Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS

References

• Achim C L, Wiley C A. Inflammation in AIDS and the role of the macrophage in brain pathology. Curr Opin Neurol 1996; 9: 221–225
   Google Scholar
• Alirezaei M, Watry D D, Flynn C F, Kiosses W B, Masliah E, Williams B R, Kaul M, Lipton S A, Fox H S. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci 2007; 27: 11047–11055
   PubMed Web of Science ®Google Scholar
• Anderson E R, Boyle J, Zink W E, Persidsky Y, Gendelman H E, Xiong H. Hippocampal synaptic dysfunction in a murine model of human immunodeficiency virus type 1 encephalitis. Neuroscience 2003; 118: 359–369
   Google Scholar
• Bansal A K, Mactutus C F, Nath A, Maragos W, Hauser K F, Booze R M. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum. Brain Res 2000; 879: 42–49
   Google Scholar
• Barker P B, Lee R R, McArthur J C. AIDS dementia complex: evaluation with proton MR spectroscopic imaging. Radiology 1995; 195: 58–64
   Google Scholar
• Bell J E. An update on the neuropathology of HIV in the HAART era. Histopathology 2004; 45: 549–559
   Web of Science ®Google Scholar
• Bellizzi M J, Lu S M, Masliah E, Gelbard H A. Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. J Clin Invest 2005; 115: 3185–3192
   Google Scholar
• Bissel S J, Wang G, Ghosh M, Reinhart T A, Capuano S, 3rd, Stefano Cole K, Murphey-Corb M, Piatak M, Jr, Lifson J D, Wiley C A. Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis. Am J Pathol 2002; 160: 927–941
   Google Scholar
• Brandimarti R, Khan M Z, Fatatis A, Meucci O. Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis?. J Neuro Virol 2004; 10(Suppl 1)108–112
   Google Scholar
• Brew B, Rosenblum M, Cronin K, Price R. AIDS dementia comples and HIV-1 brain infection: clinical-virological correlations. Ann Neurol 1995; 38: 563–570
   PubMed Web of Science ®Google Scholar
• Brown J, Cooper-Kuhn C M, Kempermann G, Van Praag H, Winkler J, Gage F H, Kuhn H G. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 2003; 17: 2042–2046
   PubMed Web of Science ®Google Scholar
• Bruce-Keller A J, Chauhan A, Dimayuga F O, Gee J, Keller J N, Nath A. Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J Neurosci 2003; 23: 8417–8422
   Google Scholar
• Bruel-Jungerman E, Laroche S, Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci 2005; 21: 513–521
   PubMed Web of Science ®Google Scholar
• Budka H, Costanzi G, Cristina S, Lechi A, Parravicini C, Trabattoni R, Vago L. Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol (Berl) 1987; 75: 185–198
   PubMed Web of Science ®Google Scholar
• Buscemi L, Ramonet D, Geiger J D. Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity. Neurobiol Dis 2007; 26: 661–670
   Google Scholar
• Chana G, Everall I P, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users. Neurology 2006; 67: 1486–1489
   PubMed Web of Science ®Google Scholar
• Chang L, Ernst T, Leonido-Yee M, Witt M, Speck O, Walot I, Miller E N. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia. Neurology 1999; 53: 782–789
   PubMed Web of Science ®Google Scholar
• Cherner M, Masliah E, Ellis R J, Marcotte T D, Moore D J, Grant I, Heaton R K. Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology 2002; 59: 1563–1567
   PubMed Web of Science ®Google Scholar
• Chong W K, Sweeney B, Wilkinson I D, Paley M, Hall-Craggs M A, Kendall B E, Shepard J K, Beecham M, Miller R F, Weller I V, et al. Proton spectroscopy of the brain in HIV infection: correlation with clinical, immunologic, and MR imaging findings. Radiology 1993; 188: 119–124
   PubMed Web of Science ®Google Scholar
• Clements J E, Babas T, Mankowski J L, Suryanarayana K, Piatak M, Jr, Tarwater P M, Lifson J D, Zink M C. The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis 2002; 186: 905–913
   PubMed Web of Science ®Google Scholar
• Del Corno M, Liu Q H, Schols D, de Clercq E, Gessani S, Freedman B D, Collman R G. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood 2001; 98: 2909–2916
   PubMed Web of Science ®Google Scholar
• Desrosiers R C. HIV-1 origins. A finger on the missing link. Nature 1990a; 345: 288–289
   PubMed Web of Science ®Google Scholar
• Desrosiers R C. The simian immunodeficiency viruses. Annu Rev Immunol 1990b; 8: 557–578
   PubMed Web of Science ®Google Scholar
• D'Hooge R, Franck F, Mucke L, De Deyn P P. Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. Eur J Neurosci 1999; 11: 4398–4402
   Google Scholar
• Diesing T S, Swindells S, Gelbard H, Gendelman H E. HIV-1-associated dementia: a basic science and clinical perspective. AIDS Read 2002; 12: 358–368
   PubMedGoogle Scholar
• Dou H, Birusingh K, Faraci J, Gorantla S, Poluektova L Y, Maggirwar S B, Dewhurst S, Gelbard H A, Gendelman H E. Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. J Neurosci 2003; 23: 9162–9170
   PubMed Web of Science ®Google Scholar
• Dou H, Ellison B, Bradley J, Kasiyanov A, Poluektova L Y, Xiong H, Maggirwar S, Dewhurst S, Gelbard H A, Gendelman H E. Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. J Neurosci 2005; 25: 8375–8385
   PubMed Web of Science ®Google Scholar
• Ellis R, Langford D, Masliah E. HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nat Rev Neurosci 2007; 8: 33–44
   PubMed Web of Science ®Google Scholar
• Everall I, Luthert P, Lantos P. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991; 337: 1119–1121
   PubMed Web of Science ®Google Scholar
• Everall I P, Bell C, Mallory M, Langford D, Adame A, Rockestein E, Masliah E. Lithium ameliorates HIV-gp120-mediated neurotoxicity. Mol Cell Neurosci 2002; 21: 493–501
   PubMed Web of Science ®Google Scholar
• Everall I P, Hansen L A, Masliah E. The shifting patterns of HIV encephalitis neuropathology. Neurotox Res 2005; 8: 51–61
   Web of Science ®Google Scholar
• Fischer A, Sananbenesi F, Pang P T, Lu B, Tsai L H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 2005; 48: 825–838
   PubMed Web of Science ®Google Scholar
• Fox L, Mallory M, Achim C, Masliah E. Neurodegeneration od somatostatin-immunoreactive neurons in HIV encephalitis. J Neuropathol Exp Neurol 1997; 56: 360–368
   Web of Science ®Google Scholar
• Gage F H, Kempermann G, Palmer T D, Peterson D A, Ray J. Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol 1998; 36: 249–266
   PubMedGoogle Scholar
• Gao F, Bailes E, Robertson D L, Chen Y, Rodenburg C M, Michael S F, Cummins L B, Arthur L O, Peeters M, Shaw G M, Sharp P M, Hahn B H. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 1999; 397: 436–441
   PubMed Web of Science ®Google Scholar
• Gelbard H, Nottet H, Swindells S, Jett M, Dzenko K, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton S, Tourtellotte W, Epstein L, Gendelman H. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 1994; 68: 4628–4635
   PubMed Web of Science ®Google Scholar
• Gendelman H, Lipton S, Tardieu M, Bukrinsky M, Nottet H. The neuropathogenesis of HIV-1 infection. J Leukoc Biol 1994; 56: 389–398
   PubMed Web of Science ®Google Scholar
• Gendelman H E, Persidsky Y, Ghorpade A, Limoges J, Stins M, Fiala M, Morrisett R. The neuropathogenesis of the AIDS dementia complex. AIDS 1997; 11(Suppl A)S35–S45
   Google Scholar
• Giulian D, Vaca K, Noonan C. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1990; 250: 1593–1596
   PubMed Web of Science ®Google Scholar
• Glass J, Fedor H, Wesselingh S, McArthur J. Immunocytochemical quantification of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995; 38: 755–762
   PubMed Web of Science ®Google Scholar
• Gonzalez R G, Cheng L L, Westmoreland S V, Sakaie K E, Becerra L R, Lee P L, Masliah E, Lackner A A. Early brain injury in the SIV-macaque model of AIDS. AIDS 2000; 14: 2841–2849
   Web of Science ®Google Scholar
• Gonzalez R G, Greco J B, He J, Lentz M R, O'Neil S, Pilkenton S J, Ratai E M, Westmoreland S. New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy. J Neuroimmune Pharmacol 2006; 1: 152–159
   Google Scholar
• Gonzalez-Scarano F, Martin-Garcia J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005; 5: 69–81
   PubMed Web of Science ®Google Scholar
• Gray F, Chretien F, Vallat-Decouvelaere A V, Scaravilli F. The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 2003; 62: 429–440
   PubMed Web of Science ®Google Scholar
• Greco J B, Sakaie K E, Aminipour S, Lee P L, Chang L L, He J, Westmoreland S, Lackner A A, Gonzalez R G. Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques. J Med Primatol 2002; 31: 228–236
   Google Scholar
• Greco J B, Westmoreland S V, Ratai E M, Lentz M R, Sakaie K, He J, Sehgal P K, Masliah E, Lackner A A, Gonzalez R G. In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuro AIDS. Magn Reson Med 2004; 51: 1108–1114
   Google Scholar
• Hashimoto M, Sagara Y, Everall I P, Mallory M, Everson A, Langford D, Masliah E. Fibroblast growth factor 1 regulates signaling via the GSK3beta pathway: implications for neuroprotection. J Biol Chem 2002; 277: 32985–32991
   PubMedGoogle Scholar
• Haughey N J, Mattson M P. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr 2002; 31(Suppl 2)S55–S61
   Google Scholar
• Haughey N J, Nath A, Mattson M P, Slevin J T, Geiger J D. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem 2001; 78: 457–467
   PubMed Web of Science ®Google Scholar
• Heaton R, Grant I, Butters N, White D, Kirson D, Atkinson J, McCutchan J, Taylor M, Kelly M, Ellis R, Wolfson T, Velin R, Marcotte T, Hesselink J, Jernigan T, Cahndler J, Wallace M, Abramson I, Group H. The HNRC 500—neuropsychology of HIV infection at different disease stages. J Int Neuropsych Soc 1995; 1: 231–251
   PubMedGoogle Scholar
• Jarvik J G, Lenkinski R E, Grossman R I, Gomori J M, Schnall M D, Frank I. Proton MR spectroscopy of HIV-infected patients: characterization of abnormalities with imaging and clinical correlation. Radiology 1993; 186: 739–744
   PubMed Web of Science ®Google Scholar
• Johansson J U, Lilja L, Chen X L, Higashida H, Meister B, Noda M, Zhong Z G, Yokoyama S, Berggren P O, Bark C. Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses. Brain Res Mol Brain Res 2005; 138: 215–227
   Google Scholar
• Jones M, Olafson K, Del Bigio M R, Peeling J, Nath A. Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. J Neuropathol Exp Neurol 1998; 57: 563–570
   PubMed Web of Science ®Google Scholar
• Kaul M, Garden G A, Lipton S A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001; 410: 988–994
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton S A. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A 1999; 96: 8212–8216
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton S A. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Curr HIV Res 2006; 4: 307–318
   PubMed Web of Science ®Google Scholar
• Kodama T, Mori K, Kawahara T, Ringler D J, Desrosiers R C. Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDS. J Virol 1993; 67: 6522–6534
   Google Scholar
• Krathwohl M D, Kaiser J L. HIV-1 promotes quiescence in human neural progenitor cells. J Infect Dis 2004; 190: 216–226
   PubMed Web of Science ®Google Scholar
• Lackner A, Smith M, Munn R, Martfeld D, Gardner M, Marx P, Dandekar S. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991; 139: 609–621
   Google Scholar
• Lackner A A, Vogel P, Ramos R A, Kluge J D, Marthas M. Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus. Am J Pathol 1994; 145: 428–439
   Google Scholar
• Langford D, Adame A, Grigorian A, Grant I, McCutchan J A, Ellis R J, Marcotte T D, Masliah E. Patterns of selective neuronal damage in methamphetamine-user AIDS patients. J Acquir Immune Defic Syndr 2003; 34: 467–474
   PubMed Web of Science ®Google Scholar
• Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E. The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin-positive neurons. J Neuro Virol 2004; 10: 327–337
   PubMed Web of Science ®Google Scholar
• Langford D, Hurford R, Hashimoto M, Digicaylioglu M, Masliah E. Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120. BMC Neurosci 2005; 6: 8
   PubMed Web of Science ®Google Scholar
• Langford D, Masliah E. Crosstalk between components of the blood brain barrier and cells of the CNS in microglial activation in AIDS. Brain Pathol 2001; 11: 306–312
   PubMed Web of Science ®Google Scholar
• Langford T D, Letendre S L, Marcotte T D, Ellis R J, McCutchan J A, Grant I, Mallory M E, Hansen L A, Archibald S, Jernigan T, Masliah E. Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy. AIDS 2002; 16: 1019–1029
   PubMed Web of Science ®Google Scholar
• Lannuzel A, Barnier J V, Hery C, Huynh V T, Guibert B, Gray F, Vincent J D, Tardieu M. Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. Ann Neurol 1997; 42: 847–856
   Google Scholar
• Laubenberger J, Haussinger D, Bayer S, Thielemann S, Schneider B, Mundinger A, Hennig J, Langer M. HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times. Radiology 1996; 199: 805–810
   PubMed Web of Science ®Google Scholar
• Lawrence D M, Durham L C, Schwartz L, Seth P, Maric D, Major E O. Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J Virol 2004; 78: 7319–7328
   PubMed Web of Science ®Google Scholar
• Lawrence D M, Major E O. HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology. Microbes Infect 2002; 4: 301–308
   PubMed Web of Science ®Google Scholar
• Lee P L, Yiannoutsos C T, Ernst T, Chang L, Marra C M, Jarvik J G, Richards T L, Kwok E W, Kolson D L, Simpson D, Tang C Y, Schifitto G, Ketonen L M, Meyerhoff D J, Lenkinski R E, Gonzalez R G, Navia B A. A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. J Magn Reson Imaging 2003; 17: 625–633
   PubMed Web of Science ®Google Scholar
• Lentz M R, Kim J P, Westmoreland S V, Greco J B, Fuller R A, Ratai E M, He J, Sehgal P K, Halpern E F, Lackner A A, Masliah E, Gonzalez R G. Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology 2005; 235: 461–468
   Google Scholar
• Letendre S L, Woods S P, Ellis R J, Atkinson J H, Masliah E, van den Brande G, Durelle J, Grant I, Everall I. Lithium improves HIV-associated neurocognitive impairment. Aids 2006; 20: 1885–1888
   PubMed Web of Science ®Google Scholar
• Li W, Galey D, Mattson M P, Nath A. Molecular and cellular mechanisms of neuronal cell death in HIV dementia. Neurotox Res 2005; 8: 119–134
   PubMed Web of Science ®Google Scholar
• Lie D C, Colamarino S A, Song H J, Desire L, Mira H, Consiglio A, Lein E S, Jessberger S, Lansford H, Dearie A R, Gage F H. Wnt signalling regulates adult hippocampal neurogenesis. Nature 2005; 437: 1370–1375
   PubMed Web of Science ®Google Scholar
• Lipton S. HIV-related neurotoxicity. Brain Pathol 1992a; 1: 193–199
   Google Scholar
• Lipton S. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuro Report 1992b; 3: 913–915
   PubMed Web of Science ®Google Scholar
• Lipton S A, Brenneman D E, Silverstein F S, Masliah E, Mucke L. gp120 and neurotoxicity in vivo. Trends Pharmacol Sci 1995; 16: 122
   Google Scholar
• Lopez-Villegas D, Lenkinski R E, Frank I. Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 1997; 94: 9854–9859
   PubMed Web of Science ®Google Scholar
• Maggirwar S B, Tong N, Ramirez S, Gelbard H A, Dewhurst S. HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. J Neurochem 1999; 73: 578–586
   PubMed Web of Science ®Google Scholar
• Maragos W F, Young K L, Turchan J T, Guseva M, Pauly J R, Nath A, Cass W A. Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function. J Neurochem 2002; 83: 955–963
   PubMedGoogle Scholar
• Marcondes M C, Burudi E M, Huitron-Resendiz S, Sanchez-Alavez M, Watry D, Zandonatti M, Henriksen S J, Fox H S. Highly activated CD8(+) T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. J Immunol 2001; 167: 5429–5438
   PubMed Web of Science ®Google Scholar
• Marcus C D, Taylor-Robinson S D, Sargentoni J, Ainsworth J G, Frize G, Easterbrook P J, Shaunak S, Bryant D J. 1H MR spectroscopy of the brain in HIV-1-seropositive subjects: evidence for diffuse metabolic abnormalities. Metab Brain Dis 1998; 13: 123–136
   PubMed Web of Science ®Google Scholar
• Martin-Garcia J, Kolson D L, Gonzalez-Scarano F. Chemokine receptors in the brain: their role in HIV infection and pathogenesis. AIDS 2002; 16: 1709–1730
   PubMed Web of Science ®Google Scholar
• Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 2000; 69: 376–380
   PubMed Web of Science ®Google Scholar
• Masliah E, Achim C, Ge N, DeTeresa R, Terry R, Wiley C. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 1992a; 32: 321–329
   PubMed Web of Science ®Google Scholar
• Masliah E, Ge N, Achim C, DeTeresa R, Wiley C. Patterns of neurodegeneration in HIV encephalitis. Neuro AIDS 1996; 1: 161–173
   PubMedGoogle Scholar
• Masliah E, Ge N, Achim C, Hansen L, Wiley C. Selective neuronal vulnerability in HIV encephalitis. J Neuropathol Exp Neurol 1992b; 51: 585–593
   PubMed Web of Science ®Google Scholar
• Masliah E, Ge N, Achim C, Wiley C. Differential vulnerability of calbindin-immunoreactive neurons in HIV encephalitis. J Neuropathol Exp Neurol 1995; 54: 350–357
   PubMedGoogle Scholar
• Masliah E, Heaton R K, Marcotte T D, Ellis R J, Wiley C A, Mallory M, Achim C L, McCutchan J A, Nelson J A, Atkinson J H, Grant I. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol 1997; 42: 963–972
   PubMed Web of Science ®Google Scholar
• Masliah E, Roberts E S, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox H S. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol 2004; 157: 163–175
   Web of Science ®Google Scholar
• Mattson M P. Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease. J Neuro Virol 2002; 8: 539–550
   PubMed Web of Science ®Google Scholar
• Mattson M P, Haughey N J, Nath A. Cell death in HIV dementia. Cell Death Differ 2005; 12(Suppl 1)893–904
   PubMedGoogle Scholar
• McArthur J C, Haughey N, Gartner S, Conant K, Pardo C, Nath A, Sacktor N. Human immunodeficiency virus-associated dementia: an evolving disease. J Neuro Virol 2003; 9: 205–221
   PubMed Web of Science ®Google Scholar
• McArthur J C, McClernon D R, Cronin M F, Nance-Sproson T E, Saah A J, St Clair M, Lanier E R. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 1997; 42: 689–698
   PubMed Web of Science ®Google Scholar
• Menon D K, Ainsworth J G, Cox I J, Coker R C, Sargentoni J, Coutts G A, Baudouin C J, Kocsis A E, Harris J R. Proton MR spectroscopy of the brain in AIDS dementia complex. J Comput Assist Tomogr 1992; 16: 538–542
   Google Scholar
• Meucci O, Fatatis A, Simen A A, Bushell T J, Gray P W, Miller R J. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 1998; 95: 14500–14505
   PubMed Web of Science ®Google Scholar
• Meyerhoff D J, Bloomer C, Cardenas V, Norman D, Weiner M W, Fein G. Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 1999; 52: 995–1003
   PubMed Web of Science ®Google Scholar
• Meyerhoff D J, MacKay S, Bachman L, Poole N, Dillon W P, Weiner M W, Fein G. Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging. Neurology 1993; 43: 509–515
   Google Scholar
• Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 2002; 202: 13–23
   PubMed Web of Science ®Google Scholar
• Mirra S, del Rio C. The fine structure of acquired immunodeficiency syndrome encephalopathy. Arch Pathol Lab Med 1989; 113: 858–865
   Google Scholar
• Moore D J, Masliah E, Rippeth J D, Gonzalez R, Carey C L, Cherner M, Ellis R J, Achim C L, Marcotte T D, Heaton R K, Grant I. Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. AIDS 2006; 20: 879–887
   PubMed Web of Science ®Google Scholar
• Narayan O, Joag S, Stephens E. Selected models of HIV-induced neurological disease. Curr Topics Microbiol Immunol 1995; 202: 151–166
   PubMed Web of Science ®Google Scholar
• Nath A. Pathobiology of human immunodeficiency virus dementia. Semin Neurol 1999; 19: 113–127
   Google Scholar
• Nath A. Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia. J Infect Dis 2002; 186(Suppl 2)S193–S198
   PubMed Web of Science ®Google Scholar
• Nath A, Maragos W F, Avison M J, Schmitt F A, Berger J R. Acceleration of HIV dementia with methamphetamine and cocaine. J Neuro Virol 2001; 7: 66–71
   PubMed Web of Science ®Google Scholar
• Okamoto S, Kang Y-J, Brechtel C W, Siviglia E, Russo R, Clemente A, Harrop A, McKercher S, Kaul M, Lipton S A. HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell- cycle withdrawal and G1 arrest. Cell Stem Cell 2007; 1: 230–236
   PubMed Web of Science ®Google Scholar
• Olson A K, Eadie B D, Ernst C, Christie B R. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 2006; 16: 250–260
   PubMed Web of Science ®Google Scholar
• Orandle M S, MacLean A G, Sasseville V G, Alvarez X, Lackner A A. Enhanced expression of proinflammatory cytokines in the central nervous system is associated with neuroinvasion by simian immunodeficiency virus and the development of encephalitis. J Virol 2002; 76: 5797–5802
   Google Scholar
• Persidsky Y, Gendelman H E. Murine models for human immunodeficiency virus type 1-associated dementia: the development of new treatment testing paradigms. J Neuro Virol 2002; 8(Suppl 2)49–52
   Google Scholar
• Pulliam L, Clarke J A, McGuire D, McGrath M S. Investigation of HIV-infected macrophage neurotoxin production from patients with AIDS dementia. Adv Neuroimmunol 1994; 4: 195–198
   PubMedGoogle Scholar
• Pulliam L, Herndier B, Tang N, McGrath M. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 1991; 87: 503–512
   PubMedGoogle Scholar
• Pulliam L, Zhou M, Stubblebine M, Bitler C M. Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. J Neurosci Res 1998; 54: 530–538
   PubMed Web of Science ®Google Scholar
• Reid W, Sadowska M, Denaro F, Rao S, Foulke J, Jr, Hayes N, Jones O, Doodnauth D, Davis H, Sill A, O'Driscoll P, Huso D, Fouts T, Lewis G, Hill M, Kamin-Lewis R, Wei C, Ray P, Gallo R C, Reitz M, Bryant J. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc Natl Acad Sci U S A 2001; 98: 9271–9276
   PubMed Web of Science ®Google Scholar
• Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose J B, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci 2007; 27: 1981–1991
   PubMed Web of Science ®Google Scholar
• Rusnati M, Urbinati C, Musulin B, Ribatti D, Albini A, Noonan D, Marchisone C, Waltenberger J, Presta M. Activation of endothelial cell mitogen activated protein kinase ERK(1/2) by extracellular HIV-1 Tat protein. Endothelium 2001; 8: 65–74
   PubMed Web of Science ®Google Scholar
• Ryan L A, Cotter R L, Zink W E, 2nd, Gendelman H E, Zheng J. Macrophages, chemokines and neuronal injury in HIV-1-associated dementia. Cell Mol Biol (Noisy-le-grand) 2002; 48: 137–150
   Google Scholar
• Sacktor N, McDermott M P, Marder K, Schifitto G, Selnes O A, McArthur J C, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida J A, Cohen B, Epstein L. HIV-associated cognitive impairment before and after the advent of combination therapy. J Neuro Virol 2002; 8: 136–142
   PubMed Web of Science ®Google Scholar
• Sanders V J, Pittman C A, White M G, Wang G, Wiley C A, Achim C L. Chemokines and receptors in HIV encephalitis. AIDS 1998; 12: 1021–1026
   PubMed Web of Science ®Google Scholar
• Schmitz J E, Kuroda M J, Santra S, Sasseville V G, Simon M A, Lifton M A, Racz P, Tenner-Racz K, Dalesandro M, Scallon B J, Ghrayeb J, Forman M A, Montefiori D C, Rieber E P, Letvin N L, Reimann K A. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 1999a; 283: 857–860
   PubMed Web of Science ®Google Scholar
• Schmitz J E, Simon M A, Kuroda M J, Lifton M A, Ollert M W, Vogel C W, Racz P, Tenner-Racz K, Scallon B J, Dalesandro M, Ghrayeb J, Rieber E P, Sasseville V G, Reimann K A. A nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody. Am J Pathol 1999b; 154: 1923–1932
   PubMedGoogle Scholar
• Schwartz G K, Shah M A. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 2005; 23: 9408–9421
   PubMed Web of Science ®Google Scholar
• Simon M A, Chalifoux L V, Ringler D J. Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution. AIDS Res Hum Retroviruses 1992; 8: 327–337
   Google Scholar
• Sopper S, Sauer U, Hemm S, Demuth M, Muller J, Stahl-Hennig C, Hunsmann G, ter Meulen V, Dorries R. Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques. J Virol 1998; 72: 9940–9947
   Google Scholar
• Speth C, Dierich M P, Sopper S. HIV-infection of the central nervous system: the tightrope walk of innate immunity. Mol Immunol 2005; 42: 213–228
   PubMed Web of Science ®Google Scholar
• Stankoff B, Tourbah A, Suarez S, Turell E, Stievenart J L, Payan C, Coutellier A, Herson S, Baril L, Bricaire F, Calvez V, Cabanis E A, Lacomblez L, Lubetzki C. Clinical and spectroscopic improvement in HIV-associated cognitive impairment. Neurology 2001; 56: 112–115
   PubMed Web of Science ®Google Scholar
• Stephens E B, Liu Z Q, Zhu G W, Adany I, Joag S V, Foresman L, Berman N E, Narayan O. Lymphocyte-tropic simian immunodeficiency virus causes persistent infection in the brains of rhesus monkeys. Virology 1995; 213: 600–614
   Google Scholar
• Sundar S, Cierpial M, Kamaraju L, Long S, Hsieh S, Lorenz C, Aaron M, Ritchie J, Weiss J. Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decreased peripheral cellular immune responses. Proc Natl Acad Sci U S A 1991; 88: 11246–11250
   PubMed Web of Science ®Google Scholar
• Tarasow E, Wiercinska-Drapalo A, Kubas B, Dzienis W, Orzechowska-Bobkiewicz A, Prokopowicz D, Walecki J. Cerebral MR spectroscopy in neurologically asymptomatic HIV-infected patients. Acta Radiol 2003; 44: 206–212
   Google Scholar
• Toggas S, Masliah E, Mucke L. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor atagonist memantine. Brain Res 1996; 706: 303–307
   PubMed Web of Science ®Google Scholar
• Toggas S, Masliah E, Rockenstein E, Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 1994; 367: 188–193
   PubMed Web of Science ®Google Scholar
• Tracey I, Carr C A, Guimaraes A R, Worth J L, Navia B A, Gonzalez R G. Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: a proton magnetic resonance spectroscopic study. Neurology 1996; 46: 783–788
   Google Scholar
• Tracey I, Hamberg L M, Guimaraes A R, Hunter G, Chang I, Navia B A, Gonzalez R G. Increased cerebral blood volume in HIV-positive patients detected by functional MRI. Neurology 1998; 50: 1821–1826
   Web of Science ®Google Scholar
• Tran P B, Miller R J. HIV-1, chemokines and neurogenesis. Neurotox Res 2005; 8: 149–158
   Google Scholar
• Turchan J, Pocernich C B, Gairola C, Chauhan A, Schifitto G, Butterfield D A, Buch S, Narayan O, Sinai A, Geiger J, Berger J R, Elford H, Nath A. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 2003; 60: 307–314
   PubMed Web of Science ®Google Scholar
• van Marle G, Antony J M, Silva C, Sullivan A, Power C. Aberrant cortical neurogenesis in a pediatric neuro AIDS model: neurotrophic effects of growth hormone. AIDS 2005; 19: 1781–1791
   PubMed Web of Science ®Google Scholar
• Vigorito M, LaShomb A L, Chang S L. Spatial learning and memory in HIV-1 transgenic rats. J Neuroimmune Pharmacol 2007; 2: 319–328
   Google Scholar
• Wang Z, Trillo-Pazos G, Kim S Y, Canki M, Morgello S, Sharer L R, Gelbard H A, Su Z Z, Kang D C, Brooks A I, Fisher P B, Volsky D J. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J Neuro Virol 2004; 10(Suppl 1)25–32
   PubMedGoogle Scholar
• Weis S, Haug H, Budka H. Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study. Acta Neuropathol 1993; 85: 185–189
   Google Scholar
• Westmoreland S V, Halpern E, Lackner A A. Simian immunodeficiency virus encephalitis in rhesus macaques is asociated with rapid disease progression. J Neuro Virol 1998; 4: 260–268
   Web of Science ®Google Scholar
• Westmoreland S V, Kolson D, Gonzalez-Scarano F. Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. J Neuro Virol 1996; 2: 118–126
   PubMed Web of Science ®Google Scholar
• Wiley C, Achim C. HIV encephalitis is the pathologic correlate of dementia in AIDS. Ann Neurol 1994; 36: 673–676
   PubMedGoogle Scholar
• Wiley C, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R. Neocortical damage during HIV infection. Ann Neurol 1991a; 29: 651–657
   PubMed Web of Science ®Google Scholar
• Wiley C A. Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol 2003; 13: 415, author reply 415–416
   Google Scholar
• Wiley C A, Masliah E, Achim C L. Measurement of CNS HIV burden and its association with neurologic damage. Adv Neuroimmunol 1994; 4: 319–325
   PubMedGoogle Scholar
• Wiley C A, Schrier R D, Morey M, Achim C, Venable J C, Nelson J A. Pathogenesis of HIV encephalitis. Acta Pathol Jpn 1991b; 41: 192–196
   Google Scholar
• Wilkinson I D, Lunn S, Miszkiel K A, Miller R F, Paley M N, Williams I, Chinn R J, Hall-Craggs M A, Newman S P, Kendall B E, Harrison M J. Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS. J Neurol Neurosurg Psychiatry 1997; 63: 477–482
   Google Scholar
• Williams K, Westmoreland S, Greco J, Ratai E, Lentz M, Kim W K, Fuller R A, Kim J P, Autissier P, Sehgal P K, Schinazi R F, Bischofberger N, Piatak M, Lifson J D, Masliah E, Gonzalez R G. Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS. J Clin Invest 2005; 115: 2534–2545
   PubMed Web of Science ®Google Scholar
• Williams K C, Corey S, Westmoreland S V, Pauley D, Knight H, deBakker C, Alvarez X, Lackner A A. Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS. J Exp Med 2001; 193: 905–915
   PubMed Web of Science ®Google Scholar
• Xiong H, Zeng Y C, Lewis T, Zheng J, Persidsky Y, Gendelman H E. HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. J Neuro Virol 2000; 6(Suppl 1)S14–S23
   Google Scholar
• Yi Y, Lee C, Liu Q H, Freedman B D, Collman R G. Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis. J Neuro Virol 2004; 10(Suppl 1)91–96
   Google Scholar
• Zink M C, Clements J E. A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. J Neuro Virol 2002; 8(Suppl 2)42–48
   PubMed Web of Science ®Google Scholar
• Zink M C, Spelman J P, Robinson R B, Clements J E. SIV infection of macaques—modeling the progression to AIDS dementia. J Neuro Virol 1998; 4: 249–259
   Web of Science ®Google Scholar
• Zink W E, Anderson E, Boyle J, Hock L, Rodriguez-Sierra J, Xiong H, Gendelman H E, Persidsky Y. Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. J Neurosci 2002; 22: 2096–2105
   Google Scholar