35
Views
1
CrossRef citations to date
0
Altmetric
Case Report

Virological and immunological characteristics of fatal Epstein-Barr virus mononucleosis in a 17-year-old Caucasian male presenting with meningoencephalitis and hemophagocytic syndrome

, , , , , & show all
Pages 389-396 | Received 26 Jan 2006, Accepted 13 Apr 2007, Published online: 10 Jul 2009

References

  • Attarbaschi T, Willheim M, Ramharter M, Hofmann A, Wahl K, Winkler H, Graninger W, Winkler S. T cell cytokine profile during primary Epstein-Barr virus infection (infectious mononucleosis). Eur Cytokine Netw 2003; 14: 34–39
  • Christensen T. The role of EBV in MS pathogenesis. Int Mult Scler J 2006; 13: 52–57
  • Doja A, Bitnun A, Jones E L, Richardson S, Tellier R, Petric M, Heurter H, Macgregor D. Pediatric Epstein-Barr virus-associated encephalitis: 10-year review. J Child Neurol 2006; 21: 385–391
  • Drebber U, Kasper H U, Krupacz J, Haferkamp K, Kern M A, Steffen H M, Quasdorff M, zur Hausen A, Odenthal M, Dienes H P. The role of Epstein-Barr virus in acute and chronic hepatitis. J Hepatol 2006; 44: 879–885
  • Francisci D, Sensini A, Fratini D, Moretti M V, Luchetta M L, Di Caro A, Stagni G, Baldelli F. Acute fatal necrotizing hemorrhagic encephalitis caused by Epstein-Barr virus in a young adult immunocompetent man. J NeuroVirol 2004; 10: 414–417
  • Hinedi T B, Koff R S. Cholestatic hepatitis induced by Epstein-Barr virus infection in an adult. Dig Dis Sci 2003; 48: 539–541
  • Hiroshima K, Iyoda A, Isobe K, Ishii G, Toyozaki T, Shibuya K, Shimamura F, Haga Y, Okimoto Y, Horie H, Harigaya K, Ohwada H. Fatal infectious mononucleosis with evidence suggestive of the developmenot of B cell lymphoma. Pathol Int 2003; 53: 642–648
  • Hislop A D, Annels N E, Gudgeon N H, Leese A M, Rickinson A B. Epitope-specific evolution of human CD8+ T cell responses from primary to persistent phases of Epstein-Barr virus infection. J Exp Med 2002; 195: 893–905
  • Holmoy T, Kvale E O, Vartdal F. Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patients cross-recognize Epstein-Barr virus and myelin basic protein. J NeuroVirol 2004; 10: 278–283
  • Imashuku S. Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Crit Rev Oncol Hematol 2002; 44: 259–272
  • Kasahara Y, Yachie A, Takei K, Kanegane C, Okada K, Ohta K, Seki H, Igarashi N, Maruhashi K, Katayama K, Katoh E, Terao G, Sakiyama Y, Koizumi S. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 2001; 98: 1882–1888
  • Khamma S, Kumar A. Infectious mononucleosis presenting as acute hepatitis, with marked leukocytosis and renal involvement. Indian J Gastroenterol 2003; 22: 62
  • Kivisäkk P, Trebst C, Liu Z, Tucky B H, Sorensen T L, Rudick R A, Mack M, Ransohoff R M. T cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin Exp Immunol 2002; 129: 510–518
  • Kobbervig C, Norback D, Kahl B. Infectious mononucleosis progressing to fatal malignant lymphoma: a case report and review of the literature. Leuk Lymphoma 2003; 44: 1215–1221
  • Kumakura S. Hemophagocytic syndrome. Intern Med 2005; 4: 278–280
  • Lay J D, Tsao C J, Chen J Y, Kadin M E, Su I J. Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest 1997; 100: 1969–1979
  • Lehrnbecher T, Chittka B, Nanan R, Seidenspinner S, Kreth H W, Schuster V. Activated T lymphocytes in the cerebrospinal fluid of a patient with Epstein-Barr virus-associated meningoencephalitis. Pediatr Infect Dis 1996; 15: 631–363
  • Majid A, Galetta S L, Sweeney C J, Robinson C, Mahalingam R, Smith J, Forghani B, Gliden D H. Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitis. Brain 2002; 125: 159–165
  • Markin R S. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver 1994; 14: 1–13
  • Merelli E, Bedin R, Sola P, Gentilini M, Pietrosemoli P, Meacci M, Portolani M. Encephalomyeloradiculopathy associated with Epstein-Barr virus: primary infection or reactivation?. Acta Neurol Scand 1997; 96: 416–420
  • Mizuno I, Takanashi Y, Onodera H, Shigeta M, Tanaka N, Yuya H, Kitaichi M, Nakajima K. A case of lymphomatoid granulomatosis/angiocentric immunoproliferative lesions with long clinical course and diffuse brain involvement. J Neurol Sci 2003; 213: 67–76
  • Negro F. The paradox of Epstein-Barr virus-associated hepatitis. J Hepatol 2006; 44: 839–841
  • Neuenburg J K, Cho T A, Nilsson A, Bredt B M, Hebert S J, Grant R M, Price R W. T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection. J Acquir Immune Defic Syndr 2005; 39: 16–22
  • Pelletier L L, Borel D M, Romig D A, Liu C. Disseminated intravascular coagulation and hepatic necrosis. Complications of infectious mononucleosis. JAMA 1976; 235: 1144–1146
  • Riemer G, Stenvik O, Dahl O P, Slungaard S, Ringstad J, Bruu A L. Encephalitis after acute Epstein-Barr virus infection. Tidsskr Nor Laegeforen 2001; 121: 1798–1800
  • Sato S, Kawashima H, Oshiro H, Hasegawa D, Kashiwagi Y, Takekuma K, Hoshika A. Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Virol 2004; 31: 235–238
  • Schellinger P D, Sommer C, Leithauser F, Schwab S, Storch-Hagenlocher B, Hacke W, Kiessling M. Epstein-Barr virus meningoencephalitis with a lymphoma-like response in an immunocompetent host. Ann Neurol 1999; 45: 659–662
  • Tselis A, Duman R, Storch G A, Lisak R P. Epstein-Barr virus encephalomyelitis diagnosed by polymerase chain reaction: detection of the genome in the CSF. Neurology 1997; 48: 1351–1353
  • Yamashita S, Murakami C, Izumi Y, Sawada H, Yamazaki Y, Yokota T A, Matsumoto N, Matsukura S. Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. Psychiatry Clin Neurosci 1998; 52: 449–452
  • Zephir H, De Seze J, Ferriby D, Stojkovic T, Vermersch P. Epstein-Barr meningoencephaloradiculitis in a immunocompetent woman. Rev Neurol 2002; 158: 830–832
  • Židovec Lepej S, Vince A, Dakovic Rode O, Remenar A, Jeren T. Increased numbers of CD38 molecules on bright CD8+ T lymphocytes in infectious mononucleosis caused by Epstein-Barr virus infection. Clin Exp Immunol 2003; 133: 384–390

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.