner R, Gossmann A, Fischer I G, Gorboulev V, Murphy D L, Koepsell H, Lesch K P. Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J Neurosci Res 2003; 71: 701–709
  • Schwartzberg P L, Stall A M, Hardin J D, Bowdish K S, Humaran T, Boast S, Harbison M L, Robertson E J, Goff S P. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 1991; 65: 1165–1175
  • Spielhaupter C, Schatzl H M. PrPC directly interacts with proteins involved in signaling pathways. J Biol Chem 2001; 276: 44604–44612
  • Supattapone S, Nguyen H O, Cohen F E, Prusiner S B, Scott M R. Elimination of prions by branched polyamines and implications for therapeutics. Proc Natl Acad Sci U S A 1999; 96: 14529–14534
  • Supattapone S, Wille H, Uyechi L, Safar J, Tremblay P, Szoka F C, Cohen F E, Prusiner S B, Scott M R. Branched polyamines cure prion-infected neuroblastoma cells. J Virol 2001; 75: 3453–3461
  • Takayama N, Sato N, O'Brien S G, Ikeda Y, Okamoto S. Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid. Br J Haematol 2002; 119: 106–108
  • Thomas J, Wang L, Clark R E, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104: 3739–3745
  • Tybulewicz V L, Crawford C E, Jackson P K, Bronson R T, Mulligan R C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 1991; 65: 1153–1163
  • Wang H, Cheng F, Cuenca A, Horna P, Zheng Z, Bhalla K, Sotomayor E M. Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood 2005; 105: 1135–1143
  • Weissmann C, Aguzzi A. Approaches to therapy of prion diseases. Annu Rev Med 2005; 56: 321–344
  • Wolff N C, Richardson J A, Egorin M, Ilaria R L, Jr. The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. Blood 2003; 101: 5010–5013
  • Woodring P J, Hunter T, Wang J Y. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci 2003; 116: 2613–2626
  • Yun S W, Gerlach M, Riederer P, Klein M A. Oxidative stress in the brain at early preclinical stages of mouse scrapie. Exp Neurol 2006; 201: 90–98

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.