Herbal teas can be harmful: a case of Peganum harmala induced coma in a patient with Parkinson’s disease

References

• Abdel-Fattah, A.-F. M., Matsumoto, K., Murakami, Y., El-Hady, K. A.-W., Mohamed, M. F., & Watanabe, H. (1996). Facilitatory and inhibitory effects of harmaline on the tryptophan-induced 5-hydroxytryptamine syndrome and body temperature changes in pargyline-pretreated rats. Japanese Journal of Pharmacology, 72 (1), 39–47. https://doi.org/10.1254/jjp.72.39
   Google Scholar
• Arshad, N., Zitterl‐Eglseer, K., Hasnain, S., & Hess, M. (2008). Effect of Peganum harmala or its β‐carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22, 1533–1538. https://doi.org/10.1002/ptr.2528
   Google Scholar
• Ben, N. S., Amamou, M., Jerbi, Z., Ben, F. S., & Yacoub, M. (1986). A case of overdose with Peganum harmala L. Journal de toxicologie clinique et experimentale, 6, 319–322.
   PubMedGoogle Scholar
• Chen, Q., Chao, R., Chen, H., Hou, X., Yan, H., Zhou, S., Peng, W., & Xu, A. (2005). Antitumor and neurotoxic effects of novel harmine derivatives and structure‐activity relationship analysis. International Journal of Cancer, 114, 675–682. https://doi.org/10.1002/ijc.20703
   PubMed Web of Science ®Google Scholar
• Di Giorgio, C., Delmas, F., Ollivier, E., Elias, R., Balansard, G., & Timon-David, P. (2004). In vitro activity of the β-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Experimental Parasitology, 106, 67–74. https://doi.org/10.1016/j.exppara.2004.04.002
   PubMed Web of Science ®Google Scholar
• Edmondson, D. E., & Binda, C. (2018). Monoamine oxidases. In J. R. Harris & E. Boekema (Eds.), Membrane protein complexes: Structure and function (pp. 117–139). Springer.
   Google Scholar
• Fortunato, J. J., Reus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2009). Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33, 1425–1430. https://www.ncbi.nlm.nih.gov/pubmed/19632287
   PubMed Web of Science ®Google Scholar
• Handforth, A. (2012). Harmaline tremor: Underlying mechanisms in a potential animal model of essential tremor. Tremor and Other Hyperkinetic Movements, 2. https://doi.org/10.5334/tohm.108
   PubMedGoogle Scholar
• Herraiz, T., González, D., Ancín-Azpilicueta, C., Arán, V., & Guillén, H. (2010). β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48, 839–845. https://doi.org/10.1016/j.fct.2009.12.019
   PubMed Web of Science ®Google Scholar
• Kaplan, M. (2020). Holistic/integrated approach in folk medicine: The example of Peganum Harmala (Üzerlik). Ankara University the Journal of the Faculty of Languages and History-Geography, 60, 415–430.
   Google Scholar
• Kosmowska, B., Ossowska, K., & Wardas, J. (2020). Pramipexole reduces zif-268 mRNA expression in brain structures involved in the generation of harmaline-induced tremor. Neurochemical Research, 1–8. https://doi.org/10.1007/s11064-019-02924-z
   PubMed Web of Science ®Google Scholar
• Lamchouri, F., Settaf, A., Cherrah, Y., El Hamidi, M., Tligui, N., Lyoussi, B., & Hassar, M. (2002). Experimental toxicity of Peganum harmala seeds. Annales Pharmaceutiques Francaises, 60, 123–129. https://www.ncbi.nlm.nih.gov/pubmed/11976557
   PubMedGoogle Scholar
• Li, S., Liu, W., Teng, L., Cheng, X., Wang, Z., & Wang, C. (2014). Metabolites identification of harmane in vitro/in vivo in rats by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 92, 53–62. https://www.ncbi.nlm.nih.gov/pubmed/24486683
   PubMed Web of Science ®Google Scholar
• Mahmoudian, M., Jalipour, H., & Salehian Dardashti, P. (2002). Toxicity of Peganum harmala: Review and a case report. Iranian Journal of Pharmacology and Therapeutics, 1, 1.
   Google Scholar
• Moloudizargari, M., Mikaili, P., Aghajanshakeri, S., Asghari, M. H., & Shayegh, J. (2013). Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy Reviews, 7, 199. https://doi.org/10.4103/0973-7847.120524
   PubMedGoogle Scholar
• Ossowska, K., Głowacka, U., Kosmowska, B., & Wardas, J. (2015). Apomorphine enhances harmaline-induced tremor in rats. Pharmacological Reports, 67, 435–441. https://doi.org/10.1016/j.pharep.2014.11.008
   PubMed Web of Science ®Google Scholar
• Paterson, N. E., Malekiani, S. A., Foreman, M. M., Olivier, B., & Hanania, T. (2009). Pharmacological characterization of harmaline-induced tremor activity in mice. European Journal of Pharmacology, 616, 73–80. https://doi.org/10.1016/j.ejphar.2009.05.031
   PubMed Web of Science ®Google Scholar
• Ruiz-Durántez, E., Ruiz-Ortega, J. Á., Pineda, J., & Ugedo, L. (2001). Stimulatory effect of harmane and other β-carbolines on locus coeruleus neurons in anaesthetized rats. Neuroscience Letters, 308, 197–200. https://doi.org/10.1016/S0304-3940(01)02010-9
   PubMed Web of Science ®Google Scholar
• Shi, -C.-C., Liao, J.-F., & Chen, C.-F. (2001). Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro. Japanese Journal of Pharmacology, 85, 299–305. https://doi.org/10.1254/jjp.85.299
   PubMedGoogle Scholar
• Wang, Y., Wang, H., Zhang, L., Zhang, Y., Sheng, Y., Deng, G., Wang, Y., Wang, H., Cao, N., Guan, H., Cheng, X., & Li, S. (2019). Subchronic toxicity and concomitant toxicokinetics of long-term oral administration of total alkaloid extracts from seeds of Peganum harmala Linn: A 28-day study in rats. Journal of Ethnopharmacology, 238, 111866. https://doi.org/10.1016/j.jep.2019.111866
   PubMed Web of Science ®Google Scholar
• Xing, M., Shen, F., Liu, L., Chen, Z., Guo, N., Wang, X., Zhang, X., Wu, X., Wang, X., Li, Y., Sun, S., Yu, L., & Wang, W. (2012). Antimicrobial efficacy of the alkaloid harmaline alone and in combination with chlorhexidine digluconate against clinical isolates of Staphylococcus aureus grown in planktonic and biofilm cultures. Letters in Applied Microbiology, 54, 475–482. https://doi.org/10.1111/j.1472-765X.2012.03233.x
   PubMed Web of Science ®Google Scholar
• Yu, A.-M., Idle, J. R., Krausz, K. W., Küpfer, A., & Gonzalez, F. J. (2003). Contribution of individual cytochrome P450 isozymes to the O-Demethylation of the psychotropic β-carboline alkaloids harmaline and harmine. Journal of Pharmacology and Experimental Therapeutics, 305, 315–322. https://doi.org/10.1124/jpet.102.047050
   PubMed Web of Science ®Google Scholar
• Yuruktumen, A., Karaduman, S., Bengi, F., & Fowler, J. (2008). Syrian rue tea: A recipe for disaster. Clinical Toxicology, 46, 749–752. https://doi.org/10.1080/15563650701323205
   Web of Science ®Google Scholar