The proteoglycan bamacan is a host cellular ligand of vaccinia virus neurovirulence factor N1L

References

• Abrahams MR, Zhang Z, Chien S, Skerns T, Kotwal G. The vaccinia virus N1L ORF may encode a multifunctional protein possibly targeting different kinases, one of which influences ATP levels in vivo. Ann N Y Acad Sci 2005; 1056: 87–99
   Google Scholar
• Agnes JT, Garcia A, Meseda CA, He Y, Weiss C, Kumar A, Weir JP, Merchlinsky M. Identification and preliminary characterization of vaccinia virus (Dryvax) antigens recognized by vaccinia immune globulin. Virology 2005; 343: 128–140
   Google Scholar
• Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci 2007; 16: 118–124
   PubMed Web of Science ®Google Scholar
• Argyris EG, Acheampong E, Nunnari G, Mukhtar M, Williams KJ, Pomerantz RJ. Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts. J Virol 2003; 77: 12140–12151
   PubMed Web of Science ®Google Scholar
• Bartlett N, Symons JA, Tscharke DC, Smith GL. The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence. J Gen Virol 2002; 83: 1965–1976
   PubMedGoogle Scholar
• Billings B, Smith SA, Zhang Z, Lahiri DK, Kotwal GJ. Lack of N1L gene expression results in a significant decrease of vaccinia virus replication in mouse brain. Ann N Y Acad Sci 2004; 1030: 297–302
   Google Scholar
• Bobardt MD, Salmon P, Wang L, Esko JD, Gabuzda D, Fiala M, Trono D, Van der Schueren B, David G, Gallay PA. Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol 2004; 78: 6567–6584
   PubMed Web of Science ®Google Scholar
• Chung CS, Hsiao JC, Chang YS, Chang W. A27L protein mediates vaccinia virus interaction with cell surface heparan sulfate. J Virol 1998; 72: 1577–1585
   PubMed Web of Science ®Google Scholar
• Cono J, Casey CJ, Bell DM. Centers for Disease Control and Prevention, Smallpox vaccination and adverse reactions. Guidance for clinicians. MMWR Recomm Rep 2003; 52: 1–28
   PubMedGoogle Scholar
• Cooray S, Bahar MW, Abrescia NG, McVey CE, Bartlett NW, Chen RA, Stuart DI, Grimes JM, Smith GL. Functional and structural studies of the vaccinia virus virulence factor N1L reveal a Bcl-2-like anti-apoptotic protein. J Gen Virol 2007; 88: 1656–1666
   PubMedGoogle Scholar
• DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem 2004; 279: 36570–36578
   PubMed Web of Science ®Google Scholar
• Eijpe M, Heyting C, Gross B, Jessberger R. Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes. J Cell Sci 2000; 113: 673–682
   PubMedGoogle Scholar
• Fields S, Song O. A novel genetic system to detect protein-protein interactions. Nature 1989; 340: 245–246
   PubMed Web of Science ®Google Scholar
• Ghiselli G, Iozzo RV. Overexpression of bamacan/SMC3 causes transformation. J Biol Chem 2000; 275: 20235–20238
   PubMed Web of Science ®Google Scholar
• Ghiselli G, Siracusa LD, Iozzo RV. Complete cDNA cloning, genomic organization, chromosomal assignment, functional characterization of the promoter, and expression of the murine Bamacan gene. J Biol Chem 1999; 274: 17384–17393
   Google Scholar
• Guharoy R, Panzik R, Noviasky JA, Krenzelok EP, Blair DC. Smallpox: clinical features, prevention, and management. Ann Pharmacother 2004; 38: 440–447
   PubMed Web of Science ®Google Scholar
• Hsiao JC, Chung CS, Chang W. Vaccinia virus envelope D8L protein binds to cell surface chondroitin sulfate and mediates the adsorption of intracellular mature virions to cells. J Virol 1999; 73: 8750–8761
   PubMed Web of Science ®Google Scholar
• Kotwal GJ, Hugin AW, Moss B. Mapping and insertional mutagenesis of a vaccinia virus gene encoding a 13,800-Da secreted protein. Virology 1989; 171: 579–587
   PubMedGoogle Scholar
• Li Z, Rubin SA, Taffs RE, Merchlinsky M, Ye Z, Carbone KM. Mouse neurotoxicity test for vaccinia-based smallpox vaccines. Vaccine 2004; 22: 1486–1493
   Google Scholar
• Lin CL, Chung CS, Hiene HG, Chang W. Vaccinia virus envelope H3L protein binds to cell surface heparan sulfate and is important for intracellular mature virion morphogenesis and virus infection in vitro and in vivo. J Virol 2000; 74: 3353–3365
   PubMed Web of Science ®Google Scholar
• Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS ONE 2008; 3: e3323
   Google Scholar
• Misinzo G, Delputte PL, Meerts P, Lefebvre DJ, Nauwynck HJ. Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells. J Virol 2006; 80: 3487–3494
   PubMed Web of Science ®Google Scholar
• Mohan KV, Ghebrehiwet B, Atreya CD. The N-terminal conserved domain of rubella virus capsid interacts with the C-terminal region of cellular p32 and overexpression of p32 enhances the viral infectivity. Virus Res 2002; 85: 151–161
   Google Scholar
• Mohan KV, Som I, Atreya CD. Identification of a peroxisomal targeting signal 1(PTS1) containing viral protein and its targeting to peroxisomes. J Virol 2002; 76: 2543–2547
   Google Scholar
• Mohan KV, Som I, Muller J, Atreya CD. The N- and C-terminal regions of rotavirus NSP5 are the critical determinants for the formation of viroplasm-like structures independent of NSP2. J Virol 2003; 77: 12184–12192
   Google Scholar
• Pouvelle B, Buffet PA, Lépolard C, Scherf A, Gysin J. Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes. Nat Med 2000; 6: 1264–1268
   Google Scholar
• Romanov VA, Bereshkova RV. Pathomorphological and immunofluorescent studies of smallpox vaccine neurotropism. Zh Mikrobiol Epidemiol Immunobiol (Russian) 1975; 6: 66–72
   Google Scholar
• Smith GL, McFadden G. Smallpox: anything to declare?. Nat Rev Immunol 2002; 2: 521–527
   PubMed Web of Science ®Google Scholar
• Wu RR, Couchman JR. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs. J Cell Biol 1997; 136: 433–444
   PubMed Web of Science ®Google Scholar
• Zhang Z, Abrahams MR, Hunt LA, Suttles J, Marshall W, Lahiri DK, Kotwal GJ. The vaccinia virus N1L protein influences cytokine secretion in vitro after infection. Ann N Y Acad Sci 2005; 1056: 69–86
   Google Scholar